UniProtKB - Q04307 (RPC10_YEAST)
Protein
DNA-directed RNA polymerase III subunit RPC10
Gene
RPC11
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Involved in Pol III transcription reinitiation and RNA cleavage during transcription termination.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 5 – 29 | C4-typeSequence analysisAdd BLAST | 25 | |
Zinc fingeri | 65 – 108 | TFIIS-typePROSITE-ProRule annotationAdd BLAST | 44 |
GO - Molecular functioni
- DNA-directed 5'-3' RNA polymerase activity Source: UniProtKB-KW
- nucleic acid binding Source: InterPro
- zinc ion binding Source: InterPro
GO - Biological processi
- termination of RNA polymerase III transcription Source: SGD
- tRNA 3'-trailer cleavage Source: InterPro
- tRNA transcription by RNA polymerase III Source: SGD
Keywordsi
Biological process | Transcription |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-SCE-76061, RNA Polymerase III Transcription Initiation From Type 1 Promoter R-SCE-76066, RNA Polymerase III Transcription Initiation From Type 2 Promoter |
Names & Taxonomyi
Protein namesi | Recommended name: DNA-directed RNA polymerase III subunit RPC10Short name: RNA polymerase III subunit C10 Alternative name(s): DNA-directed RNA polymerases III 12.5 kDa polypeptide RNA polymerase III subunit C11 |
Gene namesi | Name:RPC11 Ordered Locus Names:YDR045C ORF Names:YD9609.01C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YDR045C |
SGDi | S000002452, RPC11 |
Subcellular locationi
Nucleus
- nucleolus By similarity
Nucleus
- nucleolus Source: UniProtKB-SubCell
- nucleoplasm Source: Reactome
- RNA polymerase III complex Source: SGD
Keywords - Cellular componenti
DNA-directed RNA polymerase, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000121478 | 1 – 110 | DNA-directed RNA polymerase III subunit RPC10Add BLAST | 110 |
Proteomic databases
MaxQBi | Q04307 |
PaxDbi | Q04307 |
PRIDEi | Q04307 |
PTM databases
iPTMneti | Q04307 |
Interactioni
Subunit structurei
Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
Protein-protein interaction databases
BioGRIDi | 32100, 301 interactors |
ComplexPortali | CPX-2660, DNA-directed RNA polymerase III complex |
DIPi | DIP-887N |
IntActi | Q04307, 6 interactors |
MINTi | Q04307 |
STRINGi | 4932.YDR045C |
Miscellaneous databases
RNActi | Q04307, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q04307 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 5 – 29 | C4-typeSequence analysisAdd BLAST | 25 | |
Zinc fingeri | 65 – 108 | TFIIS-typePROSITE-ProRule annotationAdd BLAST | 44 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG2906, Eukaryota |
GeneTreei | ENSGT00550000075071 |
HOGENOMi | CLU_093932_3_0_1 |
InParanoidi | Q04307 |
OMAi | MEFCDEC |
Family and domain databases
CDDi | cd10509, Zn-ribbon_RPC11, 1 hit |
InterProi | View protein in InterPro IPR019761, DNA-dir_RNA_pol-M_15_CS IPR001529, DNA-dir_RNA_pol_M/15kDasu IPR012164, Rpa12/Rpb9/Rpc10/TFS IPR034014, Zn_ribbon_RPC11_C IPR001222, Znf_TFIIS |
Pfami | View protein in Pfam PF02150, RNA_POL_M_15KD, 1 hit PF01096, TFIIS_C, 1 hit |
PIRSFi | PIRSF005586, RNApol_RpoM, 1 hit |
SMARTi | View protein in SMART SM00661, RPOL9, 1 hit SM00440, ZnF_C2C2, 1 hit |
PROSITEi | View protein in PROSITE PS01030, RNA_POL_M_15KD, 1 hit PS51133, ZF_TFIIS_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q04307-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLSFCPSCNN MLLITSGDSG VYTLACRSCP YEFPIEGIEI YDRKKLPRKE
60 70 80 90 100
VDDVLGGGWD NVDQTKTQCP NYDTCGGESA YFFQLQIRSA DEPMTTFYKC
110
VNCGHRWKEN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF108188 Genomic DNA Translation: AAD12060.1 Z49209 Genomic DNA Translation: CAA89076.1 AY557636 Genomic DNA Translation: AAS55962.1 AY899253 mRNA Translation: AAX83938.1 BK006938 Genomic DNA Translation: DAA11893.1 |
PIRi | S54031 |
RefSeqi | NP_010330.1, NM_001180353.1 |
Genome annotation databases
EnsemblFungii | YDR045C_mRNA; YDR045C; YDR045C |
GeneIDi | 851615 |
KEGGi | sce:YDR045C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF108188 Genomic DNA Translation: AAD12060.1 Z49209 Genomic DNA Translation: CAA89076.1 AY557636 Genomic DNA Translation: AAS55962.1 AY899253 mRNA Translation: AAX83938.1 BK006938 Genomic DNA Translation: DAA11893.1 |
PIRi | S54031 |
RefSeqi | NP_010330.1, NM_001180353.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3QT1 | X-ray | 4.30 | I | 85-110 | [»] | |
5FJ8 | electron microscopy | 3.90 | I | 1-110 | [»] | |
5FJ9 | electron microscopy | 4.60 | I | 1-110 | [»] | |
5FJA | electron microscopy | 4.65 | I | 1-110 | [»] | |
6CNB | electron microscopy | 4.10 | I | 1-110 | [»] | |
6CNC | electron microscopy | 4.10 | I | 1-110 | [»] | |
6CND | electron microscopy | 4.80 | I | 1-110 | [»] | |
6CNF | electron microscopy | 4.50 | I | 1-110 | [»] | |
6EU0 | electron microscopy | 4.00 | I | 1-110 | [»] | |
6EU1 | electron microscopy | 3.40 | I | 1-110 | [»] | |
6EU2 | electron microscopy | 3.40 | I | 1-110 | [»] | |
6EU3 | electron microscopy | 3.30 | I | 1-110 | [»] | |
6F40 | electron microscopy | 3.70 | I | 1-110 | [»] | |
6F41 | electron microscopy | 4.30 | I | 1-110 | [»] | |
6F42 | electron microscopy | 5.50 | I | 1-110 | [»] | |
6F44 | electron microscopy | 4.20 | I | 1-110 | [»] | |
6TUT | electron microscopy | 3.25 | I | 1-110 | [»] | |
SMRi | Q04307 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 32100, 301 interactors |
ComplexPortali | CPX-2660, DNA-directed RNA polymerase III complex |
DIPi | DIP-887N |
IntActi | Q04307, 6 interactors |
MINTi | Q04307 |
STRINGi | 4932.YDR045C |
PTM databases
iPTMneti | Q04307 |
Proteomic databases
MaxQBi | Q04307 |
PaxDbi | Q04307 |
PRIDEi | Q04307 |
Genome annotation databases
EnsemblFungii | YDR045C_mRNA; YDR045C; YDR045C |
GeneIDi | 851615 |
KEGGi | sce:YDR045C |
Organism-specific databases
EuPathDBi | FungiDB:YDR045C |
SGDi | S000002452, RPC11 |
Phylogenomic databases
eggNOGi | KOG2906, Eukaryota |
GeneTreei | ENSGT00550000075071 |
HOGENOMi | CLU_093932_3_0_1 |
InParanoidi | Q04307 |
OMAi | MEFCDEC |
Enzyme and pathway databases
Reactomei | R-SCE-76061, RNA Polymerase III Transcription Initiation From Type 1 Promoter R-SCE-76066, RNA Polymerase III Transcription Initiation From Type 2 Promoter |
Miscellaneous databases
PROi | PR:Q04307 |
RNActi | Q04307, protein |
Family and domain databases
CDDi | cd10509, Zn-ribbon_RPC11, 1 hit |
InterProi | View protein in InterPro IPR019761, DNA-dir_RNA_pol-M_15_CS IPR001529, DNA-dir_RNA_pol_M/15kDasu IPR012164, Rpa12/Rpb9/Rpc10/TFS IPR034014, Zn_ribbon_RPC11_C IPR001222, Znf_TFIIS |
Pfami | View protein in Pfam PF02150, RNA_POL_M_15KD, 1 hit PF01096, TFIIS_C, 1 hit |
PIRSFi | PIRSF005586, RNApol_RpoM, 1 hit |
SMARTi | View protein in SMART SM00661, RPOL9, 1 hit SM00440, ZnF_C2C2, 1 hit |
PROSITEi | View protein in PROSITE PS01030, RNA_POL_M_15KD, 1 hit PS51133, ZF_TFIIS_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RPC10_YEAST | |
Accessioni | Q04307Primary (citable) accession number: Q04307 Secondary accession number(s): D6VS33, Q2VQW5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 182 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome IV
Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names