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Entry version 161 (07 Oct 2020)
Sequence version 1 (01 Nov 1997)
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Protein

Clustered mitochondria protein 1

Gene

CLU1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.UniRule annotation1 Publication

Miscellaneous

Present with 17000 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Clustered mitochondria protein 1
Alternative name(s):
Translation initiation factor 31
eIF3-associated protein p135
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CLU1UniRule annotation
Synonyms:TIF31UniRule annotation
Ordered Locus Names:YMR012W
ORF Names:YM8270.16
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XIII

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YMR012W

Saccharomyces Genome Database

More...
SGDi
S000004614, CLU1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Causes mitochondria to cluster within cells.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001235571 – 1277Clustered mitochondria protein 1Add BLAST1277

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1247PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q03690

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q03690

PRoteomics IDEntifications database

More...
PRIDEi
Q03690

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q03690

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is increased in intermediate compared to fully aerobic conditions.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May associate with the eukaryotic translation initiation factor 3 (eIF-3) complex. Associates with the 80S ribosome.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
35182, 133 interactors

Database of interacting proteins

More...
DIPi
DIP-5924N

Protein interaction database and analysis system

More...
IntActi
Q03690, 78 interactors

Molecular INTeraction database

More...
MINTi
Q03690

STRING: functional protein association networks

More...
STRINGi
4932.YMR012W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q03690, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini339 – 596CluPROSITE-ProRule annotationAdd BLAST258
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati704 – 738TPR 1Add BLAST35
Repeati1020 – 1053TPR 2Add BLAST34
Repeati1148 – 1181TPR 3Add BLAST34

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CLU family.UniRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1839, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000012485

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003256_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q03690

KEGG Orthology (KO)

More...
KOi
K03255

Identification of Orthologs from Complete Genome Data

More...
OMAi
VGFPMDG

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15466, CLU-central, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_03013, CLU, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027523, CLU
IPR033646, CLU-central
IPR025697, CLU_dom
IPR028275, CLU_N
IPR011990, TPR-like_helical_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13236, CLU, 1 hit
PF15044, CLU_N, 1 hit
PF12807, eIF3_p135, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452, SSF48452, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51823, CLU, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q03690-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEKKEEVKN ATVKVTVKLP KEDNHSHNTK HLKKTQSSKN NDISFEIGKE
60 70 80 90 100
SKIQTVLDVL AMIPSSKYLT NVGLKTIEGD SQLSDEMSIK EIVGEKSELK
110 120 130 140 150
LQLILKPYSA REALKHVITV RDFIGFAQET SDGLSEFAIS TGSSFSSLPL
160 170 180 190 200
GPIKERSKQE EKDEKSDPEE KKNTFKDVTD EEKLKFNEMV HEVFSSFKNS
210 220 230 240 250
SINKLLTSES NIITPCVRSL SFAPYNPVPP FYRSKGHLFY LQIVTLEGES
260 270 280 290 300
FYITAIPSGF YVNKSNSTKF DPSPKENTDE NAHSSLIYYS LFDLIASRSK
310 320 330 340 350
KFISHVQAFE KKLSALDSTS YVRPSNTFLH KPWFVSSLPP NNPDYLRLQT
360 370 380 390 400
AALDTTPERN FNDEFQAIKD LTTSTLQDRI EMERLFSKVV HEFSVTAASG
410 420 430 440 450
AMSIFYSDFV AMNPESPTRD QIFLKDNIFY SYVSDVSGNY EGKGGDEAAI
460 470 480 490 500
AASNQDLKTI NILNRLHMHE VRYLLTTVVE FAGRRILAQT PVPGLLATMG
510 520 530 540 550
NKIVKDANTG EEVTEDFVND INVKYGLDEG LGKIVYDADF DSVLEKKFVK
560 570 580 590 600
AFHLKKHKVN GTELAFSSQS KGIVGFDKRR YILDLANTYP LDINFARQNF
610 620 630 640 650
DNIEETGNRY PHRQTLLRPE LVEKWWNNKV EKEGVEFEKA YEENLFSYNP
660 670 680 690 700
DAYQVEGIED ANVDEMSNYL QKEVIPSVIQ DYLSGNLSTP YNGEHLADTL
710 720 730 740 750
HKNGINMRYL GKIIELSQKE LDSQIVHYEQ NLKAVEQDNK EYEDWEKSYL
760 770 780 790 800
QKIENMIKER QAKINKLVQE GKEVPKELTE DLKLNDEEIK KPTDGKPVVV
810 820 830 840 850
AYDELVPLIK ISELEIVSRS LKHVLKDLSK DVPVFLVPSL VAYVFNMLVG
860 870 880 890 900
INYNADPKPE PVDEFYPVNK CSFAKLTRSE LLEAVSKQAF LRFRHQLPSN
910 920 930 940 950
WIEAYMENPF TLIRSVSYKF GIQLLNKEYF FTREQLESYK QSLDKKIRNK
960 970 980 990 1000
FVEPPTTFSL SDLTIIPRVK FSEYTSSVSE EFWAQGASMI NEDKQSALTL
1010 1020 1030 1040 1050
LAQSITVLED VNNILHPAVA EKYLSLSAIY NKLALYPEAI AFCRKACTIY
1060 1070 1080 1090 1100
ERVSGIDSFE MMRALTNLAI LEFSNESPYN ATVVYNRLAE ILKVYELPKI
1110 1120 1130 1140 1150
HHPAPTSIFN HLEQLALGVQ DTKLAIEVLG QLSSYVVELE GKDSLAYGYT
1160 1170 1180 1190 1200
ESRLGNLFAA LKDFHRALEH ITVTQGIFTK QLGMNHTHSA QSRQWVNGLS
1210 1220 1230 1240 1250
SLIMDLKQKK QLAQDQMSTT GSNSAGHKKT NHRQKKDDVK PELANKSVDE
1260 1270
LLTFIEGDSS NSKSKNKTNN KKKHGKK
Length:1,277
Mass (Da):145,166
Last modified:November 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1E643F4EE77ED5B5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF004911 Genomic DNA Translation: AAB82415.1
Z48613 Genomic DNA Translation: CAA88529.1
BK006946 Genomic DNA Translation: DAA09910.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S53043

NCBI Reference Sequences

More...
RefSeqi
NP_013725.1, NM_001182508.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YMR012W_mRNA; YMR012W; YMR012W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
855025

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YMR012W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004911 Genomic DNA Translation: AAB82415.1
Z48613 Genomic DNA Translation: CAA88529.1
BK006946 Genomic DNA Translation: DAA09910.1
PIRiS53043
RefSeqiNP_013725.1, NM_001182508.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi35182, 133 interactors
DIPiDIP-5924N
IntActiQ03690, 78 interactors
MINTiQ03690
STRINGi4932.YMR012W

PTM databases

iPTMnetiQ03690

Proteomic databases

MaxQBiQ03690
PaxDbiQ03690
PRIDEiQ03690

Genome annotation databases

EnsemblFungiiYMR012W_mRNA; YMR012W; YMR012W
GeneIDi855025
KEGGisce:YMR012W

Organism-specific databases

EuPathDBiFungiDB:YMR012W
SGDiS000004614, CLU1

Phylogenomic databases

eggNOGiKOG1839, Eukaryota
GeneTreeiENSGT00390000012485
HOGENOMiCLU_003256_2_0_1
InParanoidiQ03690
KOiK03255
OMAiVGFPMDG

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q03690
RNActiQ03690, protein

Family and domain databases

CDDicd15466, CLU-central, 1 hit
Gene3Di1.25.40.10, 1 hit
HAMAPiMF_03013, CLU, 1 hit
InterProiView protein in InterPro
IPR027523, CLU
IPR033646, CLU-central
IPR025697, CLU_dom
IPR028275, CLU_N
IPR011990, TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF13236, CLU, 1 hit
PF15044, CLU_N, 1 hit
PF12807, eIF3_p135, 1 hit
SUPFAMiSSF48452, SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS51823, CLU, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLU_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q03690
Secondary accession number(s): D6VZI6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 7, 2020
This is version 161 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names
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