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UniProtKB - Q03829 (MME1_YEAST)
Protein
Mitochondrial magnesium exporter 1
Gene
MME1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Transporter of the mitochondrial inner membrane that exports magnesium and thus, plays a key role in mitochondrial Mg2+ homeostasis.
1 Publication1 PublicationMiscellaneous
Present with 2060 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- magnesium ion transmembrane transporter activity Source: SGD
GO - Biological processi
- magnesium ion export from mitochondrion Source: SGD
- magnesium ion transport Source: SGD
Keywordsi
Biological process | Transport |
Protein family/group databases
TCDBi | 2.A.29.18.6, the mitochondrial carrier (mc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Mitochondrial magnesium exporter 11 Publication |
Gene namesi | Name:MME11 Publication Ordered Locus Names:YMR166C ORF Names:YM8520.15C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000004776, MME1 |
VEuPathDBi | FungiDB:YMR166C |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Mitochondrion
- mitochondrial inner membrane Source: SGD
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 56 – 77 | Helical; Name=1Sequence analysisAdd BLAST | 22 | |
Transmembranei | 115 – 135 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Transmembranei | 149 – 165 | Helical; Name=3Sequence analysisAdd BLAST | 17 | |
Transmembranei | 219 – 239 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Transmembranei | 260 – 280 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Transmembranei | 332 – 353 | Helical; Name=6Sequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000090699 | 1 – 368 | Mitochondrial magnesium exporter 1Add BLAST | 368 |
Proteomic databases
PaxDbi | Q03829 |
PTM databases
iPTMneti | Q03829 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 35344, 146 interactors |
STRINGi | 4932.YMR166C |
Miscellaneous databases
RNActi | Q03829, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q03829 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 51 – 138 | Solcar 1Add BLAST | 88 | |
Repeati | 146 – 240 | Solcar 2Add BLAST | 95 | |
Repeati | 254 – 360 | Solcar 3Add BLAST | 107 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 48 | DisorderedSequence analysisAdd BLAST | 48 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 30 – 48 | Basic and acidic residuesSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0770, Eukaryota |
HOGENOMi | CLU_015166_3_2_1 |
InParanoidi | Q03829 |
OMAi | FYEQEQR |
Family and domain databases
Gene3Di | 1.50.40.10, 2 hits |
InterProi | View protein in InterPro IPR002067, Mit_carrier IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
PRINTSi | PR00926, MITOCARRIER |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
i Sequence
Sequence statusi: Complete.
Q03829-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNSWNLSSSI PIIHTPHDHP PTSEGTPDQP NNNRKDDKLH KKRGDSDEDL
60 70 80 90 100
SPIWHCVVSG GIGGKIGDSA MHSLDTVKTR QQGAPNVKKY RNMISAYRTI
110 120 130 140 150
WLEEGVRRGL YGGYMAAMLG SFPSAAIFFG TYEYTKRTMI EDWQINDTIT
160 170 180 190 200
HLSAGFLGDF ISSFVYVPSE VLKTRLQLQG RFNNPFFQSG YNYSNLRNAI
210 220 230 240 250
KTVIKEEGFR SLFFGYKATL ARDLPFSALQ FAFYEKFRQL AFKIEQKDGR
260 270 280 290 300
DGELSIPNEI LTGACAGGLA GIITTPMDVV KTRVQTQQPP SQSNKSYSVT
310 320 330 340 350
HPHVTNGRPA ALSNSISLSL RTVYQSEGVL GFFSGVGPRF VWTSVQSSIM
360
LLLYQMTLRG LSNAFPTD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z49705 Genomic DNA Translation: CAA89802.1 AY558121 Genomic DNA Translation: AAS56447.1 BK006946 Genomic DNA Translation: DAA10062.1 |
PIRi | S54524 |
RefSeqi | NP_013889.1, NM_001182670.1 |
Genome annotation databases
EnsemblFungii | YMR166C_mRNA; YMR166C; YMR166C |
GeneIDi | 855202 |
KEGGi | sce:YMR166C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z49705 Genomic DNA Translation: CAA89802.1 AY558121 Genomic DNA Translation: AAS56447.1 BK006946 Genomic DNA Translation: DAA10062.1 |
PIRi | S54524 |
RefSeqi | NP_013889.1, NM_001182670.1 |
3D structure databases
AlphaFoldDBi | Q03829 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 35344, 146 interactors |
STRINGi | 4932.YMR166C |
Protein family/group databases
TCDBi | 2.A.29.18.6, the mitochondrial carrier (mc) family |
PTM databases
iPTMneti | Q03829 |
Proteomic databases
PaxDbi | Q03829 |
Genome annotation databases
EnsemblFungii | YMR166C_mRNA; YMR166C; YMR166C |
GeneIDi | 855202 |
KEGGi | sce:YMR166C |
Organism-specific databases
SGDi | S000004776, MME1 |
VEuPathDBi | FungiDB:YMR166C |
Phylogenomic databases
eggNOGi | KOG0770, Eukaryota |
HOGENOMi | CLU_015166_3_2_1 |
InParanoidi | Q03829 |
OMAi | FYEQEQR |
Miscellaneous databases
PROi | PR:Q03829 |
RNActi | Q03829, protein |
Family and domain databases
Gene3Di | 1.50.40.10, 2 hits |
InterProi | View protein in InterPro IPR002067, Mit_carrier IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
PRINTSi | PR00926, MITOCARRIER |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | MME1_YEAST | |
Accessioni | Q03829Primary (citable) accession number: Q03829 Secondary accession number(s): D6VZY8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | May 25, 2022 | |
This is version 158 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XIII
Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names - SIMILARITY comments
Index of protein domains and families