UniProtKB - Q03ZQ2 (EFG_LEUMM)
Protein
Elongation factor G
Gene
fusA
Organism
Leuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / DSM 20343 / BCRC 11652 / CCM 1803 / JCM 6124 / NCDO 523 / NBRC 100496 / NCIMB 8023 / NCTC 12954 / NRRL B-1118 / 37Y)
Status
Functioni
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.UniRule annotation
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 18 – 25 | GTPUniRule annotation | 8 | |
Nucleotide bindingi | 91 – 95 | GTPUniRule annotation | 5 | |
Nucleotide bindingi | 145 – 148 | GTPUniRule annotation | 4 |
GO - Molecular functioni
- GTPase activity Source: InterPro
- GTP binding Source: UniProtKB-UniRule
- translation elongation factor activity Source: UniProtKB-UniRule
Keywordsi
Molecular function | Elongation factor |
Biological process | Protein biosynthesis |
Ligand | GTP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Elongation factor GUniRule annotationShort name: EF-GUniRule annotation |
Gene namesi | Name:fusAUniRule annotation Ordered Locus Names:LEUM_0189 |
Organismi | Leuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / DSM 20343 / BCRC 11652 / CCM 1803 / JCM 6124 / NCDO 523 / NBRC 100496 / NCIMB 8023 / NCTC 12954 / NRRL B-1118 / 37Y) |
Taxonomic identifieri | 203120 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Lactobacillales › Leuconostocaceae › Leuconostoc › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000335847 | 1 – 703 | Elongation factor GAdd BLAST | 703 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 9 – 292 | tr-type GAdd BLAST | 284 |
Sequence similaritiesi
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.UniRule annotation
Phylogenomic databases
eggNOGi | COG0480, Bacteria |
HOGENOMi | CLU_002794_4_1_9 |
OMAi | AATTCHW |
OrthoDBi | 88967at2 |
Family and domain databases
CDDi | cd16262, EFG_III, 1 hit cd01434, EFG_mtEFG1_IV, 1 hit cd03713, EFG_mtEFG_C, 1 hit |
Gene3Di | 3.30.230.10, 1 hit |
HAMAPi | MF_00054_B, EF_G_EF_2_B, 1 hit |
InterProi | View protein in InterPro IPR041095, EFG_II IPR009022, EFG_III IPR035647, EFG_III/V IPR035649, EFG_V IPR000640, EFG_V-like IPR004161, EFTu-like_2 IPR031157, G_TR_CS IPR027417, P-loop_NTPase IPR020568, Ribosomal_S5_D2-typ_fold IPR014721, Ribosomal_S5_D2-typ_fold_subgr IPR005225, Small_GTP-bd_dom IPR000795, TF_GTP-bd_dom IPR009000, Transl_B-barrel_sf IPR004540, Transl_elong_EFG/EF2 IPR005517, Transl_elong_EFG/EF2_IV |
Pfami | View protein in Pfam PF00679, EFG_C, 1 hit PF14492, EFG_III, 1 hit PF03764, EFG_IV, 1 hit PF00009, GTP_EFTU, 1 hit PF03144, GTP_EFTU_D2, 1 hit |
PRINTSi | PR00315, ELONGATNFCT |
SMARTi | View protein in SMART SM00838, EFG_C, 1 hit SM00889, EFG_IV, 1 hit |
SUPFAMi | SSF50447, SSF50447, 1 hit SSF52540, SSF52540, 1 hit SSF54211, SSF54211, 1 hit SSF54980, SSF54980, 2 hits |
TIGRFAMsi | TIGR00484, EF-G, 1 hit TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS00301, G_TR_1, 1 hit PS51722, G_TR_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q03ZQ2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAKREYPLER TRNIGIMAHI DAGKTTTTER ILYYTGKIHK IGETHDGASQ
60 70 80 90 100
MDFMEQEKER GITIQSAATT AVWHGFFDQF AKTPYRVNII DTPGHVDFTI
110 120 130 140 150
EVERALRVLD GAVAVLDGAA GVEPQTETVW RQATTYDVPR IVFVNKMDKL
160 170 180 190 200
GADFQMSVDS IHERLQVNAE AIQWPIGAED DFEAVIDLIT QEAYYPEDDL
210 220 230 240 250
GEKWAPREIP EELKELAEEK RNTLIEAVAD VDDDLMEKYL EGEDISIEEL
260 270 280 290 300
KAAIRRATLA LQFYPVLAGS AYKDKGVQMM LDAVVDYLPG PLDVKPYIAN
310 320 330 340 350
DPKTDEEIDL IADDSKPFAA LAFKIMTDPF VGRLTFMRVY TGTLKSGSYV
360 370 380 390 400
QNTSSDTRER VGRLLQMHAT SRTEIEEVFS GDIAAAIGLK NTTTGDSLTD
410 420 430 440 450
VSHQLILESM EFPEPVIELA IEPKTKADQD KLSNAIQKLA EEDPSFRATT
460 470 480 490 500
NQETGQTLIA GMGELQLDIM VDRMRREFNV EATVGAPQVA YREAFTKTVQ
510 520 530 540 550
ARGFFKRQSG GKGQYGDVYI EFAPNEEGAG FEFEDAIVGG VVPREYIPSV
560 570 580 590 600
EAGLKDALNA GPLAGFPLVD LKAKLYDGSY HDVDSSEAAF KIAASLALKE
610 620 630 640 650
AAKTAGAVIL EPIMAVDIVA PEDNLGDVMG HVSARRGMIE GQESRGPVLA
660 670 680 690 700
VKAKVPLSEM FGYATTLRSA TQGRGTFQMV FDHYEAVPKN IQEEIIKTNG
QED
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000414 Genomic DNA Translation: ABJ61320.1 |
RefSeqi | WP_011679127.1, NC_008531.1 |
Genome annotation databases
EnsemblBacteriai | ABJ61320; ABJ61320; LEUM_0189 |
GeneIDi | 29577288 |
KEGGi | lme:LEUM_0189 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000414 Genomic DNA Translation: ABJ61320.1 |
RefSeqi | WP_011679127.1, NC_008531.1 |
3D structure databases
SMRi | Q03ZQ2 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 203120.LEUM_0189 |
Genome annotation databases
EnsemblBacteriai | ABJ61320; ABJ61320; LEUM_0189 |
GeneIDi | 29577288 |
KEGGi | lme:LEUM_0189 |
Phylogenomic databases
eggNOGi | COG0480, Bacteria |
HOGENOMi | CLU_002794_4_1_9 |
OMAi | AATTCHW |
OrthoDBi | 88967at2 |
Family and domain databases
CDDi | cd16262, EFG_III, 1 hit cd01434, EFG_mtEFG1_IV, 1 hit cd03713, EFG_mtEFG_C, 1 hit |
Gene3Di | 3.30.230.10, 1 hit |
HAMAPi | MF_00054_B, EF_G_EF_2_B, 1 hit |
InterProi | View protein in InterPro IPR041095, EFG_II IPR009022, EFG_III IPR035647, EFG_III/V IPR035649, EFG_V IPR000640, EFG_V-like IPR004161, EFTu-like_2 IPR031157, G_TR_CS IPR027417, P-loop_NTPase IPR020568, Ribosomal_S5_D2-typ_fold IPR014721, Ribosomal_S5_D2-typ_fold_subgr IPR005225, Small_GTP-bd_dom IPR000795, TF_GTP-bd_dom IPR009000, Transl_B-barrel_sf IPR004540, Transl_elong_EFG/EF2 IPR005517, Transl_elong_EFG/EF2_IV |
Pfami | View protein in Pfam PF00679, EFG_C, 1 hit PF14492, EFG_III, 1 hit PF03764, EFG_IV, 1 hit PF00009, GTP_EFTU, 1 hit PF03144, GTP_EFTU_D2, 1 hit |
PRINTSi | PR00315, ELONGATNFCT |
SMARTi | View protein in SMART SM00838, EFG_C, 1 hit SM00889, EFG_IV, 1 hit |
SUPFAMi | SSF50447, SSF50447, 1 hit SSF52540, SSF52540, 1 hit SSF54211, SSF54211, 1 hit SSF54980, SSF54980, 2 hits |
TIGRFAMsi | TIGR00484, EF-G, 1 hit TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS00301, G_TR_1, 1 hit PS51722, G_TR_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EFG_LEUMM | |
Accessioni | Q03ZQ2Primary (citable) accession number: Q03ZQ2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 20, 2008 |
Last sequence update: | November 14, 2006 | |
Last modified: | December 2, 2020 | |
This is version 100 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |