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Entry version 66 (12 Aug 2020)
Sequence version 1 (01 Nov 1996)
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Protein

Cysteine-rich, acidic integral membrane protein

Gene

CRAM

Organism
Trypanosoma brucei brucei
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Supposed to function as cell surface receptor. Possibly involved in receptor-mediated endocytosis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processEndocytosis

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.B.87.1.23, the selenoprotein p receptor (selp-receptor) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cysteine-rich, acidic integral membrane protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CRAM
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTrypanosoma brucei brucei
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaDiscobaEuglenozoaKinetoplasteaMetakinetoplastinaTrypanosomatidaTrypanosomatidaeTrypanosoma

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 882ExtracellularSequence analysisAdd BLAST859
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei883 – 903HelicalSequence analysisAdd BLAST21
Topological domaini904 – 945CytoplasmicSequence analysisAdd BLAST42

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002099324 – 945Cysteine-rich, acidic integral membrane proteinSequence analysisAdd BLAST922

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi34N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi43N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi67N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi79N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi139N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi151N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi175N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi199N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi211N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi223N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi235N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi247N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi259N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi283N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi295N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi307N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi319N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi331N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi343N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi367N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi379N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi391N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi403N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi415N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi439N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi463N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi475N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi487N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi499N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi511N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi523N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi547N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi559N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi571N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi583N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi595N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi619N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi643N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi655N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi667N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi679N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi691N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi703N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi727N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi739N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi751N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi763N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi775N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi799N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi823N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q03650

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q03650

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati40 – 511Add BLAST12
Repeati52 – 632Add BLAST12
Repeati64 – 753Add BLAST12
Repeati76 – 874Add BLAST12
Repeati88 – 995Add BLAST12
Repeati100 – 1116Add BLAST12
Repeati112 – 1237Add BLAST12
Repeati124 – 1358Add BLAST12
Repeati136 – 1479Add BLAST12
Repeati148 – 15910Add BLAST12
Repeati160 – 17111Add BLAST12
Repeati172 – 18312Add BLAST12
Repeati184 – 19513Add BLAST12
Repeati196 – 20714Add BLAST12
Repeati208 – 21915Add BLAST12
Repeati220 – 23116Add BLAST12
Repeati232 – 24317Add BLAST12
Repeati244 – 25518Add BLAST12
Repeati256 – 26719Add BLAST12
Repeati268 – 27920Add BLAST12
Repeati280 – 29121Add BLAST12
Repeati292 – 30322Add BLAST12
Repeati304 – 31523Add BLAST12
Repeati316 – 32724Add BLAST12
Repeati328 – 33925Add BLAST12
Repeati340 – 35126Add BLAST12
Repeati352 – 36327Add BLAST12
Repeati364 – 37528Add BLAST12
Repeati376 – 38729Add BLAST12
Repeati388 – 39930Add BLAST12
Repeati400 – 41131Add BLAST12
Repeati412 – 42332Add BLAST12
Repeati424 – 43533Add BLAST12
Repeati436 – 44734Add BLAST12
Repeati448 – 45935Add BLAST12
Repeati460 – 47136Add BLAST12
Repeati472 – 48337Add BLAST12
Repeati484 – 49538Add BLAST12
Repeati496 – 50739Add BLAST12
Repeati508 – 51940Add BLAST12
Repeati520 – 53141Add BLAST12
Repeati532 – 54342Add BLAST12
Repeati544 – 55543Add BLAST12
Repeati556 – 56744Add BLAST12
Repeati568 – 57945Add BLAST12
Repeati580 – 59146Add BLAST12
Repeati592 – 60347Add BLAST12
Repeati604 – 61548Add BLAST12
Repeati616 – 62749Add BLAST12
Repeati628 – 63950Add BLAST12
Repeati640 – 65151Add BLAST12
Repeati652 – 66352Add BLAST12
Repeati664 – 67553Add BLAST12
Repeati676 – 68754Add BLAST12
Repeati688 – 69955Add BLAST12
Repeati700 – 71156Add BLAST12
Repeati712 – 72357Add BLAST12
Repeati724 – 73558Add BLAST12
Repeati736 – 74759Add BLAST12
Repeati748 – 75960Add BLAST12
Repeati760 – 77161Add BLAST12
Repeati772 – 78362Add BLAST12
Repeati784 – 79563Add BLAST12
Repeati796 – 80764Add BLAST12
Repeati808 – 81965Add BLAST12
Repeati820 – 83166Add BLAST12

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni40 – 83166 X 12 AA tandem repeats of D-D-C-[ND]-I-T-G-D-G-N-E-TAdd BLAST792

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009745, CRAM_rpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07016, CRAM_rpt, 65 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q03650-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNEAGPIFE ESNAEVGTPP ADAVHDDFFF DYKNATGYAD DCNITGDCNE
60 70 80 90 100
TDDCDITGDC NETDDCNITG DCNETDDCNI TGDCNETDDC NITGDCNETD
110 120 130 140 150
DCNITGDCNE TDDCDITGDC NETDDCNITG DCNETDDCNI TGDCNETDDC
160 170 180 190 200
NITGDCNETD DCDITGDCNE TDDCNITGDC NETDDCDITG DCNETDDCNI
210 220 230 240 250
TGDCNETDDC NITGDCNETD DCNITGDCNE TDDCNITGDC NETDDCNITG
260 270 280 290 300
DCNETDDCNI TGDCNETDDC DITGDCNETD DCNITGDCNE TDDCNITGDC
310 320 330 340 350
NETDDCNITG DCNETDDCNI TGDCNETDDC NITGDCNETD DCNITGDCNE
360 370 380 390 400
TDDCDITGDC NETDDCNITG DCNETDDCNI TGDCNETDDC NITGDCNETD
410 420 430 440 450
DCNITGDCNE TDDCNITGDC NETDDCDITG DCNETDDCNI TGDCNETDDC
460 470 480 490 500
DITGDCNETD DCNITGDCNE TDDCNITGDC NETDDCNITG DCNETDDCNI
510 520 530 540 550
TGDCNETDDC NITGDCNETD DCNITGDCNE TDDCDITGDC NETDDCNITG
560 570 580 590 600
DCNETDDCNI TGDCNETDDC NITGDCNETD DCNITGDCNE TDDCNITGDC
610 620 630 640 650
NETDDCDITG DCNETDDCNI TGDCNETDDC DITGDCNETD DCNITGDCNE
660 670 680 690 700
TDDCNITGDC NETDDCNITG DCNETDDCNI TGDCNETDDC NITGDCNETD
710 720 730 740 750
DCNITGDCNE TDDCDITGDC NETDDCNITG DCNETDDCNI TGDCNETDDC
760 770 780 790 800
NITGDCNETD DCNITGDCNE TDDCNITGDC NETDDCDITG DCNETDDCNI
810 820 830 840 850
TGDCNETDDC DITGDCNETD DCNITGDCNE TEVSDAADGT DGMFLKSSSS
860 870 880 890 900
LKLVALCDGC PTEDSPKSSN AKGKGSSVSA GLLLLAGSTF LVLAVGLSAV
910 920 930 940
LFLGRERQNA VVICDNEVMM EEVPGCLSDA SFAVPVTQSS DEARP
Length:945
Mass (Da):100,382
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2F57C893ACA4129E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M55686 mRNA Translation: AAA30169.1
M61131 mRNA Translation: AAA30170.1 Sequence problems.

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55686 mRNA Translation: AAA30169.1
M61131 mRNA Translation: AAA30170.1 Sequence problems.

3D structure databases

SMRiQ03650
ModBaseiSearch...

Protein family/group databases

TCDBi9.B.87.1.23, the selenoprotein p receptor (selp-receptor) family

Proteomic databases

PRIDEiQ03650

Family and domain databases

InterProiView protein in InterPro
IPR009745, CRAM_rpt
PfamiView protein in Pfam
PF07016, CRAM_rpt, 65 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCRAM_TRYBB
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q03650
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: November 1, 1996
Last modified: August 12, 2020
This is version 66 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
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