RELA

Functionⁱ

NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The inhibitory effect of I-kappa-B on NF-kappa-B through retention in the cytoplasm is exerted primarily through the interaction with RELA. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Beside its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681). The NF-kappa-B homodimeric RELA-RELA complex appears to be involved in invasin-mediated activation of IL-8 expression. Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148).9 Publications

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Host-virus interaction, Transcription, Transcription regulation

Enzyme and pathway databases

PathwayCommonsⁱ	Q04206
Reactomeⁱ	R-HSA-1169091, Activation of NF-kappaB in B cells R-HSA-1810476, RIP-mediated NFkB activation via ZBP1 R-HSA-193692, Regulated proteolysis of p75NTR R-HSA-202424, Downstream TCR signaling R-HSA-209560, NF-kB is activated and signals survival R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP) R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-3134963, DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3214841, PKMTs methylate histone lysines R-HSA-381340, Transcriptional regulation of white adipocyte differentiation R-HSA-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-HSA-448706, Interleukin-1 processing R-HSA-4755510, SUMOylation of immune response proteins R-HSA-5603029, IkBA variant leads to EDA-ID R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607764, CLEC7A (Dectin-1) signaling R-HSA-5621575, CD209 (DC-SIGN) signaling R-HSA-5660668, CLEC7A/inflammasome pathway R-HSA-844456, The NLRP3 inflammasome R-HSA-8853884, Transcriptional Regulation by VENTX R-HSA-9020702, Interleukin-1 signaling R-HSA-933542, TRAF6 mediated NF-kB activation R-HSA-9660826, Purinergic signaling in leishmaniasis infection
SABIO-RKⁱ	Q04206
SignaLinkⁱ	Q04206
SIGNORⁱ	Q04206

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription factor p65 Alternative name(s): Nuclear factor NF-kappa-B p65 subunit Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
Gene namesⁱ	Name:RELA Synonyms:NFKB3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9955, RELA
MIMⁱ	164014, gene
neXtProtⁱ	NX_Q04206
VEuPathDBⁱ	HostDB:ENSG00000173039.18

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

A chromosomal aberration involving C11orf95 is found in more than two-thirds of supratentorial ependymomas. Translocation with C11orf95 produces a C11orf95-RELA fusion protein. C11orf95-RELA translocations are potent oncogenes that probably transform neural stem cells by driving an aberrant NF-kappa-B transcription program (PubMed:24553141).1 Publication

Mucocutaneous ulceration, chronic (CMCU)1 Publication

The disease may be caused by variants affecting the gene represented in this entry.

Disease descriptionAn autosomal dominant, mucocutaneous disease characterized by chronic mucosal lesions, in absence of recurrent infections.

Related information in OMIM

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	254	T → A: Abolishes interaction with PIN1. 1 Publication		1
Mutagenesisⁱ	276	S → C: Loss of phosphorylation. 1 Publication		1

Keywords - Diseaseⁱ

Disease variant

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5970
MalaCards human disease database More...MalaCardsⁱ	RELA
MIMⁱ	618287, phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000173039
Orphanetⁱ	251636, Ependymoma 530792, RELA fusion-positive ependymoma
PharmGKBⁱ	PA296

Miscellaneous databases

Pharosⁱ	Q04206, Tchem

Pharosⁱ

Q04206, Tchem

Chemistry databases

ChEMBLⁱ	CHEMBL5533
Drug and drug target database More...DrugBankⁱ	DB08908, Dimethyl fumarate DB14059, SC-236
DrugCentral More...DrugCentralⁱ	Q04206

Genetic variation databases

BioMutaⁱ	RELA
DMDMⁱ	62906901

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000205169	1 – 551	Transcription factor p65Add BLAST		551

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources	1
Cross-linkⁱ	37	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO3)1 Publication
Modified residueⁱ	38	Cysteine persulfide; alternateBy similarity	1
Modified residueⁱ	38	S-nitrosocysteine; alternateBy similarity	1
Modified residueⁱ	122	N6-acetyllysine; by PCAF and EP300; alternate1 Publication	1
Cross-linkⁱ	122	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO3); alternate
Modified residueⁱ	123	N6-acetyllysine; by PCAF and EP300; alternate1 Publication	1
Cross-linkⁱ	123	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO3); alternate
Modified residueⁱ	218	N6-acetyllysine1 Publication	1
Modified residueⁱ	221	N6-acetyllysine1 Publication	1
Modified residueⁱ	254	Phosphothreonine1 Publication	1
Modified residueⁱ	276	Phosphoserine; by RPS6KA4 and RPS6KA51 Publication	1
Modified residueⁱ	281	Phosphoserine1 Publication	1
Modified residueⁱ	310	N6-acetyllysine; alternateCombined sources4 Publications	1
Modified residueⁱ	310	N6-methyllysine; by SETD6; alternateBy similarity	1
Modified residueⁱ	311	Phosphoserine; by PKC/PRKCZBy similarity	1
Modified residueⁱ	435	Phosphothreonine1 Publication	1
Modified residueⁱ	468	Phosphoserine; by IKKB and IKKE2 Publications	1
Modified residueⁱ	505	Phosphothreonine; by CHEK11 Publication	1
Modified residueⁱ	529	Phosphoserine; by CK21 Publication	1
Modified residueⁱ	536	Phosphoserine; by IKKB2 Publications	1

Post-translational modificationⁱ

Ubiquitinated by RNF182, leading to its proteasomal degradation. Degradation is required for termination of NF-kappa-B response.2 Publications

Monomethylated at Lys-310 by SETD6. Monomethylation at Lys-310 is recognized by the ANK repeats of EHMT1 and promotes the formation of repressed chromatin at target genes, leading to down-regulation of NF-kappa-B transcription factor activity. Phosphorylation at Ser-311 disrupts the interaction with EHMT1 without preventing monomethylation at Lys-310 and relieves the repression of target genes (By similarity).By similarity

Phosphorylation at Ser-311 disrupts the interaction with EHMT1 and promotes transcription factor activity (By similarity). Phosphorylation on Ser-536 stimulates acetylation on Lys-310 and interaction with CBP; the phosphorylated and acetylated forms show enhanced transcriptional activity. Phosphorylation at Ser-276 by RPS6KA4 and RPS6KA5 promotes its transactivation and transcriptional activities.By similarity14 Publications

Reversibly acetylated; the acetylation seems to be mediated by CBP, the deacetylation by HDAC3 and SIRT2. Acetylation at Lys-122 enhances DNA binding and impairs association with NFKBIA. Acetylation at Lys-310 is required for full transcriptional activity in the absence of effects on DNA binding and NFKBIA association. Acetylation at Lys-310 promotes interaction with BRD4. Acetylation can also lower DNA-binding and results in nuclear export. Interaction with BRMS1 promotes deacetylation of Lys-310. Lys-310 is deacetylated by SIRT2.5 Publications

S-nitrosylation of Cys-38 inactivates the enzyme activity.By similarity

Sulfhydration at Cys-38 mediates the anti-apoptotic activity by promoting the interaction with RPS3 and activating the transcription factor activity.By similarity

Sumoylation by PIAS3 negatively regulates DNA-bound activated NF-kappa-B.1 Publication

Proteolytically cleaved within a conserved N-terminus region required for base-specific contact with DNA in a CPEN1-mediated manner, and hence inhibits NF-kappa-B transcriptional activity (PubMed:18212740).1 Publication

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, S-nitrosylation, Ubl conjugation

Proteomic databases

EPDⁱ	Q04206
jPOSTⁱ	Q04206
MassIVEⁱ	Q04206
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q04206
PaxDbⁱ	Q04206
PeptideAtlas More...PeptideAtlasⁱ	Q04206
PRIDEⁱ	Q04206
ProteomicsDBⁱ	58236 [Q04206-1] 58237 [Q04206-2] 58238 [Q04206-3] 58239 [Q04206-4]

PTM databases

GlyGenⁱ	Q04206, 1 site, 1 O-linked glycan (1 site)
iPTMnetⁱ	Q04206
MetOSiteⁱ	Q04206
PhosphoSitePlusⁱ	Q04206
SwissPalmⁱ	Q04206

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000173039, Expressed in tibial artery and 238 other tissues
ExpressionAtlasⁱ	Q04206, baseline and differential
Genevisibleⁱ	Q04206, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000173039, Low tissue specificity

HPAⁱ

ENSG00000173039, Low tissue specificity

Interactionⁱ

Subunit structureⁱ

Component of the NF-kappa-B p65-p50 complex.

Component of the NF-kappa-B p65-c-Rel complex. Homodimer; component of the NF-kappa-B p65-p65 complex.

Component of the NF-kappa-B p65-p52 complex. May interact with ETHE1. Binds TLE5 and TLE1.

Interacts with TP53BP2. Binds to and is phosphorylated by the activated form of either RPS6KA4 or RPS6KA5.

Interacts with ING4 and this interaction may be indirect.

Interacts with CARM1, USP48 and UNC5CL.

Interacts with IRAK1BP1 (By similarity).

Interacts with NFKBID (By similarity).

Interacts with NFKBIA (PubMed:1493333).

Interacts with GSK3B.

Interacts with NFKBIB (By similarity).

Interacts with NFKBIE.

Interacts with NFKBIZ.

Interacts with EHMT1 (via ANK repeats) (By similarity).

Part of a 70-90 kDa complex at least consisting of CHUK, IKBKB, NFKBIA, RELA, ELP1 and MAP3K14.

Interacts with HDAC3; HDAC3 mediates the deacetylation of RELA.

Interacts with HDAC1; the interaction requires non-phosphorylated RELA.

Interacts with CBP; the interaction requires phosphorylated RELA.

Interacts (phosphorylated at 'Thr-254') with PIN1; the interaction inhibits p65 binding to NFKBIA.

Interacts with SOCS1.

Interacts with UXT.

Interacts with MTDH and PHF11.

Interacts with ARRB2.

Interacts with NFKBIA (when phosphorylated), the interaction is direct; phosphorylated NFKBIA is part of a SCF(BTRC)-like complex lacking CUL1.

Interacts with RNF25.

Interacts (via C-terminus) with DDX1.

Interacts with UFL1 and COMMD1.

Interacts with BRMS1; this promotes deacetylation of 'Lys-310'.

Interacts with NOTCH2 (By similarity). Directly interacts with MEN1; this interaction represses NFKB-mediated transactivation.

Interacts with AKIP1, which promotes the phosphorylation and nuclear retention of RELA.

Interacts (via the RHD) with GFI1; the interaction, after bacterial lipopolysaccharide (LPS) stimulation, inhibits the transcriptional activity by interfering with the DNA-binding activity to target gene promoter DNA.

Interacts (when acetylated at Lys-310) with BRD4; leading to activation of the NF-kappa-B pathway.

Interacts with MEFV.

Interacts with CLOCK (By similarity).

Interacts (via N-terminus) with CPEN1; this interaction induces proteolytic cleavage of p65/RELA subunit and inhibition of NF-kappa-B transcriptional activity (PubMed:18212740).

Interacts with FOXP3.

Interacts with CDK5RAP3; stimulates the interaction of RELA with HDAC1, HDAC2 and HDAC3 thereby inhibiting NF-kappa-B transcriptional activity (PubMed:17785205).

Interacts with DHX9; this interaction is direct and activates NF-kappa-B-mediated transcription (PubMed:15355351).

Interacts with LRRC25 (PubMed:29044191).

Interacts with TBX21 (By similarity).

Interacts with KAT2A (By similarity).

Interacts with ZBTB7A; involved in the control by RELA of the accessibility of target gene promoters (PubMed:29813070). Directly interacts with DDX3X; this interaction may trap RELA in the cytoplasm, impairing nuclear relocalization upon TNF activating signals (PubMed:27736973).

By similarity8 Publications

(Microbial infection) Interacts with human respiratory syncytial virus (HRSV) protein M2-1.

1 Publication

(Microbial infection) Interacts with molluscum contagiosum virus MC132.

1 Publication

(Microbial infection) Interacts with herpes virus 8 virus protein LANA1.

1 Publication

Binary interactionsⁱ

Q04206

With	#Exp.	IntAct
AATF [Q9NY61]	3	EBI-73886,EBI-372428
ATF3 - isoform 3 [P18847-3]	5	EBI-73886,EBI-9844134
BRD4 [O60885]	8	EBI-73886,EBI-723869
CASP6 [P55212]	3	EBI-73886,EBI-718729
CCK [P06307]	3	EBI-73886,EBI-6624398
CDK5RAP3 [Q96JB5]	4	EBI-73886,EBI-718818
CHAT - isoform R [P28329-3]	3	EBI-73886,EBI-25837549
CHUK [O15111]	2	EBI-73886,EBI-81249
COMMD1 [Q8N668]	7	EBI-73886,EBI-1550112
CREBBP [Q92793]	6	EBI-73886,EBI-81215
CRIP2 [P52943]	2	EBI-73886,EBI-947590
CTNNB1 [P35222]	3	EBI-73886,EBI-491549
DAXX [Q9UER7]	5	EBI-73886,EBI-77321
DHX9 [Q08211]	4	EBI-73886,EBI-352022
EHMT1 [Q9H9B1]	3	EBI-73886,EBI-766087
ESR1 [P03372]	9	EBI-73886,EBI-78473
FGFR3 [P22607]	3	EBI-73886,EBI-348399
GFI1 [Q99684]	2	EBI-73886,EBI-949368
GSN [P06396]	3	EBI-73886,EBI-351506
HDAC1 [Q13547]	6	EBI-73886,EBI-301834
IER3 [P46695]	6	EBI-73886,EBI-1748945
IKBKB [O14920]	2	EBI-73886,EBI-81266
IRF5 [Q13568]	4	EBI-73886,EBI-3931258
KDM2A [Q9Y2K7]	2	EBI-73886,EBI-765758
KEAP1 [Q14145]	4	EBI-73886,EBI-751001
KLF6 [Q99612]	6	EBI-73886,EBI-714994
LAMP2 - isoform LAMP-2B [P13473-2]	3	EBI-73886,EBI-21591415
LMO2 [P25791]	3	EBI-73886,EBI-739696
MACROD1 [Q9BQ69]	7	EBI-73886,EBI-5324932
MAPK10 [P53779]	2	EBI-73886,EBI-713543
MEN1 - isoform 2 [O00255-2]	4	EBI-73886,EBI-9869387
NFE2L2 [Q16236]	5	EBI-73886,EBI-2007911
NFKB1 [P19838]	12	EBI-73886,EBI-300010
Nuclear factor NF-kappa-B p50 subunit (PRO_0000030311)	7	EBI-73886,EBI-697771
NFKBIA [P25963]	25	EBI-73886,EBI-307386
NFKBIB [Q15653]	6	EBI-73886,EBI-352889
NR4A1 - isoform 1 [P22736-1]	3	EBI-73886,EBI-16085263
NSD1 [Q96L73]	2	EBI-73886,EBI-2862434
OGT [O15294]	2	EBI-73886,EBI-539828
PDCD4 [Q53EL6]	6	EBI-73886,EBI-935824
PIAS4 [Q8N2W9]	2	EBI-73886,EBI-473160
PPP2CA [P67775]	6	EBI-73886,EBI-712311
PPP2R1A [P30153]	2	EBI-73886,EBI-302388
PRPF40A - isoform 2 [O75400-2]	3	EBI-73886,EBI-5280197
RAN [P62826]	3	EBI-73886,EBI-286642
itself	3	EBI-73886,EBI-73886
RPS3 [P23396]	8	EBI-73886,EBI-351193
SETD7 [Q8WTS6]	12	EBI-73886,EBI-1268586
SIRT1 [Q96EB6]	5	EBI-73886,EBI-1802965
SIRT2 [Q8IXJ6]	2	EBI-73886,EBI-477232
SIRT6 [Q8N6T7]	4	EBI-73886,EBI-712415
SNAI1 [O95863]	5	EBI-73886,EBI-1045459
SOCS1 [O15524]	2	EBI-73886,EBI-968198
STAT3 [P40763]	4	EBI-73886,EBI-518675
TARDBP [Q13148]	3	EBI-73886,EBI-372899
TGM2 [P21980]	3	EBI-73886,EBI-727668
TP53BP2 [Q13625]	4	EBI-73886,EBI-77642
TP53BP2 - isoform 2 [Q13625-2]	6	EBI-73886,EBI-287091
UBC [P0CG48]	6	EBI-73886,EBI-3390054
UBQLN1 [Q9UMX0]	3	EBI-73886,EBI-741480
UXT [Q9UBK9]	5	EBI-73886,EBI-357355
Q9Y649	3	EBI-73886,EBI-25900580
Brd4 [Q9ESU6] from Mus musculus.	6	EBI-73886,EBI-6260864
GAMMAHV.ORF73 [O41974] from Murid herpesvirus 4.	3	EBI-73886,EBI-6933128
Myocd - isoform 1 [Q8VIM5-1] from Mus musculus.	2	EBI-73886,EBI-15626132
nleC [Q8X834] from Escherichia coli O157:H7.	2	EBI-73886,EBI-10039193
OTT_0753 [B3CRR2] from Orientia tsutsugamushi (strain Ikeda).	3	EBI-73886,EBI-26357571
OTT_1912 [B3CTB0] from Orientia tsutsugamushi (strain Ikeda).	2	EBI-73886,EBI-26357538
P/V [P0C774] from Measles virus (strain Ichinose-B95a).	3	EBI-73886,EBI-3650423
UL42 [P10226] from Human herpesvirus 1 (strain 17).	6	EBI-73886,EBI-1029310
yerA [P31491] from Yersinia pestis.	2	EBI-73886,EBI-2840013
YPO2940 [A0A384KL23] from Yersinia pestis.	2	EBI-73886,EBI-20592225
YPO3877 [A0A380PFV1] from Yersinia pestis.	2	EBI-73886,EBI-20592206
yscL [P69976] from Yersinia pestis.	2	EBI-73886,EBI-2846298

Isoform 1 [Q04206-1]

With	#Exp.	IntAct
SIX2 [Q9NPC8]	2	EBI-10826776,EBI-12695166
Myocd - isoform 1 [Q8VIM5-1] from Mus musculus.	2	EBI-10826776,EBI-15626132

Isoform 2 [Q04206-2]

With	#Exp.	IntAct
NFKBIA [P25963]	2	EBI-289947,EBI-307386
REL [Q04864]	2	EBI-289947,EBI-307352
RELB [Q01201]	2	EBI-289947,EBI-357837

Isoform 3 [Q04206-3]

With	#Exp.	IntAct
FUS [P35637]	3	EBI-10223388,EBI-400434
REL [Q04864]	3	EBI-10223388,EBI-307352
TCF4 [P15884]	3	EBI-10223388,EBI-533224

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	111902, 350 interactors
ComplexPortalⁱ	CPX-5828, NF-kappaB DNA-binding transcription factor complex, p50/p65 CPX-5829, NF-kappaB DNA-binding transcription factor complex, p52/p65 CPX-5834, NF-kappaB DNA-binding transcription factor complex, p65/c-Rel CPX-5835, NF-kappaB DNA-binding transcription factor complex, p65/p65
CORUMⁱ	Q04206
Database of interacting proteins More...DIPⁱ	DIP-24238N
ELMⁱ	Q04206
IntActⁱ	Q04206, 179 interactors
Molecular INTeraction database More...MINTⁱ	Q04206
STRINGⁱ	9606.ENSP00000384273

Chemistry databases

BindingDBⁱ

Q04206

Miscellaneous databases

RNActⁱ	Q04206, protein

RNActⁱ

Q04206, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	21 – 25	Combined sources	5
Beta strandⁱ	30 – 32	Combined sources	3
Beta strandⁱ	39 – 41	Combined sources	3
Beta strandⁱ	53 – 55	Combined sources	3
Beta strandⁱ	60 – 63	Combined sources	4
Beta strandⁱ	68 – 80	Combined sources	13
Beta strandⁱ	87 – 92	Combined sources	6
Beta strandⁱ	97 – 104	Combined sources	8
Beta strandⁱ	109 – 112	Combined sources	4
Beta strandⁱ	117 – 119	Combined sources	3
Helixⁱ	123 – 125	Combined sources	3
Helixⁱ	126 – 129	Combined sources	4
Turnⁱ	130 – 137	Combined sources	8
Turnⁱ	145 – 148	Combined sources	4
Beta strandⁱ	156 – 166	Combined sources	11
Beta strandⁱ	168 – 173	Combined sources	6
Beta strandⁱ	183 – 188	Combined sources	6
Beta strandⁱ	196 – 200	Combined sources	5
Beta strandⁱ	202 – 205	Combined sources	4
Beta strandⁱ	211 – 217	Combined sources	7
Beta strandⁱ	225 – 230	Combined sources	6
Beta strandⁱ	233 – 238	Combined sources	6
Helixⁱ	241 – 243	Combined sources	3
Turnⁱ	246 – 248	Combined sources	3
Beta strandⁱ	249 – 253	Combined sources	5
Beta strandⁱ	258 – 260	Combined sources	3
Beta strandⁱ	266 – 273	Combined sources	8
Turnⁱ	275 – 277	Combined sources	3
Beta strandⁱ	284 – 289	Combined sources	6
Helixⁱ	294 – 302	Combined sources	9
Helixⁱ	306 – 312	Combined sources	7
Beta strandⁱ	527 – 534	Combined sources	8
Turnⁱ	535 – 540	Combined sources	6
Helixⁱ	542 – 550	Combined sources	9

Show more details

3D structure databases

SMRⁱ	Q04206
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q04206

EvolutionaryTraceⁱ

Q04206

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	19 – 306	RHDPROSITE-ProRule annotationAdd BLAST		288

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	342 – 389	Transcriptional activation domain 3By similarityAdd BLAST	48
Regionⁱ	415 – 476	Transcriptional activation domain 11 PublicationAdd BLAST	62
Regionⁱ	520 – 551	Transcriptional activation domain 2By similarityAdd BLAST	32

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	301 – 304	Nuclear localization signalSequence analysis		4
Motifⁱ	536 – 544	9aaTADSequence analysis		9

Domainⁱ

The transcriptional activation domain 3/TA3 does not participate in the direct transcriptional activity of RELA but is involved in the control by RELA of the accessibility of target gene promoters. Mediates interaction with ZBTB7A.By similarity

The transcriptional activation domain 1/TA1 and the transcriptional activation domain 2/TA2 have direct transcriptional activation properties (By similarity). The 9aaTAD motif found within the transcriptional activation domain 2 is a conserved motif present in a large number of transcription factors that is required for their transcriptional transactivation activity (PubMed:17467953).By similarity1 Publication

Phylogenomic databases

eggNOGⁱ	ENOG502QT4Z, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000159867
InParanoidⁱ	Q04206
OMAⁱ	PTAEPML
Database of Orthologous Groups More...OrthoDBⁱ	916931at2759
PhylomeDBⁱ	Q04206
TreeFamⁱ	TF325632

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01177, IPT_NFkappaB, 1 hit
Database of protein disorder More...DisProtⁱ	DP00085
Gene3Dⁱ	2.60.40.10, 1 hit 2.60.40.340, 1 hit
IDEALⁱ	IID00207
InterProⁱ	View protein in InterPro IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR033926, IPT_NFkappaB IPR000451, NFkB/Dor IPR008967, p53-like_TF_DNA-bd IPR030495, RelA IPR030492, RHD_CS IPR032397, RHD_dimer IPR011539, RHD_DNA_bind_dom IPR037059, RHD_DNA_bind_dom_sf
PANTHERⁱ	PTHR24169, PTHR24169, 1 hit PTHR24169:SF1, PTHR24169:SF1, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16179, RHD_dimer, 1 hit PF00554, RHD_DNA_bind, 1 hit
PRINTSⁱ	PR00057, NFKBTNSCPFCT
SMARTⁱ	View protein in SMART SM00429, IPT, 1 hit
SUPFAMⁱ	SSF49417, SSF49417, 1 hit SSF81296, SSF81296, 1 hit
PROSITEⁱ	View protein in PROSITE PS01204, REL_1, 1 hit PS50254, REL_2, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 17 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q04206-1) [UniParc]FASTA Add to basket

Also known as: p65

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDELFPLIFP AEPAQASGPY VEIIEQPKQR GMRFRYKCEG RSAGSIPGER 
        60         70         80         90        100
STDTTKTHPT IKINGYTGPG TVRISLVTKD PPHRPHPHEL VGKDCRDGFY 
       110        120        130        140        150
EAELCPDRCI HSFQNLGIQC VKKRDLEQAI SQRIQTNNNP FQVPIEEQRG 
       160        170        180        190        200
DYDLNAVRLC FQVTVRDPSG RPLRLPPVLS HPIFDNRAPN TAELKICRVN 
       210        220        230        240        250
RNSGSCLGGD EIFLLCDKVQ KEDIEVYFTG PGWEARGSFS QADVHRQVAI 
       260        270        280        290        300
VFRTPPYADP SLQAPVRVSM QLRRPSDREL SEPMEFQYLP DTDDRHRIEE 
       310        320        330        340        350
KRKRTYETFK SIMKKSPFSG PTDPRPPPRR IAVPSRSSAS VPKPAPQPYP 
       360        370        380        390        400
FTSSLSTINY DEFPTMVFPS GQISQASALA PAPPQVLPQA PAPAPAPAMV 
       410        420        430        440        450
SALAQAPAPV PVLAPGPPQA VAPPAPKPTQ AGEGTLSEAL LQLQFDDEDL 
       460        470        480        490        500
GALLGNSTDP AVFTDLASVD NSEFQQLLNQ GIPVAPHTTE PMLMEYPEAI 
       510        520        530        540        550
TRLVTGAQRP PDPAPAPLGA PGLPNGLLSG DEDFSSIADM DFSALLSQIS 

S

Length:551

Mass (Da):60,219

Last modified:April 26, 2005 - v2

Checksum:ⁱ8147A6AF9F2445C6

GO

Isoform 2 (identifier: Q04206-2) [UniParc]FASTA Add to basket

Also known as: p65 delta 2

The sequence of this isoform differs from the canonical sequence as follows:
13-25: Missing.
506-506: Missing.

« Hide

        10         20         30         40         50
MDELFPLIFP AEQPKQRGMR FRYKCEGRSA GSIPGERSTD TTKTHPTIKI 
        60         70         80         90        100
NGYTGPGTVR ISLVTKDPPH RPHPHELVGK DCRDGFYEAE LCPDRCIHSF 
       110        120        130        140        150
QNLGIQCVKK RDLEQAISQR IQTNNNPFQV PIEEQRGDYD LNAVRLCFQV 
       160        170        180        190        200
TVRDPSGRPL RLPPVLSHPI FDNRAPNTAE LKICRVNRNS GSCLGGDEIF 
       210        220        230        240        250
LLCDKVQKED IEVYFTGPGW EARGSFSQAD VHRQVAIVFR TPPYADPSLQ 
       260        270        280        290        300
APVRVSMQLR RPSDRELSEP MEFQYLPDTD DRHRIEEKRK RTYETFKSIM 
       310        320        330        340        350
KKSPFSGPTD PRPPPRRIAV PSRSSASVPK PAPQPYPFTS SLSTINYDEF 
       360        370        380        390        400
PTMVFPSGQI SQASALAPAP PQVLPQAPAP APAPAMVSAL AQAPAPVPVL 
       410        420        430        440        450
APGPPQAVAP PAPKPTQAGE GTLSEALLQL QFDDEDLGAL LGNSTDPAVF 
       460        470        480        490        500
TDLASVDNSE FQQLLNQGIP VAPHTTEPML MEYPEAITRL VTAQRPPDPA 
       510        520        530 
PAPLGAPGLP NGLLSGDEDF SSIADMDFSA LLSQISS

Show »

Length:537

Mass (Da):58,807

Checksum:ⁱA1F26DF2F53E662E

GO

Isoform 3 (identifier: Q04206-3) [UniParc]FASTA Add to basket

Also known as: p65 delta

The sequence of this isoform differs from the canonical sequence as follows:
222-231: Missing.

« Hide

        10         20         30         40         50
MDELFPLIFP AEPAQASGPY VEIIEQPKQR GMRFRYKCEG RSAGSIPGER 
        60         70         80         90        100
STDTTKTHPT IKINGYTGPG TVRISLVTKD PPHRPHPHEL VGKDCRDGFY 
       110        120        130        140        150
EAELCPDRCI HSFQNLGIQC VKKRDLEQAI SQRIQTNNNP FQVPIEEQRG 
       160        170        180        190        200
DYDLNAVRLC FQVTVRDPSG RPLRLPPVLS HPIFDNRAPN TAELKICRVN 
       210        220        230        240        250
RNSGSCLGGD EIFLLCDKVQ KGWEARGSFS QADVHRQVAI VFRTPPYADP 
       260        270        280        290        300
SLQAPVRVSM QLRRPSDREL SEPMEFQYLP DTDDRHRIEE KRKRTYETFK 
       310        320        330        340        350
SIMKKSPFSG PTDPRPPPRR IAVPSRSSAS VPKPAPQPYP FTSSLSTINY 
       360        370        380        390        400
DEFPTMVFPS GQISQASALA PAPPQVLPQA PAPAPAPAMV SALAQAPAPV 
       410        420        430        440        450
PVLAPGPPQA VAPPAPKPTQ AGEGTLSEAL LQLQFDDEDL GALLGNSTDP 
       460        470        480        490        500
AVFTDLASVD NSEFQQLLNQ GIPVAPHTTE PMLMEYPEAI TRLVTGAQRP 
       510        520        530        540 
PDPAPAPLGA PGLPNGLLSG DEDFSSIADM DFSALLSQIS S

Show »

Length:541

Mass (Da):59,068

Checksum:ⁱ49F0493E19798AD1

GO

Isoform 4 (identifier: Q04206-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
143-145: Missing.

« Hide

        10         20         30         40         50
MDELFPLIFP AEPAQASGPY VEIIEQPKQR GMRFRYKCEG RSAGSIPGER 
        60         70         80         90        100
STDTTKTHPT IKINGYTGPG TVRISLVTKD PPHRPHPHEL VGKDCRDGFY 
       110        120        130        140        150
EAELCPDRCI HSFQNLGIQC VKKRDLEQAI SQRIQTNNNP FQEEQRGDYD 
       160        170        180        190        200
LNAVRLCFQV TVRDPSGRPL RLPPVLSHPI FDNRAPNTAE LKICRVNRNS 
       210        220        230        240        250
GSCLGGDEIF LLCDKVQKED IEVYFTGPGW EARGSFSQAD VHRQVAIVFR 
       260        270        280        290        300
TPPYADPSLQ APVRVSMQLR RPSDRELSEP MEFQYLPDTD DRHRIEEKRK 
       310        320        330        340        350
RTYETFKSIM KKSPFSGPTD PRPPPRRIAV PSRSSASVPK PAPQPYPFTS 
       360        370        380        390        400
SLSTINYDEF PTMVFPSGQI SQASALAPAP PQVLPQAPAP APAPAMVSAL 
       410        420        430        440        450
AQAPAPVPVL APGPPQAVAP PAPKPTQAGE GTLSEALLQL QFDDEDLGAL 
       460        470        480        490        500
LGNSTDPAVF TDLASVDNSE FQQLLNQGIP VAPHTTEPML MEYPEAITRL 
       510        520        530        540 
VTGAQRPPDP APAPLGAPGL PNGLLSGDED FSSIADMDFS ALLSQISS

Show »

Length:548

Mass (Da):59,910

Checksum:ⁱED40EF8B91F0A19A

GO

Computationally mapped potential isoform sequencesⁱ

There are 17 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	A0A087X0W8	A0A087X0W8_HUMAN	Transcription factor p65 Transcription factor p65	RELA	448	Annotation score:
	Q2TAM5	Q2TAM5_HUMAN	RELA protein RELA protein (Transcription factor p65)	RELA	377	Annotation score:
	E9PKH5	E9PKH5_HUMAN	Transcription factor p65 Transcription factor p65	RELA	418	Annotation score:
	E9PI38	E9PI38_HUMAN	Transcription factor p65 Transcription factor p65	RELA	185	Annotation score:
	E9PMD5	E9PMD5_HUMAN	Transcription factor p65 Transcription factor p65	RELA	161	Annotation score:
	E9PNK5	E9PNK5_HUMAN	Transcription factor p65 Transcription factor p65	RELA	85	Annotation score:
	E9PJR1	E9PJR1_HUMAN	Transcription factor p65 Transcription factor p65	RELA	89	Annotation score:
	E9PN69	E9PN69_HUMAN	Transcription factor p65 Transcription factor p65	RELA	134	Annotation score:
	E9PNV4	E9PNV4_HUMAN	Transcription factor p65 Transcription factor p65	RELA	153	Annotation score:
	E9PRX2	E9PRX2_HUMAN	Transcription factor p65 Transcription factor p65	RELA	95	Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	49	E → R in CAA80524 (PubMed:8281153).Curated	1
Sequence conflictⁱ	180	S → P in AAA36408 (PubMed:2006423).Curated	1
Sequence conflictⁱ	372 – 380	QISQASALA → RSARPRLG in CAA80524 (PubMed:8281153).Curated	9

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_081858	246 – 549	Missing Found in a patient diagnosed with autoimmune lymphoproliferative syndrome; unknown pathological significance. 1 PublicationAdd BLAST		304

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_005587	13 – 25	Missing in isoform 2. 1 PublicationAdd BLAST	13
Alternative sequenceⁱVSP_031245	143 – 145	Missing in isoform 4. 1 Publication	3
Alternative sequenceⁱVSP_012031	222 – 231	Missing in isoform 3. 1 Publication	10
Alternative sequenceⁱVSP_005588	506	Missing in isoform 2. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M62399 mRNA Translation: AAA36408.1 Z22948 Z22951 Genomic DNA Translation: CAA80524.2 L19067 mRNA Translation: AAA20946.1 BC033522 mRNA Translation: AAH33522.1 AY455868 Genomic DNA Translation: AAR13863.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31609.1 [Q04206-1] CCDS44651.1 [Q04206-4]
PIRⁱ	A40851 I53719 S51782, A42017
NCBI Reference Sequences More...RefSeqⁱ	NP_001138610.1, NM_001145138.1 [Q04206-4] NP_001230913.1, NM_001243984.1 NP_068810.3, NM_021975.3 [Q04206-1]

Genome annotation databases

Ensemblⁱ	ENST00000308639; ENSP00000311508; ENSG00000173039 [Q04206-4] ENST00000406246; ENSP00000384273; ENSG00000173039 [Q04206-1]
GeneIDⁱ	5970
KEGGⁱ	hsa:5970
UCSC genome browser More...UCSCⁱ	uc001ofg.4, human [Q04206-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Chromosomal rearrangement

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q04206	RELA proto-oncogene, NF-kB subunit		GORGO		551	UniRef100_Q04206
RELA (Fragment)		PANPA		206
RELA (Fragment)		PANTR		364
RELA (Fragment)		western gorilla		364
RELA protein		HUMAN		220

Protein	Similar proteins		Species	Score	Length	Source
Q04206	RELA proto-oncogene, NF-kB subunit		GORGO		551	UniRef90_Q04206
RELA (Fragment)		PANPA		206
RELA (Fragment)		PANTR		364
RELA (Fragment)		western gorilla		364
RELA protein		HUMAN		220
+31
Q04206-4	transcription factor p65		NEOAA		562	UniRef90_Q04206-4
transcription factor p65 isoform X2		TURTR		520
transcription factor p65		Bison bison bison		562
Transcription factor p65 (Fragment)		wild yak		551
transcription factor p65 isoform X2		PHYMC		562
+24

Protein	Similar proteins		Species	Score	Length	Source
Q04206	Transcription factor p65	)	MOUSE		549	UniRef50_Q04206
Transcription factor p65		CHICK		558
RELA proto-oncogene, NF-kB subunit		GORGO		551
RELA (Fragment)		PANPA		206
RELA (Fragment)		PANTR		364
+292

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

SeattleSNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M62399 mRNA Translation: AAA36408.1 Z22948 Z22951 Genomic DNA Translation: CAA80524.2 L19067 mRNA Translation: AAA20946.1 BC033522 mRNA Translation: AAH33522.1 AY455868 Genomic DNA Translation: AAR13863.1
CCDSⁱ	CCDS31609.1 [Q04206-1] CCDS44651.1 [Q04206-4]
PIRⁱ	A40851 I53719 S51782, A42017
RefSeqⁱ	NP_001138610.1, NM_001145138.1 [Q04206-4] NP_001230913.1, NM_001243984.1 NP_068810.3, NM_021975.3 [Q04206-1]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1NFI	X-ray	2.70	A/C	20-320	[»]
	2LSP	NMR	-	A	304-316	[»]
	2O61	X-ray	2.80	A	20-291	[»]
	3GUT	X-ray	3.59	A/C/E/G	20-291	[»]
	3QXY	X-ray	2.09	P/Q	302-316	[»]
	3RC0	X-ray	2.19	P/Q	302-316	[»]
	4KV1	X-ray	1.50	C/D	308-314	[»]
	4KV4	X-ray	2.00	B	308-314	[»]
	5U4K	NMR	-	B	521-551	[»]
	5URN	NMR	-	B	521-551	[»]
	6NV2	X-ray	1.13	P	39-51	[»]
	6QHL	X-ray	1.20	P	38-51	[»]
	6QHM	X-ray	1.25	P	275-287	[»]
	6YOW	X-ray	1.23	P	39-51	[»]
	6YOX	X-ray	2.05	P	39-51	[»]
	6YOY	X-ray	1.80	P	39-51	[»]
	6YP2	X-ray	1.80	P	39-51	[»]
	6YP3	X-ray	1.80	P	39-51	[»]
	6YP8	X-ray	1.80	P	39-51	[»]
	6YPL	X-ray	1.80	P	39-51	[»]
	6YPY	X-ray	1.40	P	39-51	[»]
	6YQ2	X-ray	1.40	P	39-51	[»]
SMRⁱ	Q04206
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	111902, 350 interactors
ComplexPortalⁱ	CPX-5828, NF-kappaB DNA-binding transcription factor complex, p50/p65 CPX-5829, NF-kappaB DNA-binding transcription factor complex, p52/p65 CPX-5834, NF-kappaB DNA-binding transcription factor complex, p65/c-Rel CPX-5835, NF-kappaB DNA-binding transcription factor complex, p65/p65
CORUMⁱ	Q04206
DIPⁱ	DIP-24238N
ELMⁱ	Q04206
IntActⁱ	Q04206, 179 interactors
MINTⁱ	Q04206
STRINGⁱ	9606.ENSP00000384273

Chemistry databases

BindingDBⁱ	Q04206
ChEMBLⁱ	CHEMBL5533
DrugBankⁱ	DB08908, Dimethyl fumarate DB14059, SC-236
DrugCentralⁱ	Q04206

PTM databases

GlyGenⁱ	Q04206, 1 site, 1 O-linked glycan (1 site)
iPTMnetⁱ	Q04206
MetOSiteⁱ	Q04206
PhosphoSitePlusⁱ	Q04206
SwissPalmⁱ	Q04206

Genetic variation databases

BioMutaⁱ	RELA
DMDMⁱ	62906901

Proteomic databases

EPDⁱ	Q04206
jPOSTⁱ	Q04206
MassIVEⁱ	Q04206
MaxQBⁱ	Q04206
PaxDbⁱ	Q04206
PeptideAtlasⁱ	Q04206
PRIDEⁱ	Q04206
ProteomicsDBⁱ	58236 [Q04206-1] 58237 [Q04206-2] 58238 [Q04206-3] 58239 [Q04206-4]

Protocols and materials databases

Antibodypediaⁱ	3557, 3731 antibodies
The DNASU plasmid repository More...DNASUⁱ	5970

Genome annotation databases

Ensemblⁱ	ENST00000308639; ENSP00000311508; ENSG00000173039 [Q04206-4] ENST00000406246; ENSP00000384273; ENSG00000173039 [Q04206-1]
GeneIDⁱ	5970
KEGGⁱ	hsa:5970
UCSCⁱ	uc001ofg.4, human [Q04206-1]

Organism-specific databases

CTDⁱ	5970
DisGeNETⁱ	5970
GeneCardsⁱ	RELA
HGNCⁱ	HGNC:9955, RELA
HPAⁱ	ENSG00000173039, Low tissue specificity
MalaCardsⁱ	RELA
MIMⁱ	164014, gene 618287, phenotype
neXtProtⁱ	NX_Q04206
OpenTargetsⁱ	ENSG00000173039
Orphanetⁱ	251636, Ependymoma 530792, RELA fusion-positive ependymoma
PharmGKBⁱ	PA296
VEuPathDBⁱ	HostDB:ENSG00000173039.18
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG502QT4Z, Eukaryota
GeneTreeⁱ	ENSGT00940000159867
InParanoidⁱ	Q04206
OMAⁱ	PTAEPML
OrthoDBⁱ	916931at2759
PhylomeDBⁱ	Q04206
TreeFamⁱ	TF325632

Enzyme and pathway databases

PathwayCommonsⁱ	Q04206
Reactomeⁱ	R-HSA-1169091, Activation of NF-kappaB in B cells R-HSA-1810476, RIP-mediated NFkB activation via ZBP1 R-HSA-193692, Regulated proteolysis of p75NTR R-HSA-202424, Downstream TCR signaling R-HSA-209560, NF-kB is activated and signals survival R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP) R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-3134963, DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3214841, PKMTs methylate histone lysines R-HSA-381340, Transcriptional regulation of white adipocyte differentiation R-HSA-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-HSA-448706, Interleukin-1 processing R-HSA-4755510, SUMOylation of immune response proteins R-HSA-5603029, IkBA variant leads to EDA-ID R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607764, CLEC7A (Dectin-1) signaling R-HSA-5621575, CD209 (DC-SIGN) signaling R-HSA-5660668, CLEC7A/inflammasome pathway R-HSA-844456, The NLRP3 inflammasome R-HSA-8853884, Transcriptional Regulation by VENTX R-HSA-9020702, Interleukin-1 signaling R-HSA-933542, TRAF6 mediated NF-kB activation R-HSA-9660826, Purinergic signaling in leishmaniasis infection
SABIO-RKⁱ	Q04206
SignaLinkⁱ	Q04206
SIGNORⁱ	Q04206

Miscellaneous databases

BioGRID-ORCSⁱ	5970, 124 hits in 1019 CRISPR screens
ChiTaRSⁱ	RELA, human
EvolutionaryTraceⁱ	Q04206
GeneWikiⁱ	RELA
GenomeRNAiⁱ	5970
Pharosⁱ	Q04206, Tchem
Protein Ontology More...PROⁱ	PR:Q04206
RNActⁱ	Q04206, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000173039, Expressed in tibial artery and 238 other tissues
ExpressionAtlasⁱ	Q04206, baseline and differential
Genevisibleⁱ	Q04206, HS

Family and domain databases

CDDⁱ	cd01177, IPT_NFkappaB, 1 hit
DisProtⁱ	DP00085
Gene3Dⁱ	2.60.40.10, 1 hit 2.60.40.340, 1 hit
IDEALⁱ	IID00207
InterProⁱ	View protein in InterPro IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR033926, IPT_NFkappaB IPR000451, NFkB/Dor IPR008967, p53-like_TF_DNA-bd IPR030495, RelA IPR030492, RHD_CS IPR032397, RHD_dimer IPR011539, RHD_DNA_bind_dom IPR037059, RHD_DNA_bind_dom_sf
PANTHERⁱ	PTHR24169, PTHR24169, 1 hit PTHR24169:SF1, PTHR24169:SF1, 1 hit
Pfamⁱ	View protein in Pfam PF16179, RHD_dimer, 1 hit PF00554, RHD_DNA_bind, 1 hit
PRINTSⁱ	PR00057, NFKBTNSCPFCT
SMARTⁱ	View protein in SMART SM00429, IPT, 1 hit
SUPFAMⁱ	SSF49417, SSF49417, 1 hit SSF81296, SSF81296, 1 hit
PROSITEⁱ	View protein in PROSITE PS01204, REL_1, 1 hit PS50254, REL_2, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TF65_HUMAN
Accessionⁱ	Q04206Primary (citable) accession number: Q04206 Secondary accession number(s): Q6GTV1, Q6SLK1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
	Last sequence update:	April 26, 2005
	Last modified:	April 7, 2021
	This is version 244 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

Annotation systems

Supporting data

UniProtKB - Q04206 (TF65_HUMAN)

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Transcription factor p65

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoplasm and Cytosol

Nucleus

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Miscellaneous databases

Chemistry databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ