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UniProtKB - Q03554 (GOT1_YEAST)
Protein
Protein transport protein GOT1
Gene
GOT1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Nonessential protein required for the fusion of ER-derived transport vesicles with the Golgi complex. Can be replaced by SFT2.
1 PublicationGO - Biological processi
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: SGD
- protein transport Source: UniProtKB-KW
- retrograde transport, endosome to Golgi Source: SGD
Keywordsi
Biological process | Protein transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Protein transport protein GOT1Alternative name(s): Golgi transport protein 1 |
Gene namesi | Name:GOT1 Ordered Locus Names:YMR292W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000004906, GOT1 |
VEuPathDBi | FungiDB:YMR292W |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane 1 Publication; Multi-pass membrane protein 1 Publication
Cytosol
- cytosol Source: GOC
Endoplasmic reticulum
- endoplasmic reticulum Source: SGD
Golgi apparatus
- Golgi apparatus Source: SGD
- Golgi cis cisterna Source: SGD
- Golgi membrane Source: SGD
Other locations
- COPII-coated ER to Golgi transport vesicle Source: SGD
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 8 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 9 – 29 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 30 – 31 | LumenalSequence analysis | 2 | |
Transmembranei | 32 – 52 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 53 – 67 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 68 – 88 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 89 – 112 | LumenalSequence analysisAdd BLAST | 24 | |
Transmembranei | 113 – 133 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 134 – 138 | CytoplasmicSequence analysis | 5 |
Keywords - Cellular componenti
Golgi apparatus, MembranePathology & Biotechi
Disruption phenotypei
Lack of GOT1 is lethal in a strain lacking SFT2.1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 73 | G → S in got1-1; loss of function. ER-Golgi transport defect when associated with lack of SFT2. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000218586 | 1 – 138 | Protein transport protein GOT1Add BLAST | 138 |
Proteomic databases
MaxQBi | Q03554 |
PaxDbi | Q03554 |
PRIDEi | Q03554 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 35472, 126 interactors |
DIPi | DIP-8271N |
IntActi | Q03554, 15 interactors |
MINTi | Q03554 |
STRINGi | 4932.YMR292W |
Miscellaneous databases
RNActi | Q03554, protein |
Structurei
Family & Domainsi
Sequence similaritiesi
Belongs to the GOT1 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1743, Eukaryota |
HOGENOMi | CLU_124519_1_0_1 |
InParanoidi | Q03554 |
OMAi | KLRGTIC |
Family and domain databases
InterProi | View protein in InterPro IPR045176, Got1 IPR007305, Vesicle_transpt_Got1/SFT2 |
PANTHERi | PTHR21493, PTHR21493, 1 hit |
Pfami | View protein in Pfam PF04178, Got1, 1 hit |
i Sequence
Sequence statusi: Complete.
Q03554-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWLTEAQKFG VAFTFGGFLF FLFGIFTFFD RALLALGNIL FLIGVFLIIG
60 70 80 90 100
SQKTYIFFTR PNKRRGSLFF LVGAFLILLK WTFLGFIIES LGIIGLFGDF
110 120 130
FGVIVQFLRS MPIIGPILSH PAIAPIVDKL AGVRVLPV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X80836 Genomic DNA Translation: CAA56801.1 BK006946 Genomic DNA Translation: DAA10193.1 |
PIRi | S47453 |
RefSeqi | NP_014020.1, NM_001182800.1 |
Genome annotation databases
EnsemblFungii | YMR292W_mRNA; YMR292W; YMR292W |
GeneIDi | 855337 |
KEGGi | sce:YMR292W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X80836 Genomic DNA Translation: CAA56801.1 BK006946 Genomic DNA Translation: DAA10193.1 |
PIRi | S47453 |
RefSeqi | NP_014020.1, NM_001182800.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 35472, 126 interactors |
DIPi | DIP-8271N |
IntActi | Q03554, 15 interactors |
MINTi | Q03554 |
STRINGi | 4932.YMR292W |
Proteomic databases
MaxQBi | Q03554 |
PaxDbi | Q03554 |
PRIDEi | Q03554 |
Genome annotation databases
EnsemblFungii | YMR292W_mRNA; YMR292W; YMR292W |
GeneIDi | 855337 |
KEGGi | sce:YMR292W |
Organism-specific databases
SGDi | S000004906, GOT1 |
VEuPathDBi | FungiDB:YMR292W |
Phylogenomic databases
eggNOGi | KOG1743, Eukaryota |
HOGENOMi | CLU_124519_1_0_1 |
InParanoidi | Q03554 |
OMAi | KLRGTIC |
Miscellaneous databases
PROi | PR:Q03554 |
RNActi | Q03554, protein |
Family and domain databases
InterProi | View protein in InterPro IPR045176, Got1 IPR007305, Vesicle_transpt_Got1/SFT2 |
PANTHERi | PTHR21493, PTHR21493, 1 hit |
Pfami | View protein in Pfam PF04178, Got1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GOT1_YEAST | |
Accessioni | Q03554Primary (citable) accession number: Q03554 Secondary accession number(s): D6W0B9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | February 23, 2022 | |
This is version 141 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XIII
Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names - Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries - SIMILARITY comments
Index of protein domains and families