UniProtKB - Q03QN6 (TIG_LACBA)
Protein
Trigger factor
Gene
tig
Organism
Lactobacillus brevis (strain ATCC 367 / JCM 1170)
Status
Functioni
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.UniRule annotation
Catalytic activityi
- EC:5.2.1.8UniRule annotation
GO - Molecular functioni
- peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-UniRule
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
- protein folding Source: UniProtKB-UniRule
- protein transport Source: UniProtKB-UniRule
Keywordsi
Molecular function | Chaperone, Isomerase, Rotamase |
Biological process | Cell cycle, Cell division |
Names & Taxonomyi
Protein namesi | Recommended name: Trigger factorUniRule annotation (EC:5.2.1.8UniRule annotation)Short name: TFUniRule annotation Alternative name(s): PPIaseUniRule annotation |
Gene namesi | Name:tigUniRule annotation Ordered Locus Names:LVIS_1388 |
Organismi | Lactobacillus brevis (strain ATCC 367 / JCM 1170) |
Taxonomic identifieri | 387344 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Lactobacillales › Lactobacillaceae › Levilactobacillus › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm Note: About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000022694 | 1 – 436 | Trigger factorAdd BLAST | 436 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 163 – 248 | PPIase FKBP-typeUniRule annotationAdd BLAST | 86 |
Domaini
Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.UniRule annotation
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0544, Bacteria |
HOGENOMi | CLU_033058_3_2_9 |
OMAi | MAMIEDR |
OrthoDBi | 932993at2 |
Family and domain databases
Gene3Di | 1.10.3120.10, 1 hit 3.30.70.1050, 1 hit |
HAMAPi | MF_00303, Trigger_factor_Tig, 1 hit |
InterProi | View protein in InterPro IPR001179, PPIase_FKBP_dom IPR005215, Trig_fac IPR008880, Trigger_fac_C IPR037041, Trigger_fac_C_sf IPR008881, Trigger_fac_ribosome-bd_bac IPR036611, Trigger_fac_ribosome-bd_sf IPR027304, Trigger_fact/SurA_dom_sf |
PANTHERi | PTHR30560, PTHR30560, 1 hit |
Pfami | View protein in Pfam PF00254, FKBP_C, 1 hit PF05698, Trigger_C, 1 hit PF05697, Trigger_N, 1 hit |
PIRSFi | PIRSF003095, Trigger_factor, 1 hit |
SUPFAMi | SSF102735, SSF102735, 1 hit SSF109998, SSF109998, 1 hit |
TIGRFAMsi | TIGR00115, tig, 1 hit |
PROSITEi | View protein in PROSITE PS50059, FKBP_PPIASE, 1 hit |
i Sequence
Sequence statusi: Complete.
Q03QN6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAKWEKKDN NQGELTFEIA PDKIKEGLDK AFQRTKKNLA VPGFRKGRVP
60 70 80 90 100
RQIFNQMYGE EALYQDALNI VLPEAYDAAI KEAGIEPVDQ PQVDVESMDK
110 120 130 140 150
DQPWVLKAVV TVKPDVKLGE YKGLSVTKQN TRVYQKDIDA EIEKQRQQQA
160 170 180 190 200
ELVLKEDEAA AKGDTVVIDF DGYVDGKQFD GGKADNYSLE LGSNSFIPGF
210 220 230 240 250
EDQLVGHKAG EDVDVKVTFP ADYQAEDLRD KEATFKVTIH EVKEKQLPEL
260 270 280 290 300
DDEFAKDVDE DVDSLEELEA KTKDRLKEQK VTAAHDAIED EAISEAVDNA
310 320 330 340 350
EIAAVPEAML KDDIDRQMDQ YLANMQQQGI EPKMYFQLTG TTEDDLRKQF
360 370 380 390 400
ADGAEKRIKT NLVLEAVVEA EKIEPSEDEV AAEVKDLASQ YGMEESAVRS
410 420 430
ALSDDMLKHD IAIKSAVDLI ADSAKQDKKK DAEDDE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000416 Genomic DNA Translation: ABJ64486.1 |
RefSeqi | WP_011668059.1, NC_008497.1 |
Genome annotation databases
EnsemblBacteriai | ABJ64486; ABJ64486; LVIS_1388 |
KEGGi | lbr:LVIS_1388 |
PATRICi | fig|387344.15.peg.1324 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000416 Genomic DNA Translation: ABJ64486.1 |
RefSeqi | WP_011668059.1, NC_008497.1 |
3D structure databases
SMRi | Q03QN6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 387344.LVIS_1388 |
Genome annotation databases
EnsemblBacteriai | ABJ64486; ABJ64486; LVIS_1388 |
KEGGi | lbr:LVIS_1388 |
PATRICi | fig|387344.15.peg.1324 |
Phylogenomic databases
eggNOGi | COG0544, Bacteria |
HOGENOMi | CLU_033058_3_2_9 |
OMAi | MAMIEDR |
OrthoDBi | 932993at2 |
Family and domain databases
Gene3Di | 1.10.3120.10, 1 hit 3.30.70.1050, 1 hit |
HAMAPi | MF_00303, Trigger_factor_Tig, 1 hit |
InterProi | View protein in InterPro IPR001179, PPIase_FKBP_dom IPR005215, Trig_fac IPR008880, Trigger_fac_C IPR037041, Trigger_fac_C_sf IPR008881, Trigger_fac_ribosome-bd_bac IPR036611, Trigger_fac_ribosome-bd_sf IPR027304, Trigger_fact/SurA_dom_sf |
PANTHERi | PTHR30560, PTHR30560, 1 hit |
Pfami | View protein in Pfam PF00254, FKBP_C, 1 hit PF05698, Trigger_C, 1 hit PF05697, Trigger_N, 1 hit |
PIRSFi | PIRSF003095, Trigger_factor, 1 hit |
SUPFAMi | SSF102735, SSF102735, 1 hit SSF109998, SSF109998, 1 hit |
TIGRFAMsi | TIGR00115, tig, 1 hit |
PROSITEi | View protein in PROSITE PS50059, FKBP_PPIASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TIG_LACBA | |
Accessioni | Q03QN6Primary (citable) accession number: Q03QN6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | November 14, 2006 | |
Last modified: | February 10, 2021 | |
This is version 82 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families