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Protein

Toxin RTX-III translocation ATP-binding protein

Gene

apxIIIB

Organism
Actinobacillus pleuropneumoniae (Haemophilus pleuropneumoniae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the transport of the toxin RTX-III.

Miscellaneous

The sequence shown is that of serotype 2.

Caution

Tyr-13 is present instead of the conserved Cys which is expected to be the active site residue of peptidase C39. Thus they are presumed to be without peptidase activity.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei87PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi506 – 513ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCytolysis, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Toxin RTX-III translocation ATP-binding protein
Alternative name(s):
APX-IIIB
Cytolysin IIIB
Short name:
CLY-IIIB
RTX-III toxin determinant B
Gene namesi
Name:apxIIIB
Synonyms:clyIIIB, rtxB
OrganismiActinobacillus pleuropneumoniae (Haemophilus pleuropneumoniae)
Taxonomic identifieri715 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei162 – 182HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei195 – 215HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei273 – 293HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei299 – 319HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei392 – 412HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000923911 – 711Toxin RTX-III translocation ATP-binding proteinAdd BLAST711

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ04473
SMRiQ04473
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 129Peptidase C39PROSITE-ProRule annotationAdd BLAST129
Domaini158 – 440ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST283
Domaini472 – 707ABC transporterPROSITE-ProRule annotationAdd BLAST236

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd02417 Peptidase_C39_likeA, 1 hit
Gene3Di1.20.1560.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR010132 ATPase_T1SS_HlyB
IPR027417 P-loop_NTPase
IPR005074 Peptidase_C39
IPR039395 Peptidase_C39_likeA
PfamiView protein in Pfam
PF00664 ABC_membrane, 1 hit
PF00005 ABC_tran, 1 hit
PF03412 Peptidase_C39, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF90123 SSF90123, 1 hit
TIGRFAMsiTIGR01846 type_I_sec_HlyB, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit
PS50990 PEPTIDASE_C39, 1 hit

Sequencei

Sequence statusi: Complete.

Q04473-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESQMPFNEK IDYGLHALVI LAQYHNVAVN PEEVKHKFDL DGKGLDLVAW
60 70 80 90 100
LLAAKSLELK MKRVKKSIER LPFIHLPALI WRDDGQHVIL MKIDTQTNRY
110 120 130 140 150
LIFDLEERNP KVLSAAEFHE IFQGGMILIT SRASIMGQLA KFDFTWFIPA
160 170 180 190 200
VIKYRKIFVE TIIVSIFLQL FALITPLFFQ VVMDKVLVHR GFSTLNVITV
210 220 230 240 250
ALSVVVIFEI VLSGLRTYIF SHSTSRIDVE LGAKLFRHLL ALPISYFENR
260 270 280 290 300
RVGDTVARVR ELDQIRNFLT GQALTSVLDL LFSFIFFAVM WYYSPKLTIV
310 320 330 340 350
ILLSLPCYIA WSIFISPILR RRLDEKFARN ADNQSFLVES VSAIDTIKAL
360 370 380 390 400
AVTPQMTNIW DKQLASYVSA DFRVTVLATI GQQGVQLIQK TVMIINLWLG
410 420 430 440 450
AHLVISGDLS IGQLITFNML SGQVIAPVVR LAQLWQDFQQ VGISITRLGD
460 470 480 490 500
VLNSPTENYQ GKLSLPEIFG DIAFKHIRFR YKPDAPIILD DVNLSVKQGE
510 520 530 540 550
VIGIVGRSGS GKSTLTKLLQ RFYIPENGQV LIDGHDLALA DPNWLRRQIG
560 570 580 590 600
VVLQDNVLLN RSIRDNIALT DPSMSMERVI YAAKLAGAHD FISELREGYN
610 620 630 640 650
TIVGELGAGL SGGQRQRIAI ARALVNNPRI LIFDEATSAL DYESEHIIMQ
660 670 680 690 700
NMQKICHGRT VIIIAHRLST VKNADRIIVM EKGHIVEQGK HNQLLENENG
710
LYYYLNQLQS N
Length:711
Mass (Da):80,406
Last modified:November 1, 1995 - v1
Checksum:i5B8E46B889D12D92
GO

Sequence cautioni

The sequence CAA48712 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti61M → A in serotype 8. 1
Natural varianti91M → T in serotype 8. 1
Natural varianti125 – 126GM → DV in serotype 8. 2
Natural varianti213S → N in serotype 8. 1
Natural varianti416T → A in serotype 8. 1
Natural varianti469F → K in serotype 8. 1
Natural varianti606L → Q in serotype 8. 1
Natural varianti638S → R in serotype 8. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12145 Genomic DNA Translation: AAA21925.1
X80055 Genomic DNA Translation: CAA56359.1
X68815 Genomic DNA Translation: CAA48712.1 Different initiation.
PIRiS51785 C49219

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12145 Genomic DNA Translation: AAA21925.1
X80055 Genomic DNA Translation: CAA56359.1
X68815 Genomic DNA Translation: CAA48712.1 Different initiation.
PIRiS51785 C49219

3D structure databases

ProteinModelPortaliQ04473
SMRiQ04473
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd02417 Peptidase_C39_likeA, 1 hit
Gene3Di1.20.1560.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR010132 ATPase_T1SS_HlyB
IPR027417 P-loop_NTPase
IPR005074 Peptidase_C39
IPR039395 Peptidase_C39_likeA
PfamiView protein in Pfam
PF00664 ABC_membrane, 1 hit
PF00005 ABC_tran, 1 hit
PF03412 Peptidase_C39, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF90123 SSF90123, 1 hit
TIGRFAMsiTIGR01846 type_I_sec_HlyB, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit
PS50990 PEPTIDASE_C39, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRTX3B_ACTPL
AccessioniPrimary (citable) accession number: Q04473
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 12, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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