UniProtKB - Q03784 (TRS23_YEAST)
Trafficking protein particle complex subunit 23
TRS23
Functioni
Component of the TRAPP I, TRAPP II and TRAPP III complexes which act as guanine nucleotide exchange factors (GEF) for YPT1. TRAPP I plays a key role in the late stages of endoplasmic reticulum to Golgi traffic. TRAPP II plays a role in intra-Golgi transport. TRAPP III plays a role in autophagosome formation.
3 PublicationsMiscellaneous
GO - Biological processi
- autophagy Source: UniProtKB-KW
- chromosome organization Source: SGD
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: ComplexPortal
- regulation of catalytic activity Source: GOC
Keywordsi
Biological process | Autophagy, ER-Golgi transport, Transport |
Enzyme and pathway databases
Reactomei | R-SCE-204005, COPII-mediated vesicle transport R-SCE-8876198, RAB GEFs exchange GTP for GDP on RABs |
Names & Taxonomyi
Protein namesi | Recommended name: Trafficking protein particle complex subunit 23Short name: TRAPP subunit 23 Alternative name(s): Transport protein particle 23 kDa subunit |
Gene namesi | Name:TRS23 Ordered Locus Names:YDR246W ORF Names:YD8419.13 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000002654, TRS23 |
VEuPathDBi | FungiDB:YDR246W |
Subcellular locationi
Endoplasmic reticulum
Golgi apparatus
Other locations
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB-SubCell
Endosome
- TRAPPII protein complex Source: SGD
Golgi apparatus
- TRAPPII protein complex Source: SGD
- TRAPPIII protein complex Source: SGD
Other locations
- phagophore assembly site Source: UniProtKB-SubCell
- TRAPP complex Source: GO_Central
- TRAPPI protein complex Source: SGD
Keywords - Cellular componenti
Endoplasmic reticulum, Golgi apparatusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000211571 | 1 – 219 | Trafficking protein particle complex subunit 23Add BLAST | 219 |
Proteomic databases
MaxQBi | Q03784 |
PaxDbi | Q03784 |
PRIDEi | Q03784 |
Interactioni
Subunit structurei
Part of the multisubunit TRAPP (transport protein particle) I complex composed of BET3, BET5, TRS20, TRS23, TRS31 and TRS33. Part of the multisubunit TRAPP (transport protein particle) II complex composed of BET3, BET5, TRS20, TRS23, TRS31, TRS33, TRS65, TRS85, TRS120 and TRS130. Part of the multisubunit TRAPP (transport protein particle) III complex composed of BET3, BET5, TRS20, TRS23, TRS31, TRS33 and TRS85.
5 PublicationsBinary interactionsi
Q03784
With | #Exp. | IntAct |
---|---|---|
BET3 [P36149] | 11 | EBI-19474,EBI-3567 |
Protein-protein interaction databases
BioGRIDi | 32297, 552 interactors |
ComplexPortali | CPX-1383, TRAPPIII protein complex CPX-1939, TRAPPII protein complex CPX-1940, TRAPPI protein complex |
DIPi | DIP-5813N |
IntActi | Q03784, 5 interactors |
MINTi | Q03784 |
STRINGi | 4932.YDR246W |
Miscellaneous databases
RNActi | Q03784, protein |
Structurei
3D structure databases
SMRi | Q03784 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q03784 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3369, Eukaryota |
GeneTreei | ENSGT00940000153761 |
HOGENOMi | CLU_053380_0_0_1 |
InParanoidi | Q03784 |
OMAi | YSMEMPI |
Family and domain databases
InterProi | View protein in InterPro IPR011012, Longin-like_dom_sf IPR007233, TRAPPC |
PANTHERi | PTHR23249, PTHR23249, 1 hit |
Pfami | View protein in Pfam PF04099, Sybindin, 3 hits |
SMARTi | View protein in SMART SM01399, Sybindin, 1 hit |
SUPFAMi | SSF64356, SSF64356, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MAIETILVIN KSGGLIYQRN FTNDEQKLNS NEYLILASTL HGVFAIASQL
60 70 80 90 100
TPKALQLTQQ TNIENTIPYI PYVGMSSNRS DTRNGGGNNN KHTNNEKLGS
110 120 130 140 150
FKGDDFFKEP FTNWNKSGLR QLCTDQFTMF IYQTLTGLKF VAISSSVMPQ
160 170 180 190 200
RQPTIATTDK PDRPKSTSNL AIQIADNFLR KVYCLYSDYV MKDPSYSMEM
210
PIRSNLFDEK VKKMVENLQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z49701 Genomic DNA Translation: CAA89732.1 BK006938 Genomic DNA Translation: DAA12086.1 |
PIRi | S54542 |
RefSeqi | NP_010532.3, NM_001180554.3 |
Genome annotation databases
EnsemblFungii | YDR246W_mRNA; YDR246W; YDR246W |
GeneIDi | 851833 |
KEGGi | sce:YDR246W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z49701 Genomic DNA Translation: CAA89732.1 BK006938 Genomic DNA Translation: DAA12086.1 |
PIRi | S54542 |
RefSeqi | NP_010532.3, NM_001180554.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3CUE | X-ray | 3.70 | A/G/M/S | 1-219 | [»] | |
7KMT | electron microscopy | 3.70 | H | 1-219 | [»] | |
SMRi | Q03784 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 32297, 552 interactors |
ComplexPortali | CPX-1383, TRAPPIII protein complex CPX-1939, TRAPPII protein complex CPX-1940, TRAPPI protein complex |
DIPi | DIP-5813N |
IntActi | Q03784, 5 interactors |
MINTi | Q03784 |
STRINGi | 4932.YDR246W |
Proteomic databases
MaxQBi | Q03784 |
PaxDbi | Q03784 |
PRIDEi | Q03784 |
Genome annotation databases
EnsemblFungii | YDR246W_mRNA; YDR246W; YDR246W |
GeneIDi | 851833 |
KEGGi | sce:YDR246W |
Organism-specific databases
SGDi | S000002654, TRS23 |
VEuPathDBi | FungiDB:YDR246W |
Phylogenomic databases
eggNOGi | KOG3369, Eukaryota |
GeneTreei | ENSGT00940000153761 |
HOGENOMi | CLU_053380_0_0_1 |
InParanoidi | Q03784 |
OMAi | YSMEMPI |
Enzyme and pathway databases
Reactomei | R-SCE-204005, COPII-mediated vesicle transport R-SCE-8876198, RAB GEFs exchange GTP for GDP on RABs |
Miscellaneous databases
EvolutionaryTracei | Q03784 |
PROi | PR:Q03784 |
RNActi | Q03784, protein |
Family and domain databases
InterProi | View protein in InterPro IPR011012, Longin-like_dom_sf IPR007233, TRAPPC |
PANTHERi | PTHR23249, PTHR23249, 1 hit |
Pfami | View protein in Pfam PF04099, Sybindin, 3 hits |
SMARTi | View protein in SMART SM01399, Sybindin, 1 hit |
SUPFAMi | SSF64356, SSF64356, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TRS23_YEAST | |
Accessioni | Q03784Primary (citable) accession number: Q03784 Secondary accession number(s): D6VSM6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2002 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 171 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome IV
Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families