EKI1

Functionⁱ

Catalyzes the committed step of phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway. Also exhibits choline kinase activity but its preferred substrate is ethanolamine.

Miscellaneous

Present with 3420 molecules/cell in log phase SD medium.1 Publication

Catalytic activityⁱ

ATP + ethanolamine = ADP + O-phosphoethanolamine.

Pathwayⁱ: phosphatidylethanolamine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes phosphatidylethanolamine from ethanolamine.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:

Ethanolamine kinase (EKI1)
Ethanolamine-phosphate cytidylyltransferase (ECT1)
Choline/ethanolaminephosphotransferase 1 (EPT1)

This subpathway is part of the pathway phosphatidylethanolamine biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidylethanolamine from ethanolamine, the pathway phosphatidylethanolamine biosynthesis and in Phospholipid metabolism.

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
choline kinase activity
Source: SGD
Inferred from direct assayⁱ
- 10329685
ethanolamine kinase activity
Source: SGD
Inferred from direct assayⁱ
- 10329685

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

phosphatidylcholine biosynthetic process
Source: SGD
Inferred from mutant phenotypeⁱ
- 10329685
phosphatidylethanolamine biosynthetic process
Source: SGD
Inferred from mutant phenotypeⁱ
- 10329685

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Transferase
Biological process	Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCycⁱ	YEAST:YDR147W-MONOMER
Reactomeⁱ	R-SCE-1483191 Synthesis of PC R-SCE-1483213 Synthesis of PE
UniPathwayⁱ	UPA00558;UER00741

Chemistry databases

SwissLipidsⁱ	SLP:000000065

SwissLipidsⁱ

SLP:000000065

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ethanolamine kinase (EC:2.7.1.82) Short name: EK
Gene namesⁱ	Name:EKI1 Ordered Locus Names:YDR147W ORF Names:YD8358.04
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome IV

Organism-specific databases

EuPathDBⁱ	FungiDB:YDR147W
Saccharomyces Genome Database More...SGDⁱ	S000002554 EKI1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000206230	1 – 534	Ethanolamine kinaseAdd BLAST		534

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	23	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q03764
PaxDbⁱ	Q03764
PRIDEⁱ	Q03764

PTM databases

iPTMnetⁱ	Q03764

iPTMnetⁱ

Q03764

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	32201, 108 interactors
Molecular INTeraction database More...MINTⁱ	Q03764
STRINGⁱ	4932.YDR147W

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q03764
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the choline/ethanolamine kinase family.Curated

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000062991
HOGENOMⁱ	HOG000246747
InParanoidⁱ	Q03764
KEGG Orthology (KO) More...KOⁱ	K00894
OMAⁱ	PIAYDIT
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C0QOM

Family and domain databases

InterProⁱ	View protein in InterPro IPR007521 Choline_kin_N IPR011009 Kinase-like_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04428 Choline_kin_N, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q03764-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MYTNYSLTSS DAMPRTYLVG TASPEMSKKK RQSANCDKPT RRVIHIIDTN 
        60         70         80         90        100
EHSEVDLKNE LPITCTNEDG EMTSSSWTSQ TANDFLKLAY VNAKLDPSLP 
       110        120        130        140        150
SQYFKQDIIN VLQSLEIPGW SVPGSKESSL NKNLLTLTQI KGALTNVIYK 
       160        170        180        190        200
IHYPNLPPLL MRIFGDSIDS VIDREYELKV IARLSFYDLG PKLEGFFENG 
       210        220        230        240        250
RFEKYIEGSR TSTQADFIDR DTSIKIAKKL KELHCTVPLT HKEITDQPSC 
       260        270        280        290        300
WTTFDQWIKL IDSHKEWVSN NVNISENLRC SSWNFFLKSF KNYKRWLYND 
       310        320        330        340        350
SAFTSKLLRE DDKDSMINSG LKMVFCHNDL QHGNLLFKSK GKDDISVGDL 
       360        370        380        390        400
TIIDFEYAGP NPVVFDLSNH LNEWMQDYND VQSFKSHIDK YPKEEDILVF 
       410        420        430        440        450
AQSYINHMNE NHVKIASQEV RILYNLIIEW RPCTQLFWCL WALLQSGRLP 
       460        470        480        490        500
QRPLIEGEKL MSEKAGLGDE THLMEHKNKE NGKYDCSEDD SFNYLGFCKE 
       510        520        530 
KMSVFWGDLI TLGVIDKDCP DIGKTDYLDT KLIF

Length:534

Mass (Da):61,657

Last modified:November 1, 1996 - v1

Checksum:ⁱ47B417841D5005A8

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z50046 Genomic DNA Translation: CAA90370.1 BK006938 Genomic DNA Translation: DAA11990.1
PIRⁱ	S57974
NCBI Reference Sequences More...RefSeqⁱ	NP_010431.3, NM_001180454.3

Genome annotation databases

EnsemblFungiⁱ	YDR147W; YDR147W; YDR147W
GeneIDⁱ	851725
KEGGⁱ	sce:YDR147W

Protein	Similar proteins		Species	Score	Length	Source
Q03764	K7_Eki1p		YEASK		534	UniRef100_Q03764
Eki1p		YEASC		534

Protein	Similar proteins		Species	Score	Length	Source
Q03764	K7_Eki1p		YEASK		534	UniRef90_Q03764
Eki1p		YEASC		534
Ethanolamine kinase		YEAS1		534
EKI1p Ethanolamine kinase		Saccharomyces sp. 'boulardii'		534
Eki1p		YEAS8		534
+4

Protein	Similar proteins		Species	Score	Length	Source
Q03764	K7_Eki1p		YEASK		534	UniRef50_Q03764
Eki1p		YEASC		534
Eki1p		YEAS2		534
Ethanolamine kinase		YEAS1		534
EKI1p Ethanolamine kinase		Saccharomyces sp. 'boulardii'		534
+7

Entry informationⁱ

Entry nameⁱ	EKI1_YEAST
Accessionⁱ	Q03764Primary (citable) accession number: Q03764 Secondary accession number(s): D6VSD0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	November 1, 1996
	Last modified:	September 12, 2018
	This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB - Q03764 (EKI1_YEAST)

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Ethanolamine kinase

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Functionⁱ

Miscellaneous

Catalytic activityⁱ

Pathwayⁱ: phosphatidylethanolamine biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Enzyme and pathway databases

Chemistry databases

Names & Taxonomyⁱ

Organism-specific databases

PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

Interactionⁱ

Protein-protein interaction databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProt is an ELIXIR core data resource

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q03764 (EKI1_YEAST)

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Ethanolamine kinase

EKI1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: phosphatidylethanolamine biosynthesis

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

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Functionⁱ

Pathwayⁱ: phosphatidylethanolamine biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ