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Entry version 149 (12 Aug 2020)
Sequence version 2 (29 May 2007)
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Protein

AT-rich interactive domain-containing protein 5A

Gene

ARID5A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to AT-rich stretches in the modulator region upstream of the human cytomegalovirus major intermediate early gene enhancer. May act as repressor and down-regulate enhancer-dependent gene expressison (PubMed:8649988). May positively regulate chondrocyte-specific transcription such as of COL2A1 in collaboration with SOX9 and positively regulate histone H3 acetylation at chondrocyte-specific genes. May stimulate early-stage chondrocyte differentiation and inhibit later stage differention (By similarity). Can repress ESR1-mediated transcriptional activation; proposed to act as corepressor for selective nuclear hormone receptors (PubMed:15941852). As RNA-binding protein involved in the regulation of inflammatory response by stabilizing selective inflammation-related mRNAs, such as IL6, STAT3 and TBX21. Binds to stem loop structures located in the 3'UTRs of IL6, STAT3 and TBX21 mRNAs; at least for STAT3 prevents binding of ZC3H12A to the mRNA stem loop structure thus inhibiting its degradation activity. Contributes to elevated IL6 levels possibly implicated in autoimmunity processes. IL6-dependent stabilization of STAT3 mRNA may promote differentiation of naive CD4+ T-cells into T-helper Th17 cells. In CD4+ T-cells may also inhibit RORC-induced Th17 cell differentiation independently of IL6 signaling. Stabilization of TBX21 mRNA contributes to elevated interferon-gamma secretion in Th1 cells possibly implicated in the establishment of septic shock (By similarity). Stabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR; thereby competing with the mRNA-destabilizing functions of RC3H1 and endoribonuclease ZC3H12A (By similarity).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Repressor, RNA-binding
Biological processImmunity, Innate immunity, Transcription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q03989

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AT-rich interactive domain-containing protein 5A
Short name:
ARID domain-containing protein 5A
Alternative name(s):
Modulator recognition factor 1
Short name:
MRF-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARID5A
Synonyms:MRF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000196843.15

Human Gene Nomenclature Database

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HGNCi
HGNC:17361, ARID5A

Online Mendelian Inheritance in Man (OMIM)

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MIMi
611583, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q03989

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10865

Open Targets

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OpenTargetsi
ENSG00000196843

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134937822

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q03989, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
ARID5A

Domain mapping of disease mutations (DMDM)

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DMDMi
148840818

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002889301 – 594AT-rich interactive domain-containing protein 5AAdd BLAST594

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei23PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki85Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki94Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei256PhosphoserineBy similarity1
Modified residuei289PhosphoserineBy similarity1
Modified residuei438PhosphoserineBy similarity1
Modified residuei463PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by MAPK14 on serine residues involving a TLR4 signaling pathway upon lipopolysaccharide (LPS) stimulation leading to its ubiquitination and proteasomal degradation.By similarity
Ubiquitinated leading to proteasomal degradation; involving WWP1 linked to MAPK14-mediated phosphorylation upon LPS stimulation.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q03989

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q03989

MaxQB - The MaxQuant DataBase

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MaxQBi
Q03989

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q03989

PeptideAtlas

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PeptideAtlasi
Q03989

PRoteomics IDEntifications database

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PRIDEi
Q03989

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
58234
8111

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q03989

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q03989

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000196843, Expressed in tibial artery and 226 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q03989, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q03989, HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000196843, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SOX9 (By similarity).

Interacts with ESR1 (PubMed:15941852).

Interacts with RORC (By similarity).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q03989
With#Exp.IntAct
ANKRD11 [X5D778]3EBI-948603,EBI-17183751
itself3EBI-948603,EBI-948603
ATP6V0D2 [Q8N8Y2]3EBI-948603,EBI-3923949
ATXN1 [P54253]3EBI-948603,EBI-930964
ATXN1L [P0C7T5]3EBI-948603,EBI-8624731
BAG4 [O95429]3EBI-948603,EBI-2949658
BAHD1 [Q8TBE0]3EBI-948603,EBI-742750
BANP - isoform 2 [Q8N9N5-2]3EBI-948603,EBI-11524452
BOLL - isoform 4 [Q8N9W6-4]3EBI-948603,EBI-11983447
C14orf119 [Q9NWQ9]3EBI-948603,EBI-725606
C19orf54 - isoform 3 [Q5BKX5-3]3EBI-948603,EBI-11976299
CAMK2A [Q9UQM7]3EBI-948603,EBI-1383687
CATSPER1 [Q8NEC5]3EBI-948603,EBI-744545
CCDC120 [Q96HB5]3EBI-948603,EBI-744556
CCDC57 - isoform 2 [Q2TAC2-2]3EBI-948603,EBI-10961624
CKS1B [P61024]5EBI-948603,EBI-456371
COX5B [P10606]3EBI-948603,EBI-1053725
CRYBA1 [P05813]3EBI-948603,EBI-7043337
CRYBA2 [P53672]3EBI-948603,EBI-750444
CYSRT1 [A8MQ03]3EBI-948603,EBI-3867333
DAZAP2 [Q15038]8EBI-948603,EBI-724310
DOK6 [Q6PKX4]3EBI-948603,EBI-2880244
DTX2 [Q86UW9]3EBI-948603,EBI-740376
ESR1 [P03372]9EBI-948603,EBI-78473
ESRP1 [Q6NXG1]3EBI-948603,EBI-10213520
FAM168B - isoform 2 [A1KXE4-2]3EBI-948603,EBI-12193763
FHL3 [Q13643]3EBI-948603,EBI-741101
FOXD2 [O60548]3EBI-948603,EBI-17282008
FOXH1 [O75593]4EBI-948603,EBI-1759806
GATA5 [Q9BWX5]3EBI-948603,EBI-12132270
GLIS2 [Q9BZE0]3EBI-948603,EBI-7251368
GRB2 [P62993]3EBI-948603,EBI-401755
HDAC7 - isoform 6 [Q8WUI4-6]3EBI-948603,EBI-12094670
HOXA1 [P49639]3EBI-948603,EBI-740785
HSD3B7 [Q9H2F3]3EBI-948603,EBI-3918847
INIP [Q9NRY2]3EBI-948603,EBI-2881520
IRX6 [P78412]3EBI-948603,EBI-12100506
KAZN - isoform 2 [Q674X7-2]3EBI-948603,EBI-12024294
KCTD9 [Q7L273]3EBI-948603,EBI-4397613
KDF1 [Q8NAX2]3EBI-948603,EBI-11997992
KRTAP10-8 [P60410]3EBI-948603,EBI-10171774
KRTAP12-2 [P59991]5EBI-948603,EBI-10176379
KRTAP15-1 [Q3LI76]3EBI-948603,EBI-11992140
KRTAP19-3 [Q7Z4W3]3EBI-948603,EBI-12020132
KRTAP19-5 [Q3LI72]3EBI-948603,EBI-1048945
KRTAP19-7 [Q3SYF9]3EBI-948603,EBI-10241353
KRTAP26-1 [Q6PEX3]3EBI-948603,EBI-3957672
KRTAP3-3 [Q9BYR6]3EBI-948603,EBI-3957694
KRTAP6-1 [Q3LI64]3EBI-948603,EBI-12111050
KRTAP6-2 [Q3LI66]3EBI-948603,EBI-11962084
KRTAP7-1 [Q8IUC3]3EBI-948603,EBI-18394498
KRTAP8-1 [Q8IUC2]3EBI-948603,EBI-10261141
LASP1 - isoform 2 [Q14847-2]3EBI-948603,EBI-9088686
LENG8 [Q96PV6]3EBI-948603,EBI-739546
LIMS4 [P0CW20]3EBI-948603,EBI-10196832
LITAF [Q99732]3EBI-948603,EBI-725647
LMO2 - isoform 3 [P25791-3]3EBI-948603,EBI-11959475
MAB21L2 [Q9Y586]3EBI-948603,EBI-6659161
MAGED1 [Q9Y5V3]3EBI-948603,EBI-716006
MDFI [Q99750]5EBI-948603,EBI-724076
MIEN1 [Q9BRT3]3EBI-948603,EBI-6137472
MKRN3 [Q13064]3EBI-948603,EBI-2340269
MORN3 [Q6PF18]3EBI-948603,EBI-9675802
MYLIP [Q8WY64]3EBI-948603,EBI-6952711
NUDT22 [Q9BRQ3]3EBI-948603,EBI-10297093
ODAM [A1E959]3EBI-948603,EBI-5774125
OLIG3 [Q7RTU3]4EBI-948603,EBI-10225049
OTX1 [P32242]3EBI-948603,EBI-740446
PHF1 [O43189]3EBI-948603,EBI-530034
PIBF1 [Q4G0R1]3EBI-948603,EBI-14066006
PIN1 [Q13526]3EBI-948603,EBI-714158
PITX1 [P78337]3EBI-948603,EBI-748265
PLA2G10 [O15496]3EBI-948603,EBI-726466
PLAGL2 [Q9UPG8]3EBI-948603,EBI-2876622
PLEKHN1 - isoform 3 [Q494U1-3]3EBI-948603,EBI-12014286
PNMA1 [Q8ND90]5EBI-948603,EBI-302345
POU1F1 [P28069]3EBI-948603,EBI-8673859
PRDM6 [Q9NQX0]3EBI-948603,EBI-11320284
PRKAB2 [O43741]3EBI-948603,EBI-1053424
PRR20D [P86480]3EBI-948603,EBI-12754095
QRICH1 [Q2TAL8]3EBI-948603,EBI-2798044
RBFOX1 - isoform 5 [Q9NWB1-5]3EBI-948603,EBI-12123390
RBPMS - isoform C [Q93062-3]3EBI-948603,EBI-740343
RBPMS2 [Q6ZRY4]3EBI-948603,EBI-11987469
RFC5 [P40937]3EBI-948603,EBI-712376
RNF44 [Q7L0R7]3EBI-948603,EBI-2845060
ROR2 [Q01974]3EBI-948603,EBI-6422642
SEC24A - isoform 2 [O95486-2]3EBI-948603,EBI-12320085
SMYD1 [Q8NB12]3EBI-948603,EBI-8463848
SOHLH1 [Q5JUK2]3EBI-948603,EBI-12288855
TEKT3 [Q9BXF9]3EBI-948603,EBI-8644516
TEKT4 [Q8WW24]3EBI-948603,EBI-750487
TENT5D [Q8NEK8]3EBI-948603,EBI-744726
TGM7 [Q96PF1]3EBI-948603,EBI-12029034
TNS2 [Q63HR2]3EBI-948603,EBI-949753
TRAF1 [Q13077]3EBI-948603,EBI-359224
TRIM27 [P14373]3EBI-948603,EBI-719493
TRIM74 - isoform 2 [Q86UV6-2]3EBI-948603,EBI-10259086
TSC1 [Q86WV8]3EBI-948603,EBI-12806590
TSEN15 [Q8WW01]3EBI-948603,EBI-372432
TSSK3 [Q96PN8]3EBI-948603,EBI-3918381
UBTD2 [Q8WUN7]3EBI-948603,EBI-12867288
USP20 [A0A024R8A9]3EBI-948603,EBI-14096082
VAC14 [Q08AM6]3EBI-948603,EBI-2107455
VENTX [O95231]5EBI-948603,EBI-10191303
ZC3H10 [Q96K80]3EBI-948603,EBI-742550
ZIC1 [Q15915]3EBI-948603,EBI-11963196
ZNF503 [Q96F45]3EBI-948603,EBI-8832437
ZNF765 - isoform 2 [Q7L2R6-2]3EBI-948603,EBI-12834294

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
116074, 20 interactors

Protein interaction database and analysis system

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IntActi
Q03989, 121 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000350078

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q03989, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q03989

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini55 – 147ARIDPROSITE-ProRule annotationAdd BLAST93

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 300Interaction with SOX9By similarityAdd BLAST300

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2744, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000161253

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q03989

Identification of Orthologs from Complete Genome Data

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OMAi
HPRDFFP

Database of Orthologous Groups

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OrthoDBi
368297at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q03989

TreeFam database of animal gene trees

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TreeFami
TF324725

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.150.60, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001606, ARID_dom
IPR036431, ARID_dom_sf

Pfam protein domain database

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Pfami
View protein in Pfam
PF01388, ARID, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00501, BRIGHT, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF46774, SSF46774, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51011, ARID, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q03989-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAPVKGNRK QSTEGDALDP PASPKPAGKQ NGIQNPISLE DSPEAGGERE
60 70 80 90 100
EEQEREEEQA FLVSLYKFMK ERHTPIERVP HLGFKQINLW KIYKAVEKLG
110 120 130 140 150
AYELVTGRRL WKNVYDELGG SPGSTSAATC TRRHYERLVL PYVRHLKGED
160 170 180 190 200
DKPLPTSKPR KQYKMAKENR GDDGATERPK KAKEERRMDQ MMPGKTKADA
210 220 230 240 250
ADPAPLPSQE PPRNSTEQQG LASGSSVSFV GASGCPEAYK RLLSSFYCKG
260 270 280 290 300
THGIMSPLAK KKLLAQVSKV EALQCQEEGC RHGAEPQASP AVHLPESPQS
310 320 330 340 350
PKGLTENSRH RLTPQEGLQA PGGSLREEAQ AGPCPAAPIF KGCFYTHPTE
360 370 380 390 400
VLKPVSQHPR DFFSRLKDGV LLGPPGKEGL SVKEPQLVWG GDANRPSAFH
410 420 430 440 450
KGGSRKGILY PKPKACWVSP MAKVPAESPT LPPTFPSSPG LGSKRSLEEE
460 470 480 490 500
GAAHSGKRLR AVSPFLKEAD AKKCGAKPAG SGLVSCLLGP ALGPVPPEAY
510 520 530 540 550
RGTMLHCPLN FTGTPGPLKG QAALPFSPLV IPAFPAHFLA TAGPSPMAAG
560 570 580 590
LMHFPPTSFD SALRHRLCPA SSAWHAPPVT TYAAPHFFHL NTKL
Length:594
Mass (Da):64,074
Last modified:May 29, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i89A494C4560416FF
GO
Isoform 2 (identifier: Q03989-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.

Show »
Length:526
Mass (Da):56,694
Checksum:i2CB14C05D57D1A35
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6Q9D3F6Q9D3_HUMAN
AT-rich interactive domain-containi...
ARID5A
58Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A669KBH0A0A669KBH0_HUMAN
AT-rich interactive domain-containi...
ARID5A
327Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA36325 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti392D → G in BC047390 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0589691 – 68Missing in isoform 2. Add BLAST68

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M62324 mRNA Translation: AAA36325.1 Different initiation.
AC013270 Genomic DNA No translation available.
CH471207 Genomic DNA Translation: EAW71359.1
BC047390 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33251.1 [Q03989-1]
CCDS82484.1 [Q03989-5]

Protein sequence database of the Protein Information Resource

More...
PIRi
S27962

NCBI Reference Sequences

More...
RefSeqi
NP_001306021.1, NM_001319092.1 [Q03989-5]
NP_997646.1, NM_212481.2 [Q03989-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000357485; ENSP00000350078; ENSG00000196843 [Q03989-1]
ENST00000454558; ENSP00000400785; ENSG00000196843 [Q03989-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10865

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10865

UCSC genome browser

More...
UCSCi
uc002swe.4, human [Q03989-1]
uc031ron.2, human

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62324 mRNA Translation: AAA36325.1 Different initiation.
AC013270 Genomic DNA No translation available.
CH471207 Genomic DNA Translation: EAW71359.1
BC047390 mRNA No translation available.
CCDSiCCDS33251.1 [Q03989-1]
CCDS82484.1 [Q03989-5]
PIRiS27962
RefSeqiNP_001306021.1, NM_001319092.1 [Q03989-5]
NP_997646.1, NM_212481.2 [Q03989-1]

3D structure databases

SMRiQ03989
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116074, 20 interactors
IntActiQ03989, 121 interactors
STRINGi9606.ENSP00000350078

PTM databases

iPTMnetiQ03989
PhosphoSitePlusiQ03989

Polymorphism and mutation databases

BioMutaiARID5A
DMDMi148840818

Proteomic databases

jPOSTiQ03989
MassIVEiQ03989
MaxQBiQ03989
PaxDbiQ03989
PeptideAtlasiQ03989
PRIDEiQ03989
ProteomicsDBi58234
8111

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1050, 215 antibodies

The DNASU plasmid repository

More...
DNASUi
10865

Genome annotation databases

EnsembliENST00000357485; ENSP00000350078; ENSG00000196843 [Q03989-1]
ENST00000454558; ENSP00000400785; ENSG00000196843 [Q03989-5]
GeneIDi10865
KEGGihsa:10865
UCSCiuc002swe.4, human [Q03989-1]
uc031ron.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10865
DisGeNETi10865
EuPathDBiHostDB:ENSG00000196843.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ARID5A
HGNCiHGNC:17361, ARID5A
HPAiENSG00000196843, Low tissue specificity
MIMi611583, gene
neXtProtiNX_Q03989
OpenTargetsiENSG00000196843
PharmGKBiPA134937822

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2744, Eukaryota
GeneTreeiENSGT00940000161253
InParanoidiQ03989
OMAiHPRDFFP
OrthoDBi368297at2759
PhylomeDBiQ03989
TreeFamiTF324725

Enzyme and pathway databases

PathwayCommonsiQ03989

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
10865, 22 hits in 895 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ARID5A, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10865
PharosiQ03989, Tbio

Protein Ontology

More...
PROi
PR:Q03989
RNActiQ03989, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000196843, Expressed in tibial artery and 226 other tissues
ExpressionAtlasiQ03989, baseline and differential
GenevisibleiQ03989, HS

Family and domain databases

Gene3Di1.10.150.60, 1 hit
InterProiView protein in InterPro
IPR001606, ARID_dom
IPR036431, ARID_dom_sf
PfamiView protein in Pfam
PF01388, ARID, 1 hit
SMARTiView protein in SMART
SM00501, BRIGHT, 1 hit
SUPFAMiSSF46774, SSF46774, 1 hit
PROSITEiView protein in PROSITE
PS51011, ARID, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARI5A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q03989
Secondary accession number(s): C9J1Q0, Q6NX37
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: August 12, 2020
This is version 149 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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