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Entry version 133 (18 Sep 2019)
Sequence version 1 (01 Nov 1997)
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Protein

Silent chromatin protein ESC1

Gene

ESC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the clustering of telomeres at the nuclear periphery, forming discrete subcompartments that accumulate a complex of histone-binding silencing factors like SIR4. Required for SIR4-mediated anchoring and partitioning of plasmids.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-32901-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Silent chromatin protein ESC1
Alternative name(s):
Establishes silent chromatin protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ESC1
Ordered Locus Names:YMR219W
ORF Names:YM8261.13, YM9959.01
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XIII

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YMR219W

Saccharomyces Genome Database

More...
SGDi
S000004832 ESC1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002033331 – 1658Silent chromatin protein ESC1Add BLAST1658

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei500PhosphothreonineCombined sources1
Modified residuei532PhosphoserineCombined sources1
Modified residuei579PhosphoserineCombined sources1
Modified residuei583PhosphoserineCombined sources1
Modified residuei608PhosphoserineCombined sources1
Modified residuei662PhosphoserineCombined sources1
Modified residuei865PhosphoserineCombined sources1
Modified residuei866PhosphoserineCombined sources1
Modified residuei888PhosphoserineCombined sources1
Modified residuei911PhosphoserineCombined sources1
Modified residuei937PhosphoserineCombined sources1
Modified residuei1092PhosphoserineCombined sources1
Modified residuei1096PhosphoserineCombined sources1
Modified residuei1098PhosphoserineCombined sources1
Modified residuei1166PhosphoserineCombined sources1
Modified residuei1176PhosphoserineCombined sources1
Modified residuei1178PhosphoserineCombined sources1
Modified residuei1214PhosphoserineCombined sources1
Modified residuei1254PhosphoserineCombined sources1
Modified residuei1290PhosphoserineCombined sources1
Modified residuei1326PhosphoserineCombined sources1
Modified residuei1332PhosphoserineCombined sources1
Modified residuei1403PhosphoserineCombined sources1
Modified residuei1409PhosphoserineCombined sources1
Modified residuei1450PhosphoserineCombined sources1
Modified residuei1454PhosphoserineCombined sources1
Modified residuei1539PhosphoserineCombined sources1
Modified residuei1590PhosphoserineCombined sources1
Modified residuei1591PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
Q03661

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q03661

PRoteomics IDEntifications database

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PRIDEi
Q03661

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q03661

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SIR4.

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
35397, 213 interactors

Database of interacting proteins

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DIPi
DIP-7971N

Protein interaction database and analysis system

More...
IntActi
Q03661, 2 interactors

Molecular INTeraction database

More...
MINTi
Q03661

STRING: functional protein association networks

More...
STRINGi
4932.YMR219W

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q03661

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q03661

Identification of Orthologs from Complete Genome Data

More...
OMAi
MVEEQEV

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001611 Leu-rich_rpt

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450 LRR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q03661-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKKKETFTP RANKLKLTTP RRKLKILSSL LDADEDSKMK DQHGYSRVHN
60 70 80 90 100
DKYRVAKPTQ HSTLHESISS RRSSHIHNKS LHEDSARALS WVDSLINRGK
110 120 130 140 150
SILTTLEKED ALFERSLEEE RQRFQLHDSL MNKYTGNSKS HQRLIDLRKS
160 170 180 190 200
QYGTDTSFQN NDEIPLDSFI SSPLPDAEDE SSSNIDSDKD EDLEGKQSLI
210 220 230 240 250
KDFDLENDEY ELSEEEKNSD GQSSPSIMIL SDEEYAEEGA LQDVSNDEYA
260 270 280 290 300
EEEGQVERKN IGQEQANVEN ATQISSSDSS EGQNYSEGVE MELEDDIDVE
310 320 330 340 350
SDAEKDESQG AEGTEHSVDF SKYMQPRTDN TKIPVIEKYE SDEHKVHQRY
360 370 380 390 400
SEDGAFDFGS VNISVDDESE DEESQAESYS ANAENVYHHN EHELDDKELI
410 420 430 440 450
EDIESSDSES QSAQESEQGS EDDFEYKMKN EKSTSEETEN TSESRDQGFA
460 470 480 490 500
KDAYTKNKVE QQENDEEPEK DDIIRSSLDK NFHGNNNKSE YSENVLENET
510 520 530 540 550
DPAIVERENQ INDVEGYDVT GKSVESDLHE HSPDNLYDLA ARAMLQFQQS
560 570 580 590 600
RNSNCPQKEE QVSESYLGHS NGSNLSGRSL DESEEQIPLK DFTGENNNNL
610 620 630 640 650
KTDRGDLSSS VEIEVEKVSE KKLDGSTEKE LVPLSTDTTI NNSSLGNEDS
660 670 680 690 700
IYYSLDDADA ISENLTDVPL MEIKTTPKYE VVISESVYSS TSYEDNTVAM
710 720 730 740 750
PPQVEYTSPF MNDPFNSLND DYEKKHDLLK STLAALAPAF TKKDAEFVEA
760 770 780 790 800
GVTKSCLTST SGHTNIFHTS KETKQVSDLD ESTENVTFEN ENTGDENKNQ
810 820 830 840 850
SKNFPGVANS TDKSTEDNTD EKYFSAINYT NVTGDSSCED IIETASNVEE
860 870 880 890 900
NLRYCEKDMN EAEMSSGDEC VKQNDDGSKT QISFSTDSPD NFQESNDNTE
910 920 930 940 950
FSSTKYKVRN SDLEDDESLK KELTKAEVVD KLDEEESEDS YEQDYADPEP
960 970 980 990 1000
GNDEGSNENI VKGTKKDTLG IVEPENEKVN KVHEEETLFE ANVSSSVNVQ
1010 1020 1030 1040 1050
NKDMHTDVIN QEAQANYEAG ERKYYIQNTD TEEAHISIIE RIDENAIGNN
1060 1070 1080 1090 1100
MEIPERSCVE KTHNEVLFER RATTIENTKA LENNTNMHDQ VSQACSDSDR
1110 1120 1130 1140 1150
DQDSTAEKNV EGSAKHNLDI RVSSSEIESV EPLKPESDRS NIFSSPIRVI
1160 1170 1180 1190 1200
GAVVKGVGKV VDVAESFVKK IDVMDSESDD NVDIGDYNQD IFNKSNSTDA
1210 1220 1230 1240 1250
SVNMKSVSSK ERDSDEDEAV ILGGVTAEAH NDNGNNSRVI NIDPTTNGAY
1260 1270 1280 1290 1300
EEDSEVFRQQ VKDKENLHKS EEPLVEGLQS EQHFEKKDHS ENEEEFDTIY
1310 1320 1330 1340 1350
GDITSANIHS NAPDDIKRQQ LLKNLSDLEN YSQRLIEDSR RGKNQEESDE
1360 1370 1380 1390 1400
VNTSRERDLT FEKSVNEKYA GAIEEDTFSE LDISIQHPEH EEDLDLSNNQ
1410 1420 1430 1440 1450
ERSIEELNSE PEEAELYELE IEGPTETAAS SKMNDDERQR GNIPSTDLPS
1460 1470 1480 1490 1500
DPPSDKEEVT DSYPYSNSEN ITAEKSAPTS PEVYEIFSDT PNEVPMEIND
1510 1520 1530 1540 1550
EIPATTLEKH DKTNVTSVLD DRSEHLSSHD VDNEPHDNSI NIKVNEGEEP
1560 1570 1580 1590 1600
EHQAVDIPVK VEVKEEQEEM PSKSVLEEQK PSMELINDKS SPENNNDEET
1610 1620 1630 1640 1650
NREKDKTKAK KKSRKRNYNS RRRKRKITEG SSAASNTKRR RGHEPKSRGQ

NTHPSVDK
Length:1,658
Mass (Da):187,138
Last modified:November 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3893F968305A757D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z49809 Genomic DNA Translation: CAA89934.1
Z49939 Genomic DNA Translation: CAA90190.1
BK006946 Genomic DNA Translation: DAA10118.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S55101

NCBI Reference Sequences

More...
RefSeqi
NP_013946.1, NM_001182726.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YMR219W_mRNA; YMR219W; YMR219W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
855259

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YMR219W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49809 Genomic DNA Translation: CAA89934.1
Z49939 Genomic DNA Translation: CAA90190.1
BK006946 Genomic DNA Translation: DAA10118.1
PIRiS55101
RefSeqiNP_013946.1, NM_001182726.1

3D structure databases

SMRiQ03661
ModBaseiSearch...

Protein-protein interaction databases

BioGridi35397, 213 interactors
DIPiDIP-7971N
IntActiQ03661, 2 interactors
MINTiQ03661
STRINGi4932.YMR219W

PTM databases

iPTMnetiQ03661

Proteomic databases

MaxQBiQ03661
PaxDbiQ03661
PRIDEiQ03661

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR219W_mRNA; YMR219W; YMR219W
GeneIDi855259
KEGGisce:YMR219W

Organism-specific databases

EuPathDBiFungiDB:YMR219W
SGDiS000004832 ESC1

Phylogenomic databases

InParanoidiQ03661
OMAiMVEEQEV

Enzyme and pathway databases

BioCyciYEAST:G3O-32901-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q03661

Family and domain databases

InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
PROSITEiView protein in PROSITE
PS51450 LRR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiESC1_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q03661
Secondary accession number(s): D6W044, Q04988
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 18, 2019
This is version 133 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names
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