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Entry version 181 (17 Jun 2020)
Sequence version 3 (25 Nov 2008)
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Protein

Zinc finger protein 85

Gene

ZNF85

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be a transcriptional repressor.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri146 – 168C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri174 – 196C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri202 – 224C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri230 – 252C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri258 – 280C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri286 – 308C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri314 – 336C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri342 – 364C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri370 – 392C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri398 – 420C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri426 – 448C2H2-type 11; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri454 – 476C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri482 – 504C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri510 – 532C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri538 – 560C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri566 – 588C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 85
Alternative name(s):
Zinc finger protein HPF4
Zinc finger protein HTF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF85
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000105750.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13160 ZNF85

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603899 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q03923

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
7639

Open Targets

More...
OpenTargetsi
ENSG00000105750

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37733

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q03923 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF85

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215274175

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000473981 – 595Zinc finger protein 85Add BLAST595

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q03923

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q03923

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q03923

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q03923

PeptideAtlas

More...
PeptideAtlasi
Q03923

PRoteomics IDEntifications database

More...
PRIDEi
Q03923

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
58224 [Q03923-1]
58225 [Q03923-2]
58226 [Q03923-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q03923

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q03923

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, including in testis.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000105750 Expressed in sperm and 193 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q03923 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q03923 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000105750 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
113455, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q03923, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000329793

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q03923 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q03923

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 75KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri146 – 168C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri174 – 196C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri202 – 224C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri230 – 252C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri258 – 280C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri286 – 308C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri314 – 336C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri342 – 364C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri370 – 392C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri398 – 420C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri426 – 448C2H2-type 11; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri454 – 476C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri482 – 504C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri510 – 532C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri538 – 560C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri566 – 588C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154251

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_69_11_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q03923

KEGG Orthology (KO)

More...
KOi
K09228

Identification of Orthologs from Complete Genome Data

More...
OMAi
PTVMCSH

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q03923

TreeFam database of animal gene trees

More...
TreeFami
TF342117

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 13 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 15 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 9 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 15 hits
PS50157 ZINC_FINGER_C2H2_2, 15 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q03923-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGPLTFRDVA IEFSLKEWQC LDTAQRNLYR NVMLENYRNL VFLGITVSKP
60 70 80 90 100
DLITCLEQGK EAWSMKRHEI MVAKPTVMCS HFAQDLWPEQ NIKDSFQKVT
110 120 130 140 150
LKRYGKCRHE NLPLRKGCES MDECKMHKGG CNGLNQCLTA TQSKIFQCDK
160 170 180 190 200
YVKVAHKFSN SNRHEIRHTK KKPFKCTKCG KSFGMISCLT EHSRIHTRVN
210 220 230 240 250
FYKCEECGKA FNWSSTLTKH KRIHTGEKPY KCEECGKAFN QSSNLIKHKK
260 270 280 290 300
IHTGEKPYKC EECGKTFNRF STLTTHKIIH TGEKPYKCKE CGKAFNRSST
310 320 330 340 350
LTTHRKIHTG EKPYKCEECG KAFKQSSNLT THKIIHTGEK PYKCKKCGKA
360 370 380 390 400
FNQSAHLTTH EVIHTGEKPY KCEKCGKAFN HFSHLTTHKI IHTGEKPYKC
410 420 430 440 450
KECGKAFKHS STLTKHKIIH TGEKPYKCKE CEKAFNQSSK LTEHKKIHTG
460 470 480 490 500
EKPYECEKCG KAFNQSSNLT RHKKSHTEEK PYKCEECGKG FKWPSTLTIH
510 520 530 540 550
KIIHTGEKPY KCEECGKAFN QSSKLTKHKK IHTGEKPYTC EECGKAFNQS
560 570 580 590
SNLTKHKRIH TGEKPYKCEE CDKAFKWSSV LTKHKIIHTG EKLQI
Length:595
Mass (Da):68,736
Last modified:November 25, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF21FA8927C28DE90
GO
Isoform 2 (identifier: Q03923-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     44-76: Missing.

Show »
Length:562
Mass (Da):65,056
Checksum:i8CC193C2680A8A11
GO
Isoform 3 (identifier: Q03923-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-87: VMCSHFAQDLW → ESYSVTQSGMQ
     88-595: Missing.

Show »
Length:87
Mass (Da):10,088
Checksum:i254588D03599BA03
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q96HE0Q96HE0_HUMAN
ZNF85 protein
ZNF85
55Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QXL2M0QXL2_HUMAN
Zinc finger protein 85
ZNF85
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZ75M0QZ75_HUMAN
Zinc finger protein 85
ZNF85
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R0V3M0R0V3_HUMAN
Zinc finger protein 85
ZNF85
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R0J7M0R0J7_HUMAN
Zinc finger protein 85
ZNF85
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q49A12Q49A12_HUMAN
ZNF85 protein
ZNF85
536Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZN6M0QZN6_HUMAN
Zinc finger protein 85
ZNF85
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti428C → S in AAA79179 (PubMed:9839802).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03355260K → T. Corresponds to variant dbSNP:rs7254311Ensembl.1
Natural variantiVAR_06193284Q → R2 PublicationsCorresponds to variant dbSNP:rs56321708Ensembl.1
Natural variantiVAR_061933115R → I1 PublicationCorresponds to variant dbSNP:rs56231962Ensembl.1
Natural variantiVAR_061934177T → R1 PublicationCorresponds to variant dbSNP:rs56393308Ensembl.1
Natural variantiVAR_033553184G → R1 PublicationCorresponds to variant dbSNP:rs11665978Ensembl.1
Natural variantiVAR_047515266T → A1 PublicationCorresponds to variant dbSNP:rs1063156Ensembl.1
Natural variantiVAR_033554270F → S. Corresponds to variant dbSNP:rs11670246Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03577144 – 76Missing in isoform 2. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_04215477 – 87VMCSHFAQDLW → ESYSVTQSGMQ in isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_04215588 – 595Missing in isoform 3. 1 PublicationAdd BLAST508

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U35376 mRNA Translation: AAA79179.1
AC008739 Genomic DNA No translation available.
BC068066 mRNA Translation: AAH68066.1
M61866 mRNA Translation: AAA52689.1
M61868 mRNA Translation: AAA58671.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS32977.1 [Q03923-1]
CCDS58657.1 [Q03923-3]

Protein sequence database of the Protein Information Resource

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PIRi
A39384
C39384
G02075

NCBI Reference Sequences

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RefSeqi
NP_001243101.1, NM_001256172.1 [Q03923-3]
NP_003420.2, NM_003429.4 [Q03923-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000300540; ENSP00000300540; ENSG00000105750 [Q03923-3]
ENST00000328178; ENSP00000329793; ENSG00000105750 [Q03923-1]
ENST00000345030; ENSP00000342340; ENSG00000105750 [Q03923-2]
ENST00000613159; ENSP00000479316; ENSG00000278091 [Q03923-2]
ENST00000615320; ENSP00000483118; ENSG00000278091 [Q03923-1]
ENST00000615882; ENSP00000479120; ENSG00000278091 [Q03923-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
7639

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7639

UCSC genome browser

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UCSCi
uc002npf.5 human [Q03923-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35376 mRNA Translation: AAA79179.1
AC008739 Genomic DNA No translation available.
BC068066 mRNA Translation: AAH68066.1
M61866 mRNA Translation: AAA52689.1
M61868 mRNA Translation: AAA58671.1
CCDSiCCDS32977.1 [Q03923-1]
CCDS58657.1 [Q03923-3]
PIRiA39384
C39384
G02075
RefSeqiNP_001243101.1, NM_001256172.1 [Q03923-3]
NP_003420.2, NM_003429.4 [Q03923-1]

3D structure databases

SMRiQ03923
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi113455, 3 interactors
IntActiQ03923, 2 interactors
STRINGi9606.ENSP00000329793

PTM databases

iPTMnetiQ03923
PhosphoSitePlusiQ03923

Polymorphism and mutation databases

BioMutaiZNF85
DMDMi215274175

Proteomic databases

jPOSTiQ03923
MassIVEiQ03923
MaxQBiQ03923
PaxDbiQ03923
PeptideAtlasiQ03923
PRIDEiQ03923
ProteomicsDBi58224 [Q03923-1]
58225 [Q03923-2]
58226 [Q03923-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
28656 108 antibodies

Genome annotation databases

EnsembliENST00000300540; ENSP00000300540; ENSG00000105750 [Q03923-3]
ENST00000328178; ENSP00000329793; ENSG00000105750 [Q03923-1]
ENST00000345030; ENSP00000342340; ENSG00000105750 [Q03923-2]
ENST00000613159; ENSP00000479316; ENSG00000278091 [Q03923-2]
ENST00000615320; ENSP00000483118; ENSG00000278091 [Q03923-1]
ENST00000615882; ENSP00000479120; ENSG00000278091 [Q03923-3]
GeneIDi7639
KEGGihsa:7639
UCSCiuc002npf.5 human [Q03923-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7639
DisGeNETi7639
EuPathDBiHostDB:ENSG00000105750.14

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF85
HGNCiHGNC:13160 ZNF85
HPAiENSG00000105750 Low tissue specificity
MIMi603899 gene
neXtProtiNX_Q03923
OpenTargetsiENSG00000105750
PharmGKBiPA37733

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000154251
HOGENOMiCLU_002678_69_11_1
InParanoidiQ03923
KOiK09228
OMAiPTVMCSH
OrthoDBi1318335at2759
PhylomeDBiQ03923
TreeFamiTF342117

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
7639 79 hits in 809 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF85 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7639
PharosiQ03923 Tbio

Protein Ontology

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PROi
PR:Q03923
RNActiQ03923 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000105750 Expressed in sperm and 193 other tissues
ExpressionAtlasiQ03923 baseline and differential
GenevisibleiQ03923 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 13 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 15 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 15 hits
PS50157 ZINC_FINGER_C2H2_2, 15 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZNF85_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q03923
Secondary accession number(s): B9ZVP4, Q6NVI0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 25, 2008
Last modified: June 17, 2020
This is version 181 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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