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Entry version 102 (02 Jun 2021)
Sequence version 1 (01 Nov 1996)
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Protein
Submitted name:

PrgB

Gene

prgB

Organism
Enterococcus faecalis (Streptococcus faecalis)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
PrgBImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:prgBImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates if the gene coding for the protein originates from the hydrogenosome, the mitochondrion, the nucleomorph, different plastids or a plasmid. The absence of this section means that the gene is located in one of the main chromosomal element(s).<p><a href='/help/encoded_on' target='_top'>More...</a></p>Encoded oniPlasmid pCF10Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEnterococcus faecalis (Streptococcus faecalis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1351 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1279 – 1298HelicalSequence analysisAdd BLAST20

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell wallPROSITE-ProRule annotationARBA annotation, Membrane, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 43Sequence analysisAdd BLAST43
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500416445244 – 1305Sequence analysisAdd BLAST1262
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_50183714371274 – 1305Removed by sortasePROSITE-ProRule annotationAdd BLAST32

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1273Pentaglycyl murein peptidoglycan amidated threoninePROSITE-ProRule annotation1

Keywords - PTMi

Peptidoglycan-anchorPROSITE-ProRule annotationARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q04112

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1270 – 1305GRAM_POS_ANCHORINGInterPro annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni47 – 166DisorderedSequence analysisAdd BLAST120
Regioni1230 – 1254DisorderedSequence analysisAdd BLAST25

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili198 – 243Sequence analysisAdd BLAST46

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1270 – 1274LPXTG sorting signalPROSITE-ProRule annotation5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi47 – 141Polar residuesSequence analysisAdd BLAST95
Compositional biasi1239 – 1254Pro residuesSequence analysisAdd BLAST16

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.530.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026345, Adh_isopep-form_adh_dom
IPR041324, AgI/II_N
IPR032300, Antigen_C
IPR013574, Glucan-bd_C/Surface_Ag-I/II_V
IPR019948, Gram-positive_anchor
IPR022263, KxYKxGKxW
IPR019931, LPXTG_anchor
IPR036234, SA_I/II_PAC_V_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18652, Adhesin_P1_N, 1 hit
PF17998, AgI_II_C2, 2 hits
PF16364, Antigen_C, 2 hits
PF08363, GbpC, 1 hit
PF00746, Gram_pos_anchor, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF74914, SSF74914, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR04228, isopep_sspB_C2, 3 hits
TIGR03715, KxYKxGKxW, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50847, GRAM_POS_ANCHORING, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q04112-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNQQTEVKKR FKMYKAKKHW IVAPILFLGV LGVVGLATDN VQAAELDTQP
60 70 80 90 100
GSTTVHPDNP DPQLGSATPN TAVSEESAVQ KDTTSQPTKA EEVASEKNGA
110 120 130 140 150
EQSSATPNDT TNVQQPTVGA EKSAQEQPVV SPETTNEPLG QPTEVAPAEN
160 170 180 190 200
EANKSTSILK EFETPDVDKA VDEAKKDPNI TVVEKPAEDL GNVSSKDLAA
210 220 230 240 250
KEKEVDQLQK EQAKKIAQQA AELKAKNEKI AKENAEIAAK NKAEKEPYEK
260 270 280 290 300
EVAEYNKHKN ENSYVNEAIS KNLVFDQSVV TKDTKISSIK GGKFIKATDF
310 320 330 340 350
NKVNAGDSKD IFTKLRKDMG GKATGNFQNS FVKEANLGSN GGYAVLLEKN
360 370 380 390 400
KPVTVTYTGL NASYLGRKIT KAEFVYELQS SPSQSGTLNA VFSNDPIITA
410 420 430 440 450
FIGTNRVNGK DVKTRLTIKF FDASGKEVLP DKDSPFAYAL SSLNSSLTNK
460 470 480 490 500
GGHAEFVSDF GANNAFKYIN GSYVKKQADG KFYSPEDIDY GTGPSGLKNS
510 520 530 540 550
DWDAVGHKNA YFGSGVGLAN GRISFSFGMT TKGKSNVPVS SAQWFAFSTN
560 570 580 590 600
LNAQSVKPIF NYGNPKEPEK ATIEFNGYKA NVVPVLVPNK EVTDGQKNIN
610 620 630 640 650
DLNVKRGDSL QYIVTGDTTE LAKVDPKTVT KQGIRDTFDA EKVTIDLSKV
660 670 680 690 700
KVYQADASLN EKDLKAVAAA INSGKAKDVT ASYDLNLDQN TVTAMMKTNA
710 720 730 740 750
DGSVVLAMGY KYLLVLPFVV KNVEGDFENT AVQLTNDGET VTNTVINHVP
760 770 780 790 800
SSNPSKDVKA DKNGTVGSVS LHDKDIPLQT KIYYEVKSSE RPANYGGITE
810 820 830 840 850
EWGMNDVLDT THDRFTGKWH AITNYDLKVG DKTLKAGTDI SAYILLENKD
860 870 880 890 900
NKDLTFTMNQ ALLAALNEGS NKVGKQAWSV YLEVERIKTG DVENTQTENY
910 920 930 940 950
NKELVRSNTV VTHTPDDPKP TKAVHNKKGE DINHGKVARG DVLSYEMTWD
960 970 980 990 1000
LKGYDKDFAF DTVDLATGVS FFDDYDETKV TPIKDLLRVK DSKGVDITNQ
1010 1020 1030 1040 1050
FTISWDDAKG TVTISAKDPQ AFILAYGGQE LRVTLPTKVK ADVSGDVYNS
1060 1070 1080 1090 1100
AEQNTFGQRI KTNTVVNHIP KVNPKKDVVI KVGDKQSQNG ATIKLGEKFF
1110 1120 1130 1140 1150
YEFTSSDIPA EYAGVVEEWS ISDKLDVKHD KFSGQWSVFA NSNFVLADGT
1160 1170 1180 1190 1200
KVNKGDDISK LFTMTFDKGV VKITASQAFL DAMNLKENKN VAHSWKAFIG
1210 1220 1230 1240 1250
VERIAAGDVY NTIEESFNNE KIKTNTVVTH TPEKPQTPPE KTVIVPPTPK
1260 1270 1280 1290 1300
TPQAPVEPLV VEKASVVPEL PKTGEKQNVL LTVVGSLAAM LGLAGLGFKR

RKETK
Length:1,305
Mass (Da):142,300
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i48AFD6CCCB25C7A2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY855841 Genomic DNA Translation: AAA65848.1

Protein sequence database of the Protein Information Resource

More...
PIRi
H41662

NCBI Reference Sequences

More...
RefSeqi
WP_011255111.1, NC_006827.2
YP_195774.1, NC_006827.2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY855841 Genomic DNA Translation: AAA65848.1
PIRiH41662
RefSeqiWP_011255111.1, NC_006827.2
YP_195774.1, NC_006827.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6EVUX-ray1.60A246-558[»]
6GEDX-ray1.79A246-558[»]
SMRiQ04112
ModBaseiSearch...
PDBe-KBiSearch...

Family and domain databases

Gene3Di2.60.530.10, 1 hit
InterProiView protein in InterPro
IPR026345, Adh_isopep-form_adh_dom
IPR041324, AgI/II_N
IPR032300, Antigen_C
IPR013574, Glucan-bd_C/Surface_Ag-I/II_V
IPR019948, Gram-positive_anchor
IPR022263, KxYKxGKxW
IPR019931, LPXTG_anchor
IPR036234, SA_I/II_PAC_V_sf
PfamiView protein in Pfam
PF18652, Adhesin_P1_N, 1 hit
PF17998, AgI_II_C2, 2 hits
PF16364, Antigen_C, 2 hits
PF08363, GbpC, 1 hit
PF00746, Gram_pos_anchor, 1 hit
SUPFAMiSSF74914, SSF74914, 1 hit
TIGRFAMsiTIGR04228, isopep_sspB_C2, 3 hits
TIGR03715, KxYKxGKxW, 1 hit
PROSITEiView protein in PROSITE
PS50847, GRAM_POS_ANCHORING, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ04112_ENTFL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q04112
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 2, 2021
This is version 102 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, PlasmidImported
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