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Protein

Transport/processing ATP-binding protein ComA

Gene

comA

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Required for induction of competence. Seems to transport the competence-stimulating peptide (CSP).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei17PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi517 – 524ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processCompetence, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPNE170187:G1FZB-47-MONOMER

Protein family/group databases

MEROPSiC39.001
TCDBi3.A.1.112.1 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Transport/processing ATP-binding protein ComA (EC:3.4.22.-)
Gene namesi
Name:comA
Ordered Locus Names:SP_0042
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000585 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei166 – 186HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei205 – 225HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei237 – 257HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei282 – 302HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei306 – 326HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei397 – 417HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000922341 – 717Transport/processing ATP-binding protein ComAAdd BLAST717

Structurei

3D structure databases

ProteinModelPortaliQ03727
SMRiQ03727
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 138Peptidase C39PROSITE-ProRule annotationAdd BLAST128
Domaini168 – 450ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST283
Domaini484 – 717ABC transporterPROSITE-ProRule annotationAdd BLAST234

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108JJA Bacteria
COG2274 LUCA
HOGENOMiHOG000097319
KOiK12292
OMAiPYYMQWV

Family and domain databases

Gene3Di1.20.1560.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
IPR005897 Pept_C39_ABC_bacteriocin
IPR005074 Peptidase_C39
PfamiView protein in Pfam
PF00664 ABC_membrane, 1 hit
PF00005 ABC_tran, 1 hit
PF03412 Peptidase_C39, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF90123 SSF90123, 1 hit
TIGRFAMsiTIGR01193 bacteriocin_ABC, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit
PS50990 PEPTIDASE_C39, 1 hit

Sequencei

Sequence statusi: Complete.

Q03727-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFGKRHYRP QVDQMDCGVA SLAMVFGYYG SYYFLAHLRE LAKTTMDGTT
60 70 80 90 100
ALGLVKVAEE IGFETRAIKA DMTLFDLPDL TFPFVAHVLK EGKLLHYYVV
110 120 130 140 150
TGQDKDSIHI ADPDPGVKLT KLPRERFEEE WTGVTLFMAP SPDYKPHKEQ
160 170 180 190 200
KNGLLSFIPI LVKQRGLIAN IVLATLLVTV INIVGSYYLQ SIIDTYVPDQ
210 220 230 240 250
MRSTLGIISI GLVIVYIFQQ ILSYAQEYLL LVLGQRLSID VILSYIKHVF
260 270 280 290 300
HLPMSFFATR RTGEIVSRFT DANSIIDALA STILSIFLDV STVVIISLVL
310 320 330 340 350
FSQNTNLFFM TLLALPIYTV IIFAFMKPFE KMNRDTMEAN AVLSSSIIED
360 370 380 390 400
INGIETIKSL TSESQRYQKI DKEFVDYLKK SFTYSRAESQ QKALKKVAHL
410 420 430 440 450
LLNVGILWMG AVLVMDGKMS LGQLITYNTL LVYFTNPLEN IINLQTKLQT
460 470 480 490 500
AQVANNRLNE VYLVASEFEE KKTVEDLSLM KGDMTFKQVH YKYGYGRDVL
510 520 530 540 550
SDINLTVPQG SKVAFVGISG SGKTTLAKMM VNFYDPSQGE ISLGSVNLNQ
560 570 580 590 600
IDKKALRQYI NYLSQQPYVF NGTILENLLL GAKEGTTQED ILRAVELAEI
610 620 630 640 650
REDIERMPLN YQTELTSDGA GISGGQRQRI ALARALLTDA PVLILDEATS
660 670 680 690 700
SLDILTEKRI VDNLIALDKT LIFIAHRLTI AERTEKVVVL DQGKIVEEGK
710
HADLLAQGGF YAHLVNS
Length:717
Mass (Da):80,404
Last modified:September 26, 2001 - v3
Checksum:i06A51085A902F608
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti218F → L in AAA69510 (PubMed:1987129).Curated1
Sequence conflicti545S → G in AAA69510 (PubMed:1987129).Curated1
Sequence conflicti564S → P in AAA69510 (PubMed:1987129).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36180 Genomic DNA Translation: AAA69510.1
AE005672 Genomic DNA Translation: AAK74231.1
PIRiA39203
C97877
F95004
RefSeqiWP_000668284.1, NZ_AKVY01000001.1

Genome annotation databases

EnsemblBacteriaiAAK74231; AAK74231; SP_0042
KEGGispn:SP_0042

Similar proteinsi

Entry informationi

Entry nameiCOMA_STRPN
AccessioniPrimary (citable) accession number: Q03727
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: September 26, 2001
Last modified: February 28, 2018
This is version 142 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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