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Protein

Capsid protein

Gene

HBcAg

Organism
Hepatitis B virus (HBV)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Encapsidates hepatitis delta genome.UniRule annotation
May regulate immune response to the intracellular capsid in acting as a T-cell tolerogen, by having an immunoregulatory effect which prevents destruction of infected cells by cytotoxic T-cells.UniRule annotation
Self assembles to form an icosahedral capsid. Most capsid appear to be large particles with a icosahedral symmetry of T=4 and consist of 240 copies of capsid protein, though a fraction forms smaller T=3 particles consisting of 180 capsid proteins. Entering capsid are transported along microtubules to the nucleus. Phosphorylation of the capsid is thought to induce exposure of nuclear localization signal in the C-terminal portion of the capsid protein that allows binding to the nuclear pore complex via the importin (karyopherin-) alpha and beta. Capsids are imported in intact form through the nuclear pore into the nuclear basket, where it probably binds NUP153. Only capsids that contain the mature viral genome can release the viral DNA and capsid protein into the nucleoplasm. Immature capsids get stucked in the basket. Capsids encapsulate the pre-genomic RNA and the P protein. Pre-genomic RNA is reverse transcribed into DNA while the capsid is still in the cytoplasm. The capsid can then either be directed to the nucleus, providing more genome for transcription, or bud through the endoplasmic reticulum to provide new virions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation, RNA-bindingUniRule annotation
Biological processCytoplasmic inwards viral transport, Host-virus interaction, Microtubular inwards viral transportUniRule annotation, Viral immunoevasionUniRule annotation, Viral penetration into host nucleusUniRule annotation, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Capsid proteinUniRule annotation
Alternative name(s):
Core antigenUniRule annotation
Core proteinUniRule annotation
HBcAgUniRule annotation
p21.5UniRule annotation
Gene namesi
Name:HBcAgImported
Synonyms:CUniRule annotation
OrganismiHepatitis B virus (HBV)Imported
Taxonomic identifieri10407 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesHepadnaviridaeOrthohepadnavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Pan troglodytes (Chimpanzee) [TaxID: 9598]

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Host cytoplasmUniRule annotation, T=4 icosahedral capsid proteinUniRule annotation, Virion

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075091

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei202Phosphoserine; by hostUniRule annotation1
Modified residuei209Phosphoserine; by hostUniRule annotation1
Modified residuei217Phosphoserine; by hostUniRule annotation1

Post-translational modificationi

Cleaved by host furin.UniRule annotation
Phosphorylated by host SRPK1, SRPK2, and maybe protein kinase C or GAPDH. Phosphorylation is critical for pregenomic RNA packaging. Protein kinase C phosphorylation is stimulated by HBx protein and may play a role in transport of the viral genome to the nucleus at the late step during viral replication cycle.UniRule annotation

Keywords - PTMi

PhosphoproteinUniRule annotation

Interactioni

Subunit structurei

Homodimerizes, then multimerizes. Interacts with cytosol exposed regions of viral L glycoprotein present in the reticulum-to-Golgi compartment. Interacts with human FLNB. Phosphorylated form interacts with host importin alpha; this interaction depends on the exposure of the NLS, which itself depends upon genome maturation and/or phosphorylation of the capsid protein. Interacts with host NUP153.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ03732
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 45Hep_core_NInterPro annotationAdd BLAST25

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni224 – 230RNA bindingUniRule annotation7

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi205 – 222Bipartite nuclear localization signalUniRule annotationAdd BLAST18

Sequence similaritiesi

Belongs to the orthohepadnavirus core antigen family.UniRule annotation
Belongs to the orthohepadnavirus precore antigen family.UniRule annotation

Keywords - Domaini

RepeatUniRule annotationSAAS annotation

Family and domain databases

Gene3Di1.10.4090.10, 1 hit
HAMAPiMF_04076 HBV_HBEAG, 1 hit
InterProiView protein in InterPro
IPR013195 Hepatitis_B_virus_capsid_N
IPR002006 Hepatitis_core
IPR036459 Viral_capsid_core_dom_sf_HBV
PfamiView protein in Pfam
PF08290 Hep_core_N, 1 hit
PF00906 Hepatitis_core, 2 hits
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000874 Vir_capsid_Znf-put_N_Hepatitis, 1 hit
SUPFAMiSSF47852 SSF47852, 1 hit

Sequencei

Sequence statusi: Complete.

Q03732-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIFVLGGCRH KLVCSPAPCN FFHLCLIISC SCPTVHASKL CLGWLWGMHI
60 70 80 90 100
DPYKEFGASV ELLSFLPSDF FPSIRDLLDT ASALYREALE SPEHCSPHHT
110 120 130 140 150
ALRQAILCWG ELMNLATWVG SNLEDPASRE LVVSYVNVNM GLKIRQLLWF
160 170 180 190 200
HISCLTFGRE TVLEYLVSFG VWIRTPPAYR PPNAPILSTL PETTVVRRRG
210 220 230
RSPRRRTPSP RRRRSQSPRR RRSQSRESQC
Length:230
Mass (Da):26,263
Last modified:November 1, 1996 - v1
Checksum:i4DAF2BDA13032C3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M38594 Genomic DNA Translation: AAA45490.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M38594 Genomic DNA Translation: AAA45490.1

3D structure databases

ProteinModelPortaliQ03732
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

ChEMBLiCHEMBL1075091

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.4090.10, 1 hit
HAMAPiMF_04076 HBV_HBEAG, 1 hit
InterProiView protein in InterPro
IPR013195 Hepatitis_B_virus_capsid_N
IPR002006 Hepatitis_core
IPR036459 Viral_capsid_core_dom_sf_HBV
PfamiView protein in Pfam
PF08290 Hep_core_N, 1 hit
PF00906 Hepatitis_core, 2 hits
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000874 Vir_capsid_Znf-put_N_Hepatitis, 1 hit
SUPFAMiSSF47852 SSF47852, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ03732_HBV
AccessioniPrimary (citable) accession number: Q03732
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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