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Protein

ATP-dependent helicase/deoxyribonuclease subunit B

Gene

rexB

Organism
Lactobacillus gasseri (strain ATCC 33323 / DSM 20243 / JCM 1131 / NCIMB 11718 / AM63)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' -> 3' nuclease activity.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease
Biological processDNA damage, DNA repair
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLGAS324831:G1G6Y-1032-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent helicase/deoxyribonuclease subunit BUniRule annotation (EC:3.1.-.-UniRule annotation, EC:3.6.4.12UniRule annotation)
Alternative name(s):
ATP-dependent helicase/nuclease RexBUniRule annotation
Gene namesi
Name:rexBUniRule annotation
Ordered Locus Names:LGAS_1032
OrganismiLactobacillus gasseri (strain ATCC 33323 / DSM 20243 / JCM 1131 / NCIMB 11718 / AM63)
Taxonomic identifieri324831 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003793721 – 1158ATP-dependent helicase/deoxyribonuclease subunit BAdd BLAST1158

Interactioni

Subunit structurei

Heterodimer of AddA and RexB.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ043G5
SMRiQ043G5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the helicase family. AddB/RexB type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C5N Bacteria
COG3857 LUCA
HOGENOMiHOG000033807
KOiK16899
OMAiHFASHGL

Family and domain databases

HAMAPiMF_01453 AddB_type2, 1 hit
InterProiView protein in InterPro
IPR014141 DNA_helicase_suRexB
IPR027417 P-loop_NTPase
IPR038726 PDDEXK_AddAB-type
PfamiView protein in Pfam
PF12705 PDDEXK_1, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

Q043G5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINVITGRQV DNLQNEIIDQ AVKSYYQDKT HDVFIIVPNH IKFTTEVRAL
60 70 80 90 100
SKLSVLTNKK QVAVNKLHIL SFSRLAWYFL KDEAIKLPQI LDDAASVMLL
110 120 130 140 150
EQIVKDHQDE LKLFQNKNQI TSGALRQMYE AILSVRAGNI DLENIDNEKL
160 170 180 190 200
NEETSYKVHD LQIIYDDFID RLSEKFATKD EMQLLLNEFL AKSDSLSTMV
210 220 230 240 250
FYFSDFSHFS LQELTSVRLI SKKAKNTTLA FKTKIGKIDS KAEQGDYDYV
260 270 280 290 300
VQRTIRQLEH FWQNQQLNYQ TTEFPLTKTN PSSLLNGVWT KTNGFDESLS
310 320 330 340 350
KFLQPVKADS RYAEAYFVAR TIYQQVALNN YRYQDFLVLA PNLNEYETYL
360 370 380 390 400
TPILRQNNIP FFNDLQKEMK YHPLVVAVEN LQQIFKRGFQ TDNVIALMKT
410 420 430 440 450
QLFIPEWYKS VARYQNDVDL LENFVLAHGI KGELWKKPLK SFVDAEVIAL
460 470 480 490 500
DKSEQEVEEL DRLRKYFISI LSEFFEDIET EKDPQAGVTI FWNFLIKNRV
510 520 530 540 550
AKRLEAWRKE ANDAGDLQLA QQPEQVWSTL NDLLKDYLLV AKEFSLEQFF
560 570 580 590 600
DLLISGFSEA NFSQIPSTLD AVNISEMGMV QGQGYKQVFI IGATSSNLPQ
610 620 630 640 650
IEKIPGFFSS ENLEQLNDGN NASGYLEDQQ KINNLDQNYQ FGNALSLASD
660 670 680 690 700
KIYISYPVIN TANEQLEPSI FYKQLLRLTQ ANEFSQHDLP SSAGDLLTFM
710 720 730 740 750
TNPEASLGYL TYLKGKQEVN VDSILELTEQ EIGEVAQNVL EGSNFKNVPE
760 770 780 790 800
NLPPKLAQEL YGDRIETSVS QLETYYQNSF EYFLNYGLHL KKRFENELDV
810 820 830 840 850
IQAGNYYHET FDYLVKKIKE KNLDFADLTD SKLNQLLIEV REELKEKGRY
860 870 880 890 900
RQLLNDPFNK YLFHKLDQTT SNVAHYWHSN VNKTTFRPQY SELSFGKNQK
910 920 930 940 950
VTGLSYSWKD ENNQKKIVDL RGKMDRVDLA KVNDRVLGEV IDYKSSAKKF
960 970 980 990 1000
DLGLFANGIS MQMISYLEVL KKNNKFFAQG KNLDVLGAFY QNITSSLERL
1010 1020 1030 1040 1050
SSDKMILSNY QIKDLLKEST KKLMYNGILV ADEEILDLIE PGMEKDRATS
1060 1070 1080 1090 1100
EIYSSIKRKV NGDISWPRNQ SFTPDQLELL LAYNSYLIKN AGSEILSGKI
1110 1120 1130 1140 1150
KLDPYTYGQQ SSLTYSDFKD IFFFDAMLKE NNYHKIKAID KKTLLNLIKE

KLDLDGDE
Length:1,158
Mass (Da):133,949
Last modified:November 14, 2006 - v1
Checksum:iA9C26B4CE688B3FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000413 Genomic DNA Translation: ABJ60407.1
RefSeqiWP_003647272.1, NZ_BALQ01000002.1

Genome annotation databases

EnsemblBacteriaiABJ60407; ABJ60407; LGAS_1032
GeneIDi29638793
KEGGilga:LGAS_1032

Similar proteinsi

Entry informationi

Entry nameiADDB_LACGA
AccessioniPrimary (citable) accession number: Q043G5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: November 14, 2006
Last modified: April 25, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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