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Entry version 148 (17 Jun 2020)
Sequence version 1 (01 Nov 1996)
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Protein

Protein dopey

Gene

DOP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in cellular morphogenesis. Required for traffic between late Golgi and early endosomes, and for the normal structure and organization of the endoplasmic reticulum.2 Publications

Miscellaneous

Present with 2700 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
YEAST:G3O-29738-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein dopey
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DOP1
Ordered Locus Names:YDR141C
ORF Names:YD9302.17C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YDR141C

Saccharomyces Genome Database

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SGDi
S000002548 DOP1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001909761 – 1698Protein dopeyAdd BLAST1698

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei244PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
Q03921

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q03921

PRoteomics IDEntifications database

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PRIDEi
Q03921

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q03921

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MON2.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
32195, 236 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1028 NEO1-MON2-ARL1-DOP1 membrane remodeling complex

Database of interacting proteins

More...
DIPi
DIP-2624N

Protein interaction database and analysis system

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IntActi
Q03921, 18 interactors

Molecular INTeraction database

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MINTi
Q03921

STRING: functional protein association networks

More...
STRINGi
4932.YDR141C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q03921 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dopey family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016421

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001197_1_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q03921

Identification of Orthologs from Complete Genome Data

More...
OMAi
TEWADYI

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR040314 DOP1
IPR007249 Dopey_N

The PANTHER Classification System

More...
PANTHERi
PTHR14042 PTHR14042, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04118 Dopey_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q03921-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLPLKPLTI DSNNKQLDSK QKKFRANVER ALERFDSVTE WADYIASLGT
60 70 80 90 100
LLKALQSWSP KFQNVRYYVP SPYQVSRRLT SSLSPALPAG VHQKTLEVYT
110 120 130 140 150
YIFEHIGLET LATECNIWIP GILPLMTYAS MSVRSHLIEL YDNYILLLPQ
160 170 180 190 200
TTLRLLIRPL ISSLLPGIDD ESNDFLPLTL KLIETLQENL DDDSLFWQTL
210 220 230 240 250
FLVMTANKGR RLGGLTWLTR KFPSLNAVPH LVNKIKMEAE ENPSETETND
260 270 280 290 300
SHLDRKKRKE EAFKVLLPAA KDLVTPEPGL LIRCLVGCLE DENDILIKRS
310 320 330 340 350
VLDLLLQRLR LDSPVLNVLI TSEDKKLLIM SCCRTTLSKD MSLNRRIWNW
360 370 380 390 400
LLGPTAGGML NNNGGNSMEY TTSVKSANEE SNVYFTKYGL SALLEGLSDL
410 420 430 440 450
LSEEESVLTA FRISMAVMDR WEIGSLVIPE LFIPLLYSSE KFKQNEQIMK
460 470 480 490 500
TARTFFDNTE TNIIWGKLFQ ELEDIKNLKI LDFVLTNFNI GNDEEIIVRH
510 520 530 540 550
LPLILLTLLA LPSNDKDFDN IYKLQKFSLY NKLLNYIPER ALLPLSHSKL
560 570 580 590 600
KHDDEVSCEE LLAKIRGFYT NVSNPSSILE KENIAERLPP FTTEDLTFLI
610 620 630 640 650
ADLIQKKLLS SLWDLENINE SSKLFIAIFE KIPESEELKG RSHISWSDKK
660 670 680 690 700
ITQSIFEAIP RLCESNNDAK SEEIVGIVEI FGNYLYSRME FIESMKLLKV
710 720 730 740 750
VMMAVWKSLK DPRHQILGVK NLKTLNRFIP SKFIESALVY TFVEEEDISE
760 770 780 790 800
RLSVLDLLWT QLDSDSNLIR RPLELILGEL FDDQNPFYLT VSKWILSILN
810 820 830 840 850
SGSASRLFYI LTDNILKVNR LEKERLDERD DLDMLTYEFQ MLAYVLKTNN
860 870 880 890 900
GRTRKVFSTE LTSIKSSTIW KNEDVSTYKS LLLVTLMRFL NIKSNTHAKS
910 920 930 940 950
IRSALILLDI LLDGTEQNFK DIVIFLLQMS SKYIAEEGIE PELIAVSLLD
960 970 980 990 1000
IVSKVLRLSH DNGIKLDIFD DNAAHLKYID FLVTSVSNMK SPLIVTAYVK
1010 1020 1030 1040 1050
LLSESIVYFE NSIFRMILPL SASLVQCVQR LFLLEKREGG YYQPIALLLG
1060 1070 1080 1090 1100
GLEELLEISH GYLVTEEREG YFSGSNLKGD FIQSVVSNVF SSDSSNEESK
1110 1120 1130 1140 1150
IQGERDVILQ SFRQVISCCL DIWYWAHNIS CKSNDDSSLD ATNHNSYKFK
1160 1170 1180 1190 1200
FRSKKLLETL FLLEPLELLE NLISIRSDNT TVTLVHVLDG NKPAITIPHL
1210 1220 1230 1240 1250
LYGVIIRYNR TASVKFSNRD GSRSSTTKLT KGEPSMLKRL SGESIIAFLF
1260 1270 1280 1290 1300
NYVDSVENSA MEEFYGDFLL FFREVATNYN LYSDVSLSIL KLVALISGKV
1310 1320 1330 1340 1350
SKTQFGEQKR VRREISDVFF KYLPNAFINF TNLYRGHPDS FKDLEFVVWR
1360 1370 1380 1390 1400
VQYIVNDQIG GDKFNTTLAT IVNQCLTPYI KPKSEKTIPG YVLELAAVVS
1410 1420 1430 1440 1450
HLGSKVKSWR LLIAELFQND KKLSVIGSDQ TWEKIIYEWS IYPENKSKIL
1460 1470 1480 1490 1500
NDLLLEIGSK RSSVTPTLIT FNLGSDSEVE YKCQNLLKIS YLLMVSPNDA
1510 1520 1530 1540 1550
YLLHFSSLIS CIFHYLVSKD IKLKGSCWIL LRVLLLRFSE SHFNDYWSMI
1560 1570 1580 1590 1600
SYCLQTNLQE FYESLQIQSE VDPQTILQVC KTLDLLLLLN MEGFTSTNEW
1610 1620 1630 1640 1650
IFVIDTINCV YKTNSFVALV DEIAEFKDYE ITKTDDLELP TTLKDGLPLL
1660 1670 1680 1690
RGIHKIERHT QLRSFFQNLS YLHYEKVYGL GSVDLYGCGE DLKKDILS
Length:1,698
Mass (Da):194,688
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i119459CD3785526C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z48179 Genomic DNA Translation: CAA88223.1
BK006938 Genomic DNA Translation: DAA11984.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S51869

NCBI Reference Sequences

More...
RefSeqi
NP_010425.1, NM_001180448.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YDR141C_mRNA; YDR141C; YDR141C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
851719

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YDR141C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48179 Genomic DNA Translation: CAA88223.1
BK006938 Genomic DNA Translation: DAA11984.1
PIRiS51869
RefSeqiNP_010425.1, NM_001180448.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi32195, 236 interactors
ComplexPortaliCPX-1028 NEO1-MON2-ARL1-DOP1 membrane remodeling complex
DIPiDIP-2624N
IntActiQ03921, 18 interactors
MINTiQ03921
STRINGi4932.YDR141C

PTM databases

iPTMnetiQ03921

Proteomic databases

MaxQBiQ03921
PaxDbiQ03921
PRIDEiQ03921

Genome annotation databases

EnsemblFungiiYDR141C_mRNA; YDR141C; YDR141C
GeneIDi851719
KEGGisce:YDR141C

Organism-specific databases

EuPathDBiFungiDB:YDR141C
SGDiS000002548 DOP1

Phylogenomic databases

GeneTreeiENSGT00390000016421
HOGENOMiCLU_001197_1_0_1
InParanoidiQ03921
OMAiTEWADYI

Enzyme and pathway databases

BioCyciYEAST:G3O-29738-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q03921
RNActiQ03921 protein

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR040314 DOP1
IPR007249 Dopey_N
PANTHERiPTHR14042 PTHR14042, 1 hit
PfamiView protein in Pfam
PF04118 Dopey_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDOP1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q03921
Secondary accession number(s): D6VSC4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 1, 1996
Last modified: June 17, 2020
This is version 148 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
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