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Entry version 212 (22 Apr 2020)
Sequence version 1 (01 Jun 1994)
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Protein

Antigen peptide transporter 2

Gene

TAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi503 – 510ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAdaptive immunity, Host-virus interaction, Immunity, Peptide transport, Protein transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.6.3.43 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1236974 ER-Phagosome pathway
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.1.209.1 the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Antigen peptide transporter 2
Short name:
APT2
Alternative name(s):
ATP-binding cassette sub-family B member 3
Peptide supply factor 2
Peptide transporter PSF2
Short name:
PSF-2
Peptide transporter TAP2
Peptide transporter involved in antigen processing 2
Really interesting new gene 11 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TAP21 PublicationImported
Synonyms:ABCB3, PSF2, RING11, Y1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:44 TAP2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
170261 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q03519

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 6LumenalSequence analysis6
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei7 – 27Helical; Name=1PROSITE-ProRule annotationAdd BLAST21
Topological domaini28 – 56CytoplasmicSequence analysisAdd BLAST29
Transmembranei57 – 77Helical; Name=2PROSITE-ProRule annotationAdd BLAST21
Topological domaini78 – 98LumenalSequence analysisAdd BLAST21
Transmembranei99 – 119Helical; Name=3PROSITE-ProRule annotationAdd BLAST21
Topological domaini120 – 148CytoplasmicSequence analysisAdd BLAST29
Transmembranei149 – 169Helical; Name=4PROSITE-ProRule annotationAdd BLAST21
Topological domaini170 – 187LumenalSequence analysisAdd BLAST18
Transmembranei188 – 208Helical; Name=5PROSITE-ProRule annotationAdd BLAST21
Topological domaini209 – 266CytoplasmicSequence analysisAdd BLAST58
Transmembranei267 – 287Helical; Name=6PROSITE-ProRule annotationAdd BLAST21
Topological domaini288 – 293LumenalSequence analysis6
Transmembranei294 – 314Helical; Name=7PROSITE-ProRule annotationAdd BLAST21
Topological domaini315 – 374CytoplasmicSequence analysisAdd BLAST60
Transmembranei375 – 395Helical; Name=8PROSITE-ProRule annotationAdd BLAST21
Topological domaini396 – 408LumenalSequence analysisAdd BLAST13
Transmembranei409 – 429Helical; Name=9PROSITE-ProRule annotationAdd BLAST21
Topological domaini430 – 686CytoplasmicSequence analysisAdd BLAST257

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Bare lymphocyte syndrome 1 (BLS1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA HLA class I deficiency. Contrary to bare lymphocyte syndromes type 2 and type 3, which are characterized by early-onset severe combined immunodeficiency, class I antigen deficiencies are not accompanied by particular pathologic manifestations during the first years of life. Systemic infections have not been described. Chronic bacterial infections, often beginning in the first decade of life, are restricted to the respiratory tract.
Related information in OMIM

Organism-specific databases

DisGeNET

More...
DisGeNETi
6891

MalaCards human disease database

More...
MalaCardsi
TAP2
MIMi604571 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000204267

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
34592 Immunodeficiency by defective expression of MHC class I

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35022

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q03519 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TAP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
549044

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000933291 – 686Antigen peptide transporter 2Add BLAST686

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q03519

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q03519

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q03519

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q03519

PeptideAtlas

More...
PeptideAtlasi
Q03519

PRoteomics IDEntifications database

More...
PRIDEi
Q03519

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
58215 [Q03519-1]
58216 [Q03519-2]
62921

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q03519-2 [Q03519-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q03519

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q03519

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By IFNG/IFN-gamma.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000204267 Expressed in adrenal gland and 186 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q03519 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q03519 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000204267 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of TAP1 and TAP2.

Interacts with HLA-A*02-B2M complex; this interaction is obligatory for the loading of peptide epitopes delivered to the ER by TAP1-TAP2 transporter (PubMed:8805302, PubMed:8630735). Similarly to classical MHC class I assembly, HLA-E-B2M complex binds TAP1-TAP2 heterodimer and CALR before the peptide loading (PubMed:9427624).

Interacts with HLA-F (PubMed:10605026).

4 Publications

(Microbial infection) Interacts with Epstein-Barr virus BLNF2a.

1 Publication

(Microbial infection) Interacts with herpes simplex virus ICP47.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112754, 37 interactors

Database of interacting proteins

More...
DIPi
DIP-322N

Protein interaction database and analysis system

More...
IntActi
Q03519, 27 interactors

Molecular INTeraction database

More...
MINTi
Q03519

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000364034

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q03519 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q03519

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini152 – 435ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST284
Domaini468 – 686ABC transporterPROSITE-ProRule annotationAdd BLAST219

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni301 – 389Involved in peptide-binding siteAdd BLAST89
Regioni414 – 433Involved in peptide-binding siteAdd BLAST20

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0058 Eukaryota
COG1132 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160499

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000604_84_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q03519

KEGG Orthology (KO)

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KOi
K05654

Database of Orthologous Groups

More...
OrthoDBi
684058at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q03519

TreeFam database of animal gene trees

More...
TreeFami
TF105197

Family and domain databases

Database of protein disorder

More...
DisProti
DP02210

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR013305 ABC_Tap-like
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
IPR005293 Tap2/ABCB3
IPR039421 Type_I_exporter

The PANTHER Classification System

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PANTHERi
PTHR24221 PTHR24221, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664 ABC_membrane, 1 hit
PF00005 ABC_tran, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01897 TAP2PROTEIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit
SSF90123 SSF90123, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00958 3a01208, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q03519-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRLPDLRPWT SLLLVDAALL WLLQGPLGTL LPQGLPGLWL EGTLRLGGLW
60 70 80 90 100
GLLKLRGLLG FVGTLLLPLC LATPLTVSLR ALVAGASRAP PARVASAPWS
110 120 130 140 150
WLLVGYGAAG LSWSLWAVLS PPGAQEKEQD QVNNKVLMWR LLKLSRPDLP
160 170 180 190 200
LLVAAFFFLV LAVLGETLIP HYSGRVIDIL GGDFDPHAFA SAIFFMCLFS
210 220 230 240 250
FGSSLSAGCR GGCFTYTMSR INLRIREQLF SSLLRQDLGF FQETKTGELN
260 270 280 290 300
SRLSSDTTLM SNWLPLNANV LLRSLVKVVG LYGFMLSISP RLTLLSLLHM
310 320 330 340 350
PFTIAAEKVY NTRHQEVLRE IQDAVARAGQ VVREAVGGLQ TVRSFGAEEH
360 370 380 390 400
EVCRYKEALE QCRQLYWRRD LERALYLLVR RVLHLGVQML MLSCGLQQMQ
410 420 430 440 450
DGELTQGSLL SFMIYQESVG SYVQTLVYIY GDMLSNVGAA EKVFSYMDRQ
460 470 480 490 500
PNLPSPGTLA PTTLQGVVKF QDVSFAYPNR PDRPVLKGLT FTLRPGEVTA
510 520 530 540 550
LVGPNGSGKS TVAALLQNLY QPTGGQVLLD EKPISQYEHC YLHSQVVSVG
560 570 580 590 600
QEPVLFSGSV RNNIAYGLQS CEDDKVMAAA QAAHADDFIQ EMEHGIYTDV
610 620 630 640 650
GEKGSQLAAG QKQRLAIARA LVRDPRVLIL DEATSALDVQ CEQALQDWNS
660 670 680
RGDRTVLVIA HRLQTVQRAH QILVLQEGKL QKLAQL
Length:686
Mass (Da):75,664
Last modified:June 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE7E4A7F6A2A3B48B
GO
Isoform 2 (identifier: Q03519-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     645-686: LQDWNSRGDRTVLVIAHRLQTVQRAHQILVLQEGKLQKLAQL → KTLWKFMIF

Show »
Length:653
Mass (Da):72,003
Checksum:iAA79C3E9C6FE31AB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WYD6A0A087WYD6_HUMAN
Antigen peptide transporter 2
TAP2
702Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X5CMH5X5CMH5_HUMAN
Antigen peptide transporter 2
TAP2
703Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JLV0A0A0G2JLV0_HUMAN
Antigen peptide transporter 2
TAP2
702Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T9S0A0A140T9S0_HUMAN
Antigen peptide transporter 2
TAP2
653Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti345F → I in BAD97020 (Ref. 8) Curated1
Sequence conflicti520Y → N in BAD97020 (Ref. 8) Curated1
Sequence conflicti655T → A in BAD97020 (Ref. 8) Curated1

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

4 common alleles are officially recognized: TAP2*01:01 (TAP2A or PSF2A or RING11A), TAP2*01:02 (TAP2E), TAP2*01:03 (TAP2F), and TAP2*02:01 (TAP2B or PSF2B or RING11B). Other relatively common alleles have been identified: TAP2*01D, TAP2*01E, TAP2*01F, TAP2*01G, TAP2*01H, TAP2*02B, TAP2*02C (TAP2*02:02), TAP2*02D, TAP2*02E, TAP2*02F, TAP2*03A and TAP2*04A. The sequence shown is that of TAP2*01:01.6 Publications
The allele TAP2*Bky2 is commonly found only in the Japanese population. It may be associated with susceptibility to Sjoegren syndrome, an autoimmune disorder characterized by abnormal dryness of the conjunctiva, cornea and mouth due to exocrine glands dysfunction.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03687356R → K. Corresponds to variant dbSNP:rs17220192Ensembl.1
Natural variantiVAR_014997374A → T in allele TAP2*01F, allele TAP2*01G, allele TAP2*01H, allele TAP2*02B and allele TAP2*02D. 2 PublicationsCorresponds to variant dbSNP:rs111303994EnsemblClinVar.1
Natural variantiVAR_000094379V → I in allele TAP2*01D, allele TAP2*01E, allele TAP2*01G, allele TAP2*02C and allele TAP2*02F. 3 PublicationsCorresponds to variant dbSNP:rs1800454EnsemblClinVar.1
Natural variantiVAR_014998467V → I in allele TAP2*01F and allele TAP2*02D. 2 PublicationsCorresponds to variant dbSNP:rs150253319Ensembl.1
Natural variantiVAR_014999513A → S Rare polymorphism. 1
Natural variantiVAR_000095565A → T in allele TAP2*01:02, allele TAP2*01D, allele TAP2*02E and allele TAP2*02F. 1 PublicationCorresponds to variant dbSNP:rs2228396Ensembl.1
Natural variantiVAR_015000577M → V in allele TAP2*BKY2. 1 PublicationCorresponds to variant dbSNP:rs2228391Ensembl.1
Natural variantiVAR_000096651R → C in allele TAP2*01:03 and allele TAP2*01G. 1 PublicationCorresponds to variant dbSNP:rs4148876Ensembl.1
Natural variantiVAR_000097665T → A in allele TAP2*02:01, allele TAP2*02B, allele TAP2*02C, allele TAP2*02D, allele TAP2*02E, allele TAP2*02F, allele TAP2*04A and allele TAP2*Bky2. 2 PublicationsCorresponds to variant dbSNP:rs241447Ensembl.1
Natural variantiVAR_000098686L → LQEGQDLYSRLVQQRLMD in allele TAP2*02:01, allele TAP2*02B, allele TAP2*02C, allele TAP2*02D, allele TAP2*02E, allele TAP2*02F, allele TAP2*03A and allele TAP2*BKY2. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_038904645 – 686LQDWN…KLAQL → KTLWKFMIF in isoform 2. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X66401 Genomic DNA Translation: CAA47027.1
M84748 mRNA No translation available.
M74447 mRNA Translation: AAA59841.1
Z22935 mRNA Translation: CAA80522.1
Z22936 mRNA Translation: CAA80523.1
AB073779 mRNA Translation: BAB71769.1
AF105151 mRNA Translation: AAD12059.1
X87344 Genomic DNA Translation: CAA60788.1
AK222823 mRNA Translation: BAD96543.1
AK223300 mRNA Translation: BAD97020.1
BX296564 Genomic DNA No translation available.
CR788227 Genomic DNA No translation available.
BX682530 Genomic DNA No translation available.
CR762476 Genomic DNA No translation available.
CR753889 Genomic DNA No translation available.
CT009502 Genomic DNA No translation available.
BC002751 mRNA No translation available.
U07844 mRNA Translation: AAA79901.1
AH007554 Genomic DNA Translation: AAD23381.1
L09191 mRNA Translation: AAA58648.1
L10287 mRNA Translation: AAA58649.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS4755.1 [Q03519-2]
CCDS78129.1 [Q03519-1]

Protein sequence database of the Protein Information Resource

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PIRi
B41538

NCBI Reference Sequences

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RefSeqi
NP_000535.3, NM_000544.3
NP_001276972.1, NM_001290043.1 [Q03519-1]
NP_061313.2, NM_018833.2 [Q03519-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000374897; ENSP00000364032; ENSG00000204267 [Q03519-1]
ENST00000383118; ENSP00000372599; ENSG00000206235 [Q03519-1]
ENST00000383119; ENSP00000372600; ENSG00000206235 [Q03519-2]
ENST00000383239; ENSP00000372726; ENSG00000206299 [Q03519-1]
ENST00000383240; ENSP00000372727; ENSG00000206299 [Q03519-2]
ENST00000414145; ENSP00000401377; ENSG00000228582 [Q03519-2]
ENST00000419142; ENSP00000390013; ENSG00000237599
ENST00000426977; ENSP00000387553; ENSG00000232326 [Q03519-2]
ENST00000439425; ENSP00000396156; ENSG00000225967 [Q03519-2]
ENST00000443713; ENSP00000394101; ENSG00000228582 [Q03519-1]
ENST00000451907; ENSP00000392172; ENSG00000223481 [Q03519-2]
ENST00000652259; ENSP00000498827; ENSG00000204267 [Q03519-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6891

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6891

UCSC genome browser

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UCSCi
uc063yci.1 human [Q03519-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

TAP2base

TAP2 mutation db

ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66401 Genomic DNA Translation: CAA47027.1
M84748 mRNA No translation available.
M74447 mRNA Translation: AAA59841.1
Z22935 mRNA Translation: CAA80522.1
Z22936 mRNA Translation: CAA80523.1
AB073779 mRNA Translation: BAB71769.1
AF105151 mRNA Translation: AAD12059.1
X87344 Genomic DNA Translation: CAA60788.1
AK222823 mRNA Translation: BAD96543.1
AK223300 mRNA Translation: BAD97020.1
BX296564 Genomic DNA No translation available.
CR788227 Genomic DNA No translation available.
BX682530 Genomic DNA No translation available.
CR762476 Genomic DNA No translation available.
CR753889 Genomic DNA No translation available.
CT009502 Genomic DNA No translation available.
BC002751 mRNA No translation available.
U07844 mRNA Translation: AAA79901.1
AH007554 Genomic DNA Translation: AAD23381.1
L09191 mRNA Translation: AAA58648.1
L10287 mRNA Translation: AAA58649.1
CCDSiCCDS4755.1 [Q03519-2]
CCDS78129.1 [Q03519-1]
PIRiB41538
RefSeqiNP_000535.3, NM_000544.3
NP_001276972.1, NM_001290043.1 [Q03519-1]
NP_061313.2, NM_018833.2 [Q03519-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5U1Delectron microscopy3.97B1-686[»]
SMRiQ03519
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi112754, 37 interactors
DIPiDIP-322N
IntActiQ03519, 27 interactors
MINTiQ03519
STRINGi9606.ENSP00000364034

Protein family/group databases

TCDBi3.A.1.209.1 the atp-binding cassette (abc) superfamily

PTM databases

iPTMnetiQ03519
PhosphoSitePlusiQ03519

Polymorphism and mutation databases

BioMutaiTAP2
DMDMi549044

Proteomic databases

EPDiQ03519
jPOSTiQ03519
MassIVEiQ03519
PaxDbiQ03519
PeptideAtlasiQ03519
PRIDEiQ03519
ProteomicsDBi58215 [Q03519-1]
58216 [Q03519-2]
62921
TopDownProteomicsiQ03519-2 [Q03519-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
684 221 antibodies

The DNASU plasmid repository

More...
DNASUi
6891

Genome annotation databases

EnsembliENST00000374897; ENSP00000364032; ENSG00000204267 [Q03519-1]
ENST00000383118; ENSP00000372599; ENSG00000206235 [Q03519-1]
ENST00000383119; ENSP00000372600; ENSG00000206235 [Q03519-2]
ENST00000383239; ENSP00000372726; ENSG00000206299 [Q03519-1]
ENST00000383240; ENSP00000372727; ENSG00000206299 [Q03519-2]
ENST00000414145; ENSP00000401377; ENSG00000228582 [Q03519-2]
ENST00000419142; ENSP00000390013; ENSG00000237599
ENST00000426977; ENSP00000387553; ENSG00000232326 [Q03519-2]
ENST00000439425; ENSP00000396156; ENSG00000225967 [Q03519-2]
ENST00000443713; ENSP00000394101; ENSG00000228582 [Q03519-1]
ENST00000451907; ENSP00000392172; ENSG00000223481 [Q03519-2]
ENST00000652259; ENSP00000498827; ENSG00000204267 [Q03519-2]
GeneIDi6891
KEGGihsa:6891
UCSCiuc063yci.1 human [Q03519-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6891
DisGeNETi6891

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TAP2
HGNCiHGNC:44 TAP2
HPAiENSG00000204267 Low tissue specificity
MalaCardsiTAP2
MIMi170261 gene
604571 phenotype
neXtProtiNX_Q03519
OpenTargetsiENSG00000204267
Orphaneti34592 Immunodeficiency by defective expression of MHC class I
PharmGKBiPA35022

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0058 Eukaryota
COG1132 LUCA
GeneTreeiENSGT00940000160499
HOGENOMiCLU_000604_84_3_1
InParanoidiQ03519
KOiK05654
OrthoDBi684058at2759
PhylomeDBiQ03519
TreeFamiTF105197

Enzyme and pathway databases

BRENDAi3.6.3.43 2681
ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TAP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6891
PharosiQ03519 Tbio

Protein Ontology

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PROi
PR:Q03519
RNActiQ03519 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000204267 Expressed in adrenal gland and 186 other tissues
ExpressionAtlasiQ03519 baseline and differential
GenevisibleiQ03519 HS

Family and domain databases

DisProtiDP02210
Gene3Di1.20.1560.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR013305 ABC_Tap-like
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
IPR005293 Tap2/ABCB3
IPR039421 Type_I_exporter
PANTHERiPTHR24221 PTHR24221, 1 hit
PfamiView protein in Pfam
PF00664 ABC_membrane, 1 hit
PF00005 ABC_tran, 1 hit
PRINTSiPR01897 TAP2PROTEIN
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF90123 SSF90123, 1 hit
TIGRFAMsiTIGR00958 3a01208, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTAP2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q03519
Secondary accession number(s): B0V2J8
, O95410, Q53FI6, Q5HY71, Q96PT8, Q9UQ83
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 22, 2020
This is version 212 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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