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UniProtKB - Q03719 (KCND1_MOUSE)
Protein
Potassium voltage-gated channel subfamily D member 1
Gene
Kcnd1
Organism
Mus musculus (Mouse)
Status
Functioni
Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in the heart and I(Sa) current in neurons. Channel properties are modulated by subunit assembly.
1 PublicationSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 104 | ZincBy similarity | 1 | |
Metal bindingi | 131 | ZincBy similarity | 1 | |
Metal bindingi | 132 | ZincBy similarity | 1 |
GO - Molecular functioni
- A-type (transient outward) potassium channel activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- voltage-gated potassium channel activity Source: GO_Central
GO - Biological processi
- potassium ion transmembrane transport Source: GO_Central
- protein homooligomerization Source: InterPro
- regulation of ion transmembrane transport Source: UniProtKB-KW
Keywordsi
Molecular function | Ion channel, Potassium channel, Voltage-gated channel |
Biological process | Ion transport, Potassium transport, Transport |
Ligand | Metal-binding, Potassium, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-1296072, Voltage gated Potassium channels R-MMU-5576894, Phase 1 - inactivation of fast Na+ channels |
Names & Taxonomyi
Protein namesi | Recommended name: Potassium voltage-gated channel subfamily D member 1Alternative name(s): Voltage-gated potassium channel subunit Kv4.1 Short name: mShal |
Gene namesi | Name:Kcnd1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96671, Kcnd1 |
VEuPathDBi | HostDB:ENSMUSG00000009731 |
Subcellular locationi
Other locations
- Membrane ; Multi-pass membrane protein
- dendrite By similarity
Plasma Membrane
- postsynaptic membrane Source: GO_Central
- voltage-gated potassium channel complex Source: GO_Central
Other locations
- dendritic spine Source: GO_Central
- integral component of membrane Source: GO_Central
- neuronal cell body Source: MGI
- postsynaptic density Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 184 | CytoplasmicSequence analysisAdd BLAST | 184 | |
Transmembranei | 185 – 205 | Helical; Name=Segment S1Sequence analysisAdd BLAST | 21 | |
Transmembranei | 227 – 247 | Helical; Name=Segment S2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 248 – 261 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 262 – 282 | Helical; Name=Segment S3Sequence analysisAdd BLAST | 21 | |
Transmembranei | 292 – 312 | Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 313 – 325 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 326 – 346 | Helical; Name=Segment S5Sequence analysisAdd BLAST | 21 | |
Intramembranei | 365 – 385 | Pore-forming; Name=Segment H5Sequence analysisAdd BLAST | 21 | |
Transmembranei | 387 – 407 | Helical; Name=Segment S6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 408 – 651 | CytoplasmicSequence analysisAdd BLAST | 244 |
Keywords - Cellular componenti
Cell projection, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000054062 | 1 – 651 | Potassium voltage-gated channel subfamily D member 1Add BLAST | 651 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 355 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 458 | PhosphoserineCombined sources | 1 | |
Modified residuei | 555 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
MaxQBi | Q03719 |
PaxDbi | Q03719 |
PRIDEi | Q03719 |
ProteomicsDBi | 269260 |
PTM databases
GlyGeni | Q03719, 1 site |
iPTMneti | Q03719 |
PhosphoSitePlusi | Q03719 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000009731, Expressed in dorsal root ganglion and 121 other tissues |
ExpressionAtlasi | Q03719, baseline and differential |
Genevisiblei | Q03719, MM |
Interactioni
Subunit structurei
Homotetramer or heterotetramer with KCND2 and/or KCND3. Associates with the regulatory subunits KCNIP1, KCNIP2, KCNIP3 and KCNIP4.
Interacts with DPP10 (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 200889, 2 interactors |
IntActi | Q03719, 1 interactor |
MINTi | Q03719 |
STRINGi | 10090.ENSMUSP00000009875 |
Miscellaneous databases
RNActi | Q03719, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2 – 20 | Interaction with KCNIP2By similarityAdd BLAST | 19 | |
Regioni | 144 – 164 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 474 – 489 | Mediates dendritic targetingBy similarityAdd BLAST | 16 | |
Regioni | 566 – 585 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 601 – 651 | DisorderedSequence analysisAdd BLAST | 51 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 372 – 377 | Selectivity filterBy similarity | 6 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 568 – 582 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 612 – 651 | Polar residuesSequence analysisAdd BLAST | 40 |
Domaini
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Sequence similaritiesi
Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.1/KCND1 sub-subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4390, Eukaryota |
GeneTreei | ENSGT00940000162057 |
HOGENOMi | CLU_011722_9_1_1 |
InParanoidi | Q03719 |
OMAi | FPTAFFC |
OrthoDBi | 469107at2759 |
PhylomeDBi | Q03719 |
TreeFami | TF313103 |
Family and domain databases
Gene3Di | 1.20.120.350, 1 hit 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR005821, Ion_trans_dom IPR003968, K_chnl_volt-dep_Kv IPR003975, K_chnl_volt-dep_Kv4 IPR004054, K_chnl_volt-dep_Kv4.1 IPR024587, K_chnl_volt-dep_Kv4_C IPR021645, Shal-type_N IPR011333, SKP1/BTB/POZ_sf IPR003131, T1-type_BTB IPR028325, VG_K_chnl IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR11537, PTHR11537, 1 hit |
Pfami | View protein in Pfam PF02214, BTB_2, 1 hit PF11879, DUF3399, 1 hit PF00520, Ion_trans, 1 hit PF11601, Shal-type, 1 hit |
PRINTSi | PR01516, KV41CHANNEL PR01491, KVCHANNEL PR01497, SHALCHANNEL |
SMARTi | View protein in SMART SM00225, BTB, 1 hit |
SUPFAMi | SSF54695, SSF54695, 1 hit |
i Sequence
Sequence statusi: Complete.
Q03719-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAGVATWLP FARAAAVGWL PLAQQPLPPA PEVKASRGDE VLVVNVSGRR
60 70 80 90 100
FETWKNTLDR YPDTLLGSSE KEFFYDAESG EYFFDRDPDM FRHVLNFYRT
110 120 130 140 150
GRLHCPRQEC IQAFDEELAF YGLVPELVGD CCLEEYRDRK KENAERLAED
160 170 180 190 200
EEAEQAGEGP ALPAGSSLRQ RLWRAFENPH TSTAALVFYY VTGFFIAVSV
210 220 230 240 250
IANVVETIPC RGTPRWPSKE QSCGDRFPTA FFCMDTACVL IFTGEYLLRL
260 270 280 290 300
FAAPSRCRFL RSVMSLIDVV AILPYYIGLF VPKNDDVSGA FVTLRVFRVF
310 320 330 340 350
RIFKFSRHSQ GLRILGYTLK SCASELGFLL FSLTMAIIIF ATVMFYAEKG
360 370 380 390 400
TSKTNFTSIP AAFWYTIVTM TTLGYGDMVP STIAGKIFGS ICSLSGVLVI
410 420 430 440 450
ALPVPVIVSN FSRIYHQNQR ADKRRAQQKV RLARIRLAKS GTTNAFLQYK
460 470 480 490 500
QNGGLEDSGS GDGQMLCVRS RSAFEQQHHH LLHCLEKTTC HEFTDELTFS
510 520 530 540 550
EALGAVSLGG RTSRSTSVSS QPMGPGSLFS SCCSRRVNRR AIRLANSTAS
560 570 580 590 600
VSRGSMQELD TLAGLRRSPA PQTRSSLNAK PHDSLDLNCD SRDFVAAIIS
610 620 630 640 650
IPTPPANTPD ESQPSSPSGG GGSGGTPNTT LRNSSLGTPC LLPETVKISS
L
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M64226 mRNA Translation: AAA39745.1 AK033805 mRNA Translation: BAC28480.1 |
CCDSi | CCDS29974.1 |
PIRi | A39372 |
RefSeqi | NP_032449.1, NM_008423.2 |
Genome annotation databases
Ensembli | ENSMUST00000009875; ENSMUSP00000009875; ENSMUSG00000009731 |
GeneIDi | 16506 |
KEGGi | mmu:16506 |
UCSCi | uc009sms.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M64226 mRNA Translation: AAA39745.1 AK033805 mRNA Translation: BAC28480.1 |
CCDSi | CCDS29974.1 |
PIRi | A39372 |
RefSeqi | NP_032449.1, NM_008423.2 |
3D structure databases
AlphaFoldDBi | Q03719 |
SMRi | Q03719 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 200889, 2 interactors |
IntActi | Q03719, 1 interactor |
MINTi | Q03719 |
STRINGi | 10090.ENSMUSP00000009875 |
Chemistry databases
GuidetoPHARMACOLOGYi | 552 |
PTM databases
GlyGeni | Q03719, 1 site |
iPTMneti | Q03719 |
PhosphoSitePlusi | Q03719 |
Proteomic databases
MaxQBi | Q03719 |
PaxDbi | Q03719 |
PRIDEi | Q03719 |
ProteomicsDBi | 269260 |
Protocols and materials databases
Antibodypediai | 370, 260 antibodies from 31 providers |
DNASUi | 16506 |
Genome annotation databases
Ensembli | ENSMUST00000009875; ENSMUSP00000009875; ENSMUSG00000009731 |
GeneIDi | 16506 |
KEGGi | mmu:16506 |
UCSCi | uc009sms.1, mouse |
Organism-specific databases
CTDi | 3750 |
MGIi | MGI:96671, Kcnd1 |
VEuPathDBi | HostDB:ENSMUSG00000009731 |
Phylogenomic databases
eggNOGi | KOG4390, Eukaryota |
GeneTreei | ENSGT00940000162057 |
HOGENOMi | CLU_011722_9_1_1 |
InParanoidi | Q03719 |
OMAi | FPTAFFC |
OrthoDBi | 469107at2759 |
PhylomeDBi | Q03719 |
TreeFami | TF313103 |
Enzyme and pathway databases
Reactomei | R-MMU-1296072, Voltage gated Potassium channels R-MMU-5576894, Phase 1 - inactivation of fast Na+ channels |
Miscellaneous databases
BioGRID-ORCSi | 16506, 6 hits in 74 CRISPR screens |
ChiTaRSi | Kcnd1, mouse |
PROi | PR:Q03719 |
RNActi | Q03719, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000009731, Expressed in dorsal root ganglion and 121 other tissues |
ExpressionAtlasi | Q03719, baseline and differential |
Genevisiblei | Q03719, MM |
Family and domain databases
Gene3Di | 1.20.120.350, 1 hit 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR005821, Ion_trans_dom IPR003968, K_chnl_volt-dep_Kv IPR003975, K_chnl_volt-dep_Kv4 IPR004054, K_chnl_volt-dep_Kv4.1 IPR024587, K_chnl_volt-dep_Kv4_C IPR021645, Shal-type_N IPR011333, SKP1/BTB/POZ_sf IPR003131, T1-type_BTB IPR028325, VG_K_chnl IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR11537, PTHR11537, 1 hit |
Pfami | View protein in Pfam PF02214, BTB_2, 1 hit PF11879, DUF3399, 1 hit PF00520, Ion_trans, 1 hit PF11601, Shal-type, 1 hit |
PRINTSi | PR01516, KV41CHANNEL PR01491, KVCHANNEL PR01497, SHALCHANNEL |
SMARTi | View protein in SMART SM00225, BTB, 1 hit |
SUPFAMi | SSF54695, SSF54695, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | KCND1_MOUSE | |
Accessioni | Q03719Primary (citable) accession number: Q03719 Secondary accession number(s): Q8CC68 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 7, 2003 |
Last sequence update: | November 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 174 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families