UniProtKB - Q03727 (COMA_STRPN)
Protein
Transport/processing ATP-binding protein ComA
Gene
comA
Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Functioni
Required for induction of competence. Seems to transport the competence-stimulating peptide (CSP).
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 17 | PROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 517 – 524 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATPase-coupled bacteriocin transmembrane transporter activity Source: InterPro
- ATP binding Source: UniProtKB-KW
- cysteine-type peptidase activity Source: UniProtKB-KW
GO - Biological processi
- establishment of competence for transformation Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase, Protease, Thiol protease, Translocase |
Biological process | Competence, Transport |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | SPNE170187:G1FZB-47-MONOMER |
Protein family/group databases
MEROPSi | C39.001 |
TCDBi | 3.A.1.112.1, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:comA Ordered Locus Names:SP_0042 |
Organismi | Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) |
Taxonomic identifieri | 170187 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › |
Proteomesi |
|
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 166 – 186 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 205 – 225 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 237 – 257 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 282 – 302 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 306 – 326 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 397 – 417 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 |
GO - Cellular componenti
- integral component of membrane Source: UniProtKB-KW
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000092234 | 1 – 717 | Transport/processing ATP-binding protein ComAAdd BLAST | 717 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 11 – 138 | Peptidase C39PROSITE-ProRule annotationAdd BLAST | 128 | |
Domaini | 168 – 450 | ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST | 283 | |
Domaini | 484 – 717 | ABC transporterPROSITE-ProRule annotationAdd BLAST | 234 |
Sequence similaritiesi
Belongs to the ABC transporter superfamily. Competence factor exporter (TC 3.A.1.112.1) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG2274, Bacteria |
OMAi | PYYMQWV |
Family and domain databases
Gene3Di | 1.20.1560.10, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR027417, P-loop_NTPase IPR005897, Pept_C39_ABC_bacteriocin IPR005074, Peptidase_C39 IPR039421, Type_I_exporter |
PANTHERi | PTHR24221, PTHR24221, 1 hit |
Pfami | View protein in Pfam PF00664, ABC_membrane, 1 hit PF00005, ABC_tran, 1 hit PF03412, Peptidase_C39, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF90123, SSF90123, 1 hit |
TIGRFAMsi | TIGR01193, bacteriocin_ABC, 1 hit |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 1 hit PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit PS50990, PEPTIDASE_C39, 1 hit |
i Sequence
Sequence statusi: Complete.
Q03727-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKFGKRHYRP QVDQMDCGVA SLAMVFGYYG SYYFLAHLRE LAKTTMDGTT
60 70 80 90 100
ALGLVKVAEE IGFETRAIKA DMTLFDLPDL TFPFVAHVLK EGKLLHYYVV
110 120 130 140 150
TGQDKDSIHI ADPDPGVKLT KLPRERFEEE WTGVTLFMAP SPDYKPHKEQ
160 170 180 190 200
KNGLLSFIPI LVKQRGLIAN IVLATLLVTV INIVGSYYLQ SIIDTYVPDQ
210 220 230 240 250
MRSTLGIISI GLVIVYIFQQ ILSYAQEYLL LVLGQRLSID VILSYIKHVF
260 270 280 290 300
HLPMSFFATR RTGEIVSRFT DANSIIDALA STILSIFLDV STVVIISLVL
310 320 330 340 350
FSQNTNLFFM TLLALPIYTV IIFAFMKPFE KMNRDTMEAN AVLSSSIIED
360 370 380 390 400
INGIETIKSL TSESQRYQKI DKEFVDYLKK SFTYSRAESQ QKALKKVAHL
410 420 430 440 450
LLNVGILWMG AVLVMDGKMS LGQLITYNTL LVYFTNPLEN IINLQTKLQT
460 470 480 490 500
AQVANNRLNE VYLVASEFEE KKTVEDLSLM KGDMTFKQVH YKYGYGRDVL
510 520 530 540 550
SDINLTVPQG SKVAFVGISG SGKTTLAKMM VNFYDPSQGE ISLGSVNLNQ
560 570 580 590 600
IDKKALRQYI NYLSQQPYVF NGTILENLLL GAKEGTTQED ILRAVELAEI
610 620 630 640 650
REDIERMPLN YQTELTSDGA GISGGQRQRI ALARALLTDA PVLILDEATS
660 670 680 690 700
SLDILTEKRI VDNLIALDKT LIFIAHRLTI AERTEKVVVL DQGKIVEEGK
710
HADLLAQGGF YAHLVNS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 218 | F → L in AAA69510 (PubMed:1987129).Curated | 1 | |
Sequence conflicti | 545 | S → G in AAA69510 (PubMed:1987129).Curated | 1 | |
Sequence conflicti | 564 | S → P in AAA69510 (PubMed:1987129).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M36180 Genomic DNA Translation: AAA69510.1 AE005672 Genomic DNA Translation: AAK74231.1 |
PIRi | A39203 C97877 F95004 |
RefSeqi | WP_000668284.1, NZ_AKVY01000001.1 |
Genome annotation databases
EnsemblBacteriai | AAK74231; AAK74231; SP_0042 |
KEGGi | spn:SP_0042 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M36180 Genomic DNA Translation: AAA69510.1 AE005672 Genomic DNA Translation: AAK74231.1 |
PIRi | A39203 C97877 F95004 |
RefSeqi | WP_000668284.1, NZ_AKVY01000001.1 |
3D structure databases
SMRi | Q03727 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 170187.SP_0042 |
Protein family/group databases
MEROPSi | C39.001 |
TCDBi | 3.A.1.112.1, the atp-binding cassette (abc) superfamily |
Genome annotation databases
EnsemblBacteriai | AAK74231; AAK74231; SP_0042 |
KEGGi | spn:SP_0042 |
Phylogenomic databases
eggNOGi | COG2274, Bacteria |
OMAi | PYYMQWV |
Enzyme and pathway databases
BioCyci | SPNE170187:G1FZB-47-MONOMER |
Family and domain databases
Gene3Di | 1.20.1560.10, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR027417, P-loop_NTPase IPR005897, Pept_C39_ABC_bacteriocin IPR005074, Peptidase_C39 IPR039421, Type_I_exporter |
PANTHERi | PTHR24221, PTHR24221, 1 hit |
Pfami | View protein in Pfam PF00664, ABC_membrane, 1 hit PF00005, ABC_tran, 1 hit PF03412, Peptidase_C39, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF90123, SSF90123, 1 hit |
TIGRFAMsi | TIGR01193, bacteriocin_ABC, 1 hit |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 1 hit PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit PS50990, PEPTIDASE_C39, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | COMA_STRPN | |
Accessioni | Q03727Primary (citable) accession number: Q03727 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | September 26, 2001 | |
Last modified: | December 2, 2020 | |
This is version 153 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |