UniProtKB - Q04418 (RBA50_YEAST)
Protein
RNA polymerase II-associated protein RBA50
Gene
RBA50
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation.By similarity1 Publication
Miscellaneous
Present with 688 molecules/cell in log phase SD medium.1 Publication
GO - Biological processi
- transcription by RNA polymerase II Source: SGD
Keywordsi
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: RNA polymerase II-associated protein RBA50Alternative name(s): RNA polymerase II-associated protein of 50 kDa |
Gene namesi | Name:RBA50 Ordered Locus Names:YDR527W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000002935, RBA50 |
VEuPathDBi | FungiDB:YDR527W |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000255972 | 1 – 439 | RNA polymerase II-associated protein RBA50Add BLAST | 439 |
Proteomic databases
MaxQBi | Q04418 |
PaxDbi | Q04418 |
PRIDEi | Q04418 |
Expressioni
Inductioni
Down-regulated at low calcium levels.1 Publication
Interactioni
Protein-protein interaction databases
BioGRIDi | 32576, 195 interactors |
DIPi | DIP-4127N |
IntActi | Q04418, 8 interactors |
STRINGi | 4932.YDR527W |
Miscellaneous databases
RNActi | Q04418, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the RPAP1 family.Curated
Phylogenomic databases
eggNOGi | KOG1894, Eukaryota |
GeneTreei | ENSGT00390000007594 |
HOGENOMi | CLU_031074_0_0_1 |
InParanoidi | Q04418 |
OMAi | TGFPQHK |
Family and domain databases
InterProi | View protein in InterPro IPR013929, RNA_pol_II_AP1_C IPR013930, RNA_pol_II_AP1_N IPR039913, RPAP1/Rba50 |
PANTHERi | PTHR21483, PTHR21483, 1 hit |
Pfami | View protein in Pfam PF08620, RPAP1_C, 1 hit PF08621, RPAP1_N, 1 hit |
i Sequence
Sequence statusi: Complete.
Q04418-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDLLGDIVEK DTSDSVESND NGTLSTNNCG TGFPELYKPK KISSWKERLR
60 70 80 90 100
EKRAQKKKTS GKDAEKQQTS TDAPLSEAKS IHNENIKVLQ GMSDEQIVQE
110 120 130 140 150
REDLYNSLDP KLIAKLLKNI NKRAKDENNT PLFAEIEGAS GTWVGGNKQG
160 170 180 190 200
IYDLPPLDDE DVDVALEIRP MLGKDAKHVQ FEEAGKEKDV EEEAKTNDDV
210 220 230 240 250
DDIAPLDFQM AQCIDHMKNE ELFKDVHFIK EESQNEINLE KLDINDPNFN
260 270 280 290 300
DKLHEKYFPD LPKEVDKLKW MQPVQQKTDK NYIIEDVSEC RFDFNGDLVP
310 320 330 340 350
PTRQIDSTIH SGLHHHSDSP ELAGYTIVEL EHLARSTFPS QRCIAIQTLG
360 370 380 390 400
RILYKLGQKS YYQLVPEIDA DTYKEDGSIS NVMDKIYSMF WDLIKDGKVI
410 420 430
ESLEISSDEK FTRNLSVRNY AIDALWLWKQ GGGDFRTKK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 192 – 194 | EEA → GEG in AAB64966 (PubMed:9169867).Curated | 3 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U33057 Genomic DNA Translation: AAB64966.1 BK006938 Genomic DNA Translation: DAA12358.2 |
PIRi | S69582 |
RefSeqi | NP_010816.4, NM_001180835.4 |
Genome annotation databases
EnsemblFungii | YDR527W_mRNA; YDR527W; YDR527W |
GeneIDi | 852139 |
KEGGi | sce:YDR527W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U33057 Genomic DNA Translation: AAB64966.1 BK006938 Genomic DNA Translation: DAA12358.2 |
PIRi | S69582 |
RefSeqi | NP_010816.4, NM_001180835.4 |
3D structure databases
SMRi | Q04418 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 32576, 195 interactors |
DIPi | DIP-4127N |
IntActi | Q04418, 8 interactors |
STRINGi | 4932.YDR527W |
Proteomic databases
MaxQBi | Q04418 |
PaxDbi | Q04418 |
PRIDEi | Q04418 |
Genome annotation databases
EnsemblFungii | YDR527W_mRNA; YDR527W; YDR527W |
GeneIDi | 852139 |
KEGGi | sce:YDR527W |
Organism-specific databases
SGDi | S000002935, RBA50 |
VEuPathDBi | FungiDB:YDR527W |
Phylogenomic databases
eggNOGi | KOG1894, Eukaryota |
GeneTreei | ENSGT00390000007594 |
HOGENOMi | CLU_031074_0_0_1 |
InParanoidi | Q04418 |
OMAi | TGFPQHK |
Miscellaneous databases
PROi | PR:Q04418 |
RNActi | Q04418, protein |
Family and domain databases
InterProi | View protein in InterPro IPR013929, RNA_pol_II_AP1_C IPR013930, RNA_pol_II_AP1_N IPR039913, RPAP1/Rba50 |
PANTHERi | PTHR21483, PTHR21483, 1 hit |
Pfami | View protein in Pfam PF08620, RPAP1_C, 1 hit PF08621, RPAP1_N, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RBA50_YEAST | |
Accessioni | Q04418Primary (citable) accession number: Q04418 Secondary accession number(s): D6VTE8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2006 |
Last sequence update: | July 27, 2011 | |
Last modified: | February 10, 2021 | |
This is version 133 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - SIMILARITY comments
Index of protein domains and families - Yeast chromosome IV
Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names