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UniProtKB - Q03924 (ZN117_HUMAN)
Protein
Zinc finger protein 117
Gene
ZNF117
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 109 – 131 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 137 – 159 | C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 165 – 187 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 193 – 215 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 221 – 243 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 249 – 271 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 277 – 299 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 305 – 327 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 333 – 355 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 361 – 383 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 389 – 411 | C2H2-type 11; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 417 – 439 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 445 – 467 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- zinc ion binding Source: UniProtKB
GO - Biological processi
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q03924 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 117Alternative name(s): Provirus-linked krueppel Short name: h-PLK Zinc finger protein HPF9 |
Gene namesi | Name:ZNF117 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12897, ZNF117 |
MIMi | 194624, gene |
neXtProti | NX_Q03924 |
VEuPathDBi | HostDB:ENSG00000152926 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 109504726 51351 |
OpenTargetsi | ENSG00000152926 |
PharmGKBi | PA37486 |
Miscellaneous databases
Pharosi | Q03924, Tdark |
Genetic variation databases
BioMutai | ZNF117 |
DMDMi | 327478609 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047407 | 1 – 483 | Zinc finger protein 117Add BLAST | 483 |
Proteomic databases
jPOSTi | Q03924 |
MassIVEi | Q03924 |
MaxQBi | Q03924 |
PaxDbi | Q03924 |
PeptideAtlasi | Q03924 |
PRIDEi | Q03924 |
ProteomicsDBi | 58227 |
PTM databases
iPTMneti | Q03924 |
PhosphoSitePlusi | Q03924 |
Expressioni
Developmental stagei
Expressed early during embryonic development.
Gene expression databases
Bgeei | ENSG00000152926, Expressed in adrenal tissue and 218 other tissues |
ExpressionAtlasi | Q03924, baseline and differential |
Genevisiblei | Q03924, HS |
Organism-specific databases
HPAi | ENSG00000152926, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 119493, 1 interactor |
STRINGi | 9606.ENSP00000282869 |
Miscellaneous databases
RNActi | Q03924, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 109 – 131 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 137 – 159 | C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 165 – 187 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 193 – 215 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 221 – 243 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 249 – 271 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 277 – 299 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 305 – 327 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 333 – 355 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 361 – 383 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 389 – 411 | C2H2-type 11; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 417 – 439 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 445 – 467 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161765 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | Q03924 |
OMAi | QFSTFNT |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q03924 |
TreeFami | TF342117 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 10 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 12 hits |
SUPFAMi | SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 10 hits PS50157, ZINC_FINGER_C2H2_2, 13 hits |
i Sequence
Sequence statusi: Complete.
Q03924-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKRHEMVAKH LVMFYYFAQH LWPEQNIRDS FQKVTLRRYR KCGYENLQLR
60 70 80 90 100
KGCKSVVECK QHKGDYSGLN QCLKTTLSKI FQCNKYVEVF HKISNSNRHK
110 120 130 140 150
MRHTENKHFK CKECRKTFCM LSHLTQHKRI QTRVNFYKCE AYGRAFNWSS
160 170 180 190 200
TLNKHKRIHT GEKPYKCKEC GKAFNQTSHL IRHKRIHTEE KPYKCEECGK
210 220 230 240 250
AFNQSSTLTT HNIIHTGEIP YKCEKCVRAF NQASKLTEHK LIHTGEKRYE
260 270 280 290 300
CEECGKAFNR SSKLTEHKYI HTGEKLYKCE ECGKAFNQSS TLTTHKRIHS
310 320 330 340 350
GEKPYKCEEC GKAFKQFSNL TDHKKIHTGE KPYKCEECGK AFNQLSNLTR
360 370 380 390 400
HKVIHTGEKP YKCGECGKAF NQSSALNTHK IIHTGENPHK CRESGKVFHL
410 420 430 440 450
SSKLSTCKKI HTGEKLYKCE ECGKAFNRSS TLIGHKRIHT GEKPYKCEEC
460 470 480
GKAFNQSSTL TTHKIIHTEE KQYKCDECGK AST
Sequence cautioni
The sequence AAA36010 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
The sequence AAA58666 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 40 | R → G in AAA58666 (PubMed:2023909).Curated | 1 | |
Sequence conflicti | 43 – 44 | GY → RH in AAA58666 (PubMed:2023909).Curated | 2 | |
Sequence conflicti | 131 | Q → H in AAG41761 (PubMed:2505992).Curated | 1 | |
Sequence conflicti | 131 | Q → H in AAA58666 (PubMed:2023909).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_057396 | 83 | C → Y. Corresponds to variant dbSNP:rs3807069Ensembl. | 1 | |
Natural variantiVAR_057397 | 112 | K → N. Corresponds to variant dbSNP:rs3807068Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M27879 mRNA Translation: AAG41761.1 Sequence problems. M55422 mRNA Translation: AAA36010.1 Sequence problems. AC073210 Genomic DNA No translation available. M61867 mRNA Translation: AAA58666.1 Different initiation. |
CCDSi | CCDS43593.1 |
PIRi | A35659 B39384 |
RefSeqi | NP_001334979.1, NM_001348050.1 NP_056936.2, NM_015852.3 |
Genome annotation databases
Ensembli | ENST00000282869.11; ENSP00000282869.5; ENSG00000152926.16 ENST00000620222.4; ENSP00000479944.1; ENSG00000152926.16 |
GeneIDi | 109504726 51351 |
KEGGi | hsa:109504726 hsa:51351 |
UCSCi | uc003ttr.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M27879 mRNA Translation: AAG41761.1 Sequence problems. M55422 mRNA Translation: AAA36010.1 Sequence problems. AC073210 Genomic DNA No translation available. M61867 mRNA Translation: AAA58666.1 Different initiation. |
CCDSi | CCDS43593.1 |
PIRi | A35659 B39384 |
RefSeqi | NP_001334979.1, NM_001348050.1 NP_056936.2, NM_015852.3 |
3D structure databases
AlphaFoldDBi | Q03924 |
SMRi | Q03924 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119493, 1 interactor |
STRINGi | 9606.ENSP00000282869 |
PTM databases
iPTMneti | Q03924 |
PhosphoSitePlusi | Q03924 |
Genetic variation databases
BioMutai | ZNF117 |
DMDMi | 327478609 |
Proteomic databases
jPOSTi | Q03924 |
MassIVEi | Q03924 |
MaxQBi | Q03924 |
PaxDbi | Q03924 |
PeptideAtlasi | Q03924 |
PRIDEi | Q03924 |
ProteomicsDBi | 58227 |
Protocols and materials databases
Antibodypediai | 28146, 95 antibodies from 17 providers |
DNASUi | 51351 |
Genome annotation databases
Ensembli | ENST00000282869.11; ENSP00000282869.5; ENSG00000152926.16 ENST00000620222.4; ENSP00000479944.1; ENSG00000152926.16 |
GeneIDi | 109504726 51351 |
KEGGi | hsa:109504726 hsa:51351 |
UCSCi | uc003ttr.3, human |
Organism-specific databases
CTDi | 109504726 51351 |
DisGeNETi | 109504726 51351 |
GeneCardsi | ZNF117 |
HGNCi | HGNC:12897, ZNF117 |
HPAi | ENSG00000152926, Low tissue specificity |
MIMi | 194624, gene |
neXtProti | NX_Q03924 |
OpenTargetsi | ENSG00000152926 |
PharmGKBi | PA37486 |
VEuPathDBi | HostDB:ENSG00000152926 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161765 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | Q03924 |
OMAi | QFSTFNT |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q03924 |
TreeFami | TF342117 |
Enzyme and pathway databases
PathwayCommonsi | Q03924 |
Miscellaneous databases
BioGRID-ORCSi | 51351, 10 hits in 1053 CRISPR screens |
Pharosi | Q03924, Tdark |
PROi | PR:Q03924 |
RNActi | Q03924, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000152926, Expressed in adrenal tissue and 218 other tissues |
ExpressionAtlasi | Q03924, baseline and differential |
Genevisiblei | Q03924, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 10 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 12 hits |
SUPFAMi | SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 10 hits PS50157, ZINC_FINGER_C2H2_2, 13 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN117_HUMAN | |
Accessioni | Q03924Primary (citable) accession number: Q03924 Secondary accession number(s): Q02313, Q7Z7Q7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | April 5, 2011 | |
Last modified: | May 25, 2022 | |
This is version 181 of the entry and version 5 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families