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UniProtKB - Q04307 (RPC10_YEAST)

Entry version 182 (02 Dec 2020)
Sequence version 1 (01 Nov 1996)
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Protein

DNA-directed RNA polymerase III subunit RPC10

Gene

RPC11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Involved in Pol III transcription reinitiation and RNA cleavage during transcription termination.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri5 – 29C4-typeSequence analysisAdd BLAST25
Zinc fingeri65 – 108TFIIS-typePROSITE-ProRule annotationAdd BLAST44

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

  • termination of RNA polymerase III transcription Source: SGD
  • tRNA 3'-trailer cleavage Source: InterPro
  • tRNA transcription by RNA polymerase III Source: SGD
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-SCE-76061, RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-SCE-76066, RNA Polymerase III Transcription Initiation From Type 2 Promoter

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-directed RNA polymerase III subunit RPC10
Short name:
RNA polymerase III subunit C10
Alternative name(s):
DNA-directed RNA polymerases III 12.5 kDa polypeptide
RNA polymerase III subunit C11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPC11
Ordered Locus Names:YDR045C
ORF Names:YD9609.01C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		FungiDB:YDR045C

Saccharomyces Genome Database

More...SGDi		S000002452, RPC11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001214781 – 110DNA-directed RNA polymerase III subunit RPC10Add BLAST110

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q04307

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q04307

PRoteomics IDEntifications database

More...PRIDEi		Q04307

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q04307

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		32100, 301 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-2660, DNA-directed RNA polymerase III complex

Database of interacting proteins

More...DIPi		DIP-887N

Protein interaction database and analysis system

More...IntActi		Q04307, 6 interactors

Molecular INTeraction database

More...MINTi		Q04307

STRING: functional protein association networks

More...STRINGi		4932.YDR045C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q04307, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1110
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q04307

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri5 – 29C4-typeSequence analysisAdd BLAST25
Zinc fingeri65 – 108TFIIS-typePROSITE-ProRule annotationAdd BLAST44

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2906, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00550000075071

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_093932_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q04307

Identification of Orthologs from Complete Genome Data

More...OMAi		MEFCDEC

Family and domain databases

Conserved Domains Database

More...CDDi		cd10509, Zn-ribbon_RPC11, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR019761, DNA-dir_RNA_pol-M_15_CS
IPR001529, DNA-dir_RNA_pol_M/15kDasu
IPR012164, Rpa12/Rpb9/Rpc10/TFS
IPR034014, Zn_ribbon_RPC11_C
IPR001222, Znf_TFIIS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02150, RNA_POL_M_15KD, 1 hit
PF01096, TFIIS_C, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF005586, RNApol_RpoM, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00661, RPOL9, 1 hit
SM00440, ZnF_C2C2, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01030, RNA_POL_M_15KD, 1 hit
PS51133, ZF_TFIIS_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q04307-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSFCPSCNN MLLITSGDSG VYTLACRSCP YEFPIEGIEI YDRKKLPRKE 
        60         70         80         90        100
VDDVLGGGWD NVDQTKTQCP NYDTCGGESA YFFQLQIRSA DEPMTTFYKC 
       110
VNCGHRWKEN
Length:110
Mass (Da):12,513
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE4AA802EC9F92230
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF108188 Genomic DNA Translation: AAD12060.1
Z49209 Genomic DNA Translation: CAA89076.1
AY557636 Genomic DNA Translation: AAS55962.1
AY899253 mRNA Translation: AAX83938.1
BK006938 Genomic DNA Translation: DAA11893.1

Protein sequence database of the Protein Information Resource

More...PIRi		S54031

NCBI Reference Sequences

More...RefSeqi		NP_010330.1, NM_001180353.1

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		YDR045C_mRNA; YDR045C; YDR045C

Database of genes from NCBI RefSeq genomes

More...GeneIDi		851615

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sce:YDR045C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF108188 Genomic DNA Translation: AAD12060.1
Z49209 Genomic DNA Translation: CAA89076.1
AY557636 Genomic DNA Translation: AAS55962.1
AY899253 mRNA Translation: AAX83938.1
BK006938 Genomic DNA Translation: DAA11893.1
PIRiS54031
RefSeqiNP_010330.1, NM_001180353.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3QT1X-ray4.30I85-110[»]
5FJ8electron microscopy3.90I1-110[»]
5FJ9electron microscopy4.60I1-110[»]
5FJAelectron microscopy4.65I1-110[»]
6CNBelectron microscopy4.10I1-110[»]
6CNCelectron microscopy4.10I1-110[»]
6CNDelectron microscopy4.80I1-110[»]
6CNFelectron microscopy4.50I1-110[»]
6EU0electron microscopy4.00I1-110[»]
6EU1electron microscopy3.40I1-110[»]
6EU2electron microscopy3.40I1-110[»]
6EU3electron microscopy3.30I1-110[»]
6F40electron microscopy3.70I1-110[»]
6F41electron microscopy4.30I1-110[»]
6F42electron microscopy5.50I1-110[»]
6F44electron microscopy4.20I1-110[»]
6TUTelectron microscopy3.25I1-110[»]
SMRiQ04307
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi32100, 301 interactors
ComplexPortaliCPX-2660, DNA-directed RNA polymerase III complex
DIPiDIP-887N
IntActiQ04307, 6 interactors
MINTiQ04307
STRINGi4932.YDR045C

PTM databases

iPTMnetiQ04307

Proteomic databases

MaxQBiQ04307
PaxDbiQ04307
PRIDEiQ04307

Genome annotation databases

EnsemblFungiiYDR045C_mRNA; YDR045C; YDR045C
GeneIDi851615
KEGGisce:YDR045C

Organism-specific databases

EuPathDBiFungiDB:YDR045C
SGDiS000002452, RPC11

Phylogenomic databases

eggNOGiKOG2906, Eukaryota
GeneTreeiENSGT00550000075071
HOGENOMiCLU_093932_3_0_1
InParanoidiQ04307
OMAiMEFCDEC

Enzyme and pathway databases

ReactomeiR-SCE-76061, RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-SCE-76066, RNA Polymerase III Transcription Initiation From Type 2 Promoter

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q04307
RNActiQ04307, protein

Family and domain databases

CDDicd10509, Zn-ribbon_RPC11, 1 hit
InterProiView protein in InterPro
IPR019761, DNA-dir_RNA_pol-M_15_CS
IPR001529, DNA-dir_RNA_pol_M/15kDasu
IPR012164, Rpa12/Rpb9/Rpc10/TFS
IPR034014, Zn_ribbon_RPC11_C
IPR001222, Znf_TFIIS
PfamiView protein in Pfam
PF02150, RNA_POL_M_15KD, 1 hit
PF01096, TFIIS_C, 1 hit
PIRSFiPIRSF005586, RNApol_RpoM, 1 hit
SMARTiView protein in SMART
SM00661, RPOL9, 1 hit
SM00440, ZnF_C2C2, 1 hit
PROSITEiView protein in PROSITE
PS01030, RNA_POL_M_15KD, 1 hit
PS51133, ZF_TFIIS_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRPC10_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q04307
Secondary accession number(s): D6VS33, Q2VQW5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: December 2, 2020
This is version 182 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
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