UniProtKB - Q03735 (NAB6_YEAST)
Protein
RNA-binding protein NAB6
Gene
NAB6
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
RNA-binding protein that associates with mRNAs encoding cell wall proteins.1 Publication
Miscellaneous
Present with 1540 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- mRNA binding Source: SGD
Keywordsi
Molecular function | RNA-binding |
Enzyme and pathway databases
BioCyci | YEAST:G3O-32698-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: RNA-binding protein NAB6Alternative name(s): Nucleic acid-binding protein 6 |
Gene namesi | Name:NAB6 Ordered Locus Names:YML117W ORF Names:YM8339.02 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YML117W |
SGDi | S000004585, NAB6 |
Subcellular locationi
Other locations
- Cytoplasm 1 Publication
Other locations
- cytoplasm Source: SGD
- cytoplasmic stress granule Source: SGD
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Disruption phenotypei
Displays increased sensitivity to some cell wall disrupting agents including sodium dodecyl sulfate (SDS) and calcofluor white (CFW).1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000082034 | 2 – 1134 | RNA-binding protein NAB6Add BLAST | 1133 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
Modified residuei | 464 | PhosphoserineCombined sources | 1 | |
Modified residuei | 467 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
MaxQBi | Q03735 |
PaxDbi | Q03735 |
PRIDEi | Q03735 |
PTM databases
iPTMneti | Q03735 |
Expressioni
Inductioni
Expression down-regulated by cAMP.1 Publication
Interactioni
Binary interactionsi
Q03735
With | #Exp. | IntAct |
---|---|---|
PAP1 [P29468] | 2 | EBI-27955,EBI-12917 |
Protein-protein interaction databases
BioGRIDi | 35087, 151 interactors |
DIPi | DIP-2976N |
IntActi | Q03735, 21 interactors |
MINTi | Q03735 |
STRINGi | 4932.YML117W |
Miscellaneous databases
RNActi | Q03735, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 653 – 726 | RRMPROSITE-ProRule annotationAdd BLAST | 74 |
Phylogenomic databases
eggNOGi | KOG0118, Eukaryota |
GeneTreei | ENSGT00390000002792 |
HOGENOMi | CLU_276472_0_0_1 |
InParanoidi | Q03735 |
OMAi | SDVMAQY |
Family and domain databases
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR039171, Cwc2/Slt11 IPR018885, mRNA-bd_dom IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR018835, RNA-binding_domain_put IPR000504, RRM_dom |
PANTHERi | PTHR14089, PTHR14089, 1 hit |
Pfami | View protein in Pfam PF10567, Nab6_mRNP_bdg, 1 hit PF10378, RRM, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q03735-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSNSNSKKPV ANYAYRQQQD YNGMNAMVGN PMMYHPVDFV NGAGQYGPSQ
60 70 80 90 100
HPAYYTNSPL PNIPPTPFDT AYGASLFPSH LLMGSPFVSS PNMQSGYNSA
110 120 130 140 150
RSSNLKRKAY SRPVSNHNGY NGNSNSNQNN TNNGMVTPSN YYRMGRNSFS
160 170 180 190 200
RNNNSTRNVT HNNNKGCDTR NNSGRRTFAR NNIFDDILPE MLLQRPFCIN
210 220 230 240 250
YKVLPTGDDA YRTRSLLIEN VDHSIDLHSI VKNFVKSNTL ESAYLIEGGK
260 270 280 290 300
SDDSKDVETK NLSILISFLT KGDCLNFYNN ILQRLSEFKT FLKSEALNLK
310 320 330 340 350
FVCLNYDPKC LPTFIESEAL TENAEEADIT NGSTMISASL HHNIANKDAT
360 370 380 390 400
RSIIIEFKSP VEKSDLFKKK LQFLDRSKNK RYILESIDLV NTDVPSNQFP
410 420 430 440 450
ENYAVLTFLN ISMAIEVLDY LKKYSKNLGI SKCFYVSLAP LVVSSARSSV
460 470 480 490 500
ANIYEGKTST HRLSVPSVTA GNNNDSNNNG NNNKSNMSGI TTLNNNSSIG
510 520 530 540 550
VSVYGHSNMS LTSLSSSVSL NEEIDMLATK LQGVELDGTY LEINYRDYQT
560 570 580 590 600
PTIEEHSTHL SNVKISKTTE NSRQFSQDIP SPLPLNEHMF MNDSNQSNGA
610 620 630 640 650
IIPQQLIATP SPVSPNLQMN QRVLPNPITQ SLEQNFNVSA KVASSMGSDI
660 670 680 690 700
GNRTIYIGNI NPRSKAEDIC NVVRGGILQS IKYIPEKKIC FVTFIEAPSA
710 720 730 740 750
VQFYANSFID PIVLHGNMLR VGWGHYSGPL PKLISLAVTI GASRNVYVSL
760 770 780 790 800
PEFAFKEKFI HDPQYKKLHE TLSLPDAEQL REDFSTYGDI EQINYLSDSH
810 820 830 840 850
CCWINFMNIS SAISLVEEMN KESTVQNESG EVTLKRATEE KFGGRYKGLL
860 870 880 890 900
INYGKDRCGN INKNLIAGKN SRFYKKVKRP SYNIRLSKLE EKRRQNEIDE
910 920 930 940 950
KEKAFDKPLN LESLGISLDA HKDNGGGETG TANNTGHENE SELEAENENG
960 970 980 990 1000
NETGSFGGLG LAVASSDVKR ATSDETDYED IFNKSSGSSD SSSDVEVIMH
1010 1020 1030 1040 1050
SPSDPEYALK SQTLRSSSQT VINSKRPVKI EDEEEAVGMS QLNYRSSLRQ
1060 1070 1080 1090 1100
APPRAPSTLS YNHSKNNETP MQDIFTNGET ANNRKKKRGS FARHRTIPGS
1110 1120 1130
DVMAQYLAQV QHSTFMYAAN ILGASAEDNT HPDE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z49210 Genomic DNA Translation: CAA89101.1 BK006946 Genomic DNA Translation: DAA09781.1 |
PIRi | S53955 |
RefSeqi | NP_013589.1, NM_001182479.1 |
Genome annotation databases
EnsemblFungii | YML117W_mRNA; YML117W; YML117W |
GeneIDi | 854922 |
KEGGi | sce:YML117W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z49210 Genomic DNA Translation: CAA89101.1 BK006946 Genomic DNA Translation: DAA09781.1 |
PIRi | S53955 |
RefSeqi | NP_013589.1, NM_001182479.1 |
3D structure databases
SMRi | Q03735 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 35087, 151 interactors |
DIPi | DIP-2976N |
IntActi | Q03735, 21 interactors |
MINTi | Q03735 |
STRINGi | 4932.YML117W |
PTM databases
iPTMneti | Q03735 |
Proteomic databases
MaxQBi | Q03735 |
PaxDbi | Q03735 |
PRIDEi | Q03735 |
Genome annotation databases
EnsemblFungii | YML117W_mRNA; YML117W; YML117W |
GeneIDi | 854922 |
KEGGi | sce:YML117W |
Organism-specific databases
EuPathDBi | FungiDB:YML117W |
SGDi | S000004585, NAB6 |
Phylogenomic databases
eggNOGi | KOG0118, Eukaryota |
GeneTreei | ENSGT00390000002792 |
HOGENOMi | CLU_276472_0_0_1 |
InParanoidi | Q03735 |
OMAi | SDVMAQY |
Enzyme and pathway databases
BioCyci | YEAST:G3O-32698-MONOMER |
Miscellaneous databases
PROi | PR:Q03735 |
RNActi | Q03735, protein |
Family and domain databases
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR039171, Cwc2/Slt11 IPR018885, mRNA-bd_dom IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR018835, RNA-binding_domain_put IPR000504, RRM_dom |
PANTHERi | PTHR14089, PTHR14089, 1 hit |
Pfami | View protein in Pfam PF10567, Nab6_mRNP_bdg, 1 hit PF10378, RRM, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NAB6_YEAST | |
Accessioni | Q03735Primary (citable) accession number: Q03735 Secondary accession number(s): D6W0G7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | October 7, 2020 | |
This is version 162 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast chromosome XIII
Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names - Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD