UniProtKB - Q03PY6 (ECFA2_LACBA)
Protein
Energy-coupling factor transporter ATP-binding protein EcfA2
Gene
ecfA2
Organism
Lactobacillus brevis (strain ATCC 367 / JCM 1170)
Status
Functioni
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.UniRule annotation
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 40 – 47 | ATPUniRule annotation | 8 |
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATP binding Source: UniProtKB-KW
GO - Biological processi
- transmembrane transport Source: InterPro
Keywordsi
Molecular function | Hydrolase |
Biological process | Transport |
Ligand | ATP-binding, Nucleotide-binding |
Protein family/group databases
TCDBi | 3.A.1.26.9, the atp-binding cassette (abc) superfamily 3.A.1.28.2, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Energy-coupling factor transporter ATP-binding protein EcfA2UniRule annotation (EC:3.6.3.-UniRule annotation)Short name: ECF transporter A component EcfA2UniRule annotation |
Gene namesi | Name:ecfA2UniRule annotation Synonyms:cbiO2 Ordered Locus Names:LVIS_1661 |
Organismi | Lactobacillus brevis (strain ATCC 367 / JCM 1170) |
Taxonomic identifieri | 387344 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Lactobacillales › Lactobacillaceae › Lactobacillus › |
Proteomesi |
|
Subcellular locationi
- Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation
GO - Cellular componenti
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000287943 | 1 – 290 | Energy-coupling factor transporter ATP-binding protein EcfA2Add BLAST | 290 |
Proteomic databases
PRIDEi | Q03PY6 |
Interactioni
Subunit structurei
Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).
UniRule annotationProtein-protein interaction databases
DIPi | DIP-60218N |
IntActi | Q03PY6, 2 interactors |
STRINGi | 387344.LVIS_1661 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q03PY6 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3 – 246 | ABC transporterUniRule annotationAdd BLAST | 244 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG1122, Bacteria |
HOGENOMi | CLU_000604_1_22_9 |
OMAi | GHNLLRC |
OrthoDBi | 1752365at2 |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR015856, ABC_transpr_CbiO/EcfA_su IPR030946, EcfA2 IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00005, ABC_tran, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR04521, ECF_ATPase_2, 1 hit |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit PS51246, CBIO, 1 hit |
i Sequence
Sequence statusi: Complete.
Q03PY6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAIAFEHVTY TYQAGTPMAH TALTDVSLTV PDRGYLAIIG HTGSGKSTLI
60 70 80 90 100
QQLNALLKPT SGTIKIDEFT ITPETTNAAL KPLRQHVGMV FQFPENQLFE
110 120 130 140 150
ETVRQDIAFG PKNFGMADAD ALALADEMLT TVGLDQSYAE RSPFELSGGQ
160 170 180 190 200
MRRVAIAGVL AMQPKVLVLD EPTAGLDPQG RQEMMRLFAR LHQEQGLTIV
210 220 230 240 250
LVTHQMEDVA QYAEQVAVMH EGRLMKFGTP ADVFSNREWL QDHQLDVPQA
260 270 280 290
AQFARRLRDR GLTFPKQPLT ADQLADYLAQ QWAQRGADHV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000416 Genomic DNA Translation: ABJ64736.1 |
RefSeqi | WP_011668470.1, NC_008497.1 |
Genome annotation databases
EnsemblBacteriai | ABJ64736; ABJ64736; LVIS_1661 |
GeneIDi | 4413743 |
KEGGi | lbr:LVIS_1661 |
PATRICi | fig|387344.15.peg.1574 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000416 Genomic DNA Translation: ABJ64736.1 |
RefSeqi | WP_011668470.1, NC_008497.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4HUQ | X-ray | 3.00 | A | 1-290 | [»] | |
4HZU | X-ray | 3.53 | B | 1-290 | [»] | |
4RFS | X-ray | 3.23 | A | 1-290 | [»] | |
SMRi | Q03PY6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-60218N |
IntActi | Q03PY6, 2 interactors |
STRINGi | 387344.LVIS_1661 |
Protein family/group databases
TCDBi | 3.A.1.26.9, the atp-binding cassette (abc) superfamily 3.A.1.28.2, the atp-binding cassette (abc) superfamily |
Proteomic databases
PRIDEi | Q03PY6 |
Genome annotation databases
EnsemblBacteriai | ABJ64736; ABJ64736; LVIS_1661 |
GeneIDi | 4413743 |
KEGGi | lbr:LVIS_1661 |
PATRICi | fig|387344.15.peg.1574 |
Phylogenomic databases
eggNOGi | COG1122, Bacteria |
HOGENOMi | CLU_000604_1_22_9 |
OMAi | GHNLLRC |
OrthoDBi | 1752365at2 |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR015856, ABC_transpr_CbiO/EcfA_su IPR030946, EcfA2 IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00005, ABC_tran, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR04521, ECF_ATPase_2, 1 hit |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit PS51246, CBIO, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ECFA2_LACBA | |
Accessioni | Q03PY6Primary (citable) accession number: Q03PY6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 29, 2007 |
Last sequence update: | November 14, 2006 | |
Last modified: | December 2, 2020 | |
This is version 94 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families