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UniProtKB - Q04052 (ARO80_YEAST)
Protein
Transcriptional activator ARO80
Gene
ARO80
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Transcription activator required for the expression of genes involved in the catabolism of aromatic amino acids such as the aromatic aminotransferase II ARO9 and the phenylpyruvate decarboxylase ARO10.
Miscellaneous
Present with 319 molecules/cell in log phase SD medium.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 25 – 58 | Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd BLAST | 34 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: SGD
- sequence-specific DNA binding Source: SGD
- zinc ion binding Source: InterPro
GO - Biological processi
- aromatic amino acid family catabolic process Source: SGD
- branched-chain amino acid catabolic process Source: UniProtKB-KW
- L-phenylalanine catabolic process Source: UniProtKB-KW
- positive regulation of transcription by RNA polymerase II Source: SGD
- tryptophan catabolic process Source: UniProtKB-KW
- tyrosine catabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-binding |
Biological process | Branched-chain amino acid catabolism, Phenylalanine catabolism, Transcription, Transcription regulation, Tryptophan catabolism, Tyrosine catabolism |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Transcriptional activator ARO80 |
Gene namesi | Name:ARO80 Ordered Locus Names:YDR421W ORF Names:D9461.10 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000002829, ARO80 |
VEuPathDBi | FungiDB:YDR421W |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation1 Publication
Nucleus
- nucleus Source: SGD
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000114938 | 1 – 950 | Transcriptional activator ARO80Add BLAST | 950 |
Proteomic databases
MaxQBi | Q04052 |
PaxDbi | Q04052 |
PRIDEi | Q04052 |
PTM databases
iPTMneti | Q04052 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 32480, 60 interactors |
DIPi | DIP-1012N |
IntActi | Q04052, 2 interactors |
MINTi | Q04052 |
STRINGi | 4932.YDR421W |
Miscellaneous databases
RNActi | Q04052, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 154 – 177 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 791 – 810 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 830 – 857 | DisorderedSequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 158 – 172 | Polar residuesSequence analysisAdd BLAST | 15 |
Phylogenomic databases
eggNOGi | ENOG502QQTI, Eukaryota |
GeneTreei | ENSGT00940000176681 |
HOGENOMi | CLU_005663_0_0_1 |
InParanoidi | Q04052 |
OMAi | AQDMGFM |
Family and domain databases
CDDi | cd00067, GAL4, 1 hit |
Gene3Di | 4.10.240.10, 1 hit |
InterProi | View protein in InterPro IPR001138, Zn2-C6_fun-type_DNA-bd IPR036864, Zn2-C6_fun-type_DNA-bd_sf |
Pfami | View protein in Pfam PF00172, Zn_clus, 1 hit |
SMARTi | View protein in SMART SM00066, GAL4, 1 hit |
SUPFAMi | SSF57701, SSF57701, 1 hit |
PROSITEi | View protein in PROSITE PS00463, ZN2_CY6_FUNGAL_1, 1 hit PS50048, ZN2_CY6_FUNGAL_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q04052-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSAKKRPSGN AAFELPKRRR TYQACISCRS RKVKCDLGPV DNPHDPPCAR
60 70 80 90 100
CKRELKKCIF SSNKGTSNDL PPNSINAISL PSLGKSKQEI QNDSTSPILS
110 120 130 140 150
DVPLSRKGIS SEKSFKSEGM KWKLELSSMQ NALEFLAQAA GTVAKEGAKE
160 170 180 190 200
IIKEKSTTPK PLKSSLDATN KSATDEGLKR LSKSDSTNTL YENTADMLNH
210 220 230 240 250
TLNTNRKTSQ LMEEIGKVRP PPTRKIDDFD YIGPDSLLTK EEAIELIEAF
260 270 280 290 300
FLTMHPFFPN IPLQLHDPKE LAEYPILFCA ILTVSARYHP FDTLGLDNGE
310 320 330 340 350
DGMRHIEVHD KLWVYCQKLI SQTIWAEAST RSIGTVLAFI IFTEWNPRSI
360 370 380 390 400
HYKWSDYAND PELNNVNARG SKNISTRKDE EGLTGVGAIR RSDRMSWMLT
410 420 430 440 450
GSAVRLAQDM GFIENSSKVF IVTHISETTS AMNMNQRSLL AESFSVLNLN
460 470 480 490 500
LGKIENDGNE SNEDYLGNEK FYLNEILPDE ESKLRWKRVF ENSENDHDNE
510 520 530 540 550
KNFLTDWERE FLNDEYVLYY SNKKDDTNLA QNHIPPFPLR FSFAQRAKIE
560 570 580 590 600
IIRILSIAYE TIYCEKNKRK LATTDQRHNL SVLSVFSPLI EGWLSNYREL
610 620 630 640 650
LVPLSDVPFS LADRKNKKQI FDNIDRINGE SIITDFNYCQ LYIFSLALQV
660 670 680 690 700
DGKTSRLNMN EIVTSARYVE LAYRSAKEIL SSAKRVSRQG MLKYMPVRWV
710 720 730 740 750
IRIIRSIAFI VKCYLTLTGS ELATNPDARN ILKLSAISVD ETFDIIRDTA
760 770 780 790 800
VTLKEATPDE LHLCQRYAAI LMYLCTEMKL RKKSYLERPP LLRDGTTPLE
810 820 830 840 850
SNRESSLEGQ DLTKKPIFSK RIGYNKTETT FEPSERPLTE EINSNSQNSN
860 870 880 890 900
DTSSKGIVDP FVEQNNDITT ALLNNELFQG PSLSDEVTDW FGASEDIGLE
910 920 930 940 950
FVEPWTELIE QRYMQCGDGD NNNFENLYNL FVNSNNINND INNSRPITRK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U33007 Genomic DNA Translation: AAB64863.1 BK006938 Genomic DNA Translation: DAA12261.1 |
PIRi | S69704 |
RefSeqi | NP_010709.1, NM_001180729.1 |
Genome annotation databases
EnsemblFungii | YDR421W_mRNA; YDR421W; YDR421W |
GeneIDi | 852031 |
KEGGi | sce:YDR421W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U33007 Genomic DNA Translation: AAB64863.1 BK006938 Genomic DNA Translation: DAA12261.1 |
PIRi | S69704 |
RefSeqi | NP_010709.1, NM_001180729.1 |
3D structure databases
AlphaFoldDBi | Q04052 |
SMRi | Q04052 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 32480, 60 interactors |
DIPi | DIP-1012N |
IntActi | Q04052, 2 interactors |
MINTi | Q04052 |
STRINGi | 4932.YDR421W |
PTM databases
iPTMneti | Q04052 |
Proteomic databases
MaxQBi | Q04052 |
PaxDbi | Q04052 |
PRIDEi | Q04052 |
Genome annotation databases
EnsemblFungii | YDR421W_mRNA; YDR421W; YDR421W |
GeneIDi | 852031 |
KEGGi | sce:YDR421W |
Organism-specific databases
SGDi | S000002829, ARO80 |
VEuPathDBi | FungiDB:YDR421W |
Phylogenomic databases
eggNOGi | ENOG502QQTI, Eukaryota |
GeneTreei | ENSGT00940000176681 |
HOGENOMi | CLU_005663_0_0_1 |
InParanoidi | Q04052 |
OMAi | AQDMGFM |
Miscellaneous databases
PROi | PR:Q04052 |
RNActi | Q04052, protein |
Family and domain databases
CDDi | cd00067, GAL4, 1 hit |
Gene3Di | 4.10.240.10, 1 hit |
InterProi | View protein in InterPro IPR001138, Zn2-C6_fun-type_DNA-bd IPR036864, Zn2-C6_fun-type_DNA-bd_sf |
Pfami | View protein in Pfam PF00172, Zn_clus, 1 hit |
SMARTi | View protein in SMART SM00066, GAL4, 1 hit |
SUPFAMi | SSF57701, SSF57701, 1 hit |
PROSITEi | View protein in PROSITE PS00463, ZN2_CY6_FUNGAL_1, 1 hit PS50048, ZN2_CY6_FUNGAL_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ARO80_YEAST | |
Accessioni | Q04052Primary (citable) accession number: Q04052 Secondary accession number(s): D6VT51 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | November 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 158 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome IV
Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names