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Entry version 151 (17 Jun 2020)
Sequence version 1 (01 Nov 1996)
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Protein

Transcriptional activator ARO80

Gene

ARO80

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription activator required for the expression of genes involved in the catabolism of aromatic amino acids such as the aromatic aminotransferase II ARO9 and the phenylpyruvate decarboxylase ARO10.

Miscellaneous

Present with 319 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi25 – 58Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd BLAST34

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processBranched-chain amino acid catabolism, Phenylalanine catabolism, Transcription, Transcription regulation, Tryptophan catabolism, Tyrosine catabolism
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-29962-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcriptional activator ARO80
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARO80
Ordered Locus Names:YDR421W
ORF Names:D9461.10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YDR421W

Saccharomyces Genome Database

More...
SGDi
S000002829 ARO80

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001149381 – 950Transcriptional activator ARO80Add BLAST950

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q04052

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q04052

PRoteomics IDEntifications database

More...
PRIDEi
Q04052

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q04052

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
32480, 60 interactors

Database of interacting proteins

More...
DIPi
DIP-1012N

Protein interaction database and analysis system

More...
IntActi
Q04052, 2 interactors

Molecular INTeraction database

More...
MINTi
Q04052

STRING: functional protein association networks

More...
STRINGi
4932.YDR421W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q04052 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q04052

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi921 – 943Asn-richAdd BLAST23

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000176681

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005663_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q04052

Identification of Orthologs from Complete Genome Data

More...
OMAi
VRVYTHS

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00067 GAL4, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001138 Zn2-C6_fun-type_DNA-bd
IPR036864 Zn2-C6_fun-type_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00172 Zn_clus, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00066 GAL4, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57701 SSF57701, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00463 ZN2_CY6_FUNGAL_1, 1 hit
PS50048 ZN2_CY6_FUNGAL_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q04052-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAKKRPSGN AAFELPKRRR TYQACISCRS RKVKCDLGPV DNPHDPPCAR
60 70 80 90 100
CKRELKKCIF SSNKGTSNDL PPNSINAISL PSLGKSKQEI QNDSTSPILS
110 120 130 140 150
DVPLSRKGIS SEKSFKSEGM KWKLELSSMQ NALEFLAQAA GTVAKEGAKE
160 170 180 190 200
IIKEKSTTPK PLKSSLDATN KSATDEGLKR LSKSDSTNTL YENTADMLNH
210 220 230 240 250
TLNTNRKTSQ LMEEIGKVRP PPTRKIDDFD YIGPDSLLTK EEAIELIEAF
260 270 280 290 300
FLTMHPFFPN IPLQLHDPKE LAEYPILFCA ILTVSARYHP FDTLGLDNGE
310 320 330 340 350
DGMRHIEVHD KLWVYCQKLI SQTIWAEAST RSIGTVLAFI IFTEWNPRSI
360 370 380 390 400
HYKWSDYAND PELNNVNARG SKNISTRKDE EGLTGVGAIR RSDRMSWMLT
410 420 430 440 450
GSAVRLAQDM GFIENSSKVF IVTHISETTS AMNMNQRSLL AESFSVLNLN
460 470 480 490 500
LGKIENDGNE SNEDYLGNEK FYLNEILPDE ESKLRWKRVF ENSENDHDNE
510 520 530 540 550
KNFLTDWERE FLNDEYVLYY SNKKDDTNLA QNHIPPFPLR FSFAQRAKIE
560 570 580 590 600
IIRILSIAYE TIYCEKNKRK LATTDQRHNL SVLSVFSPLI EGWLSNYREL
610 620 630 640 650
LVPLSDVPFS LADRKNKKQI FDNIDRINGE SIITDFNYCQ LYIFSLALQV
660 670 680 690 700
DGKTSRLNMN EIVTSARYVE LAYRSAKEIL SSAKRVSRQG MLKYMPVRWV
710 720 730 740 750
IRIIRSIAFI VKCYLTLTGS ELATNPDARN ILKLSAISVD ETFDIIRDTA
760 770 780 790 800
VTLKEATPDE LHLCQRYAAI LMYLCTEMKL RKKSYLERPP LLRDGTTPLE
810 820 830 840 850
SNRESSLEGQ DLTKKPIFSK RIGYNKTETT FEPSERPLTE EINSNSQNSN
860 870 880 890 900
DTSSKGIVDP FVEQNNDITT ALLNNELFQG PSLSDEVTDW FGASEDIGLE
910 920 930 940 950
FVEPWTELIE QRYMQCGDGD NNNFENLYNL FVNSNNINND INNSRPITRK
Length:950
Mass (Da):108,205
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3F86083C127D32A7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U33007 Genomic DNA Translation: AAB64863.1
BK006938 Genomic DNA Translation: DAA12261.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S69704

NCBI Reference Sequences

More...
RefSeqi
NP_010709.1, NM_001180729.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YDR421W_mRNA; YDR421W; YDR421W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
852031

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YDR421W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33007 Genomic DNA Translation: AAB64863.1
BK006938 Genomic DNA Translation: DAA12261.1
PIRiS69704
RefSeqiNP_010709.1, NM_001180729.1

3D structure databases

SMRiQ04052
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi32480, 60 interactors
DIPiDIP-1012N
IntActiQ04052, 2 interactors
MINTiQ04052
STRINGi4932.YDR421W

PTM databases

iPTMnetiQ04052

Proteomic databases

MaxQBiQ04052
PaxDbiQ04052
PRIDEiQ04052

Genome annotation databases

EnsemblFungiiYDR421W_mRNA; YDR421W; YDR421W
GeneIDi852031
KEGGisce:YDR421W

Organism-specific databases

EuPathDBiFungiDB:YDR421W
SGDiS000002829 ARO80

Phylogenomic databases

GeneTreeiENSGT00940000176681
HOGENOMiCLU_005663_0_0_1
InParanoidiQ04052
OMAiVRVYTHS

Enzyme and pathway databases

BioCyciYEAST:G3O-29962-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q04052
RNActiQ04052 protein

Family and domain databases

CDDicd00067 GAL4, 1 hit
Gene3Di4.10.240.10, 1 hit
InterProiView protein in InterPro
IPR001138 Zn2-C6_fun-type_DNA-bd
IPR036864 Zn2-C6_fun-type_DNA-bd_sf
PfamiView protein in Pfam
PF00172 Zn_clus, 1 hit
SMARTiView protein in SMART
SM00066 GAL4, 1 hit
SUPFAMiSSF57701 SSF57701, 1 hit
PROSITEiView protein in PROSITE
PS00463 ZN2_CY6_FUNGAL_1, 1 hit
PS50048 ZN2_CY6_FUNGAL_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARO80_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q04052
Secondary accession number(s): D6VT51
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: November 1, 1996
Last modified: June 17, 2020
This is version 151 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
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