UniProtKB - Q04049 (POLH_YEAST)

BLAST

>sp|Q04049|POLH_YEAST DNA polymerase eta OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=RAD30 PE=1 SV=1
MSKFTWKELIQLGSPSKAYESSLACIAHIDMNAFFAQVEQMRCGLSKEDPVVCVQWNSII
AVSYAARKYGISRMDTIQEALKKCSNLIPIHTAVFKKGEDFWQYHDGCGSWVQDPAKQIS
VEDHKVSLEPYRRESRKALKIFKSACDLVERASIDEVFLDLGRICFNMLMFDNEYELTGD
LKLKDALSNIREAFIGGNYDINSHLPLIPEKIKSLKFEGDVFNPEGRDLITDWDDVILAL
GSQVCKGIRDSIKDILGYTTSCGLSSTKNVCKLASNYKKPDAQTIVKNDCLLDFLDCGKF
EITSFWTLGGVLGKELIDVLDLPHENSIKHIRETWPDNAGQLKEFLDAKVKQSDYDRSTS
NIDPLKTADLAEKLFKLSRGRYGLPLSSRPVVKSMMSNKNLRGKSCNSIVDCISWLEVFC
AELTSRIQDLEQEYNKIVIPRTVSISLKTKSYEVYRKSGPVAYKGINFQSHELLKVGIKF
VTDLDIKGKNKSYYPLTKLSMTITNFDIIDLQKTVVDMFGNQVHTFKSSAGKEDEEKTTS
SKADEKTPKLECCKYQVTFTDQKALQEHADYHLALKLSEGLNGAEESSKNLSFGEKRLLF
SRKRPNSQHTATPQKKQVTSSKNILSFFTRKK

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History
Entry version 140 (12 Sep 2018)
Sequence version 1 (01 Nov 1996)
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Protein

DNA polymerase eta

Gene

RAD30

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers. Depending on the context, it inserts the correct base, but causes frequent base transitions and transversions. Efficiently incorporates nucleotides opposite to other UV or oxidative DNA damages like O₆-methylguanine, 7,8-dihydro-8-oxoguanine, 2,6-diamino-4-hydroxy-5-formamidopyrimidine of 2'-deoxyguanosine (FaPydG), or p-benzoquinone DNA adducts.34 Publications

Miscellaneous

Present with 1860 molecules/cell in log phase SD medium.1 Publication

Catalytic activityⁱ

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Metal bindingⁱ	30	MagnesiumPROSITE-ProRule annotation		1
Metal bindingⁱ	155	MagnesiumPROSITE-ProRule annotation		1

GO - Molecular functionⁱ

damaged DNA binding Source: InterPro
DNA-directed DNA polymerase activity
Source: SGD
Inferred from direct assayⁱ
- 10601233
- 9974380
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

chromosome segregation
Source: SGD
Inferred from mutant phenotypeⁱ
- 23326240
DNA replication Source: UniProtKB-KW
error-free translesion synthesis
Source: SGD
Inferred from direct assayⁱ
error-prone translesion synthesis
Source: SGD
Inferred from direct assayⁱ
- 10713149
mitotic sister chromatid cohesion
Source: SGD
Inferred from mutant phenotypeⁱ
- 23326240

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, DNA-directed DNA polymerase, Mutator protein, Nucleotidyltransferase, Transferase
Biological process	DNA damage, DNA repair, DNA replication, DNA synthesis
Ligand	Magnesium, Metal-binding

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-29960-MONOMER

BioCycⁱ

YEAST:G3O-29960-MONOMER

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: DNA polymerase eta (EC:2.7.7.7) Alternative name(s): Radiation-sensitive protein 30
Gene namesⁱ	Name:RAD30 Synonyms:DBH1 Ordered Locus Names:YDR419W
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome IV

Organism-specific databases

EuPathDBⁱ	FungiDB:YDR419W
Saccharomyces Genome Database More...SGDⁱ	S000002827 RAD30

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	30	D → A: Abolishes DNA polymerase activity. 1 Publication	1
Mutagenesisⁱ	34	F → L: Alters translesion activity. 1 Publication	1
Mutagenesisⁱ	39	E → A: Abolishes DNA polymerase activity. 1 Publication	1
Mutagenesisⁱ	64	Y → F or A: Decreases efficiency of nucleotide incorporation. 1 Publication	1
Mutagenesisⁱ	67	R → A: Decreases efficiency of nucleotide incorporation. 1 Publication	1
Mutagenesisⁱ	155	D → A: Abolishes DNA polymerase activity and increases UV-induced mutations. 1 Publication	1
Mutagenesisⁱ	156	E → A: Decreases efficiency of nucleotide incorporation. 1 Publication	1
Mutagenesisⁱ	279	K → A: Decreases efficiency of nucleotide incorporation. 1 Publication	1
Mutagenesisⁱ	627	F → A: Abolishes POL30-binding; when associated with A-628.	1
Mutagenesisⁱ	628	F → A: Abolishes POL30-binding; when associated with A-627.	1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000268698	1 – 632	DNA polymerase etaAdd BLAST		632

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q04049
PaxDbⁱ	Q04049
PRIDEⁱ	Q04049

Expressionⁱ

Inductionⁱ

By UV radiation and heat shock. The mRNA is stabilized during stationary phase.2 Publications

Interactionⁱ

Subunit structureⁱ

Interacts with POL30. This interaction is essential for the polymerase eta function.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
POL30	P15873	7	EBI-36214,EBI-12993

With

Entry

#Exp.

IntAct

Notes

POL30

P15873

EBI-36214,EBI-12993

Protein-protein interaction databases

BioGridⁱ	32477, 138 interactors
Database of interacting proteins More...DIPⁱ	DIP-6500N
IntActⁱ	Q04049, 19 interactors
Molecular INTeraction database More...MINTⁱ	Q04049
STRINGⁱ	4932.YDR419W

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	1 – 5	Combined sources	5
Helixⁱ	6 – 10	Combined sources	5
Helixⁱ	11 – 13	Combined sources	3
Turnⁱ	15 – 17	Combined sources	3
Helixⁱ	18 – 20	Combined sources	3
Beta strandⁱ	21 – 23	Combined sources	3
Beta strandⁱ	26 – 31	Combined sources	6
Helixⁱ	34 – 42	Combined sources	9
Beta strandⁱ	51 – 55	Combined sources	5
Beta strandⁱ	58 – 62	Combined sources	5
Helixⁱ	64 – 67	Combined sources	4
Turnⁱ	68 – 70	Combined sources	3
Helixⁱ	77 – 81	Combined sources	5
Beta strandⁱ	88 – 91	Combined sources	4
Beta strandⁱ	93 – 96	Combined sources	4
Beta strandⁱ	100 – 103	Combined sources	4
Helixⁱ	115 – 117	Combined sources	3
Beta strandⁱ	123 – 127	Combined sources	5
Helixⁱ	129 – 145	Combined sources	17
Beta strandⁱ	149 – 153	Combined sources	5
Beta strandⁱ	156 – 160	Combined sources	5
Helixⁱ	162 – 171	Combined sources	10
Beta strandⁱ	176 – 178	Combined sources	3
Helixⁱ	183 – 186	Combined sources	4
Helixⁱ	188 – 196	Combined sources	9
Beta strandⁱ	203 – 206	Combined sources	4
Helixⁱ	210 – 214	Combined sources	5
Beta strandⁱ	219 – 221	Combined sources	3
Helixⁱ	233 – 256	Combined sources	24
Beta strandⁱ	260 – 267	Combined sources	8
Helixⁱ	268 – 275	Combined sources	8
Turnⁱ	276 – 278	Combined sources	3
Beta strandⁱ	280 – 285	Combined sources	6
Helixⁱ	288 – 290	Combined sources	3
Helixⁱ	291 – 295	Combined sources	5
Beta strandⁱ	297 – 299	Combined sources	3
Helixⁱ	302 – 304	Combined sources	3
Helixⁱ	306 – 308	Combined sources	3
Helixⁱ	311 – 319	Combined sources	9
Beta strandⁱ	324 – 326	Combined sources	3
Helixⁱ	327 – 334	Combined sources	8
Helixⁱ	339 – 351	Combined sources	13
Beta strandⁱ	352 – 355	Combined sources	4
Turnⁱ	357 – 359	Combined sources	3
Helixⁱ	364 – 366	Combined sources	3
Helixⁱ	367 – 377	Combined sources	11
Turnⁱ	378 – 380	Combined sources	3
Beta strandⁱ	395 – 400	Combined sources	6
Turnⁱ	403 – 406	Combined sources	4
Helixⁱ	409 – 434	Combined sources	26
Beta strandⁱ	436 – 448	Combined sources	13
Beta strandⁱ	454 – 460	Combined sources	7
Helixⁱ	466 – 468	Combined sources	3
Helixⁱ	469 – 487	Combined sources	19
Turnⁱ	488 – 490	Combined sources	3
Beta strandⁱ	497 – 510	Combined sources	14

Show more details

3D structure databases

ProteinModelPortalⁱ	Q04049
SMRⁱ	Q04049
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

Q04049

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	26 – 309	UmuCPROSITE-ProRule annotationAdd BLAST		284

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	625 – 632	POL30-binding		8

Sequence similaritiesⁱ

Belongs to the DNA polymerase type-Y family.Curated

Phylogenomic databases

HOGENOMⁱ	HOG000065930
InParanoidⁱ	Q04049
KEGG Orthology (KO) More...KOⁱ	K03509
OMAⁱ	FGEESIW
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C18P5

Family and domain databases

Gene3Dⁱ	3.30.1490.100, 1 hit
InterProⁱ	View protein in InterPro IPR017061 DNA_pol_eta/kappa/iota/IV IPR036775 DNA_pol_Y-fam_lit_finger_sf IPR017961 DNA_pol_Y-fam_little_finger IPR001126 UmuC
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00817 IMS, 1 hit PF11799 IMS_C, 1 hit
PIRSFⁱ	PIRSF036603 DPol_eta, 1 hit
SUPFAMⁱ	SSF100879 SSF100879, 1 hit
PROSITEⁱ	View protein in PROSITE PS50173 UMUC, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q04049-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSKFTWKELI QLGSPSKAYE SSLACIAHID MNAFFAQVEQ MRCGLSKEDP 
        60         70         80         90        100
VVCVQWNSII AVSYAARKYG ISRMDTIQEA LKKCSNLIPI HTAVFKKGED 
       110        120        130        140        150
FWQYHDGCGS WVQDPAKQIS VEDHKVSLEP YRRESRKALK IFKSACDLVE 
       160        170        180        190        200
RASIDEVFLD LGRICFNMLM FDNEYELTGD LKLKDALSNI REAFIGGNYD 
       210        220        230        240        250
INSHLPLIPE KIKSLKFEGD VFNPEGRDLI TDWDDVILAL GSQVCKGIRD 
       260        270        280        290        300
SIKDILGYTT SCGLSSTKNV CKLASNYKKP DAQTIVKNDC LLDFLDCGKF 
       310        320        330        340        350
EITSFWTLGG VLGKELIDVL DLPHENSIKH IRETWPDNAG QLKEFLDAKV 
       360        370        380        390        400
KQSDYDRSTS NIDPLKTADL AEKLFKLSRG RYGLPLSSRP VVKSMMSNKN 
       410        420        430        440        450
LRGKSCNSIV DCISWLEVFC AELTSRIQDL EQEYNKIVIP RTVSISLKTK 
       460        470        480        490        500
SYEVYRKSGP VAYKGINFQS HELLKVGIKF VTDLDIKGKN KSYYPLTKLS 
       510        520        530        540        550
MTITNFDIID LQKTVVDMFG NQVHTFKSSA GKEDEEKTTS SKADEKTPKL 
       560        570        580        590        600
ECCKYQVTFT DQKALQEHAD YHLALKLSEG LNGAEESSKN LSFGEKRLLF 
       610        620        630 
SRKRPNSQHT ATPQKKQVTS SKNILSFFTR KK

Length:632

Mass (Da):71,515

Last modified:November 1, 1996 - v1

Checksum:ⁱCFB1A9FBC8AFE39B

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U33007 Genomic DNA Translation: AAB64856.1 BK006938 Genomic DNA Translation: DAA12259.1
PIRⁱ	S69702
NCBI Reference Sequences More...RefSeqⁱ	NP_010707.3, NM_001180727.3

Genome annotation databases

EnsemblFungiⁱ	YDR419W; YDR419W; YDR419W
GeneIDⁱ	852028
KEGGⁱ	sce:YDR419W

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q04049	DNA polymerase eta		YEAS1		632	UniRef100_Q04049
RAD30p DNA polymerase eta		Saccharomyces sp. 'boulardii'		632
Rad30p		YEASC		632
YDR419Wp-like protein		YEAS6		632
UPI0000D5BE24		YEASX		513

Protein	Similar proteins		Species	Score	Length	Source
Q04049	DNA polymerase eta		YEAS1		632	UniRef90_Q04049
RAD30p DNA polymerase eta		Saccharomyces sp. 'boulardii'		632
Rad30p		YEASC		632
YDR419Wp-like protein		YEAS6		632
K7_Rad30p		YEASK		632
+11

Protein	Similar proteins		Species	Score	Length	Source
Q04049	DNA polymerase eta		YEAS1		632	UniRef50_Q04049
RAD30p DNA polymerase eta		Saccharomyces sp. 'boulardii'		632
Rad30p		YEASC		632
YDR419Wp-like protein		YEAS6		632
Rad30p		YEASA		632
+15

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U33007 Genomic DNA Translation: AAB64856.1 BK006938 Genomic DNA Translation: DAA12259.1
PIRⁱ	S69702
RefSeqⁱ	NP_010707.3, NM_001180727.3

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1JIH	X-ray	2.25	A/B	1-513	[»]
	2R8J	X-ray	3.10	A/B	1-531	[»]
	2R8K	X-ray	3.30	A/B	1-531	[»]
	2WTF	X-ray	2.50	A/B	1-513	[»]
	2XGP	X-ray	2.70	A/B	1-513	[»]
	2XGQ	X-ray	2.70	A/B	1-513	[»]
	3MFH	X-ray	2.00	A	1-513	[»]
	3MFI	X-ray	1.76	A	1-513	[»]
	3OHA	X-ray	2.00	A	1-513	[»]
	3OHB	X-ray	2.00	A	1-513	[»]
	5VTP	X-ray	2.80	A	1-528	[»]
ProteinModelPortalⁱ	Q04049
SMRⁱ	Q04049
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	32477, 138 interactors
DIPⁱ	DIP-6500N
IntActⁱ	Q04049, 19 interactors
MINTⁱ	Q04049
STRINGⁱ	4932.YDR419W

Proteomic databases

MaxQBⁱ	Q04049
PaxDbⁱ	Q04049
PRIDEⁱ	Q04049

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	YDR419W; YDR419W; YDR419W
GeneIDⁱ	852028
KEGGⁱ	sce:YDR419W

Organism-specific databases

EuPathDBⁱ	FungiDB:YDR419W
SGDⁱ	S000002827 RAD30

Phylogenomic databases

HOGENOMⁱ	HOG000065930
InParanoidⁱ	Q04049
KOⁱ	K03509
OMAⁱ	FGEESIW
OrthoDBⁱ	EOG092C18P5

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-29960-MONOMER

BioCycⁱ

YEAST:G3O-29960-MONOMER

Miscellaneous databases

EvolutionaryTraceⁱ	Q04049
Protein Ontology More...PROⁱ	PR:Q04049

Family and domain databases

Gene3Dⁱ	3.30.1490.100, 1 hit
InterProⁱ	View protein in InterPro IPR017061 DNA_pol_eta/kappa/iota/IV IPR036775 DNA_pol_Y-fam_lit_finger_sf IPR017961 DNA_pol_Y-fam_little_finger IPR001126 UmuC
Pfamⁱ	View protein in Pfam PF00817 IMS, 1 hit PF11799 IMS_C, 1 hit
PIRSFⁱ	PIRSF036603 DPol_eta, 1 hit
SUPFAMⁱ	SSF100879 SSF100879, 1 hit
PROSITEⁱ	View protein in PROSITE PS50173 UMUC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	POLH_YEAST
Accessionⁱ	Q04049Primary (citable) accession number: Q04049 Secondary accession number(s): D6VT49
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
	Last sequence update:	November 1, 1996
	Last modified:	September 12, 2018
	This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
Yeast chromosome IV
Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

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UniProtKB - Q04049 (POLH_YEAST)

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DNA polymerase eta

RAD30

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Mitochondrion

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ