UniProtKB - Q04228 (UBX2_YEAST)
UBX domain-containing protein 2
UBX2
Functioni
Miscellaneous
GO - Molecular functioni
- protein-containing complex binding Source: SGD
- protein-macromolecule adaptor activity Source: SGD
GO - Biological processi
- lipid droplet organization Source: SGD
- mitochondria-associated ubiquitin-dependent protein catabolic process Source: SGD
- mitochondrial protein processing Source: SGD
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: SGD
- ubiquitin-dependent ERAD pathway Source: SGD
Keywordsi
Biological process | Ubl conjugation pathway |
Names & Taxonomyi
Protein namesi | Recommended name: UBX domain-containing protein 2Alternative name(s): Secretion lowering protein 1 |
Gene namesi | Name:UBX2 Synonyms:SEL1 Ordered Locus Names:YML013W ORF Names:YM9571.05 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YML013W |
SGDi | S000004475, UBX2 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane Curated; Multi-pass membrane protein Curated
Endoplasmic reticulum
- Doa10p ubiquitin ligase complex Source: SGD
- endoplasmic reticulum Source: SGD
- Hrd1p ubiquitin ligase ERAD-L complex Source: SGD
- integral component of endoplasmic reticulum membrane Source: SGD
Mitochondrion
- mitochondrial outer membrane Source: SGD
Plasma Membrane
- integral component of plasma membrane Source: SGD
Other locations
- lipid droplet Source: SGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 80 | CytoplasmicSequence analysisAdd BLAST | 80 | |
Transmembranei | 81 – 101 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 102 – 151 | LumenalSequence analysisAdd BLAST | 50 | |
Transmembranei | 152 – 172 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 173 – 584 | CytoplasmicSequence analysisAdd BLAST | 412 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000210999 | 1 – 584 | UBX domain-containing protein 2Add BLAST | 584 |
Proteomic databases
MaxQBi | Q04228 |
PaxDbi | Q04228 |
PRIDEi | Q04228 |
PTM databases
iPTMneti | Q04228 |
Interactioni
Subunit structurei
Component of the DOA10 complex which contains SSM4/DOA10, CDC48, NPL4, UFD1 AND UBX2/SEL1. The complex is composed of the membrane integral E3 ligase SSM4/DOA10 and the heterotrimeric UFD1-NPL4-CDC48/p97 (UNC) ATPase complex recruited by UBX2/SEL1.
Component of the HRD1 complex which contains HRD1, HRD3, USA1, DER1, YOS9, KAR2, CDC48, NPL4, UFD1 AND UBX2/SEL1. The complex is composed of the core membrane complex, consisting of the E3 ligase HRD1 and its cofactors HRD3, DER1 and USA1, the substrate recruiting factors KAR2 and YOS9, and the heterotrimeric UFD1-NPL4-CDC48/p97 (UNC) ATPase complex recruited by UBX2/SEL1.
Interacts with CDC48.
4 PublicationsBinary interactionsi
Hide detailsQ04228
With | #Exp. | IntAct |
---|---|---|
CDC48 [P25694] | 15 | EBI-27730,EBI-4308 |
HRD1 [Q08109] | 7 | EBI-27730,EBI-37613 |
SSM4 [P40318] | 5 | EBI-27730,EBI-18208 |
UFD1 [P53044] | 5 | EBI-27730,EBI-19997 |
YOS9 [Q99220] | 3 | EBI-27730,EBI-34938 |
Protein-protein interaction databases
BioGRIDi | 35156, 397 interactors |
ComplexPortali | CPX-3070, HRD1 ubiquitin ligase complex CPX-3074, Doa10 ubiquitin ligase complex |
DIPi | DIP-5073N |
IntActi | Q04228, 16 interactors |
MINTi | Q04228 |
STRINGi | 4932.YML013W |
Miscellaneous databases
RNActi | Q04228, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 426 – 570 | UBXAdd BLAST | 145 |
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1363, Eukaryota |
HOGENOMi | CLU_414514_0_0_1 |
InParanoidi | Q04228 |
OMAi | RSEWNVQ |
Family and domain databases
InterProi | View protein in InterPro IPR001012, UBX_dom |
Pfami | View protein in Pfam PF00789, UBX, 1 hit |
SMARTi | View protein in SMART SM00166, UBX, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MPVVNHEDSE FHLSHTEEDK LNEFQVITNF PPEDLPDVVR LLRNHGWQLE
60 70 80 90 100
PALSRYFDGE WKGEPDQMGE PTQTSTPMAE TLVPPALGPR PLLFTASLPV
110 120 130 140 150
VRPLPANFRN DFRTIGLNGR SNTVWSMFES FSYDGNPFLF ILLLIPRIIN
160 170 180 190 200
RLSATIFTFF CTLLSLHSIS GGGNSGKPKI SKVPKAPTRE THIPLAEILG
210 220 230 240 250
DTKDKDAFCE LKSFKPDISF NEALRIAKEE FKFMLLILVG DTYDTDTDTV
260 270 280 290 300
DVNSKLLLEK ILLNKKTLQY LRKIDNDLII YLKCVHELEP WLVARQLGVR
310 320 330 340 350
NTPEIFLIAN VANKASHSET LPSQRLSILG KLKVNSLNRF LQSLTNVVEK
360 370 380 390 400
YTPELVVNKT EMHELRMSRE IKKLQEDAYK KSLEMDRIKA IEKEKSLKHA
410 420 430 440 450
QDLKLNSTAR QLKWLKACID EIQPFETTGK QATLQFRTSS GKRFVKKFPS
460 470 480 490 500
MTTLYQIYQS IGCHIYLAVY SSDPAEWSNA LQDKIRQLSA DDDMLCFKEG
510 520 530 540 550
QLETATATTI EELGHIINNE LTSFDLERGK LEFDFELVSP FPKYTVHPNE
560 570 580
HMSVDQVPQL WPNGSLLVEA LDEEDEEDEE NEEQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z49810 Genomic DNA Translation: CAA89939.1 BK006946 Genomic DNA Translation: DAA09885.1 |
PIRi | S55106 |
RefSeqi | NP_013699.1, NM_001182371.1 |
Genome annotation databases
EnsemblFungii | YML013W_mRNA; YML013W; YML013W |
GeneIDi | 854995 |
KEGGi | sce:YML013W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z49810 Genomic DNA Translation: CAA89939.1 BK006946 Genomic DNA Translation: DAA09885.1 |
PIRi | S55106 |
RefSeqi | NP_013699.1, NM_001182371.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 35156, 397 interactors |
ComplexPortali | CPX-3070, HRD1 ubiquitin ligase complex CPX-3074, Doa10 ubiquitin ligase complex |
DIPi | DIP-5073N |
IntActi | Q04228, 16 interactors |
MINTi | Q04228 |
STRINGi | 4932.YML013W |
PTM databases
iPTMneti | Q04228 |
Proteomic databases
MaxQBi | Q04228 |
PaxDbi | Q04228 |
PRIDEi | Q04228 |
Genome annotation databases
EnsemblFungii | YML013W_mRNA; YML013W; YML013W |
GeneIDi | 854995 |
KEGGi | sce:YML013W |
Organism-specific databases
EuPathDBi | FungiDB:YML013W |
SGDi | S000004475, UBX2 |
Phylogenomic databases
eggNOGi | KOG1363, Eukaryota |
HOGENOMi | CLU_414514_0_0_1 |
InParanoidi | Q04228 |
OMAi | RSEWNVQ |
Miscellaneous databases
PROi | PR:Q04228 |
RNActi | Q04228, protein |
Family and domain databases
InterProi | View protein in InterPro IPR001012, UBX_dom |
Pfami | View protein in Pfam PF00789, UBX, 1 hit |
SMARTi | View protein in SMART SM00166, UBX, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UBX2_YEAST | |
Accessioni | Q04228Primary (citable) accession number: Q04228 Secondary accession number(s): D6VZG1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast chromosome XIII
Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names - Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD