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Protein

CCAAT/enhancer-binding protein zeta

Gene

CEBPZ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stimulates transcription from the HSP70 promoter.

GO - Molecular functioni

GO - Biological processi

  • positive regulation of transcription by RNA polymerase II Source: NTNU_SB
  • transcription by RNA polymerase II Source: ProtInc

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
CCAAT/enhancer-binding protein zeta
Alternative name(s):
CCAAT-box-binding transcription factor
Short name:
CBF
Short name:
CCAAT-binding factor
Gene namesi
Name:CEBPZ
Synonyms:CBF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115816.13
HGNCiHGNC:24218 CEBPZ
MIMi612828 gene
neXtProtiNX_Q03701

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10153
OpenTargetsiENSG00000115816
PharmGKBiPA134977051

Polymorphism and mutation databases

BioMutaiCEBPZ
DMDMi308153621

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001734701 – 1054CCAAT/enhancer-binding protein zetaAdd BLAST1054

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei113PhosphoserineCombined sources1
Modified residuei629PhosphoserineCombined sources1
Modified residuei695N6-acetyllysineCombined sources1
Modified residuei835PhosphoserineCombined sources1
Modified residuei959PhosphoserineCombined sources1
Modified residuei973PhosphoserineCombined sources1
Modified residuei978PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ03701
MaxQBiQ03701
PaxDbiQ03701
PeptideAtlasiQ03701
PRIDEiQ03701
ProteomicsDBi58219

2D gel databases

SWISS-2DPAGEiQ03701

PTM databases

iPTMnetiQ03701
PhosphoSitePlusiQ03701
SwissPalmiQ03701

Expressioni

Gene expression databases

BgeeiENSG00000115816
CleanExiHS_CEBPZ
ExpressionAtlasiQ03701 baseline and differential
GenevisibleiQ03701 HS

Organism-specific databases

HPAiHPA052065

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TP53P046372EBI-1046778,EBI-366083

Protein-protein interaction databases

BioGridi115455, 79 interactors
IntActiQ03701, 22 interactors
MINTiQ03701
STRINGi9606.ENSP00000234170

Structurei

3D structure databases

ProteinModelPortaliQ03701
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CBF/MAK21 family.Curated

Phylogenomic databases

eggNOGiKOG2038 Eukaryota
COG5593 LUCA
GeneTreeiENSGT00390000006395
HOGENOMiHOG000168357
HOVERGENiHBG050881
InParanoidiQ03701
KOiK14832
OMAiFQGPRKK
OrthoDBiEOG091G06DB
PhylomeDBiQ03701
TreeFamiTF105010

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR005612 CCAAT-binding_factor
PfamiView protein in Pfam
PF03914 CBF, 1 hit
SUPFAMiSSF48371 SSF48371, 3 hits

Sequencei

Sequence statusi: Complete.

Q03701-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVKEPLEF HAKRPWRPEE AVEDPDEEDE DNTSEAENGF SLEEVLRLGG
60 70 80 90 100
TKQDYLMLAT LDENEEVIDG GKKGAIDDLQ QGELEAFIQN LNLAKYTKAS
110 120 130 140 150
LVEEDEPAEK ENSSKKEVKI PKINNKNTAE SQRTSVNKVK NKNRPEPHSD
160 170 180 190 200
ENGSTTPKVK KDKQNIFEFF ERQTLLLRPG GKWYDLEYSN EYSLKPQPQD
210 220 230 240 250
VVSKYKTLAQ KLYQHEINLF KSKTNSQKGA SSTWMKAIVS SGTLGDRMAA
260 270 280 290 300
MILLIQDDAV HTLQFVETLV NLVKKKGSKQ QCLMALDTFK ELLITDLLPD
310 320 330 340 350
NRKLRIFSQR PFDKLEQLSS GNKDSRDRRL ILWYFEHQLK HLVAEFVQVL
360 370 380 390 400
ETLSHDTLVT TKTRALTVAH ELLCNKPEEE KALLVQVVNK LGDPQNRIAT
410 420 430 440 450
KASHLLETLL CKHPNMKGVV SGEVERLLFR SNISSKAQYY AICFLNQMAL
460 470 480 490 500
SHEESELANK LITVYFCFFR TCVKKKDVES KMLSALLTGV NRAYPYSQTG
510 520 530 540 550
DDKVREQIDT LFKVLHIVNF NTSVQALMLL FQVMNSQQTI SDRYYTALYR
560 570 580 590 600
KMLDPGLMTC SKQAMFLNLV YKSLKADIVL RRVKAFVKRL LQVTCQQMPP
610 620 630 640 650
FICGALYLVS EILKAKPGLR SQLDDHPESD DEENFIDAND DEDMEKFTDA
660 670 680 690 700
DKETEIVKKL ETEETVPETD VETKKPEVAS WVHFDNLKGG KQLNKYDPFS
710 720 730 740 750
RNPLFCGAEN TSLWELKKLS VHFHPSVALF AKTILQGNYI QYSGDPLQDF
760 770 780 790 800
TLMRFLDRFV YRNPKPHKGK ENTDSVVMQP KRKHFIKDIR HLPVNSKEFL
810 820 830 840 850
AKEESQIPVD EVFFHRYYKK VAVKEKQKRD ADEESIEDVD DEEFEELIDT
860 870 880 890 900
FEDDNCFSSG KDDMDFAGNV KKRTKGAKDN TLDEDSEGSD DELGNLDDDE
910 920 930 940 950
VSLGSMDDEE FAEVDEDGGT FMDVLDDESE SVPELEVHSK VSTKKSKRKG
960 970 980 990 1000
TDDFDFAGSF QGPRKKKRNL NDSSLFVSAE EFGHLLDENM GSKFDNIGMN
1010 1020 1030 1040 1050
AMANKDNASL KQLRWEAERD DWLHNRDAKS IIKKKKHFKK KRIKTTQKTK

KQRK
Length:1,054
Mass (Da):120,974
Last modified:October 5, 2010 - v3
Checksum:i20E33175688BA985
GO

Sequence cautioni

The sequence AAA51924 differs from that shown. Reason: Frameshift at position 998.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti589R → G in AAA51924 (PubMed:2247079).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03139915P → S. Corresponds to variant dbSNP:rs3213746Ensembl.1
Natural variantiVAR_026043102V → ICombined sources1 PublicationCorresponds to variant dbSNP:rs2098386Ensembl.1
Natural variantiVAR_031400303K → R. Corresponds to variant dbSNP:rs17020328Ensembl.1
Natural variantiVAR_055622639N → S. Corresponds to variant dbSNP:rs3180252Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37197 mRNA Translation: AAA51924.1 Frameshift.
AC007390 Genomic DNA Translation: AAY14815.1
BC034475 mRNA Translation: AAH34475.1
CCDSiCCDS1787.1
PIRiA36368
RefSeqiNP_005751.2, NM_005760.2
UniGeneiHs.135406

Genome annotation databases

EnsembliENST00000234170; ENSP00000234170; ENSG00000115816
GeneIDi10153
KEGGihsa:10153
UCSCiuc002rpz.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCEBPZ_HUMAN
AccessioniPrimary (citable) accession number: Q03701
Secondary accession number(s): Q8NE75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 5, 2010
Last modified: July 18, 2018
This is version 153 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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