Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 84 (02 Jun 2021)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
Add a publicationFeedback
Protein

Pesticidal crystal protein Cry1Fa

Gene

cry1Fa

Organism
Bacillus thuringiensis subsp. aizawai
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes colloidosmotic lysis by binding to the midgut epithelial cells of many lepidopteran larvae.

Miscellaneous

Toxic segment of the protein is located in the N-terminus.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionToxin
Biological processSporulation, Virulence

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pesticidal crystal protein Cry1Fa
Alternative name(s):
134 kDa crystal protein
Crystaline entomocidal protoxin
Insecticidal delta-endotoxin CryIF(a)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cry1Fa
Synonyms:cryIF, cryIF(a)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacillus thuringiensis subsp. aizawai
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1433 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001740421 – 1174Pesticidal crystal protein Cry1FaAdd BLAST1174

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q03746

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

The crystal protein is produced during sporulation and is accumulated both as an inclusion and as part of the spore coat.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11174
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q03746

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the delta endotoxin family.Curated

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.190.10, 1 hit
2.100.10.10, 1 hit
2.60.120.260, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041587, Cry_V
IPR008979, Galactose-bd-like_sf
IPR038979, Pest_crys
IPR005638, Pest_crys_C
IPR005639, Pest_crys_N
IPR036716, Pest_crys_N_sf
IPR001178, Pest_cryst_cen_dom
IPR036399, Pest_cryst_cen_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR37003, PTHR37003, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17997, Cry1Ac_D5, 1 hit
PF03944, Endotoxin_C, 1 hit
PF00555, Endotoxin_M, 1 hit
PF03945, Endotoxin_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49785, SSF49785, 1 hit
SSF51096, SSF51096, 1 hit
SSF56849, SSF56849, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q03746-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MENNIQNQCV PYNCLNNPEV EILNEERSTG RLPLDISLSL TRFLLSEFVP
60 70 80 90 100
GVGVAFGLFD LIWGFITPSD WSLFLLQIEQ LIEQRIETLE RNRAITTLRG
110 120 130 140 150
LADSYEIYIE ALREWEANPN NAQLREDVRI RFANTDDALI TAINNFTLTS
160 170 180 190 200
FEIPLLSVYV QAANLHLSLL RDAVSFGQGW GLDIATVNNH YNRLINLIHR
210 220 230 240 250
YTKHCLDTYN QGLENLRGTN TRQWARFNQF RRDLTLTVLD IVALFPNYDV
260 270 280 290 300
RTYPIQTSSQ LTREIYTSSV IEDSPVSANI PNGFNRAEFG VRPPHLMDFM
310 320 330 340 350
NSLFVTAETV RSQTVWGGHL VSSRNTAGNR INFPSYGVFN PGGAIWIADE
360 370 380 390 400
DPRPFYRTLS DPVFVRGGFG NPHYVLGLRG VAFQQTGTNH TRTFRNSGTI
410 420 430 440 450
DSLDEIPPQD NSGAPWNDYS HVLNHVTFVR WPGEISGSDS WRAPMFSWTH
460 470 480 490 500
RSATPTNTID PERITQIPLV KAHTLQSGTT VVRGPGFTGG DILRRTSGGP
510 520 530 540 550
FAYTIVNING QLPQRYRARI RYASTTNLRI YVTVAGERIF AGQFNKTMDT
560 570 580 590 600
GDPLTFQSFS YATINTAFTF PMSQSSFTVG ADTFSSGNEV YIDRFELIPV
610 620 630 640 650
TATFEAEYDL ERAQKAVNAL FTSINQIGIK TDVTDYHIDQ VSNLVDCLSD
660 670 680 690 700
EFCLDEKREL SEKVKHAKRL SDERNLLQDP NFKGINRQLD RGWRGSTDIT
710 720 730 740 750
IQRGDDVFKE NYVTLPGTFD ECYPTYLYQK IDESKLKPYT RYQLRGYIED
760 770 780 790 800
SQDLEIYLIR YNAKHETVNV LGTGSLWPLS VQSPIRKCGE PNRCAPHLEW
810 820 830 840 850
NPDLDCSCRD GEKCAHHSHH FSLDIDVGCT DLNEDLDVWV IFKIKTQDGH
860 870 880 890 900
ARLGNLEFLE EKPLVGEALA RVKRAEKKWR DKREKLELET NIVYKEAKES
910 920 930 940 950
VDALFVNSQY DQLQADTNIA MIHAADKRVH RIREAYLPEL SVIPGVNVDI
960 970 980 990 1000
FEELKGRIFT AFFLYDARNV IKNGDFNNGL SCWNVKGHVD VEEQNNHRSV
1010 1020 1030 1040 1050
LVVPEWEAEV SQEVRVCPGR GYILRVTAYK EGYGEGCVTI HEIENNTDEL
1060 1070 1080 1090 1100
KFSNCVEEEV YPNNTVTCND YTANQEEYGG AYTSRNRGYD ETYGSNSSVP
1110 1120 1130 1140 1150
ADYASVYEEK SYTDGRRDNP CESNRGYGDY TPLPAGYVTK ELEYFPETDK
1160 1170
VWIEIGETEG TFIVDSVELL LMEE
Length:1,174
Mass (Da):133,622
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB51E9751D7F91C61
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M63897 Genomic DNA Translation: AAA22348.1
M73254 Genomic DNA Translation: AAA22347.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A42459

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63897 Genomic DNA Translation: AAA22348.1
M73254 Genomic DNA Translation: AAA22347.1
PIRiA42459

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6DJ4X-ray3.01A470-612[»]
SMRiQ03746
ModBaseiSearch...
PDBe-KBiSearch...

Proteomic databases

PRIDEiQ03746

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
Q03746, 4 sequenced antibodies

Family and domain databases

Gene3Di1.20.190.10, 1 hit
2.100.10.10, 1 hit
2.60.120.260, 2 hits
InterProiView protein in InterPro
IPR041587, Cry_V
IPR008979, Galactose-bd-like_sf
IPR038979, Pest_crys
IPR005638, Pest_crys_C
IPR005639, Pest_crys_N
IPR036716, Pest_crys_N_sf
IPR001178, Pest_cryst_cen_dom
IPR036399, Pest_cryst_cen_dom_sf
PANTHERiPTHR37003, PTHR37003, 1 hit
PfamiView protein in Pfam
PF17997, Cry1Ac_D5, 1 hit
PF03944, Endotoxin_C, 1 hit
PF00555, Endotoxin_M, 1 hit
PF03945, Endotoxin_N, 1 hit
SUPFAMiSSF49785, SSF49785, 1 hit
SSF51096, SSF51096, 1 hit
SSF56849, SSF56849, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCR1FA_BACTA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q03746
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: June 2, 2021
This is version 84 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again