UniProtKB - Q03701 (CEBPZ_HUMAN)
Protein
CCAAT/enhancer-binding protein zeta
Gene
CEBPZ
Organism
Homo sapiens (Human)
Status
Functioni
Stimulates transcription from the HSP70 promoter.
GO - Molecular functioni
- DNA binding Source: ProtInc
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA binding Source: UniProtKB
- RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
GO - Biological processi
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- ribosome biogenesis Source: InterPro
- transcription by RNA polymerase II Source: ProtInc
Keywordsi
Molecular function | Activator |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: CCAAT/enhancer-binding protein zetaAlternative name(s): CCAAT-box-binding transcription factor Short name: CBF Short name: CCAAT-binding factor |
Gene namesi | Name:CEBPZ Synonyms:CBF2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000115816.13 |
HGNCi | HGNC:24218 CEBPZ |
MIMi | 612828 gene |
neXtProti | NX_Q03701 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 10153 |
OpenTargetsi | ENSG00000115816 |
PharmGKBi | PA134977051 |
Polymorphism and mutation databases
BioMutai | CEBPZ |
DMDMi | 308153621 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000173470 | 1 – 1054 | CCAAT/enhancer-binding protein zetaAdd BLAST | 1054 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 113 | PhosphoserineCombined sources | 1 | |
Modified residuei | 629 | PhosphoserineCombined sources | 1 | |
Modified residuei | 695 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 835 | PhosphoserineCombined sources | 1 | |
Modified residuei | 959 | PhosphoserineCombined sources | 1 | |
Modified residuei | 973 | PhosphoserineCombined sources | 1 | |
Modified residuei | 978 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q03701 |
jPOSTi | Q03701 |
MaxQBi | Q03701 |
PaxDbi | Q03701 |
PeptideAtlasi | Q03701 |
PRIDEi | Q03701 |
ProteomicsDBi | 58219 |
2D gel databases
SWISS-2DPAGEi | Q03701 |
PTM databases
iPTMneti | Q03701 |
PhosphoSitePlusi | Q03701 |
SwissPalmi | Q03701 |
Expressioni
Gene expression databases
Bgeei | ENSG00000115816 Expressed in 111 organ(s), highest expression level in testis |
ExpressionAtlasi | Q03701 baseline and differential |
Genevisiblei | Q03701 HS |
Organism-specific databases
HPAi | HPA052065 |
Interactioni
Protein-protein interaction databases
BioGridi | 115455, 84 interactors |
IntActi | Q03701, 25 interactors |
MINTi | Q03701 |
STRINGi | 9606.ENSP00000234170 |
Structurei
3D structure databases
ProteinModelPortali | Q03701 |
SMRi | Q03701 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the CBF/MAK21 family.Curated
Phylogenomic databases
eggNOGi | KOG2038 Eukaryota COG5593 LUCA |
GeneTreei | ENSGT00390000006395 |
HOGENOMi | HOG000168357 |
HOVERGENi | HBG050881 |
InParanoidi | Q03701 |
KOi | K14832 |
OMAi | PQKIKFG |
OrthoDBi | 551907at2759 |
PhylomeDBi | Q03701 |
TreeFami | TF105010 |
Family and domain databases
InterProi | View protein in InterPro IPR016024 ARM-type_fold IPR005612 CCAAT-binding_factor IPR040155 CEBPZ/Mak21-like |
PANTHERi | PTHR12048 PTHR12048, 1 hit |
Pfami | View protein in Pfam PF03914 CBF, 1 hit |
SUPFAMi | SSF48371 SSF48371, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q03701-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAVKEPLEF HAKRPWRPEE AVEDPDEEDE DNTSEAENGF SLEEVLRLGG
60 70 80 90 100
TKQDYLMLAT LDENEEVIDG GKKGAIDDLQ QGELEAFIQN LNLAKYTKAS
110 120 130 140 150
LVEEDEPAEK ENSSKKEVKI PKINNKNTAE SQRTSVNKVK NKNRPEPHSD
160 170 180 190 200
ENGSTTPKVK KDKQNIFEFF ERQTLLLRPG GKWYDLEYSN EYSLKPQPQD
210 220 230 240 250
VVSKYKTLAQ KLYQHEINLF KSKTNSQKGA SSTWMKAIVS SGTLGDRMAA
260 270 280 290 300
MILLIQDDAV HTLQFVETLV NLVKKKGSKQ QCLMALDTFK ELLITDLLPD
310 320 330 340 350
NRKLRIFSQR PFDKLEQLSS GNKDSRDRRL ILWYFEHQLK HLVAEFVQVL
360 370 380 390 400
ETLSHDTLVT TKTRALTVAH ELLCNKPEEE KALLVQVVNK LGDPQNRIAT
410 420 430 440 450
KASHLLETLL CKHPNMKGVV SGEVERLLFR SNISSKAQYY AICFLNQMAL
460 470 480 490 500
SHEESELANK LITVYFCFFR TCVKKKDVES KMLSALLTGV NRAYPYSQTG
510 520 530 540 550
DDKVREQIDT LFKVLHIVNF NTSVQALMLL FQVMNSQQTI SDRYYTALYR
560 570 580 590 600
KMLDPGLMTC SKQAMFLNLV YKSLKADIVL RRVKAFVKRL LQVTCQQMPP
610 620 630 640 650
FICGALYLVS EILKAKPGLR SQLDDHPESD DEENFIDAND DEDMEKFTDA
660 670 680 690 700
DKETEIVKKL ETEETVPETD VETKKPEVAS WVHFDNLKGG KQLNKYDPFS
710 720 730 740 750
RNPLFCGAEN TSLWELKKLS VHFHPSVALF AKTILQGNYI QYSGDPLQDF
760 770 780 790 800
TLMRFLDRFV YRNPKPHKGK ENTDSVVMQP KRKHFIKDIR HLPVNSKEFL
810 820 830 840 850
AKEESQIPVD EVFFHRYYKK VAVKEKQKRD ADEESIEDVD DEEFEELIDT
860 870 880 890 900
FEDDNCFSSG KDDMDFAGNV KKRTKGAKDN TLDEDSEGSD DELGNLDDDE
910 920 930 940 950
VSLGSMDDEE FAEVDEDGGT FMDVLDDESE SVPELEVHSK VSTKKSKRKG
960 970 980 990 1000
TDDFDFAGSF QGPRKKKRNL NDSSLFVSAE EFGHLLDENM GSKFDNIGMN
1010 1020 1030 1040 1050
AMANKDNASL KQLRWEAERD DWLHNRDAKS IIKKKKHFKK KRIKTTQKTK
KQRK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9J9W7 | C9J9W7_HUMAN | CCAAT/enhancer-binding protein zeta | CEBPZ | 146 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 589 | R → G in AAA51924 (PubMed:2247079).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_031399 | 15 | P → S. Corresponds to variant dbSNP:rs3213746Ensembl. | 1 | |
Natural variantiVAR_026043 | 102 | V → ICombined sources1 PublicationCorresponds to variant dbSNP:rs2098386Ensembl. | 1 | |
Natural variantiVAR_031400 | 303 | K → R. Corresponds to variant dbSNP:rs17020328Ensembl. | 1 | |
Natural variantiVAR_055622 | 639 | N → S. Corresponds to variant dbSNP:rs3180252Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M37197 mRNA Translation: AAA51924.1 Frameshift. AC007390 Genomic DNA Translation: AAY14815.1 BC034475 mRNA Translation: AAH34475.1 |
CCDSi | CCDS1787.1 |
PIRi | A36368 |
RefSeqi | NP_005751.2, NM_005760.2 |
UniGenei | Hs.135406 |
Genome annotation databases
Ensembli | ENST00000234170; ENSP00000234170; ENSG00000115816 |
GeneIDi | 10153 |
KEGGi | hsa:10153 |
UCSCi | uc002rpz.5 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M37197 mRNA Translation: AAA51924.1 Frameshift. AC007390 Genomic DNA Translation: AAY14815.1 BC034475 mRNA Translation: AAH34475.1 |
CCDSi | CCDS1787.1 |
PIRi | A36368 |
RefSeqi | NP_005751.2, NM_005760.2 |
UniGenei | Hs.135406 |
3D structure databases
ProteinModelPortali | Q03701 |
SMRi | Q03701 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 115455, 84 interactors |
IntActi | Q03701, 25 interactors |
MINTi | Q03701 |
STRINGi | 9606.ENSP00000234170 |
PTM databases
iPTMneti | Q03701 |
PhosphoSitePlusi | Q03701 |
SwissPalmi | Q03701 |
Polymorphism and mutation databases
BioMutai | CEBPZ |
DMDMi | 308153621 |
2D gel databases
SWISS-2DPAGEi | Q03701 |
Proteomic databases
EPDi | Q03701 |
jPOSTi | Q03701 |
MaxQBi | Q03701 |
PaxDbi | Q03701 |
PeptideAtlasi | Q03701 |
PRIDEi | Q03701 |
ProteomicsDBi | 58219 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000234170; ENSP00000234170; ENSG00000115816 |
GeneIDi | 10153 |
KEGGi | hsa:10153 |
UCSCi | uc002rpz.5 human |
Organism-specific databases
CTDi | 10153 |
DisGeNETi | 10153 |
EuPathDBi | HostDB:ENSG00000115816.13 |
GeneCardsi | CEBPZ |
H-InvDBi | HIX0001972 HIX0161881 |
HGNCi | HGNC:24218 CEBPZ |
HPAi | HPA052065 |
MIMi | 612828 gene |
neXtProti | NX_Q03701 |
OpenTargetsi | ENSG00000115816 |
PharmGKBi | PA134977051 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2038 Eukaryota COG5593 LUCA |
GeneTreei | ENSGT00390000006395 |
HOGENOMi | HOG000168357 |
HOVERGENi | HBG050881 |
InParanoidi | Q03701 |
KOi | K14832 |
OMAi | PQKIKFG |
OrthoDBi | 551907at2759 |
PhylomeDBi | Q03701 |
TreeFami | TF105010 |
Miscellaneous databases
ChiTaRSi | CEBPZ human |
GeneWikii | CCAAT/enhancer_binding_protein_zeta |
GenomeRNAii | 10153 |
PROi | PR:Q03701 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000115816 Expressed in 111 organ(s), highest expression level in testis |
ExpressionAtlasi | Q03701 baseline and differential |
Genevisiblei | Q03701 HS |
Family and domain databases
InterProi | View protein in InterPro IPR016024 ARM-type_fold IPR005612 CCAAT-binding_factor IPR040155 CEBPZ/Mak21-like |
PANTHERi | PTHR12048 PTHR12048, 1 hit |
Pfami | View protein in Pfam PF03914 CBF, 1 hit |
SUPFAMi | SSF48371 SSF48371, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | CEBPZ_HUMAN | |
Accessioni | Q03701Primary (citable) accession number: Q03701 Secondary accession number(s): Q8NE75 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 5, 2010 | |
Last modified: | February 13, 2019 | |
This is version 159 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations