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UniProtKB - Q03718 (NSE5_YEAST)
Protein
Non-structural maintenance of chromosome element 5
Gene
NSE5
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.
Miscellaneous
Present with 907 molecules/cell in log phase SD medium.1 Publication
GO - Biological processi
- DNA recombination Source: UniProtKB-KW
- DNA repair Source: SGD
Keywordsi
Biological process | DNA damage, DNA recombination, DNA repair |
Names & Taxonomyi
Protein namesi | Recommended name: Non-structural maintenance of chromosome element 5Short name: Non-SMC element 5 |
Gene namesi | Name:NSE5 Ordered Locus Names:YML023C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000004485, NSE5 |
VEuPathDBi | FungiDB:YML023C |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Other locations
- Chromosome By similarity
Nucleus
- nucleus Source: SGD
Other locations
- Smc5-Smc6 complex Source: SGD
Keywords - Cellular componenti
Chromosome, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000057963 | 1 – 556 | Non-structural maintenance of chromosome element 5Add BLAST | 556 |
Proteomic databases
MaxQBi | Q03718 |
PaxDbi | Q03718 |
PRIDEi | Q03718 |
PTM databases
iPTMneti | Q03718 |
Interactioni
Subunit structurei
Component of the Smc5-Smc6 complex which consists of KRE29, MMS21, NSE1, NSE3, NSE4, NSE5, SMC5 and SMC6.
Interacts with KRE29.
2 PublicationsBinary interactionsi
Protein-protein interaction databases
BioGRIDi | 35146, 456 interactors |
ComplexPortali | CPX-1364, SMC5-SMC6 SUMO ligase complex |
DIPi | DIP-4547N |
IntActi | Q03718, 28 interactors |
STRINGi | 4932.YML023C |
Miscellaneous databases
RNActi | Q03718, protein |
Family & Domainsi
Phylogenomic databases
eggNOGi | ENOG502QU63, Eukaryota |
HOGENOMi | CLU_035923_0_0_1 |
InParanoidi | Q03718 |
OMAi | EMLNSMC |
Family and domain databases
InterProi | View protein in InterPro IPR014803, DNA_repair_Nse5/Nse6 |
Pfami | View protein in Pfam PF08691, Nse5, 1 hit |
i Sequence
Sequence statusi: Complete.
Q03718-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDGALINSVL YVSPRNGAHY FVELTEKHLL AFEMLNSMCL LENYDHVLLF
60 70 80 90 100
LECQFGKSHN LAVIPFDIIL VLFTLSTLSE YYKEPILRAN DPYNTSRETL
110 120 130 140 150
SRRALKLLQK YLAILKEFDS EQYNLYDLEL LRCQFFLAID TLTPKKQKWG
160 170 180 190 200
FDRFRRTKSE SGVTYRQNAS VDPELDQAKT FKNPYRSYIS CLEQRNTILG
210 220 230 240 250
NRLLNLKLNE PGEFINMILW TLSNSLQEST PLFLSSHEIW MPLLEILIDL
260 270 280 290 300
FSCRQDYFIQ HEVAQNVSKS LFVQRLSESP LAVFFESLNT RNFANRFSEY
310 320 330 340 350
VFLNCDYKLP SDNYATPVHP VYNGENTIVD TYIPTIKCSP LYKSQKSLAL
360 370 380 390 400
RRKLIGSCFK LLLRVPDGHR LITPRIVADD VIQGISRTLA SFNDILQFKK
410 420 430 440 450
FFMTENLSQE SYFIPLLAEG TLSEILKDTQ ECVVILTLVE NLSDGVSFCN
460 470 480 490 500
EVIGLVKSKC FAFTEQCSQA SYEEAVLNIE KCDVCLLVLL RYLLHLIGTE
510 520 530 540 550
AILDAKEQLE MLHAIEKNDS GRRQWAKALN LGNDPPLLYP IVSQMFGVHD
KSVIIE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z46659 Genomic DNA Translation: CAA86632.1 BK006946 Genomic DNA Translation: DAA09875.1 |
PIRi | S49754 |
RefSeqi | NP_013689.1, NM_001182381.1 |
Genome annotation databases
EnsemblFungii | YML023C_mRNA; YML023C; YML023C |
GeneIDi | 854985 |
KEGGi | sce:YML023C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z46659 Genomic DNA Translation: CAA86632.1 BK006946 Genomic DNA Translation: DAA09875.1 |
PIRi | S49754 |
RefSeqi | NP_013689.1, NM_001182381.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
7LTO | electron microscopy | 3.20 | A | 1-556 | [»] | |
7OGG | X-ray | 3.29 | R | 1-556 | [»] | |
7SDE | electron microscopy | 3.20 | A | 1-556 | [»] | |
SMRi | Q03718 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 35146, 456 interactors |
ComplexPortali | CPX-1364, SMC5-SMC6 SUMO ligase complex |
DIPi | DIP-4547N |
IntActi | Q03718, 28 interactors |
STRINGi | 4932.YML023C |
PTM databases
iPTMneti | Q03718 |
Proteomic databases
MaxQBi | Q03718 |
PaxDbi | Q03718 |
PRIDEi | Q03718 |
Genome annotation databases
EnsemblFungii | YML023C_mRNA; YML023C; YML023C |
GeneIDi | 854985 |
KEGGi | sce:YML023C |
Organism-specific databases
SGDi | S000004485, NSE5 |
VEuPathDBi | FungiDB:YML023C |
Phylogenomic databases
eggNOGi | ENOG502QU63, Eukaryota |
HOGENOMi | CLU_035923_0_0_1 |
InParanoidi | Q03718 |
OMAi | EMLNSMC |
Miscellaneous databases
PROi | PR:Q03718 |
RNActi | Q03718, protein |
Family and domain databases
InterProi | View protein in InterPro IPR014803, DNA_repair_Nse5/Nse6 |
Pfami | View protein in Pfam PF08691, Nse5, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NSE5_YEAST | |
Accessioni | Q03718Primary (citable) accession number: Q03718 Secondary accession number(s): D6VZF1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | February 23, 2022 | |
This is version 132 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XIII
Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references