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Entry version 184 (02 Jun 2021)
Sequence version 1 (01 Nov 1996)
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Protein

Endosomal/prevacuolar sodium/hydrogen exchanger

Gene

NHX1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Endosomal/prevacuolar electroneutral Na+/H+ exchanger which mediates intracellular sequestration of Na+ cations, regulates vacuolar pH and contributes to osmotolerance following sudden exposure to hyperosmotic media. Contributes also to the postdiauxic/stationary phase resistance to osmotic stress and allows for the continued growth of cells until the acquired osmotolerance response can occur. Involved in hygromycin resistance probably through its influence on the electrochemical proton gradient affecting secondarily the entrance of hygromycin. Mediates pH-dependent vesicle trafficking out of the endosome. Contributes to K+ sequestration and homeostasis.

13 Publications

Miscellaneous

Present with 521 molecules/cell in log phase SD medium.1 Publication

Caution

Numerous studies suggest that the C-terminal tail of the Na+/H+ exchangers assumes a cytosolic orientation and constitutes a regulatory region. This cytosolic localization is confirmed by phosphorylation analysis (PubMed:15665377 and PubMed:18407956). However, residues Asn-515, Asn-550 and Asn-563 have been shown to be glycosylated and localized at the lumenal side (PubMed:11036065). These contradictory results suggest an unusual topology of the C-terminal tail which may contain membrane spans formed by beta-sheets or even may switch from one side to the other of the membrane.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiport, Ion transport, Potassium transport, Sodium transport, Transport
LigandPotassium, Sodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-425986, Sodium/Proton exchangers

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.36.1.12, the monovalent cation:proton antiporter-1 (cpa1) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Endosomal/prevacuolar sodium/hydrogen exchanger
Alternative name(s):
Endosomal/prevacuolar Na(+)/H(+) exchanger
Vacuolar protein sorting-associated protein 44
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NHX1
Synonyms:NHA2, VPL27, VPS44
Ordered Locus Names:YDR456W
ORF Names:D9461.40
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000002864, NHX1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YDR456W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 61LumenalSequence analysisAdd BLAST40
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Topological domaini83 – 85CytoplasmicSequence analysis3
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Topological domaini107 – 117LumenalSequence analysisAdd BLAST11
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Topological domaini139 – 152CytoplasmicSequence analysisAdd BLAST14
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Topological domaini174 – 189LumenalSequence analysisAdd BLAST16
Transmembranei190 – 211HelicalSequence analysisAdd BLAST22
Topological domaini212 – 217CytoplasmicSequence analysis6
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Topological domaini239 – 258LumenalSequence analysisAdd BLAST20
Transmembranei259 – 279HelicalSequence analysisAdd BLAST21
Topological domaini280 – 288CytoplasmicSequence analysis9
Transmembranei289 – 308HelicalSequence analysisAdd BLAST20
Topological domaini309 – 313LumenalSequence analysis5
Transmembranei314 – 333HelicalSequence analysisAdd BLAST20
Topological domaini334 – 344CytoplasmicSequence analysisAdd BLAST11
Transmembranei345 – 364HelicalSequence analysisAdd BLAST20
Topological domaini365 – 376CytoplasmicSequence analysisAdd BLAST12
Transmembranei377 – 397HelicalSequence analysisAdd BLAST21
Topological domaini398 – 431LumenalSequence analysisAdd BLAST34
Transmembranei432 – 452HelicalSequence analysisAdd BLAST21
Topological domaini453 – 457CytoplasmicSequence analysis5
Transmembranei458 – 478HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi201D → N: Impairs protein-trafficking to the vacuole. 1 Publication1
Mutagenesisi225E → Q: Impairs protein-trafficking to the vacuole. 1 Publication1
Mutagenesisi230D → N: Impairs protein-trafficking to the vacuole. 1 Publication1
Mutagenesisi355E → Q: Impairs partially resistance to osmotic stress and hygromycin. 1 Publication1
Mutagenesisi357F → A, L or I: Impairs resistance to osmotic stress and hygromycin, and blocks protein-trafficking to the vacuole. 1 Publication1
Mutagenesisi357F → V: Impairs partially resistance to osmotic stress and hygromycin. 1 Publication1
Mutagenesisi361Y → A: Impairs resistance to osmotic stress and hygromycin, and blocks protein-trafficking to the vacuole. 1 Publication1
Mutagenesisi365E → A: Impairs resistance to osmotic stress and hygromycin, and blocks protein-trafficking to the vacuole. 1 Publication1
Mutagenesisi369E → A: Impairs partially resistance to osmotic stress and hygromycin. 1 Publication1
Mutagenesisi376P → N: Impairs resistance to osmotic stress and hygromycin. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000005238022 – 633Endosomal/prevacuolar sodium/hydrogen exchangerAdd BLAST612

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi420N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei490PhosphothreonineCombined sources1
Modified residuei494PhosphoserineCombined sources1
Modified residuei498PhosphothreonineCombined sources1
Modified residuei499PhosphoserineCombined sources1
Glycosylationi515N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi550N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi563N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei569PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q04121

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q04121

PRoteomics IDEntifications database

More...
PRIDEi
Q04121

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q04121

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q04121

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CYP6.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
32510, 287 interactors

Database of interacting proteins

More...
DIPi
DIP-4145N

Protein interaction database and analysis system

More...
IntActi
Q04121, 17 interactors

Molecular INTeraction database

More...
MINTi
Q04121

STRING: functional protein association networks

More...
STRINGi
4932.YDR456W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q04121, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q04121

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni25 – 44DisorderedSequence analysisAdd BLAST20
Regioni553 – 578DisorderedSequence analysisAdd BLAST26

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi124 – 133Amiloride-binding10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi553 – 576Polar residuesSequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1965, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000170200

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005912_5_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q04121

Identification of Orthologs from Complete Genome Data

More...
OMAi
QVNFFNN

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006153, Cation/H_exchanger
IPR018422, Cation/H_exchanger_CPA1
IPR004709, NaH_exchanger

The PANTHER Classification System

More...
PANTHERi
PTHR10110, PTHR10110, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00999, Na_H_Exchanger, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01084, NAHEXCHNGR

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00840, b_cpa1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q04121-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSKVLLNIA FKVLLTTAKR AVDPDDDDEL LPSPDLPGSD DPIAGDPDVD
60 70 80 90 100
LNPVTEEMFS SWALFIMLLL LISALWSSYY LTQKRIRAVH ETVLSIFYGM
110 120 130 140 150
VIGLIIRMSP GHYIQDTVTF NSSYFFNVLL PPIILNSGYE LNQVNFFNNM
160 170 180 190 200
LSILIFAIPG TFISAVVIGI ILYIWTFLGL ESIDISFADA MSVGATLSAT
210 220 230 240 250
DPVTILSIFN AYKVDPKLYT IIFGESLLND AISIVMFETC QKFHGQPATF
260 270 280 290 300
SSVFEGAGLF LMTFSVSLLI GVLIGILVAL LLKHTHIRRY PQIESCLILL
310 320 330 340 350
IAYESYFFSN GCHMSGIVSL LFCGITLKHY AYYNMSRRSQ ITIKYIFQLL
360 370 380 390 400
ARLSENFIFI YLGLELFTEV ELVYKPLLII VAAISICVAR WCAVFPLSQF
410 420 430 440 450
VNWIYRVKTI RSMSGITGEN ISVPDEIPYN YQMMTFWAGL RGAVGVALAL
460 470 480 490 500
GIQGEYKFTL LATVLVVVVL TVIIFGGTTA GMLEVLNIKT GCISEEDTSD
510 520 530 540 550
DEFDIEAPRA INLLNGSSIQ TDLGPYSDNN SPDISIDQFA VSSNKNLPNN
560 570 580 590 600
ISTTGGNTFG GLNETENTSP NPARSSMDKR NLRDKLGTIF NSDSQWFQNF
610 620 630
DEQVLKPVFL DNVSPSLQDS ATQSPADFSS QNH
Length:633
Mass (Da):70,148
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9B771ABDE41CEB0A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U33007 Genomic DNA Translation: AAB64861.1
BK006938 Genomic DNA Translation: DAA12290.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S69734

NCBI Reference Sequences

More...
RefSeqi
NP_010744.3, NM_001180764.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YDR456W_mRNA; YDR456W; YDR456W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
852066

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YDR456W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33007 Genomic DNA Translation: AAB64861.1
BK006938 Genomic DNA Translation: DAA12290.1
PIRiS69734
RefSeqiNP_010744.3, NM_001180764.3

3D structure databases

SMRiQ04121
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi32510, 287 interactors
DIPiDIP-4145N
IntActiQ04121, 17 interactors
MINTiQ04121
STRINGi4932.YDR456W

Protein family/group databases

TCDBi2.A.36.1.12, the monovalent cation:proton antiporter-1 (cpa1) family

PTM databases

iPTMnetiQ04121

Proteomic databases

MaxQBiQ04121
PaxDbiQ04121
PRIDEiQ04121
TopDownProteomicsiQ04121

Genome annotation databases

EnsemblFungiiYDR456W_mRNA; YDR456W; YDR456W
GeneIDi852066
KEGGisce:YDR456W

Organism-specific databases

SGDiS000002864, NHX1
VEuPathDBiFungiDB:YDR456W

Phylogenomic databases

eggNOGiKOG1965, Eukaryota
GeneTreeiENSGT00940000170200
HOGENOMiCLU_005912_5_1_1
InParanoidiQ04121
OMAiQVNFFNN

Enzyme and pathway databases

ReactomeiR-SCE-425986, Sodium/Proton exchangers

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q04121
RNActiQ04121, protein

Family and domain databases

InterProiView protein in InterPro
IPR006153, Cation/H_exchanger
IPR018422, Cation/H_exchanger_CPA1
IPR004709, NaH_exchanger
PANTHERiPTHR10110, PTHR10110, 1 hit
PfamiView protein in Pfam
PF00999, Na_H_Exchanger, 1 hit
PRINTSiPR01084, NAHEXCHNGR
TIGRFAMsiTIGR00840, b_cpa1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNHX1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q04121
Secondary accession number(s): D6VT80
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: June 2, 2021
This is version 184 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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