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Entry version 90 (07 Oct 2020)
Sequence version 1 (01 Nov 1996)
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Protein

ORFB polyprotein

Gene
N/A
Organism
Cryphonectria hypovirus 1 (strain EP713) (CHV-1/EP713) (Chestnut blight fungus hypovirulence-associated virus)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Papain-like protease p48 is a cysteine protease of the peptidase family C8.PROSITE-ProRule annotation

Miscellaneous

Hypoviruses induce hypovirulence in their fungal host Cryphonectria parasitica. The consequence is attenuation of the related fungal disease, chestnut blight, that causes cankers that enlarge and kill branches and trunks. The virus-like genetic elements consist of cytoplasmically replicating double-stranded RNA.
CHV-1 strain EP713 is a highly hypovirulent strain.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei341For papain-like protease p48 activityPROSITE-ProRule annotation1
Active sitei388For papain-like protease p48 activityPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi2664 – 2671ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Thiol protease, Transferase
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ORFB polyprotein
Cleaved into the following 2 chains:
Papain-like protease p48PROSITE-ProRule annotation (EC:3.4.22.-PROSITE-ProRule annotation)
Putative RNA-directed RNA polymerase/helicase (EC:2.7.7.48, EC:3.6.4.13)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCryphonectria hypovirus 1 (strain EP713) (CHV-1/EP713) (Chestnut blight fungus hypovirulence-associated virus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri12478 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraePisuviricotaDuplopiviricetesDurnaviralesHypoviridaeHypovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiCryphonectria parasitica (Chestnut blight fungus) (Endothia parasitica) [TaxID: 5116]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007251 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei791 – 811HelicalSequence analysisAdd BLAST21
Transmembranei823 – 843HelicalSequence analysisAdd BLAST21
Transmembranei1166 – 1186HelicalSequence analysisAdd BLAST21
Transmembranei1193 – 1213HelicalSequence analysisAdd BLAST21
Transmembranei1215 – 1235HelicalSequence analysisAdd BLAST21
Transmembranei1356 – 1376HelicalSequence analysisAdd BLAST21
Transmembranei2495 – 2515HelicalSequence analysisAdd BLAST21
Transmembranei2517 – 2537HelicalSequence analysisAdd BLAST21
Transmembranei2590 – 2610HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Host membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi321D → E: No effect on cleavage. 1 Publication1
Mutagenesisi323H → S: No effect on cleavage. 1 Publication1
Mutagenesisi330D → E: No effect on cleavage. 1 Publication1
Mutagenesisi341C → S: Complete loss of cleavage. 1 Publication1
Mutagenesisi356D → E: No effect on cleavage. 1 Publication1
Mutagenesisi363D → E: No effect on cleavage. 1 Publication1
Mutagenesisi373C → S: Partial loss of cleavage. 1 Publication1
Mutagenesisi376D → E: No effect on cleavage. 1 Publication1
Mutagenesisi377S → T: No effect on cleavage. 1 Publication1
Mutagenesisi381S → T: No effect on cleavage. 1 Publication1
Mutagenesisi382H → S: No effect on cleavage. 1 Publication1
Mutagenesisi383S → T: No effect on cleavage. 1 Publication1
Mutagenesisi384D → E: No effect on cleavage. 1 Publication1
Mutagenesisi386C → S: Partial loss of cleavage. 1 Publication1
Mutagenesisi388H → S: Complete loss of cleavage. 1 Publication1
Mutagenesisi399D → E: No effect on cleavage. 1 Publication1
Mutagenesisi413P → A, R or S: No effect on cleavage. 1 Publication1
Mutagenesisi414D → A, R or S: No effect on cleavage. 1 Publication1
Mutagenesisi415I → L, R or V: Complete loss of cleavage. 1 Publication1
Mutagenesisi416L → A, E, R or S: No effect on cleavage. 1 Publication1
Mutagenesisi416L → G: Complete loss of cleavage. 1 Publication1
Mutagenesisi417V → A, G, L, M, R or S: Complete loss of cleavage. 1 Publication1
Mutagenesisi417V → I: No effect on cleavage. 1 Publication1
Mutagenesisi418G → A, E, R, S, T or V: Complete loss of cleavage. 1 Publication1
Mutagenesisi419A → G, L, S or V: No effect on cleavage. 1 Publication1
Mutagenesisi419A → R: Complete loss of cleavage. 1 Publication1
Mutagenesisi420E → A, R or S: No effect on cleavage. 1 Publication1
Mutagenesisi420E → P: Complete loss of cleavage. 1 Publication1
Mutagenesisi421E → A: No effect on cleavage. 1 Publication1
Mutagenesisi421E → P: Partial loss of cleavage. 1 Publication1
Mutagenesisi422G → P: No effect on cleavage. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000388811 – 418Papain-like protease p48Add BLAST418
ChainiPRO_0000038882419 – 3165Putative RNA-directed RNA polymerase/helicaseSequence analysisAdd BLAST2747

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Papain-like protease p48 is autocatalytically processed. The putative RNA-directed RNA polymerase/helicase may be further processed.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei418 – 419Cleavage; by papain-like protease p48PROSITE-ProRule annotation2

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q04350

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini271 – 418Peptidase C8PROSITE-ProRule annotationAdd BLAST148
Domaini2651 – 2796Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST146

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1793 – 2208RNA-directed RNA polymeraseSequence analysisAdd BLAST416

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi2751 – 2754DEFH box4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the C-terminal section; belongs to the DEAD box helicase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR021912, DUF3525
IPR014001, Helicase_ATP-bd
IPR027417, P-loop_NTPase
IPR005315, Peptidase_C8

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12039, DUF3525, 2 hits
PF03569, Peptidase_C8, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51875, HAV_P48_PRO, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q04350-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYKEAERPIE VWRTQVMDGP TWTALSESCR DRLFFASGEG GEHMTLDIIQ
60 70 80 90 100
PDSYTKIRLF RSGRFEVSVD GKSFGQGGNR YRFVFRYDSL LSTPFGYPAE
110 120 130 140 150
DKEIALQDYN HKQLLGEMFL KLPDSYVDGR PIAEAFFRYV DDLKWDVGVF
160 170 180 190 200
RDRRSLTELH LPASSGLTTA QVSVAKLEWP PLPIIQAQPT ILAGIIDNFK
210 220 230 240 250
ICFPVNGKWI YGQGLSWTRY DGDASVPTSL LSNRQHARFW NEKDIPTGLK
260 270 280 290 300
LSKEGFIKLW AQKSRKWQDH MARSIGLSHE AAVELVRATR VNEAKPHLVP
310 320 330 340 350
MEEAKEAPRQ QLVPRRSTFV DNHEEEVEID TLRVPVEEGR CFELLFNNQV
360 370 380 390 400
TPAIFDKKPL LKDVLGVFEE NVCTMDSLEI SHSDQCVHIV AGETFRNYDE
410 420 430 440 450
IKAVLEVILE NEPDILVGAE EGSVADYVKA GKHFLFENHQ WVRNGLKLAK
460 470 480 490 500
GLAEPGQRAK DNTNPSTPRP IEDADYIHPF DNGQPLPGRS DQWVSGFEVT
510 520 530 540 550
RLRHHDEMPH IRSVRNTGIH GLPGDFLSNY PRLPTPVFHR LRDLWDDVIG
560 570 580 590 600
ILMKLEFGDN CSPVLNVTAN ADWVRSETTI NFISDQPGKA QSRPREDGGF
610 620 630 640 650
DILVPCRGIA TRSIRLLPLF IRLPNRFRAV ALLNGRQSDY DNYGWPVFNP
660 670 680 690 700
VIPLPQMDSF YVEAVAAGRS MYPPGFLLGR YDALEYLVHT ATVYGAEEAF
710 720 730 740 750
LLPFTHHVRV YPPPRPGREI PFGSWCKNYK FEAERFWYDA DWKLRVHETN
760 770 780 790 800
HDFDRLIEIT KTCRRNPPEE NLQAKLEDTA RKVCSVWQYN IMIASSVAFL
810 820 830 840 850
VPLYFTLYVP YLQFYLHVDP GDYILLPPVL WLVWTNLCYG YACDAWCRLF
860 870 880 890 900
FFVEEAGKKE LVHSSEEFSS DPSSTLLIPT MGTRGDHVPP RFFANMAVLA
910 920 930 940 950
GVKTHLLKLQ TATYGDLENL KKGKLGSLLP GYLQNHYSVL RGYKAAFTPH
960 970 980 990 1000
VELDMPNATS YNLAPPRSYI NKIRYLTDEN RSGASMIDRA VTWFAEELAD
1010 1020 1030 1040 1050
TFWPDWQIGC LRGCNLPRSA DGVSLITKQP NLKTGKIGWL HGSADPAVVP
1060 1070 1080 1090 1100
KDIRDKYPLV PNGDHNEIFR HYDKIYMPGG AGAVQTAIAC GCEVVVTDVN
1110 1120 1130 1140 1150
LDRDYHTMPT QKDFHQPSIL PYFAWLWRQG FDVKLPRVLL VIGWLKFHYS
1160 1170 1180 1190 1200
IRYKHLEFAA DFVIRAGLFW WYGCLHLLPF MAAAIMAPRF VKKYLVGMAW
1210 1220 1230 1240 1250
LTEPGLLMLK ALWRFPIFMV TPRWMLPFIV TVSVYNWWWP LSQDGLNYAS
1260 1270 1280 1290 1300
KRFELIFEPV TRGKHTFSYP FGHWCLRDTN SMIVYEGKFV NPSETSIGSP
1310 1320 1330 1340 1350
FKLSKSVRPV RPGAVFHLVP FHVQKLLDSM DEAPLPYSAN HNCTTVILKG
1360 1370 1380 1390 1400
IMYRSALGFV FAYMVSWAVY LVLRPPQAAA TVYHWVYPER SWDTSRLYHL
1410 1420 1430 1440 1450
LLGFAAGGTV PMEVIDEEHV EEKPSVAGQS EPAAEIDNDK ISDYDQEWWG
1460 1470 1480 1490 1500
SQDSIDTVVN DLCYLLSFLK DTAIPEEVKL DVVELAYTQL VQDEKERIPE
1510 1520 1530 1540 1550
PKGTKILDMP NWKPGNWAKL IDETHRVLSQ FTQYTPRVLN ELVVWLKGLG
1560 1570 1580 1590 1600
ENLYRVAEPI LMLLVRAMRA AKSVSDRATR SVYHCLCHWL DVMYGGSAPT
1610 1620 1630 1640 1650
RVKTVWGLTG LVASGMTSQK AILAQNIAMM EYQGRGNFLD DYDNFVSNIK
1660 1670 1680 1690 1700
EPGKGLPGIN TIGGPQRRPI RYKNPVMSHQ AAEICGLKPG EYEVDDRYQE
1710 1720 1730 1740 1750
RINDYLAEGI PQAVDGVLFG DRNPDRIARS ISRYEPEYSG CSPEDKALVE
1760 1770 1780 1790 1800
DTARAMFEQW PEVFADRDIM LPKGVELYIK EKYSAGTPFI SSFYKSRKAL
1810 1820 1830 1840 1850
KQAGVMDVIR KNALECISTG KYPTQFYHAF AKSQAVPGQP LLAPRMKDLR
1860 1870 1880 1890 1900
TVVSEDLSAY MVDQIFQIEA NKRITWETYG AGSGMPLSQS MARIWDELHD
1910 1920 1930 1940 1950
LRKREGGQFI IADATAYDSN CKPALFHGAG KLVELGFQNH PSGKGRQFAQ
1960 1970 1980 1990 2000
VVQCKFEAMQ NAWVMGITEP SYTALTFHVP DVAVRHELES KYPAHFATFS
2010 2020 2030 2040 2050
ELLAHNNVNV TEWKRLSWEE RKACARDMQA VPGKVFLTND PALRLQGSSW
2060 2070 2080 2090 2100
QGSFTTEPKR DEFRKYQTYF YDSKAAMRED IKRIVFANRE VISNVHHKNR
2110 2120 2130 2140 2150
GGGTGQSATS WDNTATFKLG VISAWARATG KPPKDFFCSN RLYNTSDDTV
2160 2170 2180 2190 2200
WWSKDLLSSA EVDRFKQAAA DFGILLEIGS TKKITEVEYL SKLPRRPTAE
2210 2220 2230 2240 2250
DSADYRAWRQ GRIENMRSSG RFSEEQLLSI EREQLPQFLM VQNPTAILMR
2260 2270 2280 2290 2300
RTAFRYYQSS PSKFLYTSCE RGAGHALVTA FQPALYKRFA IEYAEDLNRL
2310 2320 2330 2340 2350
CKEHHINQRY ELVSQQDRMK MQVINVNPNW KRNFKLSPRQ EAFLRWIRQA
2360 2370 2380 2390 2400
KFPSYRQVLD IHLRIRDPDP SAHDRFIAKL DRAWRNPDEG IRDIVDGVYR
2410 2420 2430 2440 2450
YTDMIPEEFK RFMPSTDMLY AENPWHTHNQ YVEKFIYLKL LETTTVDELT
2460 2470 2480 2490 2500
FAQFDAVAKE SPYGICMNTI KFWEDLRDPD YLKDLLASEA MIDKVRIYQG
2510 2520 2530 2540 2550
MTVIISAMYF AMHWVELFIQ SLFLIGPLYN LFMWSFWGLS KVYGLANTFY
2560 2570 2580 2590 2600
WHGKARSSRE ISSILPRDPY MWSKRFVSTM ADFIPERFAL GIVPVTLVLD
2610 2620 2630 2640 2650
GLAEIIEVLF GRMWRLFANL KSVGTDFSDA RSGKSLNVPS NPWAAYAHTY
2660 2670 2680 2690 2700
ATKAIEHGHV TVAAKTASGK STFFPAAVWA ERRNIGIKKL WIVMPRKILR
2710 2720 2730 2740 2750
DNWEIPFDIR SQIVKRGKTL DPSADIYVTT YGHFRTRIGG LVPRDNLVFF
2760 2770 2780 2790 2800
DEFHEMDGFM LQDVEDWKGP TIFMSATPVA LHGMAGIPFL EPTLPKRFNL
2810 2820 2830 2840 2850
TVYKVDSDDV LEMWNRARNQ FADQPELLAR PMIIVPTYNE LKKTIAGLEN
2860 2870 2880 2890 2900
LDRSITWHEV SSNSPLVPKT GGLVCTPYVQ TGIDIKPAPS ILIDSGRDVI
2910 2920 2930 2940 2950
VHKGRLVTPH PYTDEKTNEQ RVNRVGRTMD GVVIQPQLAG TGNPPVKYPS
2960 2970 2980 2990 3000
GIFFSSELVA GQYKVPRLTK VNGCVHPELP YMSIKYTSEL SDPAKAREEE
3010 3020 3030 3040 3050
QSVTKSLLFI HLMALAGVRQ SEWALRYNRY FELHLPFGED EDHLERILTS
3060 3070 3080 3090 3100
GKLRYANHIP VDMAMQLLGN GHVTWGIGGV PTITRPRYPC DGMWVEDPSS
3110 3120 3130 3140 3150
RKSYAHKVLL HQREHAEIGM WQAQVNELRA QNLALQSQLR SACTRRSTAG
3160
RILRHTRPPD IPVCG
Length:3,165
Mass (Da):361,718
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i732862977C2CD344
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M57938 Genomic RNA Translation: AAA67458.1

Protein sequence database of the Protein Information Resource

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PIRi
S15010

NCBI Reference Sequences

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RefSeqi
NP_041091.1, NC_001492.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
1403614

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
vg:1403614

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57938 Genomic RNA Translation: AAA67458.1
PIRiS15010
RefSeqiNP_041091.1, NC_001492.1

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
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Proteomic databases

PRIDEiQ04350

Genome annotation databases

GeneIDi1403614
KEGGivg:1403614

Family and domain databases

InterProiView protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR021912, DUF3525
IPR014001, Helicase_ATP-bd
IPR027417, P-loop_NTPase
IPR005315, Peptidase_C8
PfamiView protein in Pfam
PF12039, DUF3525, 2 hits
PF03569, Peptidase_C8, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS51875, HAV_P48_PRO, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOLB_CHPVE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q04350
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: November 1, 1996
Last modified: October 7, 2020
This is version 90 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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