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Protein

Alanine racemase

Gene

LEUM_1812

Organism
Leuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / NCDO 523)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (LEUM_0422), Alanine racemase (LEUM_1812), Alanine racemase (LEUM_1941)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei42Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei141SubstrateUniRule annotation1
Active sitei270Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei317Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciLMES203120:GJ8T-1792-MONOMER
UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:LEUM_1812Imported
OrganismiLeuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / NCDO 523)Imported
Taxonomic identifieri203120 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeLeuconostoc
Proteomesi
  • UP000000362 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei42N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi203120.LEUM_1812

Structurei

3D structure databases

ProteinModelPortaliQ03V73
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini249 – 373Ala_racemase_CInterPro annotationAdd BLAST125

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
HOGENOMiHOG000031444
KOiK01775
OMAiYSDGYRR
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q03V73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDNDILCLR PTWLDIDLKA IQTNAKLIMR HAGAQRLIAV VKANAYGHGA
60 70 80 90 100
KQVVGALFEV GVYDFAVATI GEGVDLRKYY PQAEINIFLL GVQDVTQTEV
110 120 130 140 150
MVENRLSPAV GTTEWLDEAV NYIKDGQKLD VQLAVDTGMG RMGAHSASAV
160 170 180 190 200
EDMYHLIQGT EKFQLAGVFT HFATADDNNQ NYYDEQVQRF YQWVQSAGIP
210 220 230 240 250
KQYWHLANSG SAIWHHDEIY TDTIRVGSVL YGYNPGAPEK KMPLPLKPAL
260 270 280 290 300
QLKSKLGSVH QLTTGESVSY GATYTAEKPQ WIATLPIGYA DGYLRRMSGM
310 320 330 340 350
KVLVDGHIEH VIGRVTMDQI VITLKQKYPV GKTVTLVGLE GENQISVEEI
360 370
AEYAQTIPHE ILTNFGARLP RIY
Length:373
Mass (Da):41,458
Last modified:November 14, 2006 - v1
Checksum:iBFCB0456CA945183
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000414 Genomic DNA Translation: ABJ62899.1
RefSeqiWP_011680399.1, NC_008531.1

Genome annotation databases

EnsemblBacteriaiABJ62899; ABJ62899; LEUM_1812
GeneIDi29576986
KEGGilme:LEUM_1812

Similar proteinsi

Entry informationi

Entry nameiQ03V73_LEUMM
AccessioniPrimary (citable) accession number: Q03V73
Entry historyiIntegrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: February 28, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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