UniProtKB - Q03579 (LIP1_YEAST)
Protein
Ceramide synthase subunit LIP1
Gene
LIP1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Component of the ceramide synthase complex required for synthesis of ceramides.1 Publication
GO - Biological processi
- ceramide biosynthetic process Source: SGD
Keywordsi
Biological process | Lipid biosynthesis, Lipid metabolism |
Enzyme and pathway databases
BioCyci | MetaCyc:MONOMER3O-702 |
Chemistry databases
SwissLipidsi | SLP:000000917 |
Names & Taxonomyi
Protein namesi | Recommended name: Ceramide synthase subunit LIP1Alternative name(s): LAG1/LAC1-interacting protein 1 |
Gene namesi | Name:LIP1 Ordered Locus Names:YMR298W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YMR298W |
SGDi | S000004913, LIP1 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Single-pass type II membrane protein 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: SGD
- endoplasmic reticulum membrane Source: SGD
Nucleus
- nuclear envelope Source: SGD
Other locations
- acyl-CoA ceramide synthase complex Source: SGD
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 20 | Cytoplasmic1 PublicationAdd BLAST | 20 | |
Transmembranei | 21 – 40 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 20 | |
Topological domaini | 41 – 150 | Lumenal1 PublicationAdd BLAST | 110 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000203352 | 1 – 150 | Ceramide synthase subunit LIP1Add BLAST | 150 |
Proteomic databases
MaxQBi | Q03579 |
PaxDbi | Q03579 |
PRIDEi | Q03579 |
PTM databases
iPTMneti | Q03579 |
Interactioni
Subunit structurei
Component of the ceramide synthase complex composed of at least LAC1, LAG1 and LIP1.
Binary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 35478, 222 interactors |
ComplexPortali | CPX-1706, acyl-CoA ceramide synthase complex |
DIPi | DIP-4392N |
IntActi | Q03579, 3 interactors |
STRINGi | 4932.YMR298W |
Miscellaneous databases
RNActi | Q03579, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the LIP1 family.Curated
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S1YW, Eukaryota |
HOGENOMi | CLU_1759093_0_0_1 |
InParanoidi | Q03579 |
OMAi | VEYFKYS |
i Sequence
Sequence statusi: Complete.
Q03579-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSQPTPIITT KSAAKPKPKI FNLFRVCFIS LLLIAAVEYF KYGTRINYEW
60 70 80 90 100
FHCTPIKEPQ SGSVIKLWAR GGPSCDKRGE YKTIVKRITR DYEPNDEHLS
110 120 130 140 150
FCIIENDNVP PVHYPIHEDK GEPGYVAYVG YDTDSELVQE LCADSTIYHM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X80836 Genomic DNA Translation: CAA56807.1 BK006946 Genomic DNA Translation: DAA10199.1 |
PIRi | S47459 |
RefSeqi | NP_014027.1, NM_001182807.1 |
Genome annotation databases
EnsemblFungii | YMR298W_mRNA; YMR298W; YMR298W |
GeneIDi | 855344 |
KEGGi | sce:YMR298W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X80836 Genomic DNA Translation: CAA56807.1 BK006946 Genomic DNA Translation: DAA10199.1 |
PIRi | S47459 |
RefSeqi | NP_014027.1, NM_001182807.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 35478, 222 interactors |
ComplexPortali | CPX-1706, acyl-CoA ceramide synthase complex |
DIPi | DIP-4392N |
IntActi | Q03579, 3 interactors |
STRINGi | 4932.YMR298W |
Chemistry databases
SwissLipidsi | SLP:000000917 |
PTM databases
iPTMneti | Q03579 |
Proteomic databases
MaxQBi | Q03579 |
PaxDbi | Q03579 |
PRIDEi | Q03579 |
Genome annotation databases
EnsemblFungii | YMR298W_mRNA; YMR298W; YMR298W |
GeneIDi | 855344 |
KEGGi | sce:YMR298W |
Organism-specific databases
EuPathDBi | FungiDB:YMR298W |
SGDi | S000004913, LIP1 |
Phylogenomic databases
eggNOGi | ENOG502S1YW, Eukaryota |
HOGENOMi | CLU_1759093_0_0_1 |
InParanoidi | Q03579 |
OMAi | VEYFKYS |
Enzyme and pathway databases
BioCyci | MetaCyc:MONOMER3O-702 |
Miscellaneous databases
PROi | PR:Q03579 |
RNActi | Q03579, protein |
Family and domain databases
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LIP1_YEAST | |
Accessioni | Q03579Primary (citable) accession number: Q03579 Secondary accession number(s): D6W0C5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | October 7, 2020 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast chromosome XIII
Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names - SIMILARITY comments
Index of protein domains and families - Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD