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Protein

Probable GTPase-activating protein GYL1

Gene

GYL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable GTPase-activating protein which stimulates the GTP hydrolysis rate by GYP5 of YPT1 and SEC4. Involved in ER to Golgi trafficking and polarized exocytosis.2 Publications

Miscellaneous

Present with 2010 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: SGD
  • exocytosis Source: UniProtKB-KW
  • protein transport Source: UniProtKB-KW
  • regulation of exocytosis Source: SGD

Keywordsi

Molecular functionGTPase activation
Biological processER-Golgi transport, Exocytosis, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32879-MONOMER
ReactomeiR-SCE-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-SCE-8854214 TBC/RABGAPs

Names & Taxonomyi

Protein namesi
Recommended name:
Probable GTPase-activating protein GYL1
Alternative name(s):
GYP5-like protein 1
Gene namesi
Name:GYL1
Synonyms:APP2
Ordered Locus Names:YMR192W
ORF Names:YM9646.04
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

SGDiS000004804 GYL1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002080621 – 720Probable GTPase-activating protein GYL1Add BLAST720

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei17PhosphothreonineCombined sources1
Modified residuei37PhosphoserineCombined sources1
Modified residuei73PhosphoserineCombined sources1
Modified residuei139PhosphoserineCombined sources1
Cross-linki498Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ04322
PaxDbiQ04322
PRIDEiQ04322

PTM databases

iPTMnetiQ04322

Interactioni

Subunit structurei

Interacts with GYP5 and RVS167. Is part of SEC4-containing complexes.2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi35370, 76 interactors
DIPiDIP-2891N
IntActiQ04322, 18 interactors
MINTiQ04322
STRINGi4932.YMR192W

Structurei

3D structure databases

ProteinModelPortaliQ04322
SMRiQ04322
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini297 – 477Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST181

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili572 – 696Sequence analysisAdd BLAST125

Sequence similaritiesi

Belongs to the GYP5 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00750000117238
InParanoidiQ04322
OMAiPVLHIHF
OrthoDBiEOG092C0Q84

Family and domain databases

InterProiView protein in InterPro
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
PfamiView protein in Pfam
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00164 TBC, 1 hit
SUPFAMiSSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50086 TBC_RABGAP, 1 hit

Sequencei

Sequence statusi: Complete.

Q04322-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSNEDIHEE RIEVPRTPHQ TQPEKDSDRI ALRDEISVPE GDEKAYSDEK
60 70 80 90 100
VEMATTNASS NFGSNESAKD GESIGAFSNP HEALMQSKLR EESQSKTILP
110 120 130 140 150
SDDLSQQLET EESKVEEALK RITSPPLPPR ADCIEESASA LKSSLPPVLA
160 170 180 190 200
GNKNDQAPLD RPQLPPRQVV NAETLHLKAP HGNATPSKSP TSAVGNSSSS
210 220 230 240 250
TPPTLPPRRI EDPLDLAAQK HFLASTFKRN MLFYKSEDNS IKCDLDKNIL
260 270 280 290 300
NLKEDSKKIN NNEIPEEVSS FWLKVIGDYQ NILINDIETL HFQLSRGIPA
310 320 330 340 350
AYRLVVWQLV SYAKSKSFDP IYETYLTEMA PFDVQEFENQ LKMMDEVPSE
360 370 380 390 400
YVKRISNVLK AYLLFDPECE FSTDIAYIIN MILDVCEEEA NAFGLLVRLM
410 420 430 440 450
KVYGLRLLFL PSASEIDILC YKFDRLVEEF YPEIHNHMVE KGVRSSMFLP
460 470 480 490 500
GFFTTLFQKK LPTEIQPRIG DMVFLEGIDS IMRILATLLS NSRDHLLKMG
510 520 530 540 550
FDDMLELLKS GLLDAYIKQN DGTRGDTLLS NECMDKLLQD SMMKVAITPK
560 570 580 590 600
TMKKYSSEYE EIHRLDNEKE VQYKSITEKN LHLQKHVRKL ENDYTSLNRE
610 620 630 640 650
HVTIANELVK NRLNIESVLN ENNGYKLQIL DLKKKLDSEK KKQVLGVYVP
660 670 680 690 700
NDLKKDLEET MKKNTQVMDE NLKLQDRISE LERLIEEIKT ANKNGTLFEY
710 720
SNSKNNPLGA GWSGFKKVFK
Length:720
Mass (Da):82,131
Last modified:November 1, 1997 - v1
Checksum:iE1423DB4F15F7267
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47815 Genomic DNA Translation: CAA87813.1
BK006946 Genomic DNA Translation: DAA10090.1
PIRiS50920
RefSeqiNP_013917.1, NM_001182698.1

Genome annotation databases

EnsemblFungiiYMR192W; YMR192W; YMR192W
GeneIDi855230
KEGGisce:YMR192W

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47815 Genomic DNA Translation: CAA87813.1
BK006946 Genomic DNA Translation: DAA10090.1
PIRiS50920
RefSeqiNP_013917.1, NM_001182698.1

3D structure databases

ProteinModelPortaliQ04322
SMRiQ04322
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35370, 76 interactors
DIPiDIP-2891N
IntActiQ04322, 18 interactors
MINTiQ04322
STRINGi4932.YMR192W

PTM databases

iPTMnetiQ04322

Proteomic databases

MaxQBiQ04322
PaxDbiQ04322
PRIDEiQ04322

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR192W; YMR192W; YMR192W
GeneIDi855230
KEGGisce:YMR192W

Organism-specific databases

SGDiS000004804 GYL1

Phylogenomic databases

GeneTreeiENSGT00750000117238
InParanoidiQ04322
OMAiPVLHIHF
OrthoDBiEOG092C0Q84

Enzyme and pathway databases

BioCyciYEAST:G3O-32879-MONOMER
ReactomeiR-SCE-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-SCE-8854214 TBC/RABGAPs

Miscellaneous databases

PROiPR:Q04322

Family and domain databases

InterProiView protein in InterPro
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
PfamiView protein in Pfam
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00164 TBC, 1 hit
SUPFAMiSSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50086 TBC_RABGAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGYL1_YEAST
AccessioniPrimary (citable) accession number: Q04322
Secondary accession number(s): D6W016
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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Main funding by: National Institutes of Health

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