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Protein

Heat shock factor protein 2

Gene

HSF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi7 – 112By similarityAdd BLAST106

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processStress response, Transcription, Transcription regulation

Enzyme and pathway databases

SignaLinkiQ03933
SIGNORiQ03933

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock factor protein 2
Short name:
HSF 2
Alternative name(s):
Heat shock transcription factor 2
Short name:
HSTF 2
Gene namesi
Name:HSF2
Synonyms:HSTF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000025156.12
HGNCiHGNC:5225 HSF2
MIMi140581 gene
neXtProtiNX_Q03933

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi109R → G: Fails to translocate to nucleus. 1 Publication1
Mutagenesisi196 – 198RKR → ASS: Fails to translocate to nucleus. 1 Publication3

Organism-specific databases

DisGeNETi3298
OpenTargetsiENSG00000025156
PharmGKBiPA29494

Chemistry databases

ChEMBLiCHEMBL3988631

Polymorphism and mutation databases

BioMutaiHSF2
DMDMi462334

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001245691 – 536Heat shock factor protein 2Add BLAST536

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki2Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki82Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki135Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki139Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki151Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki210Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki218Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki237Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ03933
MaxQBiQ03933
PaxDbiQ03933
PeptideAtlasiQ03933
PRIDEiQ03933
ProteomicsDBi58228
58229 [Q03933-2]

PTM databases

iPTMnetiQ03933
PhosphoSitePlusiQ03933

Expressioni

Gene expression databases

BgeeiENSG00000025156 Expressed in 224 organ(s), highest expression level in female gonad
CleanExiHS_HSF2
ExpressionAtlasiQ03933 baseline and differential
GenevisibleiQ03933 HS

Organism-specific databases

HPAiCAB016067
HPA031455

Interactioni

Subunit structurei

DNA-binding homotrimer in stressed or heat shocked cells, otherwise found as a homodimer.

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109531, 41 interactors
CORUMiQ03933
DIPiDIP-56593N
IntActiQ03933, 65 interactors
STRINGi9606.ENSP00000357440

Structurei

Secondary structure

1536
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ03933
SMRiQ03933
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni119 – 192Hydrophobic repeat HR-A/BAdd BLAST74
Regioni360 – 385Hydrophobic repeat HR-CAdd BLAST26

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi108 – 122Nuclear localization signalSequence analysisAdd BLAST15
Motifi195 – 210Nuclear localization signalSequence analysisAdd BLAST16

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi170 – 173Poly-Gln4

Sequence similaritiesi

Belongs to the HSF family.Curated

Phylogenomic databases

eggNOGiKOG0627 Eukaryota
COG5169 LUCA
GeneTreeiENSGT00390000001182
HOGENOMiHOG000253917
HOVERGENiHBG005999
InParanoidiQ03933
KOiK09415
OMAiVSMMDSI
OrthoDBiEOG091G087O
PhylomeDBiQ03933
TreeFamiTF330401

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR027712 HSF2
IPR000232 HSF_DNA-bd
IPR027725 HSF_fam
IPR010542 Vert_HSTF_C
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR10015 PTHR10015, 1 hit
PTHR10015:SF185 PTHR10015:SF185, 1 hit
PfamiView protein in Pfam
PF00447 HSF_DNA-bind, 1 hit
PF06546 Vert_HS_TF, 1 hit
PRINTSiPR00056 HSFDOMAIN
SMARTiView protein in SMART
SM00415 HSF, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00434 HSF_DOMAIN, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q03933-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKQSSNVPAF LSKLWTLVEE THTNEFITWS QNGQSFLVLD EQRFAKEILP
60 70 80 90 100
KYFKHNNMAS FVRQLNMYGF RKVVHIDSGI VKQERDGPVE FQHPYFKQGQ
110 120 130 140 150
DDLLENIKRK VSSSKPEENK IRQEDLTKII SSAQKVQIKQ ETIESRLSEL
160 170 180 190 200
KSENESLWKE VSELRAKHAQ QQQVIRKIVQ FIVTLVQNNQ LVSLKRKRPL
210 220 230 240 250
LLNTNGAQKK NLFQHIVKEP TDNHHHKVPH SRTEGLKPRE RISDDIIIYD
260 270 280 290 300
VTDDNADEEN IPVIPETNED VISDPSNCSQ YPDIVIVEDD NEDEYAPVIQ
310 320 330 340 350
SGEQNEPARE SLSSGSDGSS PLMSSAVQLN GSSSLTSEDP VTMMDSILND
360 370 380 390 400
NINLLGKVEL LDYLDSIDCS LEDFQAMLSG RQFSIDPDLL VDLFTSSVQM
410 420 430 440 450
NPTDYINNTK SENKGLETTK NNVVQPVSEE GRKSKSKPDK QLIQYTAFPL
460 470 480 490 500
LAFLDGNPAS SVEQASTTAS SEVLSSVDKP IEVDELLDSS LDPEPTQSKL
510 520 530
VRLEPLTEAE ASEATLFYLC ELAPAPLDSD MPLLDS
Length:536
Mass (Da):60,348
Last modified:February 1, 1994 - v1
Checksum:i00DFD05CFD9DF0D3
GO
Isoform 2 (identifier: Q03933-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     393-410: Missing.

Show »
Length:518
Mass (Da):58,293
Checksum:i6682B51448E116BC
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GZ44V9GZ44_HUMAN
Heat shock factor protein 2
HSF2
214Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041128393 – 410Missing in isoform 2. 2 PublicationsAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65217 mRNA Translation: AAA36017.1
DQ492684 Genomic DNA Translation: ABF47087.1
AK294624 mRNA Translation: BAG57805.1
AK316377 mRNA Translation: BAH14748.1
AL121954 Genomic DNA No translation available.
Z99129 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48176.1
BC112323 mRNA Translation: AAI12324.1
BC121050 mRNA Translation: AAI21051.1
BC121051 mRNA Translation: AAI21052.1
BC128420 mRNA Translation: AAI28421.1
CCDSiCCDS47470.1 [Q03933-2]
CCDS5124.1 [Q03933-1]
PIRiA41138
RefSeqiNP_001129036.1, NM_001135564.1 [Q03933-2]
NP_004497.1, NM_004506.3 [Q03933-1]
UniGeneiHs.158195

Genome annotation databases

EnsembliENST00000368455; ENSP00000357440; ENSG00000025156 [Q03933-1]
ENST00000452194; ENSP00000400380; ENSG00000025156 [Q03933-2]
GeneIDi3298
KEGGihsa:3298
UCSCiuc003pyu.3 human [Q03933-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65217 mRNA Translation: AAA36017.1
DQ492684 Genomic DNA Translation: ABF47087.1
AK294624 mRNA Translation: BAG57805.1
AK316377 mRNA Translation: BAH14748.1
AL121954 Genomic DNA No translation available.
Z99129 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48176.1
BC112323 mRNA Translation: AAI12324.1
BC121050 mRNA Translation: AAI21051.1
BC121051 mRNA Translation: AAI21052.1
BC128420 mRNA Translation: AAI28421.1
CCDSiCCDS47470.1 [Q03933-2]
CCDS5124.1 [Q03933-1]
PIRiA41138
RefSeqiNP_001129036.1, NM_001135564.1 [Q03933-2]
NP_004497.1, NM_004506.3 [Q03933-1]
UniGeneiHs.158195

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5D8KX-ray1.73B8-115[»]
5D8LX-ray2.07B/D/F/H8-115[»]
5HDKX-ray1.32A/B/C/D7-112[»]
ProteinModelPortaliQ03933
SMRiQ03933
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109531, 41 interactors
CORUMiQ03933
DIPiDIP-56593N
IntActiQ03933, 65 interactors
STRINGi9606.ENSP00000357440

Chemistry databases

ChEMBLiCHEMBL3988631

PTM databases

iPTMnetiQ03933
PhosphoSitePlusiQ03933

Polymorphism and mutation databases

BioMutaiHSF2
DMDMi462334

Proteomic databases

EPDiQ03933
MaxQBiQ03933
PaxDbiQ03933
PeptideAtlasiQ03933
PRIDEiQ03933
ProteomicsDBi58228
58229 [Q03933-2]

Protocols and materials databases

DNASUi3298
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368455; ENSP00000357440; ENSG00000025156 [Q03933-1]
ENST00000452194; ENSP00000400380; ENSG00000025156 [Q03933-2]
GeneIDi3298
KEGGihsa:3298
UCSCiuc003pyu.3 human [Q03933-1]

Organism-specific databases

CTDi3298
DisGeNETi3298
EuPathDBiHostDB:ENSG00000025156.12
GeneCardsiHSF2
HGNCiHGNC:5225 HSF2
HPAiCAB016067
HPA031455
MIMi140581 gene
neXtProtiNX_Q03933
OpenTargetsiENSG00000025156
PharmGKBiPA29494
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0627 Eukaryota
COG5169 LUCA
GeneTreeiENSGT00390000001182
HOGENOMiHOG000253917
HOVERGENiHBG005999
InParanoidiQ03933
KOiK09415
OMAiVSMMDSI
OrthoDBiEOG091G087O
PhylomeDBiQ03933
TreeFamiTF330401

Enzyme and pathway databases

SignaLinkiQ03933
SIGNORiQ03933

Miscellaneous databases

GeneWikiiHSF2
GenomeRNAii3298
PROiPR:Q03933
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000025156 Expressed in 224 organ(s), highest expression level in female gonad
CleanExiHS_HSF2
ExpressionAtlasiQ03933 baseline and differential
GenevisibleiQ03933 HS

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR027712 HSF2
IPR000232 HSF_DNA-bd
IPR027725 HSF_fam
IPR010542 Vert_HSTF_C
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR10015 PTHR10015, 1 hit
PTHR10015:SF185 PTHR10015:SF185, 1 hit
PfamiView protein in Pfam
PF00447 HSF_DNA-bind, 1 hit
PF06546 Vert_HS_TF, 1 hit
PRINTSiPR00056 HSFDOMAIN
SMARTiView protein in SMART
SM00415 HSF, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00434 HSF_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHSF2_HUMAN
AccessioniPrimary (citable) accession number: Q03933
Secondary accession number(s): B4DGJ4
, Q0VAH9, Q2M1K4, Q9H445
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 7, 2018
This is version 174 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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