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Protein

U3 small nucleolar RNA-associated protein 15

Gene

UTP15

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs).2 Publications

Miscellaneous

Present with 358 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • snoRNA binding Source: SGD

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein
Biological processRibosome biogenesis, rRNA processing, Transcription

Enzyme and pathway databases

BioCyciYEAST:G3O-32793-MONOMER
ReactomeiR-SCE-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar RNA-associated protein 15
Short name:
U3 snoRNA-associated protein 15
Alternative name(s):
U three protein 15
U3 protein 15 required for transcription
t-UTP15
Gene namesi
Name:UTP15
Ordered Locus Names:YMR093W
ORF Names:YM9582.18
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR093W
SGDiS000004699 UTP15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000513281 – 513U3 small nucleolar RNA-associated protein 15Add BLAST513

Proteomic databases

MaxQBiQ04305
PaxDbiQ04305
PRIDEiQ04305

PTM databases

iPTMnetiQ04305

Interactioni

Subunit structurei

Interacts with snoRNA U3. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. In the absence of snoRNA3, forms a complex with other t-UTPs. This complex can associate with pre-18S ribosomal RNAs.2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi35268, 410 interactors
ComplexPortaliCPX-1409 UTP-A complex
DIPiDIP-1962N
IntActiQ04305, 48 interactors
MINTiQ04305
STRINGi4932.YMR093W

Structurei

3D structure databases

ProteinModelPortaliQ04305
SMRiQ04305
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati37 – 78WD 1Add BLAST42
Repeati79 – 118WD 2Add BLAST40
Repeati124 – 162WD 3Add BLAST39
Repeati166 – 206WD 4Add BLAST41
Repeati210 – 247WD 5Add BLAST38
Repeati250 – 294WD 6Add BLAST45

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

GeneTreeiENSGT00390000004228
HOGENOMiHOG000185028
InParanoidiQ04305
KOiK14549
OMAiRFKDTAY
OrthoDBiEOG092C1VIW

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR018983 U3_snoRNA-assocProt_15_C
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF09384 UTP15_C, 1 hit
PF00400 WD40, 3 hits
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q04305-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTARPRIIT SKAPLLPQQT TPEQRYWRQY TSAQLVKEHN SVTHISFNPQ
60 70 80 90 100
HPHDFAVTSS TRVQIFSSRT RQVIKTFSRF KDVVYSASFR SDGKLLCAGD
110 120 130 140 150
ATGLVSVYDS YNPRTILLSI NASTHPTHVT KFHTQDNKIL ATASDDRVTR
160 170 180 190 200
LWDISNAYEP QLELTGATDY VRTLSFIPAA PHLVATGSYD GLIRLYDTRS
210 220 230 240 250
SGSTPIYSLN HDQPVENVIA VSPTQIVSCG GNNFKVWDLT SNKKLYERGN
260 270 280 290 300
FNKAVTCLDY VENFDSPMQS ALIASSLDGH VKVFDPLDNF QVKFGWKFSG
310 320 330 340 350
PVLSCAVSPS TAQGNRHLVA GLSSGLLAIR TKKKEKRSSD KENAPASFNK
360 370 380 390 400
NAKSNNFQRM MRGSEYQGDQ EHIIHNDKVR SQRRMRAFER NINQFKWSEA
410 420 430 440 450
LDNAFVPGMA KELTLTVLQE LRKRGKVRVA LYGRDESTLE PLLNWCLKGI
460 470 480 490 500
EDVRSASIVA DWVAVVLELY GNTLESSPVL QELMIDLKTK VRHEIHKSKE
510
AQRIEGMLQL LTS
Length:513
Mass (Da):57,686
Last modified:November 1, 1997 - v1
Checksum:i2B74BA8BD496C8DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49259 Genomic DNA Translation: CAA89240.1
BK006946 Genomic DNA Translation: DAA09990.1
PIRiS54469
RefSeqiNP_013811.1, NM_001182593.1

Genome annotation databases

EnsemblFungiiYMR093W; YMR093W; YMR093W
GeneIDi855118
KEGGisce:YMR093W

Similar proteinsi

Entry informationi

Entry nameiUTP15_YEAST
AccessioniPrimary (citable) accession number: Q04305
Secondary accession number(s): D6VZR6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 12, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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