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Protein

Ethanolamine kinase

Gene

EKI1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the committed step of phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway. Also exhibits choline kinase activity but its preferred substrate is ethanolamine.

Miscellaneous

Present with 3420 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

ATP + ethanolamine = ADP + O-phosphoethanolamine.

Pathwayi: phosphatidylethanolamine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes phosphatidylethanolamine from ethanolamine.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ethanolamine kinase (EKI1)
  2. Ethanolamine-phosphate cytidylyltransferase (ECT1)
  3. Choline/ethanolaminephosphotransferase 1 (EPT1)
This subpathway is part of the pathway phosphatidylethanolamine biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidylethanolamine from ethanolamine, the pathway phosphatidylethanolamine biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • choline kinase activity Source: SGD
  • ethanolamine kinase activity Source: SGD

GO - Biological processi

  • phosphatidylcholine biosynthetic process Source: SGD
  • phosphatidylethanolamine biosynthetic process Source: SGD

Keywordsi

Molecular functionKinase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:YDR147W-MONOMER
ReactomeiR-SCE-1483191 Synthesis of PC
R-SCE-1483213 Synthesis of PE
UniPathwayi
UPA00558;UER00741

Chemistry databases

SwissLipidsiSLP:000000065

Names & Taxonomyi

Protein namesi
Recommended name:
Ethanolamine kinase (EC:2.7.1.82)
Short name:
EK
Gene namesi
Name:EKI1
Ordered Locus Names:YDR147W
ORF Names:YD8358.04
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR147W
SGDiS000002554 EKI1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002062301 – 534Ethanolamine kinaseAdd BLAST534

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ03764
PaxDbiQ03764
PRIDEiQ03764

PTM databases

iPTMnetiQ03764

Interactioni

Protein-protein interaction databases

BioGridi32201, 108 interactors
MINTiQ03764
STRINGi4932.YDR147W

Structurei

3D structure databases

ProteinModelPortaliQ03764
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the choline/ethanolamine kinase family.Curated

Phylogenomic databases

GeneTreeiENSGT00530000062991
HOGENOMiHOG000246747
InParanoidiQ03764
KOiK00894
OMAiPIAYDIT
OrthoDBiEOG092C0QOM

Family and domain databases

InterProiView protein in InterPro
IPR007521 Choline_kin_N
IPR011009 Kinase-like_dom_sf
PfamiView protein in Pfam
PF04428 Choline_kin_N, 1 hit
SUPFAMiSSF56112 SSF56112, 2 hits

Sequencei

Sequence statusi: Complete.

Q03764-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYTNYSLTSS DAMPRTYLVG TASPEMSKKK RQSANCDKPT RRVIHIIDTN
60 70 80 90 100
EHSEVDLKNE LPITCTNEDG EMTSSSWTSQ TANDFLKLAY VNAKLDPSLP
110 120 130 140 150
SQYFKQDIIN VLQSLEIPGW SVPGSKESSL NKNLLTLTQI KGALTNVIYK
160 170 180 190 200
IHYPNLPPLL MRIFGDSIDS VIDREYELKV IARLSFYDLG PKLEGFFENG
210 220 230 240 250
RFEKYIEGSR TSTQADFIDR DTSIKIAKKL KELHCTVPLT HKEITDQPSC
260 270 280 290 300
WTTFDQWIKL IDSHKEWVSN NVNISENLRC SSWNFFLKSF KNYKRWLYND
310 320 330 340 350
SAFTSKLLRE DDKDSMINSG LKMVFCHNDL QHGNLLFKSK GKDDISVGDL
360 370 380 390 400
TIIDFEYAGP NPVVFDLSNH LNEWMQDYND VQSFKSHIDK YPKEEDILVF
410 420 430 440 450
AQSYINHMNE NHVKIASQEV RILYNLIIEW RPCTQLFWCL WALLQSGRLP
460 470 480 490 500
QRPLIEGEKL MSEKAGLGDE THLMEHKNKE NGKYDCSEDD SFNYLGFCKE
510 520 530
KMSVFWGDLI TLGVIDKDCP DIGKTDYLDT KLIF
Length:534
Mass (Da):61,657
Last modified:November 1, 1996 - v1
Checksum:i47B417841D5005A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50046 Genomic DNA Translation: CAA90370.1
BK006938 Genomic DNA Translation: DAA11990.1
PIRiS57974
RefSeqiNP_010431.3, NM_001180454.3

Genome annotation databases

EnsemblFungiiYDR147W; YDR147W; YDR147W
GeneIDi851725
KEGGisce:YDR147W

Similar proteinsi

Entry informationi

Entry nameiEKI1_YEAST
AccessioniPrimary (citable) accession number: Q03764
Secondary accession number(s): D6VSD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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