UniProtKB - Q03989 (ARI5A_HUMAN)

BLAST

>sp|Q03989|ARI5A_HUMAN AT-rich interactive domain-containing protein 5A OS=Homo sapiens OX=9606 GN=ARID5A PE=1 SV=2
MAAPVKGNRKQSTEGDALDPPASPKPAGKQNGIQNPISLEDSPEAGGEREEEQEREEEQA
FLVSLYKFMKERHTPIERVPHLGFKQINLWKIYKAVEKLGAYELVTGRRLWKNVYDELGG
SPGSTSAATCTRRHYERLVLPYVRHLKGEDDKPLPTSKPRKQYKMAKENRGDDGATERPK
KAKEERRMDQMMPGKTKADAADPAPLPSQEPPRNSTEQQGLASGSSVSFVGASGCPEAYK
RLLSSFYCKGTHGIMSPLAKKKLLAQVSKVEALQCQEEGCRHGAEPQASPAVHLPESPQS
PKGLTENSRHRLTPQEGLQAPGGSLREEAQAGPCPAAPIFKGCFYTHPTEVLKPVSQHPR
DFFSRLKDGVLLGPPGKEGLSVKEPQLVWGGDANRPSAFHKGGSRKGILYPKPKACWVSP
MAKVPAESPTLPPTFPSSPGLGSKRSLEEEGAAHSGKRLRAVSPFLKEADAKKCGAKPAG
SGLVSCLLGPALGPVPPEAYRGTMLHCPLNFTGTPGPLKGQAALPFSPLVIPAFPAHFLA
TAGPSPMAAGLMHFPPTSFDSALRHRLCPASSAWHAPPVTTYAAPHFFHLNTKL

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History
Entry version 136 (12 Sep 2018)
Sequence version 2 (29 May 2007)
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Protein

AT-rich interactive domain-containing protein 5A

Gene

ARID5A

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Binds to AT-rich stretches in the modulator region upstream of the human cytomegalovirus major intermediate early gene enhancer. May act as repressor and down-regulate enhancer-dependent gene expressison (PubMed:8649988). May positively regulate chondrocyte-specific transcription such as of COL2A1 in collaboration with SOX9 and positively regulate histone H3 acetylation at chondrocyte-specific genes. May stimulate early-stage chondrocyte differentiation and inhibit later stage differention (By similarity). Can repress ESR1-mediated transcriptional activation; proposed to act as corepressor for selective nuclear hormone receptors (PubMed:15941852). As RNA-binding protein involved in the regulation of inflammatory response by stabilizing selective inflammation-related mRNAs, such as IL6, STAT3 and TBX21. Binds to stem loop structures located in the 3'UTRs of IL6, STAT3 and TBX21 mRNAs; at least for STAT3 prevents binding of ZC3H12A to the mRNA stem loop structure thus inhibiting its degradation activity. Contributes to elevated IL6 levels possibly implicated in autoimmunity processes. IL6-dependent stabilization of STAT3 mRNA may promote differentiation of naive CD4+ T-cells into T-helper Th17 cells. In CD4+ T-cells may also inhibit RORC-induced Th17 cell differentiation independently of IL6 signaling. Stabilization of TBX21 mRNA contributes to elevated interferon-gamma secretion in Th1 cells possibly implicated in the establishment of septic shock (By similarity).By similarity2 Publications

GO - Molecular functionⁱ

androgen receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15941852
DNA binding
Source: GDB
Traceable author statementⁱ
- 15640446
estrogen receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15941852
retinoid X receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15941852
RNA binding Source: UniProtKB-KW
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 15640446
thyroid hormone receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15941852
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB
transcription corepressor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 15941852
transcription factor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15941852
transcription regulatory region DNA binding Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to estrogen stimulus
Source: UniProtKB
Inferred from direct assayⁱ
- 15941852
innate immune response Source: UniProtKB-KW
negative regulation of transcription, DNA-templated
Source: GDB
Traceable author statementⁱ
- 15640446
negative regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 15941852
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Repressor, RNA-binding
Biological process	Immunity, Innate immunity, Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: AT-rich interactive domain-containing protein 5A Short name: ARID domain-containing protein 5A Alternative name(s): Modulator recognition factor 1 Short name: MRF-1
Gene namesⁱ	Name:ARID5A Synonyms:MRF1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000196843.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17361 ARID5A
MIMⁱ	611583 gene
neXtProtⁱ	NX_Q03989

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000196843
PharmGKBⁱ	PA134937822

Polymorphism and mutation databases

BioMutaⁱ	ARID5A
DMDMⁱ	148840818

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000288930	1 – 594	AT-rich interactive domain-containing protein 5AAdd BLAST		594

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	23	PhosphoserineBy similarity	1
Cross-linkⁱ	85	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linkⁱ	94	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residueⁱ	256	PhosphoserineBy similarity	1
Modified residueⁱ	289	PhosphoserineBy similarity	1
Modified residueⁱ	438	PhosphoserineBy similarity	1
Modified residueⁱ	463	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Phosphorylated by MAPK14 on serine residues involving a TLR4 signaling pathway upon lipopolysaccharide (LPS) stimulation leading to its ubiquitination and proteasomal degradation.By similarity

Ubiquitinated leading to proteasomal degradation; involving WWP1 linked to MAPK14-mediated phosphorylation upon LPS stimulation.By similarity

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q03989
PaxDbⁱ	Q03989
PeptideAtlas More...PeptideAtlasⁱ	Q03989
PRIDEⁱ	Q03989
ProteomicsDBⁱ	58234

PTM databases

iPTMnetⁱ	Q03989
PhosphoSitePlusⁱ	Q03989

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000196843 Expressed in 217 organ(s), highest expression level in tibial artery
CleanExⁱ	HS_ARID5A
ExpressionAtlasⁱ	Q03989 baseline and differential
Genevisibleⁱ	Q03989 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA002860 HPA023879

HPAⁱ

HPA002860
HPA023879

Interactionⁱ

Subunit structureⁱ

Interacts with SOX9 (By similarity). Interacts with ESR1 (PubMed:15941852). Interacts with RORC (By similarity).By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
ATXN1	P54253	3	EBI-948603,EBI-930964
CKS1B	P61024	4	EBI-948603,EBI-456371
DAZAP2	Q15038	6	EBI-948603,EBI-724310
ESR1	P03372	9	EBI-948603,EBI-78473
FAM168B	A1KXE4-2	4	EBI-948603,EBI-12193763
KRTAP12-2	P59991	4	EBI-948603,EBI-10176379
KRTAP19-5	Q3LI72	4	EBI-948603,EBI-1048945
LASP1	Q14847-2	4	EBI-948603,EBI-9088686
LOC151121	Q499Y1	4	EBI-948603,EBI-12011530
MDFI	Q99750	4	EBI-948603,EBI-724076
PNMA1	Q8ND90	4	EBI-948603,EBI-302345
RHOXF2	Q9BQY4	6	EBI-948603,EBI-372094

GO - Molecular functionⁱ

androgen receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15941852
estrogen receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15941852
retinoid X receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15941852
thyroid hormone receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15941852
transcription factor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15941852

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	116074, 20 interactors
IntActⁱ	Q03989, 123 interactors
STRINGⁱ	9606.ENSP00000350078

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q03989
SMRⁱ	Q03989
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	55 – 147	ARIDPROSITE-ProRule annotationAdd BLAST		93

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 300	Interaction with SOX9By similarityAdd BLAST		300

Phylogenomic databases

eggNOGⁱ	KOG2744 Eukaryota ENOG410Y2AP LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140901
HOGENOMⁱ	HOG000034050
HOVERGENⁱ	HBG062210
InParanoidⁱ	Q03989
OMAⁱ	HFFHLNT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0E6N
PhylomeDBⁱ	Q03989
TreeFamⁱ	TF324725

Family and domain databases

Gene3Dⁱ	1.10.150.60, 1 hit
InterProⁱ	View protein in InterPro IPR001606 ARID_dom IPR036431 ARID_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01388 ARID, 1 hit
SMARTⁱ	View protein in SMART SM00501 BRIGHT, 1 hit
SUPFAMⁱ	SSF46774 SSF46774, 1 hit
PROSITEⁱ	View protein in PROSITE PS51011 ARID, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q03989-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPVKGNRK QSTEGDALDP PASPKPAGKQ NGIQNPISLE DSPEAGGERE 
        60         70         80         90        100
EEQEREEEQA FLVSLYKFMK ERHTPIERVP HLGFKQINLW KIYKAVEKLG 
       110        120        130        140        150
AYELVTGRRL WKNVYDELGG SPGSTSAATC TRRHYERLVL PYVRHLKGED 
       160        170        180        190        200
DKPLPTSKPR KQYKMAKENR GDDGATERPK KAKEERRMDQ MMPGKTKADA 
       210        220        230        240        250
ADPAPLPSQE PPRNSTEQQG LASGSSVSFV GASGCPEAYK RLLSSFYCKG 
       260        270        280        290        300
THGIMSPLAK KKLLAQVSKV EALQCQEEGC RHGAEPQASP AVHLPESPQS 
       310        320        330        340        350
PKGLTENSRH RLTPQEGLQA PGGSLREEAQ AGPCPAAPIF KGCFYTHPTE 
       360        370        380        390        400
VLKPVSQHPR DFFSRLKDGV LLGPPGKEGL SVKEPQLVWG GDANRPSAFH 
       410        420        430        440        450
KGGSRKGILY PKPKACWVSP MAKVPAESPT LPPTFPSSPG LGSKRSLEEE 
       460        470        480        490        500
GAAHSGKRLR AVSPFLKEAD AKKCGAKPAG SGLVSCLLGP ALGPVPPEAY 
       510        520        530        540        550
RGTMLHCPLN FTGTPGPLKG QAALPFSPLV IPAFPAHFLA TAGPSPMAAG 
       560        570        580        590 
LMHFPPTSFD SALRHRLCPA SSAWHAPPVT TYAAPHFFHL NTKL

Length:594

Mass (Da):64,074

Last modified:May 29, 2007 - v2

Checksum:ⁱ89A494C4560416FF

Isoform 2 (identifier: Q03989-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-68: Missing.

« Hide

        10         20         30         40         50
MKERHTPIER VPHLGFKQIN LWKIYKAVEK LGAYELVTGR RLWKNVYDEL 
        60         70         80         90        100
GGSPGSTSAA TCTRRHYERL VLPYVRHLKG EDDKPLPTSK PRKQYKMAKE 
       110        120        130        140        150
NRGDDGATER PKKAKEERRM DQMMPGKTKA DAADPAPLPS QEPPRNSTEQ 
       160        170        180        190        200
QGLASGSSVS FVGASGCPEA YKRLLSSFYC KGTHGIMSPL AKKKLLAQVS 
       210        220        230        240        250
KVEALQCQEE GCRHGAEPQA SPAVHLPESP QSPKGLTENS RHRLTPQEGL 
       260        270        280        290        300
QAPGGSLREE AQAGPCPAAP IFKGCFYTHP TEVLKPVSQH PRDFFSRLKD 
       310        320        330        340        350
GVLLGPPGKE GLSVKEPQLV WGGDANRPSA FHKGGSRKGI LYPKPKACWV 
       360        370        380        390        400
SPMAKVPAES PTLPPTFPSS PGLGSKRSLE EEGAAHSGKR LRAVSPFLKE 
       410        420        430        440        450
ADAKKCGAKP AGSGLVSCLL GPALGPVPPE AYRGTMLHCP LNFTGTPGPL 
       460        470        480        490        500
KGQAALPFSP LVIPAFPAHF LATAGPSPMA AGLMHFPPTS FDSALRHRLC 
       510        520 
PASSAWHAPP VTTYAAPHFF HLNTKL

Show »

Length:526

Mass (Da):56,694

Checksum:ⁱ2CB14C05D57D1A35

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	F6Q9D3	F6Q9D3_HUMAN		AT-rich interactive domain-containi... AT-rich interactive domain-containing protein 5A	ARID5A	58	Annotation score:

Sequence cautionⁱ

The sequence AAA36325 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	392	D → G in BC047390 (PubMed:15489334).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_058969	1 – 68	Missing in isoform 2. Add BLAST		68

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M62324 mRNA Translation: AAA36325.1 Different initiation. AC013270 Genomic DNA No translation available. CH471207 Genomic DNA Translation: EAW71359.1 BC047390 mRNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS33251.1 [Q03989-1] CCDS82484.1 [Q03989-5]
PIRⁱ	S27962
NCBI Reference Sequences More...RefSeqⁱ	NP_001306021.1, NM_001319092.1 [Q03989-5] NP_997646.1, NM_212481.2 [Q03989-1]
UniGeneⁱ	Hs.920

Genome annotation databases

Ensemblⁱ	ENST00000357485; ENSP00000350078; ENSG00000196843 [Q03989-1] ENST00000454558; ENSP00000400785; ENSG00000196843 [Q03989-5]
GeneIDⁱ	10865
KEGGⁱ	hsa:10865
UCSC genome browser More...UCSCⁱ	uc002swe.4 human [Q03989-1] uc031ron.2 human

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q03989	Uncharacterized protein		RHIRO		594	UniRef90_Q03989
AT-rich interaction domain 5A		SAIBB		594
ARID5A isoform 2		PONAB		594
AT-rich interaction domain 5A		GORGO		594
AT-rich interactive domain-containing protein 5A		CALJA		594
+62

Protein	Similar proteins		Species	Score	Length	Source
Q03989	AT-rich interactive domain-containing protein 5A		MOUSE		590	UniRef50_Q3U108
AT-rich interactive domain-containing protein 5A		BOVIN		592
AT-rich interactive domain-containing protein 5A-like		LEPWE		666
AT-rich interactive domain-containing protein 5A isoform X1		DIPOR		585
AT-rich interactive domain-containing protein 5A		PTEAL		619
+277

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M62324 mRNA Translation: AAA36325.1 Different initiation. AC013270 Genomic DNA No translation available. CH471207 Genomic DNA Translation: EAW71359.1 BC047390 mRNA No translation available.
CCDSⁱ	CCDS33251.1 [Q03989-1] CCDS82484.1 [Q03989-5]
PIRⁱ	S27962
RefSeqⁱ	NP_001306021.1, NM_001319092.1 [Q03989-5] NP_997646.1, NM_212481.2 [Q03989-1]
UniGeneⁱ	Hs.920

3D structure databases

ProteinModelPortalⁱ	Q03989
SMRⁱ	Q03989
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116074, 20 interactors
IntActⁱ	Q03989, 123 interactors
STRINGⁱ	9606.ENSP00000350078

PTM databases

iPTMnetⁱ	Q03989
PhosphoSitePlusⁱ	Q03989

Polymorphism and mutation databases

BioMutaⁱ	ARID5A
DMDMⁱ	148840818

Proteomic databases

MaxQBⁱ	Q03989
PaxDbⁱ	Q03989
PeptideAtlasⁱ	Q03989
PRIDEⁱ	Q03989
ProteomicsDBⁱ	58234

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10865
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000357485; ENSP00000350078; ENSG00000196843 [Q03989-1] ENST00000454558; ENSP00000400785; ENSG00000196843 [Q03989-5]
GeneIDⁱ	10865
KEGGⁱ	hsa:10865
UCSCⁱ	uc002swe.4 human [Q03989-1] uc031ron.2 human

Organism-specific databases

CTDⁱ	10865
EuPathDBⁱ	HostDB:ENSG00000196843.15
GeneCardsⁱ	ARID5A
HGNCⁱ	HGNC:17361 ARID5A
HPAⁱ	HPA002860 HPA023879
MIMⁱ	611583 gene
neXtProtⁱ	NX_Q03989
OpenTargetsⁱ	ENSG00000196843
PharmGKBⁱ	PA134937822
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2744 Eukaryota ENOG410Y2AP LUCA
GeneTreeⁱ	ENSGT00900000140901
HOGENOMⁱ	HOG000034050
HOVERGENⁱ	HBG062210
InParanoidⁱ	Q03989
OMAⁱ	HFFHLNT
OrthoDBⁱ	EOG091G0E6N
PhylomeDBⁱ	Q03989
TreeFamⁱ	TF324725

Miscellaneous databases

ChiTaRSⁱ	ARID5A human
GenomeRNAiⁱ	10865
Protein Ontology More...PROⁱ	PR:Q03989
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000196843 Expressed in 217 organ(s), highest expression level in tibial artery
CleanExⁱ	HS_ARID5A
ExpressionAtlasⁱ	Q03989 baseline and differential
Genevisibleⁱ	Q03989 HS

Family and domain databases

Gene3Dⁱ	1.10.150.60, 1 hit
InterProⁱ	View protein in InterPro IPR001606 ARID_dom IPR036431 ARID_dom_sf
Pfamⁱ	View protein in Pfam PF01388 ARID, 1 hit
SMARTⁱ	View protein in SMART SM00501 BRIGHT, 1 hit
SUPFAMⁱ	SSF46774 SSF46774, 1 hit
PROSITEⁱ	View protein in PROSITE PS51011 ARID, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ARI5A_HUMAN
Accessionⁱ	Q03989Primary (citable) accession number: Q03989 Secondary accession number(s): C9J1Q0, Q6NX37
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
	Last sequence update:	May 29, 2007
	Last modified:	September 12, 2018
	This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

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Annotation systems

Supporting data

UniProtKB - Q03989 (ARI5A_HUMAN)

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AT-rich interactive domain-containing protein 5A

ARID5A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ