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Entry version 147 (02 Jun 2021)
Sequence version 1 (01 Nov 1996)
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Protein

SPS-sensor component SSY1

Gene

SSY1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Amino acid sensor component of the SPS-sensor system, which regulates the expression of several amino acid-metabolizing enzymes and amino acid- and peptide-permeases in response to extracellular amino acid levels by controlling the activity of two transcription factors, STP1 and STP2. Amino-acid permease homolog that seems to interact directly with the extracellular signaling molecules, but has no amino acid transporter activity. May recruit casein kinases YCK1 and YCK2 to hyperphosphorylate and activate downstream component PTR3 in response to amino acid stimulus.

9 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.3.10.12, the amino acid-polyamine-organocation (apc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SPS-sensor component SSY1
Alternative name(s):
Amino-acid permease homolog SSY1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SSY1
Synonyms:APF7, SHR10
Ordered Locus Names:YDR160W
ORF Names:YD8358.14
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000002567, SSY1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YDR160W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 285CytoplasmicSequence analysisAdd BLAST285
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei286 – 306HelicalSequence analysisAdd BLAST21
Topological domaini307 – 329ExtracellularSequence analysisAdd BLAST23
Transmembranei330 – 350HelicalSequence analysisAdd BLAST21
Topological domaini351 – 357CytoplasmicSequence analysis7
Transmembranei358 – 378HelicalSequence analysisAdd BLAST21
Topological domaini379 – 400ExtracellularSequence analysisAdd BLAST22
Transmembranei401 – 421HelicalSequence analysisAdd BLAST21
Topological domaini422CytoplasmicSequence analysis1
Transmembranei423 – 443HelicalSequence analysisAdd BLAST21
Topological domaini444 – 500ExtracellularSequence analysisAdd BLAST57
Transmembranei501 – 521HelicalSequence analysisAdd BLAST21
Topological domaini522 – 540CytoplasmicSequence analysisAdd BLAST19
Transmembranei541 – 561HelicalSequence analysisAdd BLAST21
Topological domaini562 – 623ExtracellularSequence analysisAdd BLAST62
Transmembranei624 – 644HelicalSequence analysisAdd BLAST21
Topological domaini645 – 673CytoplasmicSequence analysisAdd BLAST29
Transmembranei674 – 694HelicalSequence analysisAdd BLAST21
Topological domaini695 – 703ExtracellularSequence analysis9
Transmembranei704 – 724HelicalSequence analysisAdd BLAST21
Topological domaini725 – 755CytoplasmicSequence analysisAdd BLAST31
Transmembranei756 – 776HelicalSequence analysisAdd BLAST21
Topological domaini777 – 784ExtracellularSequence analysis8
Transmembranei785 – 805HelicalSequence analysisAdd BLAST21
Topological domaini806 – 852CytoplasmicSequence analysisAdd BLAST47

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi382T → H or L: Constitutively active, up-regulates amino acid permease transcription in response to subthreshold concentrations of amino acids. 1 Publication1
Mutagenesisi382T → K in SSY1-102; constitutively active, up-regulates amino acid permease transcription in the absence of amino-acids. 1 Publication1
Mutagenesisi382T → R: Constitutively active, up-regulates amino acid permease transcription in the absence of amino acids. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000541641 – 852SPS-sensor component SSY1Add BLAST852

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q03770

PRoteomics IDEntifications database

More...
PRIDEi
Q03770

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the plasma membrane SPS (SSY1-PTR3-SSY5) amino acid sensor complex.

Interacts directly with PTR3 and SSY5.

Interacts with YCK1.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
32211, 100 interactors

Database of interacting proteins

More...
DIPi
DIP-2920N

Protein interaction database and analysis system

More...
IntActi
Q03770, 4 interactors

Molecular INTeraction database

More...
MINTi
Q03770

STRING: functional protein association networks

More...
STRINGi
4932.YDR160W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q03770, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni21 – 41DisorderedSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1286, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007946_8_6_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q03770

Identification of Orthologs from Complete Genome Data

More...
OMAi
SFCEMVT

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004841, AA-permease/SLC12A_dom
IPR004762, Amino_acid_permease_fungi

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00324, AA_permease, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00913, 2A0310, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q03770-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSVNQIYDL FPNKHNIQFT DSHSQEHDTS SSLAKNDTDG TISIPGSIDT
60 70 80 90 100
GILKSIIEEQ GWNDAELYRS SIQNQRFFLT DKYTKKKHLT MEDMLSPEEE
110 120 130 140 150
QIYQEPIQDF QTYNKRVQRE YELRERMEEF FRQNTKNDLH ILNEDSLNQQ
160 170 180 190 200
YSPLGPADYV LPLDRYSRMK HIASNFFRKK LGIPRKLKRR SHYNPNAEGH
210 220 230 240 250
TKGNSSILSS TTDVIDNASY RNIAIDENVD ITHKEHAIDE INEQGASGSE
260 270 280 290 300
SVVEGGSLLH DIEKVFNRSR ATRKYHIQRK LKVRHIQMLS IGACFSVGLF
310 320 330 340 350
LTSGKAFSIA GPFGTLLGFG LTGSIILATM LSFTELSTLI PVSSGFSGLA
360 370 380 390 400
SRFVEDAFGF ALGWTYWISC MLALPAQVSS STFYLSYYNN VNISKGVTAG
410 420 430 440 450
FITLFSAFSI VVNLLDVSIM GEIVYVAGIS KVIIAILMVF TMIILNAGHG
460 470 480 490 500
NDIHEGVGFR YWDSSKSVRN LTYGLYRPTF DLADAGEGSK KGISGPKGRF
510 520 530 540 550
LATASVMLIS TFAFSGVEMT FLASGEAINP RKTIPSATKR TFSIVLISYV
560 570 580 590 600
FLIFSVGINI YSGDPRLLSY FPGISEKRYE AIIKGTGMDW RLRTNCRGGI
610 620 630 640 650
DYRQISVGTG YSSPWVVALQ NFGLCTFASA FNAILIFFTA TAGISSLFSC
660 670 680 690 700
SRTLYAMSVQ RKAPPVFEIC SKRGVPYVSV IFSSLFSVIA YIAVDQTAIE
710 720 730 740 750
NFDVLANVSS ASTSIIWMGL NLSFLRFYYA LKQRKDIISR NDSSYPYKSP
760 770 780 790 800
FQPYLAIYGL VGCSLFVIFM GYPNFIHHFW STKAFFSAYG GLMFFFISYT
810 820 830 840 850
AYKVLGTSKI QRLDQLDMDS GRREMDRTDW TEHSQYLGTY RERAKKLVTW

LI
Length:852
Mass (Da):95,744
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i81A94141DF4EEF7D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z50046 Genomic DNA Translation: CAA90380.1
BK006938 Genomic DNA Translation: DAA12000.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S57984

NCBI Reference Sequences

More...
RefSeqi
NP_010444.1, NM_001180467.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YDR160W_mRNA; YDR160W; YDR160W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
851738

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YDR160W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50046 Genomic DNA Translation: CAA90380.1
BK006938 Genomic DNA Translation: DAA12000.1
PIRiS57984
RefSeqiNP_010444.1, NM_001180467.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi32211, 100 interactors
DIPiDIP-2920N
IntActiQ03770, 4 interactors
MINTiQ03770
STRINGi4932.YDR160W

Protein family/group databases

TCDBi2.A.3.10.12, the amino acid-polyamine-organocation (apc) family

Proteomic databases

PaxDbiQ03770
PRIDEiQ03770

Genome annotation databases

EnsemblFungiiYDR160W_mRNA; YDR160W; YDR160W
GeneIDi851738
KEGGisce:YDR160W

Organism-specific databases

SGDiS000002567, SSY1
VEuPathDBiFungiDB:YDR160W

Phylogenomic databases

eggNOGiKOG1286, Eukaryota
HOGENOMiCLU_007946_8_6_1
InParanoidiQ03770
OMAiSFCEMVT

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q03770
RNActiQ03770, protein

Family and domain databases

InterProiView protein in InterPro
IPR004841, AA-permease/SLC12A_dom
IPR004762, Amino_acid_permease_fungi
PfamiView protein in Pfam
PF00324, AA_permease, 1 hit
TIGRFAMsiTIGR00913, 2A0310, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSSY1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q03770
Secondary accession number(s): D6VSE0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: June 2, 2021
This is version 147 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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