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Protein

Integrin alpha ina-1

Gene

ina-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in cell migration, axon fasciculation, and morphogenesis (PubMed:9247263). During gonad morphogenesis, involved in distal tip cells (DTC)-mediated guidance of gonad elongation, in maintaining their sharp tapering morphology and in their migration (PubMed:19023419, PubMed:22732572). Involved in the anterior-posterior positioning of QR neuroblast descendants by regulating the migratory speed of QR.p (PubMed:25373777). Probably by acting as a receptor for apoptotic cells, plays a role in the clearance of apoptotic cells during mid-embryogenesis (PubMed:20226672).5 Publications

GO - Molecular functioni

  • laminin binding Source: WormBase
  • transmembrane signaling receptor activity Source: WormBase

GO - Biological processi

  • animal organ morphogenesis Source: WormBase
  • axonal fasciculation Source: WormBase
  • body morphogenesis Source: WormBase
  • cell-cell adhesion mediated by integrin Source: WormBase
  • integrin-mediated signaling pathway Source: UniProtKB-KW
  • mesodermal cell migration Source: WormBase
  • nematode larval development Source: WormBase
  • nematode male tail tip morphogenesis Source: WormBase
  • neuron migration Source: WormBase
  • regulation of synaptic transmission, GABAergic Source: UniProtKB

Keywordsi

Molecular functionIntegrin, Receptor
Biological processCell adhesion, Neurogenesis

Enzyme and pathway databases

ReactomeiR-CEL-3000157 Laminin interactions
R-CEL-446107 Type I hemidesmosome assembly
SignaLinkiQ03600

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha ina-1
Gene namesi
Name:ina-1
ORF Names:F54G8.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF54G8.3 ; CE00205 ; WBGene00002081 ; ina-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 1084ExtracellularSequence analysisAdd BLAST1065
Transmembranei1085 – 1106HelicalSequence analysisAdd BLAST22
Topological domaini1107 – 1139CytoplasmicSequence analysisAdd BLAST33

Keywords - Cellular componenti

Cell projection, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Disruption phenotypei

RNAi-mediated knockdown in distal tip cell (DTC) causes DTC morphological and guidance defects such as precocious dorsal turns, a failure to reach the vulva and a bloated distal gonad (PubMed:19023419). Embryos at the comma, 1.5-fold and 2-fold stages have increased number of cell corpses due to a defect in cell engulfment (PubMed:20226672). RNAi-mediated knockdown with mig-38 results in enhanced gonad DTC migration (PubMed:22732572).3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001633120 – 1139Integrin alpha ina-1Add BLAST1120

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi108N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi136N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi313N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi580N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi788N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi851N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1026N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ03600
PaxDbiQ03600
PeptideAtlasiQ03600
PRIDEiQ03600

PTM databases

iPTMnetiQ03600

Expressioni

Gene expression databases

BgeeiWBGene00002081

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Alpha ina-1 associates with beta pat-3 (PubMed:9247263). Interacts (via cytoplasmic domain) with src-1 (when phosphorylated at 'Tyr-416') (PubMed:20226672).2 Publications

GO - Molecular functioni

  • laminin binding Source: WormBase

Protein-protein interaction databases

STRINGi6239.F54G8.3.1

Structurei

3D structure databases

ProteinModelPortaliQ03600
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati21 – 85FG-GAP 1PROSITE-ProRule annotationAdd BLAST65
Repeati111 – 171FG-GAP 2PROSITE-ProRule annotationAdd BLAST61
Repeati180 – 231FG-GAP 3PROSITE-ProRule annotationAdd BLAST52
Repeati242 – 302FG-GAP 4PROSITE-ProRule annotationAdd BLAST61
Repeati307 – 370FG-GAP 5PROSITE-ProRule annotationAdd BLAST64
Repeati378 – 438FG-GAP 6PROSITE-ProRule annotationAdd BLAST61
Repeati448 – 510FG-GAP 7PROSITE-ProRule annotationAdd BLAST63

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPBB Eukaryota
ENOG410XVGZ LUCA
GeneTreeiENSGT00760000118782
HOGENOMiHOG000018098
InParanoidiQ03600
OMAiYVYINQQ
OrthoDBiEOG091G02JI
PhylomeDBiQ03600

Family and domain databases

Gene3Di2.130.10.130, 1 hit
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 1 hit
PF00357 Integrin_alpha, 1 hit
PF08441 Integrin_alpha2, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 4 hits
SUPFAMiSSF69179 SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q03600-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRECIISWTL LLCLSCVKSF NLDVNAPIYR YGPSGTNFGY SVAEHFKGDK
60 70 80 90 100
PVMLIGAPRG ESGQTGTERA GAMYACDINT FYNGGSNHWC EQVRFEYENV
110 120 130 140 150
EDYAKRPNET RGRTVHPLGK NDQLLASTIV SKGTKNGSAL VCAPLIRYHQ
160 170 180 190 200
TAAYPQGACY ELESNLRLQS TYATCAQKNL PTTDRHNEYG GCMEGFSAAI
210 220 230 240 250
TQDTIVTGLI GAVKWTGGVF AKKSSANIFD SVVEKYTMNQ PNGDMIRTRL
260 270 280 290 300
VAHDYLGYSV DIGRFGFWYE DGKPITVVSG ATRYGEHGAV IFLPFIQDSS
310 320 330 340 350
SKLTLNEDKF IINGTAMGSA FGYSIEVVDL NGDGFDDLIV GAPFEHRSGI
360 370 380 390 400
DGNFGGIVYV YFSQGVQRKQ HESHLVFHPP KILKNPDFYS QFGLSITKLG
410 420 430 440 450
NVDGDKSKLN DFAVGAPFAF DGAGAVYIYL GTKNIEKFRK KPAQVIKGND
460 470 480 490 500
LPNLPPGGMR SFGFSLSGGS DMDENGYPDL LIGSPSKNFV ALLRSRPVIS
510 520 530 540 550
IETKHKMEKR MVDIDKGVNC PRGAKTCFPL DMVIYVDEET KRGAELVDFS
560 570 580 590 600
SDVFMCNLEA IPFRADTTAR GFIEGSHSHN YSWPCGSNSH VQKRTYRQLI
610 620 630 640 650
YLPVQESKDW ITPLKFRFTV SIRNEKKPVQ PPQGSQLVDL KHYPVLNKYG
660 670 680 690 700
ASYEFDVPFN TLCGEDHTCQ TDLSLKAAFK DIPLTSNGYV SNVGEKDYLD
710 720 730 740 750
LTFTVENKKE KAYQANFYLE YNEEELELPQ VQGSKRMIAE TIGKNIVHLP
760 770 780 790 800
LGNPMNGASK HQFTIQFKLT RGRTEGIGKA LKFMAHVNST SQETEEELKD
810 820 830 840 850
NKWEAEVQII KKAELEIYGI SDPDRVFFGG KARAESELEL EEDIGTMVRH
860 870 880 890 900
NYTIINHGPW TVRNVEAHIS WPYQLRSRFG RGKNALYLLD VPTITTEFTD
910 920 930 940 950
GTSEVRKCFI KQQYEYVNPA EIKLNTKYST QETAPHRVEH RMKREIDEDE
960 970 980 990 1000
EEQSDDLGAV EENIPWFSTA NFWNLFAIKG GDGRPREVKH LSCQDNTANC
1010 1020 1030 1040 1050
FTVICHFDFI DANSAVVIDL RARLWNATFI EDYSDVESVK IRSFGKLQLD
1060 1070 1080 1090 1100
ESQGIDDDPN NNAAFVETSA DPDRPTIGDS RPIPWWIYVI AAVIGVLILS
1110 1120 1130
LIIICLSKCG FFKRNRLDQP SLYTAQLKHE REEWADTGL
Length:1,139
Mass (Da):127,767
Last modified:February 1, 1994 - v1
Checksum:iC9AE2C6B97493B8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z19155 Genomic DNA Translation: CAA79561.1
PIRiS28277
RefSeqiNP_499032.1, NM_066631.4
UniGeneiCel.17710

Genome annotation databases

EnsemblMetazoaiF54G8.3; F54G8.3; WBGene00002081
GeneIDi176296
KEGGicel:CELE_F54G8.3
UCSCiF54G8.3 c. elegans

Similar proteinsi

Entry informationi

Entry nameiINA1_CAEEL
AccessioniPrimary (citable) accession number: Q03600
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 23, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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