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Protein

DnaJ homolog subfamily C member 5 homolog

Gene

Csp

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May have an important role in presynaptic function.3 Publications

GO - Biological processi

  • exocytosis Source: FlyBase
  • negative regulation of response to wounding Source: FlyBase
  • neuron cellular homeostasis Source: FlyBase
  • protein folding Source: FlyBase
  • regulation of neuromuscular synaptic transmission Source: FlyBase
  • synaptic vesicle exocytosis Source: FlyBase

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

ReactomeiR-DME-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 5 homologBy similarity
Alternative name(s):
Cysteine string protein1 Publication
Gene namesi
Name:CspImported
ORF Names:CG6395
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0004179 Csp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000710751 – 249DnaJ homolog subfamily C member 5 homologAdd BLAST249

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12Phosphoserine1 Publication1
Modified residuei13Phosphothreonine1 Publication1
Modified residuei14Phosphoserine1 Publication1
Modified residuei17Phosphoserine1 Publication1
Modified residuei19Phosphotyrosine1 Publication1

Post-translational modificationi

Fatty acylated. Heavily palmitoylated in the cysteine string motif.1 Publication

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ03751
PRIDEiQ03751

PTM databases

iPTMnetiQ03751
SwissPalmiQ03751

Expressioni

Tissue specificityi

Expressed in wide range of synaptic terminals: embryonic nervous system, larval neuromuscular junctions, adult visual system (neuropil of optic ganglia and terminal of R1-8 photoreceptors) and thoracic neuromuscular junctions. Also expressed in non-neuronal cells: follicle cells, spermatheca, testis and ejaculatory bulb. Low level of expression is found in many neuronal and non-neuronal tissues.3 Publications

Gene expression databases

BgeeiFBgn0004179
ExpressionAtlasiQ03751 baseline and differential
GenevisibleiQ03751 DM

Interactioni

Protein-protein interaction databases

BioGridi65696, 8 interactors
IntActiQ03751, 2 interactors
STRINGi7227.FBpp0078146

Structurei

3D structure databases

ProteinModelPortaliQ03751
SMRiQ03751
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 84JPROSITE-ProRule annotationAdd BLAST70

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi121 – 131Poly-CysAdd BLAST11

Phylogenomic databases

eggNOGiKOG0716 Eukaryota
COG0484 LUCA
InParanoidiQ03751
KOiK09525
OrthoDBiEOG091G0QJP

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR018253 DnaJ_domain_CS
IPR036869 J_dom_sf
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
PROSITEiView protein in PROSITE
PS00636 DNAJ_1, 1 hit
PS50076 DNAJ_2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform CSP1 (identifier: Q03751-1) [UniParc]FASTAAdd to basket
Also known as: CSP32, B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAPGMDKRK LSTSGDSLYE ILGLPKTATG DDIKKTYRKL ALKYHPDKNP
60 70 80 90 100
DNVDAADKFK EVNRAHSILS NQTKRNIYDN YGSLGLYIAE QFGEENVNAY
110 120 130 140 150
FVVTSPAVKA VVICCAVITG CCCCCCCCCC CNFCCGKFKP PVNESHDQYS
160 170 180 190 200
HLNRPDGNRE GNDMPTHLGQ PPRLEDVDLD DVNLGAGGAP VTSQPREQAG
210 220 230 240
GQPVFAMPPP SGAVGVNPFT GAPVAANENT SLNTTEQTTY TPDMVNQKY
Length:249
Mass (Da):26,896
Last modified:October 1, 1996 - v1
Checksum:i3EF97C3BF2553EB8
GO
Isoform CSP2 (identifier: Q03751-2) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     154-174: Missing.

Show »
Length:228
Mass (Da):24,557
Checksum:iC0F94C47CCA55BE5
GO
Isoform CSP3 (identifier: Q03751-3) [UniParc]FASTAAdd to basket
Also known as: CSP29, A

The sequence of this isoform differs from the canonical sequence as follows:
     154-174: Missing.
     243-249: DMVNQKY → GI

Show »
Length:223
Mass (Da):23,848
Checksum:iB39935CBBB29D9D1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti71N → D in AAA28432 (PubMed:2129171).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001293154 – 174Missing in isoform CSP3 and isoform CSP2. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_001294243 – 249DMVNQKY → GI in isoform CSP3. 2 Publications7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63421 mRNA Translation: AAA28432.1
M63008 mRNA Translation: AAA28431.1
AF057167 Genomic DNA Translation: AAD09428.1
AF057167 Genomic DNA Translation: AAD09430.1
AF057167 Genomic DNA Translation: AAD09431.1
AE014296 Genomic DNA Translation: AAF51816.1
AE014296 Genomic DNA Translation: AAF51817.1
AE014296 Genomic DNA Translation: AAN12195.2
AY059457 mRNA Translation: AAL13363.1 Sequence problems.
RefSeqiNP_001287144.1, NM_001300215.1
NP_524213.1, NM_079489.3
NP_730713.1, NM_168949.2
NP_730714.2, NM_168950.4
UniGeneiDm.5140

Genome annotation databases

GeneIDi40459
KEGGidme:Dmel_CG6395

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiDNJC5_DROME
AccessioniPrimary (citable) accession number: Q03751
Secondary accession number(s): O61664
, O61665, Q95TD7, Q9VNV1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase

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