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Protein

Antigen peptide transporter 1

Gene

TAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules.

Caution

It is uncertain whether Met-1 or Met-61 is the initiator.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi598 – 605ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ADP binding Source: UniProtKB
  • ATPase activity, coupled to transmembrane movement of substances Source: GO_Central
  • ATP binding Source: UniProtKB
  • MHC class Ib protein binding Source: UniProtKB
  • MHC class I protein binding Source: Ensembl
  • peptide antigen binding Source: UniProtKB
  • peptide antigen-transporting ATPase activity Source: InterPro
  • peptide transmembrane transporter activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • TAP1 binding Source: UniProtKB
  • TAP2 binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAdaptive immunity, Host-virus interaction, Immunity, Peptide transport, Protein transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.6.3.43 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1236974 ER-Phagosome pathway
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q03518

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.1.209.1 the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Antigen peptide transporter 1
Short name:
APT1
Alternative name(s):
ATP-binding cassette sub-family B member 2
Peptide supply factor 1
Peptide transporter PSF1
Short name:
PSF-1
Peptide transporter TAP1
Peptide transporter involved in antigen processing 1
Really interesting new gene 4 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TAP1
Synonyms:ABCB2, PSF1, RING4, Y3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000168394.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:43 TAP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
170260 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q03518

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini61 – 75CytoplasmicSequence analysisAdd BLAST15
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei76 – 96Helical; Name=1PROSITE-ProRule annotationAdd BLAST21
Topological domaini97 – 113LumenalSequence analysisAdd BLAST17
Transmembranei114 – 136Helical; Name=2PROSITE-ProRule annotationAdd BLAST23
Topological domaini137 – 152CytoplasmicSequence analysisAdd BLAST16
Transmembranei153 – 173Helical; Name=3PROSITE-ProRule annotationAdd BLAST21
Topological domaini174 – 193LumenalSequence analysisAdd BLAST20
Transmembranei194 – 214Helical; Name=4PROSITE-ProRule annotationAdd BLAST21
Topological domaini215 – 246CytoplasmicSequence analysisAdd BLAST32
Transmembranei247 – 267Helical; Name=5PROSITE-ProRule annotationAdd BLAST21
Topological domaini268 – 287LumenalSequence analysisAdd BLAST20
Transmembranei288 – 308Helical; Name=6PROSITE-ProRule annotationAdd BLAST21
Topological domaini309 – 358CytoplasmicSequence analysisAdd BLAST50
Transmembranei359 – 379Helical; Name=7PROSITE-ProRule annotationAdd BLAST21
Topological domaini380 – 388LumenalSequence analysis9
Transmembranei389 – 409Helical; Name=8PROSITE-ProRule annotationAdd BLAST21
Topological domaini410 – 478CytoplasmicSequence analysisAdd BLAST69
Transmembranei479 – 499Helical; Name=9PROSITE-ProRule annotationAdd BLAST21
Topological domaini500 – 503LumenalSequence analysis4
Transmembranei504 – 524Helical; Name=10PROSITE-ProRule annotationAdd BLAST21
Topological domaini525 – 808CytoplasmicSequence analysisAdd BLAST284

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Bare lymphocyte syndrome 1 (BLS1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA HLA class I deficiency. Contrary to bare lymphocyte syndromes type 2 and type 3, which are characterized by early-onset severe combined immunodeficiency, class I antigen deficiencies are not accompanied by particular pathologic manifestations during the first years of life. Systemic infections have not been described. Chronic bacterial infections, often beginning in the first decade of life, are restricted to the respiratory tract.
See also OMIM:604571

Organism-specific databases

DisGeNET

More...
DisGeNETi
6890

MalaCards human disease database

More...
MalaCardsi
TAP1
MIMi604571 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000168394

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
34592 Immunodeficiency by defective expression of HLA class 1

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35021

Chemistry databases

Drug and drug target database

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DrugBanki
DB01259 Lapatinib

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TAP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215273957

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000933261 – 808Antigen peptide transporter 1Add BLAST808

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q03518

MaxQB - The MaxQuant DataBase

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MaxQBi
Q03518

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q03518

PeptideAtlas

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PeptideAtlasi
Q03518

PRoteomics IDEntifications database

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PRIDEi
Q03518

ProteomicsDB human proteome resource

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ProteomicsDBi
58214

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q03518

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q03518

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q03518

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By IFNG/IFN-gamma.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000168394 Expressed in 206 organ(s), highest expression level in epithelium of bronchus

CleanEx database of gene expression profiles

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CleanExi
HS_TAP1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q03518 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q03518 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB009516
HPA072354

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of TAP1 and TAP2. Interacts with PSMB5 and PSMB8 (PubMed:15488952). Similarly to classical MHC class I assembly, HLA-E-B2M complex binds TAP1-TAP2 heterodimer and CALR before the peptide loading (PubMed:9427624).2 Publications
(Microbial infection) Interacts with Epstein-Barr virus BNLF2a.1 Publication
(Microbial infection) Interacts with herpes simplex virus ICP47.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112753, 45 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q03518

Database of interacting proteins

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DIPi
DIP-35626N

Protein interaction database and analysis system

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IntActi
Q03518, 53 interactors

Molecular INTeraction database

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MINTi
Q03518

STRING: functional protein association networks

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STRINGi
9606.ENSP00000346206

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1808
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q03518

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q03518

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q03518

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini247 – 530ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST284
Domaini563 – 802ABC transporterPROSITE-ProRule annotationAdd BLAST240

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni435 – 480Involved in peptide-binding siteAdd BLAST46
Regioni513 – 547Involved in peptide-binding siteAdd BLAST35

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0058 Eukaryota
COG1132 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159023

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG008358

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q03518

KEGG Orthology (KO)

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KOi
K05653

Identification of Orthologs from Complete Genome Data

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OMAi
QNQTGAI

Database of Orthologous Groups

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OrthoDBi
EOG09370VL2

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q03518

TreeFam database of animal gene trees

More...
TreeFami
TF105197

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.1560.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR013305 ABC_Tap-like
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
IPR013306 Tap1/ABCB2
IPR039421 Type_I_exporter

The PANTHER Classification System

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PANTHERi
PTHR24221 PTHR24221, 1 hit
PTHR24221:SF249 PTHR24221:SF249, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00664 ABC_membrane, 1 hit
PF00005 ABC_tran, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00382 AAA, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52540 SSF52540, 1 hit
SSF90123 SSF90123, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00958 3a01208, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q03518-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAELLASAGS ACSWDFPRAP PSFPPPAASR GGLGGTRSFR PHRGAESPRP
60 70 80 90 100
GRDRDGVRVP MASSRCPAPR GCRCLPGASL AWLGTVLLLL ADWVLLRTAL
110 120 130 140 150
PRIFSLLVPT ALPLLRVWAV GLSRWAVLWL GACGVLRATV GSKSENAGAQ
160 170 180 190 200
GWLAALKPLA AALGLALPGL ALFRELISWG APGSADSTRL LHWGSHPTAF
210 220 230 240 250
VVSYAAALPA AALWHKLGSL WVPGGQGGSG NPVRRLLGCL GSETRRLSLF
260 270 280 290 300
LVLVVLSSLG EMAIPFFTGR LTDWILQDGS ADTFTRNLTL MSILTIASAV
310 320 330 340 350
LEFVGDGIYN NTMGHVHSHL QGEVFGAVLR QETEFFQQNQ TGNIMSRVTE
360 370 380 390 400
DTSTLSDSLS ENLSLFLWYL VRGLCLLGIM LWGSVSLTMV TLITLPLLFL
410 420 430 440 450
LPKKVGKWYQ LLEVQVRESL AKSSQVAIEA LSAMPTVRSF ANEEGEAQKF
460 470 480 490 500
REKLQEIKTL NQKEAVAYAV NSWTTSISGM LLKVGILYIG GQLVTSGAVS
510 520 530 540 550
SGNLVTFVLY QMQFTQAVEV LLSIYPRVQK AVGSSEKIFE YLDRTPRCPP
560 570 580 590 600
SGLLTPLHLE GLVQFQDVSF AYPNRPDVLV LQGLTFTLRP GEVTALVGPN
610 620 630 640 650
GSGKSTVAAL LQNLYQPTGG QLLLDGKPLP QYEHRYLHRQ VAAVGQEPQV
660 670 680 690 700
FGRSLQENIA YGLTQKPTME EITAAAVKSG AHSFISGLPQ GYDTEVDEAG
710 720 730 740 750
SQLSGGQRQA VALARALIRK PCVLILDDAT SALDANSQLQ VEQLLYESPE
760 770 780 790 800
RYSRSVLLIT QHLSLVEQAD HILFLEGGAI REGGTHQQLM EKKGCYWAMV

QAPADAPE
Length:808
Mass (Da):87,218
Last modified:November 25, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9CA5FF96FADD6A1B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140T9T7A0A140T9T7_HUMAN
Antigen peptide transporter 1
TAP1
808Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0S2Z4R8A0A0S2Z4R8_HUMAN
Antigen peptide transporter 1
TAP1
323Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA47025 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA60785 differs from that shown. Reason: Erroneous initiation.Curated

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

There are five common alleles; TAP1*01:01 (PSF1A), TAP1*02:01 (PSF1B), TAP1*03:01 (PSF1C), TAP1*01:04 and TAP1*x. The sequence of TAP1*01:01 is shown here.5 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01680167P → S1 PublicationCorresponds to variant dbSNP:rs375389015EnsemblClinVar.1
Natural variantiVAR_01680277G → R1 PublicationCorresponds to variant dbSNP:rs57640466EnsemblClinVar.1
Natural variantiVAR_048137170L → V. Corresponds to variant dbSNP:rs2228108EnsemblClinVar.1
Natural variantiVAR_060987304V → L. Corresponds to variant dbSNP:rs36229525EnsemblClinVar.1
Natural variantiVAR_048138346S → F. Corresponds to variant dbSNP:rs2228111EnsemblClinVar.1
Natural variantiVAR_000092393I → V in allele TAP1*02:01, allele TAP1*03:01, allele TAP1*04:01 and allele TAP1*x. 4 PublicationsCorresponds to variant dbSNP:rs1057141EnsemblClinVar.1
Natural variantiVAR_013151430A → V in allele TAP1*x. 2 PublicationsCorresponds to variant dbSNP:rs2127679EnsemblClinVar.1
Natural variantiVAR_016803479G → C1 PublicationCorresponds to variant dbSNP:rs2228110EnsemblClinVar.1
Natural variantiVAR_013152518V → L in allele TAP1*04:01. 3 PublicationsCorresponds to variant dbSNP:rs41550019EnsemblClinVar.1
Natural variantiVAR_013153578V → I in allele TAP1*x. 1 PublicationCorresponds to variant dbSNP:rs41561219EnsemblClinVar.1
Natural variantiVAR_000093697D → G in allele TAP1*02:01, allele TAP1*04:01 and allele TAP1*x. 5 PublicationsCorresponds to variant dbSNP:rs1135216EnsemblClinVar.1
Natural variantiVAR_013154708R → Q in allele TAP1*04:01. 4 PublicationsCorresponds to variant dbSNP:rs1057149EnsemblClinVar.1
Natural variantiVAR_013173719R → Q in a lung cancer cell line deficient in MHC class I presentation. 1 PublicationCorresponds to variant dbSNP:rs121917702EnsemblClinVar.1
Natural variantiVAR_047514768Q → R. Corresponds to variant dbSNP:rs1057149EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X57522 mRNA Translation: CAA40741.1
X66401 Genomic DNA Translation: CAA47025.1 Different initiation.
X87344 Genomic DNA Translation: CAA60785.1 Different initiation.
AL669918 Genomic DNA No translation available.
AL671681 Genomic DNA No translation available.
AL935043 Genomic DNA No translation available.
BX927138 Genomic DNA No translation available.
CR762476 Genomic DNA No translation available.
CR933844 Genomic DNA No translation available.
CR753889 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03647.1
BC014081 mRNA Translation: AAH14081.1
L21204 mRNA Translation: AAC12902.1
L21205 mRNA Translation: AAC12903.1
L21206 mRNA Translation: AAC12904.1
L21207 mRNA Translation: AAC12905.1
L21208 mRNA Translation: AAC12906.1
X57521 mRNA Translation: CAA40740.1
S70274 mRNA Translation: AAD14056.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS4758.1

Protein sequence database of the Protein Information Resource

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PIRi
S13427 A41538

NCBI Reference Sequences

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RefSeqi
NP_000584.2, NM_000593.5
NP_001278951.1, NM_001292022.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.352018
Hs.731555

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000354258; ENSP00000346206; ENSG00000168394
ENST00000383235; ENSP00000372722; ENSG00000206297
ENST00000414467; ENSP00000405356; ENSG00000226173
ENST00000418205; ENSP00000401149; ENSG00000227816
ENST00000424897; ENSP00000413080; ENSG00000230705
ENST00000439781; ENSP00000415660; ENSG00000224212
ENST00000440894; ENSP00000402316; ENSG00000232367

Database of genes from NCBI RefSeq genomes

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GeneIDi
6890

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6890

UCSC genome browser

More...
UCSCi
uc003ocg.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

TAP1base

TAP1 mutation db

ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57522 mRNA Translation: CAA40741.1
X66401 Genomic DNA Translation: CAA47025.1 Different initiation.
X87344 Genomic DNA Translation: CAA60785.1 Different initiation.
AL669918 Genomic DNA No translation available.
AL671681 Genomic DNA No translation available.
AL935043 Genomic DNA No translation available.
BX927138 Genomic DNA No translation available.
CR762476 Genomic DNA No translation available.
CR933844 Genomic DNA No translation available.
CR753889 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03647.1
BC014081 mRNA Translation: AAH14081.1
L21204 mRNA Translation: AAC12902.1
L21205 mRNA Translation: AAC12903.1
L21206 mRNA Translation: AAC12904.1
L21207 mRNA Translation: AAC12905.1
L21208 mRNA Translation: AAC12906.1
X57521 mRNA Translation: CAA40740.1
S70274 mRNA Translation: AAD14056.1
CCDSiCCDS4758.1
PIRiS13427 A41538
RefSeqiNP_000584.2, NM_000593.5
NP_001278951.1, NM_001292022.1
UniGeneiHs.352018
Hs.731555

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JJ7X-ray2.40A549-808[»]
5U1Delectron microscopy3.97A61-808[»]
ProteinModelPortaliQ03518
SMRiQ03518
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112753, 45 interactors
CORUMiQ03518
DIPiDIP-35626N
IntActiQ03518, 53 interactors
MINTiQ03518
STRINGi9606.ENSP00000346206

Chemistry databases

DrugBankiDB01259 Lapatinib

Protein family/group databases

TCDBi3.A.1.209.1 the atp-binding cassette (abc) superfamily

PTM databases

iPTMnetiQ03518
PhosphoSitePlusiQ03518
SwissPalmiQ03518

Polymorphism and mutation databases

BioMutaiTAP1
DMDMi215273957

Proteomic databases

EPDiQ03518
MaxQBiQ03518
PaxDbiQ03518
PeptideAtlasiQ03518
PRIDEiQ03518
ProteomicsDBi58214

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6890
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354258; ENSP00000346206; ENSG00000168394
ENST00000383235; ENSP00000372722; ENSG00000206297
ENST00000414467; ENSP00000405356; ENSG00000226173
ENST00000418205; ENSP00000401149; ENSG00000227816
ENST00000424897; ENSP00000413080; ENSG00000230705
ENST00000439781; ENSP00000415660; ENSG00000224212
ENST00000440894; ENSP00000402316; ENSG00000232367
GeneIDi6890
KEGGihsa:6890
UCSCiuc003ocg.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6890
DisGeNETi6890
EuPathDBiHostDB:ENSG00000168394.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TAP1
HGNCiHGNC:43 TAP1
HPAiCAB009516
HPA072354
MalaCardsiTAP1
MIMi170260 gene
604571 phenotype
neXtProtiNX_Q03518
OpenTargetsiENSG00000168394
Orphaneti34592 Immunodeficiency by defective expression of HLA class 1
PharmGKBiPA35021

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0058 Eukaryota
COG1132 LUCA
GeneTreeiENSGT00940000159023
HOVERGENiHBG008358
InParanoidiQ03518
KOiK05653
OMAiQNQTGAI
OrthoDBiEOG09370VL2
PhylomeDBiQ03518
TreeFamiTF105197

Enzyme and pathway databases

BRENDAi3.6.3.43 2681
ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC
SIGNORiQ03518

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TAP1 human
EvolutionaryTraceiQ03518

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TAP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6890

Protein Ontology

More...
PROi
PR:Q03518

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000168394 Expressed in 206 organ(s), highest expression level in epithelium of bronchus
CleanExiHS_TAP1
ExpressionAtlasiQ03518 baseline and differential
GenevisibleiQ03518 HS

Family and domain databases

Gene3Di1.20.1560.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR013305 ABC_Tap-like
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
IPR013306 Tap1/ABCB2
IPR039421 Type_I_exporter
PANTHERiPTHR24221 PTHR24221, 1 hit
PTHR24221:SF249 PTHR24221:SF249, 1 hit
PfamiView protein in Pfam
PF00664 ABC_membrane, 1 hit
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF90123 SSF90123, 1 hit
TIGRFAMsiTIGR00958 3a01208, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTAP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q03518
Secondary accession number(s): Q16149, Q96CP4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 25, 2008
Last modified: December 5, 2018
This is version 201 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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