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Entry version 81 (26 Feb 2020)
Sequence version 1 (14 Nov 2006)
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Protein

ATP-dependent helicase/deoxyribonuclease subunit B

Gene

rexB

Organism
Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' -> 3' nuclease activity.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease
Biological processDNA damage, DNA repair
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
PPEN278197:G1G70-1798-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP-dependent helicase/deoxyribonuclease subunit BUniRule annotation (EC:3.1.-.-UniRule annotation, EC:3.6.4.12UniRule annotation)
Alternative name(s):
ATP-dependent helicase/nuclease RexBUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rexBUniRule annotation
Ordered Locus Names:PEPE_1833
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri278197 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaePediococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000773 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003793861 – 1192ATP-dependent helicase/deoxyribonuclease subunit BAdd BLAST1192

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q03D70

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of AddA and RexB.

UniRule annotation

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
278197.PEPE_1833

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q03D70

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the helicase family. AddB/RexB type 2 subfamily.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105C5N Bacteria
COG3857 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007838_0_0_9

KEGG Orthology (KO)

More...
KOi
K16899

Identification of Orthologs from Complete Genome Data

More...
OMAi
DRLENYV

Database of Orthologous Groups

More...
OrthoDBi
1283891at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.320.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01453 AddB_type2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014141 DNA_helicase_suRexB
IPR000212 DNA_helicase_UvrD/REP
IPR011604 Exonuc_phg/RecB_C
IPR027417 P-loop_NTPase
IPR038726 PDDEXK_AddAB-type

The PANTHER Classification System

More...
PANTHERi
PTHR11070 PTHR11070, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12705 PDDEXK_1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q03D70-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLQFMYGPA SIDHLEGIAD RVIELQQQNV GQPVYYLVPN HIKFQSEIQL
60 70 80 90 100
LQKLRQRRDV KSHIFAEKDV QILSISRLAW FFLRNSSIYQ YPRVTSSSSN
110 120 130 140 150
MLLYRVILEH QDELTLFHNI DAQLGLVQKI ATQLAEFKQG NVGPDELGRV
160 170 180 190 200
AENIAENSDA GMDIKAKLHD LGIIYSAYEE EIQSRFIDAS DITHTLTDEL
210 220 230 240 250
SKMDLSGQSF IISGFSNFTA EEMSLIQALM KANGNVVIDL IMDKFPLYEK
260 270 280 290 300
VSENSLFFEN EKIIFKFNAW AHENKVKSLE PVRLHRVRVN SDLLKLEKYW
310 320 330 340 350
IESSEGQVGG SKQENNACVT IFQANSRYAE VEHVATLIRQ KMAKDPSLKF
360 370 380 390 400
SDFSVLTRHL SDYSTIIKPI FDQMELPIFY DLQIAMKDHP LLELINALFD
410 420 430 440 450
IRAHHFRYED VMRLLKTGLL FPETEDDPHG MDFFKSVHIT ENYVLKQGIY
460 470 480 490 500
GDRWLQKKDW KYSRFNDIDE EKQTDEEIEI NQRINTVKNY VAETVVPFFN
510 520 530 540 550
QLSTATTGVE AAKALYDFLI KNGIDQCLLA WRDQWIEEGR LAKAAEPEQT
560 570 580 590 600
WETFIQMLDE FVDILGDQPF DPDNFMGLLN AGFEGATYSQ IPSTLDQILV
610 620 630 640 650
SESGMVQMVD RKIVFIIGAT DRVMPEQIQD NDFLNQDGKN QIDPFLDDDQ
660 670 680 690 700
FLRISNDRQM RQEPYLNYLT FMIGSDELIF SYPKSGNDGV ELKISPYVER
710 720 730 740 750
IGKHFGIIAQ SLPSRPTTEP VRLDPPFIEL FIGSNRSTLS HLIQYARAMH
760 770 780 790 800
EAKSEADPRW NLIYTILRQS TLGSLTDQLL SSLEYKNIPE KLKPEIVEGL
810 820 830 840 850
YGDTIYASVS KLEEFYRNEY SYFLKYGLKL QERETSDLSP ADTGQYFHAA
860 870 880 890 900
MDKLIKMITT ENLNFNEVNQ EQIEQIAKRL VQQMEQDQQF DQFNGTYRMG
910 920 930 940 950
FLRKQLDRTV QAMVEAIFKQ LARTRMRPIA SEQLFGQIGS QSGLPALNFK
960 970 980 990 1000
VGEGKEINVR GKIDRIDKIE IGDKDYLGIV DYKSSNRKFD FTDAYYGLAM
1010 1020 1030 1040 1050
QMLMYLDVVQ RNKEKIDPAT KAEISSALYM IFQYPLLKSK EWKGSDANQL
1060 1070 1080 1090 1100
NQSIFKKFSL NGFLLKDEEL IKEIDKTIED TRKSDVFPIA FTTKGTLTKV
1110 1120 1130 1140 1150
SENSILSEDE LQNLIKHAEL KVREAGEKIF KGELDMNPVQ WPNRRTVMEY
1160 1170 1180 1190
SPYKDVMQFD AMLPENNYRI IEKLDKDKVL EQIREEQEKN GR
Length:1,192
Mass (Da):137,874
Last modified:November 14, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i547C47F993826C39
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP000422 Genomic DNA Translation: ABJ68852.1

NCBI Reference Sequences

More...
RefSeqi
WP_011673919.1, NC_008525.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ABJ68852; ABJ68852; PEPE_1833

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
33061292

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ppe:PEPE_1833

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000422 Genomic DNA Translation: ABJ68852.1
RefSeqiWP_011673919.1, NC_008525.1

3D structure databases

SMRiQ03D70
ModBaseiSearch...

Protein-protein interaction databases

STRINGi278197.PEPE_1833

Proteomic databases

PRIDEiQ03D70

Genome annotation databases

EnsemblBacteriaiABJ68852; ABJ68852; PEPE_1833
GeneIDi33061292
KEGGippe:PEPE_1833

Phylogenomic databases

eggNOGiENOG4105C5N Bacteria
COG3857 LUCA
HOGENOMiCLU_007838_0_0_9
KOiK16899
OMAiDRLENYV
OrthoDBi1283891at2

Enzyme and pathway databases

BioCyciPPEN278197:G1G70-1798-MONOMER

Family and domain databases

Gene3Di3.90.320.10, 1 hit
HAMAPiMF_01453 AddB_type2, 1 hit
InterProiView protein in InterPro
IPR014141 DNA_helicase_suRexB
IPR000212 DNA_helicase_UvrD/REP
IPR011604 Exonuc_phg/RecB_C
IPR027417 P-loop_NTPase
IPR038726 PDDEXK_AddAB-type
PANTHERiPTHR11070 PTHR11070, 1 hit
PfamiView protein in Pfam
PF12705 PDDEXK_1, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiADDB_PEDPA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q03D70
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: November 14, 2006
Last modified: February 26, 2020
This is version 81 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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