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UniProtKB - Q04162 (YD387_YEAST)

Entry version 163 (25 May 2022)
Sequence version 1 (01 Nov 1996)
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Protein

Probable metabolite transport protein YDR387C

Gene

YDR387C

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processSugar transport, Transport

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.1.1.101, the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable metabolite transport protein YDR387C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:YDR387C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

Saccharomyces Genome Database

More...SGDi		S000002795, YDR387C

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:YDR387C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 39CytoplasmicSequence analysisAdd BLAST39
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei40 – 60HelicalSequence analysisAdd BLAST21
Topological domaini61 – 83ExtracellularSequence analysisAdd BLAST23
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
Topological domaini105 – 118CytoplasmicSequence analysisAdd BLAST14
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Topological domaini140ExtracellularSequence analysis1
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Topological domaini162 – 168CytoplasmicSequence analysis7
Transmembranei169 – 189HelicalSequence analysisAdd BLAST21
Topological domaini190 – 200ExtracellularSequence analysisAdd BLAST11
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Topological domaini222 – 356CytoplasmicSequence analysisAdd BLAST135
Transmembranei357 – 377HelicalSequence analysisAdd BLAST21
Topological domaini378 – 384ExtracellularSequence analysis7
Transmembranei385 – 405HelicalSequence analysisAdd BLAST21
Topological domaini406 – 413CytoplasmicSequence analysis8
Transmembranei414 – 434HelicalSequence analysisAdd BLAST21
Topological domaini435 – 440ExtracellularSequence analysis6
Transmembranei441 – 461HelicalSequence analysisAdd BLAST21
Topological domaini462 – 474CytoplasmicSequence analysisAdd BLAST13
Transmembranei475 – 497HelicalSequence analysisAdd BLAST23
Topological domaini498 – 506ExtracellularSequence analysis9
Transmembranei507 – 527HelicalSequence analysisAdd BLAST21
Topological domaini528 – 555CytoplasmicSequence analysisAdd BLAST28

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002522741 – 555Probable metabolite transport protein YDR387CAdd BLAST555

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q04162

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q04162

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		32448, 55 interactors

Database of interacting proteins

More...DIPi		DIP-4084N

STRING: functional protein association networks

More...STRINGi		4932.YDR387C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q04162, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q04162

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q04162

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni289 – 313DisorderedSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0254, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155870

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001265_30_5_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q04162

Identification of Orthologs from Complete Genome Data

More...OMAi		CISCTNW

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1250.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR020846, MFS_dom
IPR005828, MFS_sugar_transport-like
IPR036259, MFS_trans_sf
IPR003663, Sugar/inositol_transpt
IPR005829, Sugar_transporter_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00083, Sugar_tr, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00171, SUGRTRNSPORT

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103473, SSF103473, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50850, MFS, 1 hit
PS00216, SUGAR_TRANSPORT_1, 1 hit
PS00217, SUGAR_TRANSPORT_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q04162-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTDESEDVY SDLYSIISQV TSNTANDIEQ LPYALTFKTS LIFVGATIGG 
        60         70         80         90        100
LLFGYDTGVI SGVLLSLKPE DLSLVVLTDV QKELITSSTS VGSFFGSILA 
       110        120        130        140        150
FPLADRYGRR ITLAICCSIF ILAAIGMAIA RTLTFLICGR LLVGIAVGVS 
       160        170        180        190        200
AQCVPLFLSE ISPSRIRGFM LTLNIIAITG GQLVSYVIAS LMKEIDNSWR 
       210        220        230        240        250
YLFALSAIPA ILFLSILDFI PESPRWSISK GDILYTRDSL RMLYPTASTY 
       260        270        280        290        300
HVNSKIKQLI IELDKLRLYE DASEPLLVQS QSVIRYMDSS TSGTLSPPNI 
       310        320        330        340        350
KRLSSNTERT SNTMSSSSAY LSALRGPAPN GALASNKKKR HRMEPRTIRA 
       360        370        380        390        400
LIVGCMLMFF QQITGFNAFM YYAAIIFSKF NIKNPLLPPI LIASTNFIFT 
       410        420        430        440        450
FFAMYTMDSL GRRAILLRTI LIMTVGLLLC SVGFGHDQVN LLLISVVIYV 
       460        470        480        490        500
AAYASAMGSV PWTCVEFLPL NRRSFGASCI ACTNWLTNAF VSMTYLSTIN 
       510        520        530        540        550
TIGDENTMLI FAFFTVCAWF FVYFWYPEVK GLSLEEVGRV FDNGIDVHYV 

FRTYH
Length:555
Mass (Da):61,509
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD1EF726664D3A494
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U32274 Genomic DNA Translation: AAB64829.1
BK006938 Genomic DNA Translation: DAA12231.1

Protein sequence database of the Protein Information Resource

More...PIRi		S69671

NCBI Reference Sequences

More...RefSeqi		NP_010675.3, NM_001180695.3

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		YDR387C_mRNA; YDR387C; YDR387C

Database of genes from NCBI RefSeq genomes

More...GeneIDi		851995

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sce:YDR387C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32274 Genomic DNA Translation: AAB64829.1
BK006938 Genomic DNA Translation: DAA12231.1
PIRiS69671
RefSeqiNP_010675.3, NM_001180695.3

3D structure databases

AlphaFoldDBiQ04162
SMRiQ04162
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi32448, 55 interactors
DIPiDIP-4084N
STRINGi4932.YDR387C

Protein family/group databases

TCDBi2.A.1.1.101, the major facilitator superfamily (mfs)

PTM databases

iPTMnetiQ04162

Proteomic databases

PaxDbiQ04162

Genome annotation databases

EnsemblFungiiYDR387C_mRNA; YDR387C; YDR387C
GeneIDi851995
KEGGisce:YDR387C

Organism-specific databases

SGDiS000002795, YDR387C
VEuPathDBiFungiDB:YDR387C

Phylogenomic databases

eggNOGiKOG0254, Eukaryota
GeneTreeiENSGT00940000155870
HOGENOMiCLU_001265_30_5_1
InParanoidiQ04162
OMAiCISCTNW

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q04162
RNActiQ04162, protein

Family and domain databases

Gene3Di1.20.1250.20, 2 hits
InterProiView protein in InterPro
IPR020846, MFS_dom
IPR005828, MFS_sugar_transport-like
IPR036259, MFS_trans_sf
IPR003663, Sugar/inositol_transpt
IPR005829, Sugar_transporter_CS
PfamiView protein in Pfam
PF00083, Sugar_tr, 2 hits
PRINTSiPR00171, SUGRTRNSPORT
SUPFAMiSSF103473, SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850, MFS, 1 hit
PS00216, SUGAR_TRANSPORT_1, 1 hit
PS00217, SUGAR_TRANSPORT_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYD387_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q04162
Secondary accession number(s): D6VT21
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: November 1, 1996
Last modified: May 25, 2022
This is version 163 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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