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Protein

Ceramide very long chain fatty acid hydroxylase SCS7

Gene

SCS7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ceramide hydroxylase involved in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids. Hydroxylates the very long chain fatty acid of ceramides at C2 and C3.6 Publications

Miscellaneous

Present with 3290 molecules/cell in log phase SD medium.1 Publication

Cofactori

Fe cationBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi45Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi72Iron (heme axial ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

  • fatty acid alpha-hydroxylase activity Source: SGD
  • heme binding Source: InterPro
  • iron ion binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Transport
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:YMR272C-MONOMER
YEAST:YMR272C-MONOMER
ReactomeiR-SCE-1660661 Sphingolipid de novo biosynthesis

Chemistry databases

SwissLipidsiSLP:000001842

Names & Taxonomyi

Protein namesi
Recommended name:
Ceramide very long chain fatty acid hydroxylase SCS7 (EC:1.-.-.-)
Short name:
Ceramide VLCFA hydroxylase SCS7
Alternative name(s):
Suppressor of calcium sensitivity 7
Gene namesi
Name:SCS7
Synonyms:FAH1
Ordered Locus Names:YMR272C
ORF Names:YM8156.14C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR272C
SGDiS000004885 SCS7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 196CytoplasmicSequence analysisAdd BLAST196
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Topological domaini218 – 222LumenalSequence analysis5
Transmembranei223 – 243HelicalSequence analysisAdd BLAST21
Topological domaini244 – 297CytoplasmicSequence analysisAdd BLAST54
Transmembranei298 – 318HelicalSequence analysisAdd BLAST21
Topological domaini319 – 352LumenalSequence analysisAdd BLAST34
Transmembranei353 – 373HelicalSequence analysisAdd BLAST21
Topological domaini374 – 384CytoplasmicSequence analysisAdd BLAST11

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001854071 – 384Ceramide very long chain fatty acid hydroxylase SCS7Add BLAST384

Proteomic databases

MaxQBiQ03529
PaxDbiQ03529
PRIDEiQ03529

PTM databases

iPTMnetiQ03529

Interactioni

Protein-protein interaction databases

BioGridi35451, 1020 interactors
IntActiQ03529, 35 interactors
MINTiQ03529
STRINGi4932.YMR272C

Structurei

Secondary structure

1384
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ03529
SMRiQ03529
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 90Cytochrome b5 heme-bindingPROSITE-ProRule annotationAdd BLAST82

Domaini

The histidine box domains may contain the active site and/or be involved in metal ion binding.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000002142
HOGENOMiHOG000023981
InParanoidiQ03529
KOiK19703
OMAiRWLEQYY
OrthoDBiEOG092C3MYJ

Family and domain databases

Gene3Di3.10.120.10, 1 hit
InterProiView protein in InterPro
IPR001199 Cyt_B5-like_heme/steroid-bd
IPR036400 Cyt_B5-like_heme/steroid_sf
IPR018506 Cyt_B5_heme-BS
IPR006694 Fatty_acid_hydroxylase
IPR014430 Scs7
PfamiView protein in Pfam
PF00173 Cyt-b5, 1 hit
PF04116 FA_hydroxylase, 1 hit
PIRSFiPIRSF005149 IPC-B_HD, 1 hit
PRINTSiPR00363 CYTOCHROMEB5
SMARTiView protein in SMART
SM01117 Cyt-b5, 1 hit
SUPFAMiSSF55856 SSF55856, 1 hit
PROSITEiView protein in PROSITE
PS00191 CYTOCHROME_B5_1, 1 hit
PS50255 CYTOCHROME_B5_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q03529-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTNTSKTLE LFSKKTVQEH NTANDCWVTY QNRKIYDVTR FLSEHPGGDE
60 70 80 90 100
SILDYAGKDI TEIMKDSDVH EHSDSAYEIL EDEYLIGYLA TDEEAARLLT
110 120 130 140 150
NKNHKVEVQL SADGTEFDST TFVKELPAEE KLSIATDYSN DYKKHKFLDL
160 170 180 190 200
NRPLLMQILR SDFKKDFYVD QIHRPRHYGK GSAPLFGNFL EPLTKTAWWV
210 220 230 240 250
VPVAWLPVVV YHMGVALKNM NQLFACFLFC VGVFVWTLIE YGLHRFLFHF
260 270 280 290 300
DDWLPESNIA FATHFLLHGC HHYLPMDKYR LVMPPTLFVI LCAPFYKLVF
310 320 330 340 350
ALLPLYWAYA GFAGGLFGYV CYDECHFFLH HSKLPPFMRK LKKYHLEHHY
360 370 380
KNYQLGFGVT SWFWDEVFGT YLGPDAPLSK MKYE
Length:384
Mass (Da):44,881
Last modified:November 1, 1997 - v1
Checksum:iDF4BA5F2E0EA2218
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49260 Genomic DNA Translation: CAA89255.1
AY693150 Genomic DNA Translation: AAT93169.1
BK006946 Genomic DNA Translation: DAA10172.1
PIRiS54484
RefSeqiNP_013999.1, NM_001182779.1

Genome annotation databases

EnsemblFungiiYMR272C; YMR272C; YMR272C
GeneIDi855315
KEGGisce:YMR272C

Entry informationi

Entry nameiSCS7_YEAST
AccessioniPrimary (citable) accession number: Q03529
Secondary accession number(s): D6W098
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 12, 2018
This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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