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Protein

Tensin

Gene

TNS

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in cell migration, fibrillar adhesion formation, cartilage development and in linking signal transduction pathways to the cytoskeleton.

GO - Molecular functioni

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tensin
Gene namesi
Name:TNS
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002159011 – 1744TensinAdd BLAST1744

Post-translational modificationi

Tyrosine phosphorylated.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ04205
PRIDEiQ04205

Expressioni

Tissue specificityi

Heart, gizzard, lung and skeletal muscle.

Interactioni

Subunit structurei

Binds to actin filaments and interacts with phosphotyrosine-containing proteins.

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-56927N
IntActiQ04205, 4 interactors
STRINGi9031.ENSGALP00000018665

Structurei

Secondary structure

11744
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ04205
SMRiQ04205
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ04205

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 230Phosphatase tensin-typePROSITE-ProRule annotationAdd BLAST173
Domaini235 – 361C2 tensin-typePROSITE-ProRule annotationAdd BLAST127
Domaini1472 – 1581SH2PROSITE-ProRule annotationAdd BLAST110

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG1930 Eukaryota
KOG2283 Eukaryota
COG2453 LUCA
HOGENOMiHOG000060090
HOVERGENiHBG060186
InParanoidiQ04205
KOiK18080
PhylomeDBiQ04205

Family and domain databases

CDDicd01213 PTB_tensin, 1 hit
cd09927 SH2_Tensin_like, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR013625 PTB
IPR006020 PTB/PI_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR014020 Tensin_C2-dom
IPR035012 Tensin_like_SH2
IPR029023 Tensin_phosphatase
IPR033929 Tensin_PTB
IPR003595 Tyr_Pase_cat
PfamiView protein in Pfam
PF08416 PTB, 1 hit
PF10409 PTEN_C2, 1 hit
PF00017 SH2, 1 hit
SMARTiView protein in SMART
SM00462 PTB, 1 hit
SM01326 PTEN_C2, 1 hit
SM00404 PTPc_motif, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS51182 C2_TENSIN, 1 hit
PS51181 PPASE_TENSIN, 1 hit
PS50001 SH2, 1 hit

Sequencei

Sequence statusi: Complete.

Q04205-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDFGSVMNQA ATPCSPAVNY ELPSPGQSIT KQVDTPDATR SPRGGQAHCK
60 70 80 90 100
ASRSMSVTAA MESSCELDLV YITERIIAVS YPSTAEEQSF RSNLREVAHM
110 120 130 140 150
LKSKHGDNYV LFNLSERRHD ISKLHPKVLD FGWPDLHTPA LEKICSICKA
160 170 180 190 200
MDTWLNAAAH NVVVLHNKGN RGRLGVVVAA YMHYSNISAS ADQALDRFAM
210 220 230 240 250
KRFYEDKVVP VGQPSQKRYI HYFSGLLSGS IKMNNKPLFL HHVIMHGIPN
260 270 280 290 300
FESKGGCRPF LKIYQAMQPV YTSGIYNVQG DSQTGICITI EPGLLLKGDI
310 320 330 340 350
LLKCYHKKFR SPTRDVIFRV QFHTCAVHDL DIVFGKEDLD EAFRDERFPE
360 370 380 390 400
YGKVEFVFSY GPEKIQGMEH LENGPSVSVD YNTSDPLIRW DSYENFNIQR
410 420 430 440 450
EDSAEGTWAE PALPGKHLEK EVGHTQGPLD GSLYAKVKKK DSLHGSIGAV
460 470 480 490 500
NTARLPLSAA PNHVEHTLSV SSDSGNSTAS TKTDRTDEPG APGAPTGHAV
510 520 530 540 550
LSPEEKRDVD RLLVGFGLES AAPMHNHAPG PAPARLPAGP GRHVVPAQVH
560 570 580 590 600
VNGAGTPLLA ERETDILDDE LPNQDGHSVG SLGTLSSLDG TTTASEAGFH
610 620 630 640 650
EAPRVGSLSS LPNGPASYNG AEKMLKEGLY EAEPLSNGAY PYSNQNTLMG
660 670 680 690 700
HHLRDPLAHL RPSRSAQEHL AGYPQRQPAS ASPAWLQPPV PQPYLYGYDL
710 720 730 740 750
PSAHRSQSFP AVGTAKYEAN LALPQAPARS TSSREAVQRG LNSWQQQGGS
760 770 780 790 800
RPPSQLHDGG LESHSPSLSS CSPQPSPLQP MPPHSHSMPE FPRAPSRREI
810 820 830 840 850
EQSIEALDVL MLDLAPSVHK SQSVPSAATR QDKPAAMLSS LSAQRLSGHY
860 870 880 890 900
AQPTPQVVQP RSFGTSVGTD PLAKPYSPGP LVPAARSTAE PDYTVHEYRE
910 920 930 940 950
TYTPYSYQPV PEPRSYGSAP ASILPLSASY SPAGSQQLLV SSPPSPTAPA
960 970 980 990 1000
QSQLPHKGLE SYEDLSRSGE EPLNLEGLVA HRVAGVQSRE KSPEESTVPA
1010 1020 1030 1040 1050
RRRTPSDSHY EKSSPEPGSP RSPTVLSPEV VSTIAANPGG RPKEPHLHSY
1060 1070 1080 1090 1100
KEAFEEMESA SPSSLTSGGV RSPPGLAKTP LSALGLKPHN PADILLHPVG
1110 1120 1130 1140 1150
ELEGEAGADS EEEPRSYVES VARTATTGRA GNLPAAQPVG LEVPARNGAF
1160 1170 1180 1190 1200
GNSFTVPSPV STSSPIHSVD GASLRSYPSE GSPHGTVTPP HAVAETAYRS
1210 1220 1230 1240 1250
PMVSQTPSAH SSYQTSSPSS FQAGTLGSPY ASPDYPDGRG GFQPDPQARQ
1260 1270 1280 1290 1300
QPQVSVVGVH ALPGSPRTLH RTVATNTPPS PGFGRRAANP AVASVPGSPG
1310 1320 1330 1340 1350
LGRHTVSPHA PPGSPSLARH QMAAVPPGSP MYGYSSPEER RPTLSRQSSA
1360 1370 1380 1390 1400
SGYQPPSTPS FPVSPAYYPG TSTPHSSSPD SAAYRQGSPT PQPALPEKRR
1410 1420 1430 1440 1450
MSAGERSNSL PNYATVNGKA SSPLSSGMSS PSSGSAVAFS HTLPDFSKFS
1460 1470 1480 1490 1500
MPDISPETRA NVKFVQDTSK YWYKPDISRE QAIALLKDRE PGAFIIRDSH
1510 1520 1530 1540 1550
SFRGAYGLAM KVASPPPTVM QQNKKGDITN ELVRHFLIET SPRGVKLKGC
1560 1570 1580 1590 1600
PNEPNFGCLS ALVYQHSIMP LALPCKLVIP DRDPMEEKKD AASTTNSATD
1610 1620 1630 1640 1650
LLKQGAACNV LFINSVEMES LTGPQAISKA VAETLVADPT PTATIVHFKV
1660 1670 1680 1690 1700
SAQGITLTDN QRKLFFRRHY PLNTVTFCDL DPQERKWTKT DGSGPAKLFG
1710 1720 1730 1740
FVARKQGSTT DNVCHLFAEL DPDQPAAAIV NFVSRVMLGS GQKR
Length:1,744
Mass (Da):187,214
Last modified:November 1, 1997 - v2
Checksum:i5C3C8B6211935524
GO

Sequence cautioni

The sequence AAA73949 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA79215 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49C → R in AAA73949 (PubMed:7896874).Curated1
Sequence conflicti49C → R in CAA79215 (PubMed:7896874).Curated1
Sequence conflicti61M → T in AAA73949 (PubMed:7896874).Curated1
Sequence conflicti61M → T in CAA79215 (PubMed:7896874).Curated1
Sequence conflicti88Q → PR in AAA49087 (Ref. 3) Curated1
Sequence conflicti404A → T in AAA73949 (PubMed:7896874).Curated1
Sequence conflicti404A → T in CAA79215 (PubMed:7896874).Curated1
Sequence conflicti452T → A in AAA73949 (PubMed:7896874).Curated1
Sequence conflicti452T → A in CAA79215 (PubMed:7896874).Curated1
Sequence conflicti508 – 509DV → EL in AAA73949 (PubMed:7896874).Curated2
Sequence conflicti508 – 509DV → EL in CAA79215 (PubMed:7896874).Curated2
Sequence conflicti522A → P in AAA73949 (PubMed:7896874).Curated1
Sequence conflicti522A → P in CAA79215 (PubMed:7896874).Curated1
Sequence conflicti664R → A (PubMed:7896874).Curated1
Sequence conflicti666A → T (PubMed:7896874).Curated1
Sequence conflicti875P → A in AAA73949 (PubMed:7896874).Curated1
Sequence conflicti875P → A in CAA79215 (PubMed:7896874).Curated1
Sequence conflicti909P → T in AAA73949 (PubMed:7896874).Curated1
Sequence conflicti909P → T in CAA79215 (PubMed:7896874).Curated1
Sequence conflicti1102 – 1113Missing (Ref. 3) CuratedAdd BLAST12
Sequence conflicti1240G → A in AAA73949 (PubMed:7896874).Curated1
Sequence conflicti1240G → A in CAA79215 (PubMed:7896874).Curated1
Sequence conflicti1480E → D in AAA73949 (PubMed:7896874).Curated1
Sequence conflicti1480E → D in CAA79215 (PubMed:7896874).Curated1
Sequence conflicti1711D → E in AAA73949 (PubMed:7896874).Curated1
Sequence conflicti1711D → E in CAA79215 (PubMed:7896874).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96625 mRNA Translation: AAA59053.1
L06662 mRNA Translation: AAA73949.1 Different initiation.
Z18529 mRNA Translation: CAA79215.1 Different initiation.
M74165 mRNA Translation: AAA49087.1
X66286 mRNA Translation: CAA46992.1
PIRiA54970
A57075
S27939
RefSeqiNP_990786.1, NM_205455.1
UniGeneiGga.4128

Genome annotation databases

GeneIDi396439
KEGGigga:396439

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96625 mRNA Translation: AAA59053.1
L06662 mRNA Translation: AAA73949.1 Different initiation.
Z18529 mRNA Translation: CAA79215.1 Different initiation.
M74165 mRNA Translation: AAA49087.1
X66286 mRNA Translation: CAA46992.1
PIRiA54970
A57075
S27939
RefSeqiNP_990786.1, NM_205455.1
UniGeneiGga.4128

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WVHX-ray1.50A1605-1738[»]
2GJYNMR-A1605-1744[»]
ProteinModelPortaliQ04205
SMRiQ04205
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-56927N
IntActiQ04205, 4 interactors
STRINGi9031.ENSGALP00000018665

Proteomic databases

PaxDbiQ04205
PRIDEiQ04205

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396439
KEGGigga:396439

Organism-specific databases

CTDi7145

Phylogenomic databases

eggNOGiKOG1930 Eukaryota
KOG2283 Eukaryota
COG2453 LUCA
HOGENOMiHOG000060090
HOVERGENiHBG060186
InParanoidiQ04205
KOiK18080
PhylomeDBiQ04205

Miscellaneous databases

EvolutionaryTraceiQ04205
PROiPR:Q04205

Family and domain databases

CDDicd01213 PTB_tensin, 1 hit
cd09927 SH2_Tensin_like, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR013625 PTB
IPR006020 PTB/PI_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR014020 Tensin_C2-dom
IPR035012 Tensin_like_SH2
IPR029023 Tensin_phosphatase
IPR033929 Tensin_PTB
IPR003595 Tyr_Pase_cat
PfamiView protein in Pfam
PF08416 PTB, 1 hit
PF10409 PTEN_C2, 1 hit
PF00017 SH2, 1 hit
SMARTiView protein in SMART
SM00462 PTB, 1 hit
SM01326 PTEN_C2, 1 hit
SM00404 PTPc_motif, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS51182 C2_TENSIN, 1 hit
PS51181 PPASE_TENSIN, 1 hit
PS50001 SH2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTENS_CHICK
AccessioniPrimary (citable) accession number: Q04205
Secondary accession number(s): Q91007, Q92011
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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