HSF2

Functionⁱ

DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	7 – 112	By similarityAdd BLAST		106

GO - Molecular functionⁱ

DNA-binding transcription activator activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from direct assayⁱ
- "Transcriptional activation of mouse cytosolic chaperonin CCT subunit genes by heat shock factors HSF1 and HSF2."
  Kubota H., Matsumoto S., Yokota S., Yanagi H., Yura T.
  FEBS Lett 461:125-129(1999) [PubMed] [Europe PMC] [Abstract]
DNA-binding transcription factor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
identical protein binding Source: Ensembl
RNA polymerase II cis-regulatory region sequence-specific DNA binding
Source: ARUK-UCL
Inferred from direct assayⁱ
- "HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator."
  Nakai A., Tanabe M., Kawazoe Y., Inazawa J., Morimoto R.I., Nagata K.
  Mol. Cell. Biol. 17:469-481(1997) [PubMed] [Europe PMC] [Abstract]
RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
Source: MGI
Inferred from direct assayⁱ
- "Transcriptional activation of mouse cytosolic chaperonin CCT subunit genes by heat shock factors HSF1 and HSF2."
  Kubota H., Matsumoto S., Yokota S., Yanagi H., Yura T.
  FEBS Lett 461:125-129(1999) [PubMed] [Europe PMC] [Abstract]
RNA polymerase II transcription regulatory region sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- "Transcriptional activation of mouse cytosolic chaperonin CCT subunit genes by heat shock factors HSF1 and HSF2."
  Kubota H., Matsumoto S., Yokota S., Yanagi H., Yura T.
  FEBS Lett 461:125-129(1999) [PubMed] [Europe PMC] [Abstract]
sequence-specific double-stranded DNA binding
Source: ARUK-UCL
Inferred from direct assayⁱ
- "Impact of cytosine methylation on DNA binding specificities of human transcription factors."
  Yin Y., Morgunova E., Jolma A., Kaasinen E., Sahu B., Khund-Sayeed S., Das P.K., Kivioja T., Dave K., Zhong F., Nitta K.R., Taipale M., Popov A., Ginno P.A., Domcke S., Yan J., Schubeler D., Vinson C., Taipale J.
  Science 356:0-0(2017) [PubMed] [Europe PMC] [Abstract]

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Stress response, Transcription, Transcription regulation

Enzyme and pathway databases

PathwayCommonsⁱ	Q03933
SignaLinkⁱ	Q03933
SIGNORⁱ	Q03933

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Heat shock factor protein 2 Short name: HSF 2 Alternative name(s): Heat shock transcription factor 2 Short name: HSTF 2
Gene namesⁱ	Name:HSF2 Synonyms:HSTF2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5225, HSF2
MIMⁱ	140581, gene
neXtProtⁱ	NX_Q03933
VEuPathDBⁱ	HostDB:ENSG00000025156.12

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	109	R → G: Fails to translocate to nucleus. 1 Publication		1
Mutagenesisⁱ	196 – 198	RKR → ASS: Fails to translocate to nucleus. 1 Publication		3

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3298
Open Targets More...OpenTargetsⁱ	ENSG00000025156
PharmGKBⁱ	PA29494

Miscellaneous databases

Pharosⁱ	Q03933, Tbio

Pharosⁱ

Q03933, Tbio

Chemistry databases

ChEMBLⁱ	CHEMBL3988631

ChEMBLⁱ

CHEMBL3988631

Genetic variation databases

BioMutaⁱ	HSF2
DMDMⁱ	462334

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000124569	1 – 536	Heat shock factor protein 2Add BLAST		536

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Cross-linkⁱ	2	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	82	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	135	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	139	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	151	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	210	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	218	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	237	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMⁱ

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDⁱ	Q03933
jPOSTⁱ	Q03933
MassIVEⁱ	Q03933
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q03933
PaxDbⁱ	Q03933
PeptideAtlas More...PeptideAtlasⁱ	Q03933
PRIDEⁱ	Q03933
ProteomicsDBⁱ	58228 [Q03933-1] 58229 [Q03933-2]

PTM databases

iPTMnetⁱ	Q03933
PhosphoSitePlusⁱ	Q03933

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000025156, Expressed in female gonad and 236 other tissues
ExpressionAtlasⁱ	Q03933, baseline and differential
Genevisibleⁱ	Q03933, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000025156, Low tissue specificity

HPAⁱ

ENSG00000025156, Low tissue specificity

Interactionⁱ

Subunit structureⁱ

DNA-binding homotrimer in stressed or heat shocked cells, otherwise found as a homodimer.

Binary interactionsⁱ

Hide details

Q03933

With	#Exp.	IntAct
CEP76 [Q8TAP6]	3	EBI-2556750,EBI-742887
DERA [Q9Y315]	3	EBI-2556750,EBI-1048152
HSF1 [Q00613]	8	EBI-2556750,EBI-719620
HSF2BP [O75031]	3	EBI-2556750,EBI-7116203
MTUS2 - isoform 2 [Q5JR59-3]	3	EBI-2556750,EBI-11522433
NUP62 [P37198]	5	EBI-2556750,EBI-347978
PICK1 [Q9NRD5]	6	EBI-2556750,EBI-79165
TPM3 [P06753]	10	EBI-2556750,EBI-355607
TPM3 [Q5VU62]	3	EBI-2556750,EBI-10184033
WDR5 [P61964]	7	EBI-2556750,EBI-540834

Isoform 2 [Q03933-2]

With	#Exp.	IntAct
KAT5 [Q92993]	3	EBI-10223348,EBI-399080
LMO3 - isoform 4 [Q8TAP4-4]	3	EBI-10223348,EBI-11742507
MTUS2 [Q5JR59]	3	EBI-10223348,EBI-742948
NUP62 [P37198]	3	EBI-10223348,EBI-347978
SETDB1 - isoform 2 [Q15047-2]	3	EBI-10223348,EBI-9090795
YWHAG [P61981]	3	EBI-10223348,EBI-359832

GO - Molecular functionⁱ

identical protein binding Source: Ensembl

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	109531, 48 interactors
CORUMⁱ	Q03933
Database of interacting proteins More...DIPⁱ	DIP-56593N
IntActⁱ	Q03933, 80 interactors
STRINGⁱ	9606.ENSP00000357440

Miscellaneous databases

RNActⁱ	Q03933, protein

RNActⁱ

Q03933, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	9 – 19	Combined sources	11
Helixⁱ	21 – 23	Combined sources	3
Turnⁱ	24 – 26	Combined sources	3
Beta strandⁱ	27 – 30	Combined sources	4
Turnⁱ	31 – 34	Combined sources	4
Beta strandⁱ	35 – 39	Combined sources	5
Helixⁱ	41 – 47	Combined sources	7
Helixⁱ	49 – 53	Combined sources	5
Helixⁱ	58 – 67	Combined sources	10
Beta strandⁱ	71 – 73	Combined sources	3
Beta strandⁱ	78 – 80	Combined sources	3
Beta strandⁱ	83 – 85	Combined sources	3
Beta strandⁱ	89 – 92	Combined sources	4
Helixⁱ	101 – 106	Combined sources	6

Show more details

3D structure databases

SMRⁱ	Q03933
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	119 – 192	Hydrophobic repeat HR-A/BAdd BLAST		74
Regionⁱ	360 – 385	Hydrophobic repeat HR-CAdd BLAST		26

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	108 – 122	Nuclear localization signalSequence analysisAdd BLAST		15
Motifⁱ	195 – 210	Nuclear localization signalSequence analysisAdd BLAST		16

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	170 – 173	Poly-Gln		4

Sequence similaritiesⁱ

Belongs to the HSF family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0627, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000155906
HOGENOMⁱ	CLU_038829_1_0_1
InParanoidⁱ	Q03933
OMAⁱ	QMNPTDH
Database of Orthologous Groups More...OrthoDBⁱ	1154048at2759
PhylomeDBⁱ	Q03933
TreeFamⁱ	TF330401

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR027712, HSF2 IPR000232, HSF_DNA-bd IPR027725, HSF_fam IPR010542, Vert_HSTF_C IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf
PANTHERⁱ	PTHR10015, PTHR10015, 1 hit PTHR10015:SF185, PTHR10015:SF185, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00447, HSF_DNA-bind, 1 hit PF06546, Vert_HS_TF, 1 hit
PRINTSⁱ	PR00056, HSFDOMAIN
SMARTⁱ	View protein in SMART SM00415, HSF, 1 hit
SUPFAMⁱ	SSF46785, SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS00434, HSF_DOMAIN, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q03933-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKQSSNVPAF LSKLWTLVEE THTNEFITWS QNGQSFLVLD EQRFAKEILP 
        60         70         80         90        100
KYFKHNNMAS FVRQLNMYGF RKVVHIDSGI VKQERDGPVE FQHPYFKQGQ 
       110        120        130        140        150
DDLLENIKRK VSSSKPEENK IRQEDLTKII SSAQKVQIKQ ETIESRLSEL 
       160        170        180        190        200
KSENESLWKE VSELRAKHAQ QQQVIRKIVQ FIVTLVQNNQ LVSLKRKRPL 
       210        220        230        240        250
LLNTNGAQKK NLFQHIVKEP TDNHHHKVPH SRTEGLKPRE RISDDIIIYD 
       260        270        280        290        300
VTDDNADEEN IPVIPETNED VISDPSNCSQ YPDIVIVEDD NEDEYAPVIQ 
       310        320        330        340        350
SGEQNEPARE SLSSGSDGSS PLMSSAVQLN GSSSLTSEDP VTMMDSILND 
       360        370        380        390        400
NINLLGKVEL LDYLDSIDCS LEDFQAMLSG RQFSIDPDLL VDLFTSSVQM 
       410        420        430        440        450
NPTDYINNTK SENKGLETTK NNVVQPVSEE GRKSKSKPDK QLIQYTAFPL 
       460        470        480        490        500
LAFLDGNPAS SVEQASTTAS SEVLSSVDKP IEVDELLDSS LDPEPTQSKL 
       510        520        530 
VRLEPLTEAE ASEATLFYLC ELAPAPLDSD MPLLDS

Length:536

Mass (Da):60,348

Last modified:February 1, 1994 - v1

Checksum:ⁱ00DFD05CFD9DF0D3

GO

Isoform 2 (identifier: Q03933-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
393-410: Missing.

« Hide

        10         20         30         40         50
MKQSSNVPAF LSKLWTLVEE THTNEFITWS QNGQSFLVLD EQRFAKEILP 
        60         70         80         90        100
KYFKHNNMAS FVRQLNMYGF RKVVHIDSGI VKQERDGPVE FQHPYFKQGQ 
       110        120        130        140        150
DDLLENIKRK VSSSKPEENK IRQEDLTKII SSAQKVQIKQ ETIESRLSEL 
       160        170        180        190        200
KSENESLWKE VSELRAKHAQ QQQVIRKIVQ FIVTLVQNNQ LVSLKRKRPL 
       210        220        230        240        250
LLNTNGAQKK NLFQHIVKEP TDNHHHKVPH SRTEGLKPRE RISDDIIIYD 
       260        270        280        290        300
VTDDNADEEN IPVIPETNED VISDPSNCSQ YPDIVIVEDD NEDEYAPVIQ 
       310        320        330        340        350
SGEQNEPARE SLSSGSDGSS PLMSSAVQLN GSSSLTSEDP VTMMDSILND 
       360        370        380        390        400
NINLLGKVEL LDYLDSIDCS LEDFQAMLSG RQFSIDPDLL VDSENKGLET 
       410        420        430        440        450
TKNNVVQPVS EEGRKSKSKP DKQLIQYTAF PLLAFLDGNP ASSVEQASTT 
       460        470        480        490        500
ASSEVLSSVD KPIEVDELLD SSLDPEPTQS KLVRLEPLTE AEASEATLFY 
       510 
LCELAPAPLD SDMPLLDS

Show »

Length:518

Mass (Da):58,293

Checksum:ⁱ6682B51448E116BC

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	V9GZ44	V9GZ44_HUMAN		Heat shock factor protein 2 Heat shock factor protein 2	HSF2	214	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_041128	393 – 410	Missing in isoform 2. 2 PublicationsAdd BLAST		18

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M65217 mRNA Translation: AAA36017.1 DQ492684 Genomic DNA Translation: ABF47087.1 AK294624 mRNA Translation: BAG57805.1 AK316377 mRNA Translation: BAH14748.1 AL121954 Genomic DNA No translation available. Z99129 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48176.1 BC112323 mRNA Translation: AAI12324.1 BC121050 mRNA Translation: AAI21051.1 BC121051 mRNA Translation: AAI21052.1 BC128420 mRNA Translation: AAI28421.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS47470.1 [Q03933-2] CCDS5124.1 [Q03933-1]
PIRⁱ	A41138
NCBI Reference Sequences More...RefSeqⁱ	NP_001129036.1, NM_001135564.1 [Q03933-2] NP_004497.1, NM_004506.3 [Q03933-1]

Genome annotation databases

Ensemblⁱ	ENST00000368455; ENSP00000357440; ENSG00000025156 [Q03933-1] ENST00000452194; ENSP00000400380; ENSG00000025156 [Q03933-2]
GeneIDⁱ	3298
KEGGⁱ	hsa:3298
UCSC genome browser More...UCSCⁱ	uc003pyu.3, human [Q03933-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q03933	Heat shock transcription factor 2		PANTR		536	UniRef100_Q03933
Heat shock transcription factor 2		GORGO		536
HSF2 isoform 2		PANTR		536
+1
Q03933-2	Heat shock transcription factor 2		PANTR		518	UniRef100_K7C5T3
Heat shock transcription factor 2		GORGO		518
Heat shock factor protein 2 (Fragment)		HUMAN		214
HSF2 isoform 1		PANTR		518
HSF2 isoform 3 (Fragment)		PANTR		214

Protein	Similar proteins		Species	Score	Length	Source
Q03933	Heat shock factor protein 2		MOUSE		535	UniRef90_Q03933
Heat shock transcription factor 2		PANTR		536
Heat shock transcription factor 2		GORGO		536
Heat shock transcription factor 2		MUSPF		651
heat shock factor protein 2 isoform X1		Enhydra lutris kenyoni		535
+144
Q03933-2	HSF_DOMAIN domain-containing protein		ICTTR		485	UniRef90_I3M9S4
Heat shock factor protein 2		MYOBR		598
heat shock factor protein 2 isoform X2		ACIJB		519
HSF2 isoform 1		PONAB		519
Heat shock transcription factor 2		URSAM		519
+104

Protein	Similar proteins		Species	Score	Length	Source
Q03933	Heat shock factor protein 2		MOUSE		535	UniRef50_Q03933
Heat shock transcription factor 2		PANTR		536
Heat shock transcription factor 2		GORGO		536
Heat shock transcription factor 2		MUSPF		651
heat shock factor protein 2 isoform X1		Enhydra lutris kenyoni		535
+438

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M65217 mRNA Translation: AAA36017.1 DQ492684 Genomic DNA Translation: ABF47087.1 AK294624 mRNA Translation: BAG57805.1 AK316377 mRNA Translation: BAH14748.1 AL121954 Genomic DNA No translation available. Z99129 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48176.1 BC112323 mRNA Translation: AAI12324.1 BC121050 mRNA Translation: AAI21051.1 BC121051 mRNA Translation: AAI21052.1 BC128420 mRNA Translation: AAI28421.1
CCDSⁱ	CCDS47470.1 [Q03933-2] CCDS5124.1 [Q03933-1]
PIRⁱ	A41138
RefSeqⁱ	NP_001129036.1, NM_001135564.1 [Q03933-2] NP_004497.1, NM_004506.3 [Q03933-1]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5D8K	X-ray	1.73	B	8-115	[»]
	5D8L	X-ray	2.07	B/D/F/H	8-115	[»]
	5HDK	X-ray	1.32	A/B/C/D	7-112	[»]
SMRⁱ	Q03933
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	109531, 48 interactors
CORUMⁱ	Q03933
DIPⁱ	DIP-56593N
IntActⁱ	Q03933, 80 interactors
STRINGⁱ	9606.ENSP00000357440

Chemistry databases

ChEMBLⁱ	CHEMBL3988631

ChEMBLⁱ

CHEMBL3988631

PTM databases

iPTMnetⁱ	Q03933
PhosphoSitePlusⁱ	Q03933

Genetic variation databases

BioMutaⁱ	HSF2
DMDMⁱ	462334

Proteomic databases

EPDⁱ	Q03933
jPOSTⁱ	Q03933
MassIVEⁱ	Q03933
MaxQBⁱ	Q03933
PaxDbⁱ	Q03933
PeptideAtlasⁱ	Q03933
PRIDEⁱ	Q03933
ProteomicsDBⁱ	58228 [Q03933-1] 58229 [Q03933-2]

Protocols and materials databases

Antibodypediaⁱ	4231, 665 antibodies
The DNASU plasmid repository More...DNASUⁱ	3298

Genome annotation databases

Ensemblⁱ	ENST00000368455; ENSP00000357440; ENSG00000025156 [Q03933-1] ENST00000452194; ENSP00000400380; ENSG00000025156 [Q03933-2]
GeneIDⁱ	3298
KEGGⁱ	hsa:3298
UCSCⁱ	uc003pyu.3, human [Q03933-1]

Organism-specific databases

CTDⁱ	3298
DisGeNETⁱ	3298
GeneCardsⁱ	HSF2
HGNCⁱ	HGNC:5225, HSF2
HPAⁱ	ENSG00000025156, Low tissue specificity
MIMⁱ	140581, gene
neXtProtⁱ	NX_Q03933
OpenTargetsⁱ	ENSG00000025156
PharmGKBⁱ	PA29494
VEuPathDBⁱ	HostDB:ENSG00000025156.12
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0627, Eukaryota
GeneTreeⁱ	ENSGT00940000155906
HOGENOMⁱ	CLU_038829_1_0_1
InParanoidⁱ	Q03933
OMAⁱ	QMNPTDH
OrthoDBⁱ	1154048at2759
PhylomeDBⁱ	Q03933
TreeFamⁱ	TF330401

Enzyme and pathway databases

PathwayCommonsⁱ	Q03933
SignaLinkⁱ	Q03933
SIGNORⁱ	Q03933

Miscellaneous databases

BioGRID-ORCSⁱ	3298, 26 hits in 897 CRISPR screens
ChiTaRSⁱ	HSF2, human
GeneWikiⁱ	HSF2
GenomeRNAiⁱ	3298
Pharosⁱ	Q03933, Tbio
Protein Ontology More...PROⁱ	PR:Q03933
RNActⁱ	Q03933, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000025156, Expressed in female gonad and 236 other tissues
ExpressionAtlasⁱ	Q03933, baseline and differential
Genevisibleⁱ	Q03933, HS

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR027712, HSF2 IPR000232, HSF_DNA-bd IPR027725, HSF_fam IPR010542, Vert_HSTF_C IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf
PANTHERⁱ	PTHR10015, PTHR10015, 1 hit PTHR10015:SF185, PTHR10015:SF185, 1 hit
Pfamⁱ	View protein in Pfam PF00447, HSF_DNA-bind, 1 hit PF06546, Vert_HS_TF, 1 hit
PRINTSⁱ	PR00056, HSFDOMAIN
SMARTⁱ	View protein in SMART SM00415, HSF, 1 hit
SUPFAMⁱ	SSF46785, SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS00434, HSF_DOMAIN, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HSF2_HUMAN
Accessionⁱ	Q03933Primary (citable) accession number: Q03933 Secondary accession number(s): B4DGJ4 , Q0VAH9, Q2M1K4, Q9H445
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
	Last sequence update:	February 1, 1994
	Last modified:	February 10, 2021
	This is version 191 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Direct protein sequencing, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM

UniProtKB

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UniRef

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Supporting data

UniProtKB - Q03933 (HSF2_HUMAN)

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Heat shock factor protein 2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Miscellaneous databases

Chemistry databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Q03933

Isoform 2 [Q03933-2]

GO - Molecular functioni

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ