Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Rhizopuspepsin-3

Gene
N/A
Organism
Rhizopus niveus
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1'. Clots milk and activates trypsinogen. Does not cleave 4-Gln-|-His-5, but does cleave 10-His-|-Leu-11 and 12-Val-|-Glu-13 in B chain of insulin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei102PROSITE-ProRule annotation1
Active sitei285PROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionAspartyl protease, Hydrolase, Protease

Protein family/group databases

MEROPSiA01.012

Names & Taxonomyi

Protein namesi
Recommended name:
Rhizopuspepsin-3 (EC:3.4.23.21)
Alternative name(s):
Aspartate protease
OrganismiRhizopus niveus
Taxonomic identifieri4844 [NCBI]
Taxonomic lineageiEukaryotaFungiFungi incertae sedisMucoromycotaMucoromycotinaMucoromycetesMucoralesMucorineaeRhizopodaceaeRhizopus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000002588722 – 68Activation peptideSequence analysisAdd BLAST47
ChainiPRO_000002588869 – 391Rhizopuspepsin-3Add BLAST323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi115 ↔ 118By similarity
Disulfide bondi319 ↔ 352By similarity

Keywords - PTMi

Disulfide bond, Zymogen

Structurei

3D structure databases

ProteinModelPortaliQ03699
SMRiQ03699
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini84 – 388Peptidase A1PROSITE-ProRule annotationAdd BLAST305

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.40.70.10, 2 hits
InterProiView protein in InterPro
IPR001461 Aspartic_peptidase_A1
IPR001969 Aspartic_peptidase_AS
IPR033121 PEPTIDASE_A1
IPR021109 Peptidase_aspartic_dom_sf
PANTHERiPTHR13683 PTHR13683, 1 hit
PfamiView protein in Pfam
PF00026 Asp, 1 hit
PRINTSiPR00792 PEPSIN
SUPFAMiSSF50630 SSF50630, 1 hit
PROSITEiView protein in PROSITE
PS00141 ASP_PROTEASE, 2 hits
PS51767 PEPTIDASE_A1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q03699-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKFTLISSCV TLALMTLSIE AAPSGKKVNI PLTKNKDYKP NAKNAIQKAI
60 70 80 90 100
AKYHRHRSVS SSNSTSTDGI GYVPVTDYYN DIEYYGEVTV GTPGVTLKLD
110 120 130 140 150
FDTGSSDLWF ASSLCTNCGS SQTKYNPNES STYARDGRTW SISYGDGSSA
160 170 180 190 200
SGILGTDTVI LGGLTIRHQT IELARREASQ FQSGPSDGLL GLGFDSITTV
210 220 230 240 250
RGVKTPVDNL ISQGLISNPV FGVYLGKESN GGGGEYIFGG YDSSKFKGSL
260 270 280 290 300
TTIPVDNSNG WYGITVRGTS IGGSRVSSSF DAILDTGTSL LVLPNDVASS
310 320 330 340 350
VAEAYGASDN YDGTFSISCD TSSFEPLVFT IGSSTFEVPA DSLVYEQDGY
360 370 380 390
SCIAGFGYGD YDFAIFGDVF LKNNYVVFNP EVPHVQIAPI A
Length:391
Mass (Da):41,533
Last modified:November 1, 1995 - v1
Checksum:i00814F973ED21E58
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56965 Genomic DNA Translation: CAA40285.1
PIRiJU0343

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56965 Genomic DNA Translation: CAA40285.1
PIRiJU0343

3D structure databases

ProteinModelPortaliQ03699
SMRiQ03699
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiA01.012

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.40.70.10, 2 hits
InterProiView protein in InterPro
IPR001461 Aspartic_peptidase_A1
IPR001969 Aspartic_peptidase_AS
IPR033121 PEPTIDASE_A1
IPR021109 Peptidase_aspartic_dom_sf
PANTHERiPTHR13683 PTHR13683, 1 hit
PfamiView protein in Pfam
PF00026 Asp, 1 hit
PRINTSiPR00792 PEPSIN
SUPFAMiSSF50630 SSF50630, 1 hit
PROSITEiView protein in PROSITE
PS00141 ASP_PROTEASE, 2 hits
PS51767 PEPTIDASE_A1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCARP3_RHINI
AccessioniPrimary (citable) accession number: Q03699
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 18, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again