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Protein

Secretogranin-2

Gene

Scg2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Secretogranin-2 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.

Miscellaneous

Binds calcium with a low-affinity.

GO - Molecular functioni

  • chemoattractant activity Source: HGNC
  • cytokine activity Source: HGNC

GO - Biological processi

Keywordsi

LigandCalcium

Enzyme and pathway databases

ReactomeiR-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Secretogranin-2
Alternative name(s):
Chromogranin-C
Secretogranin II
Short name:
SgII
Cleaved into the following 2 chains:
Secretoneurin
Short name:
SN
Gene namesi
Name:Scg2
Synonyms:Chgc, Scg-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:103033 Scg2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30By similarityAdd BLAST30
ChainiPRO_000000545531 – 617Secretogranin-2Add BLAST587
PeptideiPRO_0000005456184 – 216SecretoneurinAdd BLAST33
PeptideiPRO_0000432737527 – 566ManserinBy similarityAdd BLAST40

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei153SulfotyrosineBy similarity1
Modified residuei176PhosphoserineBy similarity1
Modified residuei270PhosphoserineBy similarity1
Modified residuei434PhosphoserineBy similarity1
Modified residuei532PhosphoserineCombined sources1
Modified residuei555PhosphoserineCombined sources1
Modified residuei556PhosphoserineCombined sources1

Keywords - PTMi

Cleavage on pair of basic residues, Phosphoprotein, Sulfation

Proteomic databases

MaxQBiQ03517
PaxDbiQ03517
PeptideAtlasiQ03517
PRIDEiQ03517

PTM databases

iPTMnetiQ03517
PhosphoSitePlusiQ03517

Expressioni

Gene expression databases

BgeeiENSMUSG00000050711 Expressed in 177 organ(s), highest expression level in islet of Langerhans
CleanExiMM_SCG2
ExpressionAtlasiQ03517 baseline and differential
GenevisibleiQ03517 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203090, 1 interactor
IntActiQ03517, 1 interactor
MINTiQ03517
STRINGi10090.ENSMUSP00000062556

Structurei

3D structure databases

ProteinModelPortaliQ03517
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFXN Eukaryota
ENOG4111F4G LUCA
GeneTreeiENSGT00390000010895
HOGENOMiHOG000059543
HOVERGENiHBG054148
InParanoidiQ03517
OrthoDBiEOG091G03GC
PhylomeDBiQ03517
TreeFamiTF334018

Family and domain databases

InterProiView protein in InterPro
IPR001990 Granin
IPR038858 ScgII
PANTHERiPTHR15119 PTHR15119, 1 hit
PfamiView protein in Pfam
PF01271 Granin, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q03517-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGAKAYRLG AVLLLIHLIF LISGAEAASF QRNQLLQKEP DLRLENVQKF
60 70 80 90 100
PSPEMIRALE YIEKLRQQAH REESSPDYNP YQGVSVPLQL KENGEESHLA
110 120 130 140 150
ESSRDALSED EWMRIILEAL RQAENEPPSA PKENKPYALN LEKNFPVDTP
160 170 180 190 200
DDYETQQWPE RKLKHMRFPL MYEENSRENP FKRTNEIVEE QYTPQSLATL
210 220 230 240 250
ESVFQELGKL TGPSNQKRER VDEEQKLYTD DEDDVYKTNN IAYEDVVGGE
260 270 280 290 300
DWSPIEEKIE TQTQEEVRDS KENTEKNEQI NEEMKRSGQL GLPDEENRRE
310 320 330 340 350
SKDQLSEDAS KVITYLRRLV NAVGSGRSQS GPNGDRAARL LQKPLDSQSI
360 370 380 390 400
YQLIEISRNL QIPPEDLIEM LKAGEKPNGL VEPEQDLELA VDLDDIPEAD
410 420 430 440 450
LDRPDMFQSK MLSKGGYPKA PGRGMVEALP DGLSVEDILN VLGMENVVNQ
460 470 480 490 500
KSPYFPNQYS QDKALMRLPY GPGKSRANQI PKVAWIPDVE SRQAPYENLN
510 520 530 540 550
DQELGEYLAR MLVKYPELLN TNQLKRVPSP VSSEDDLQEE EQLEQAIKEH
560 570 580 590 600
LGPGSSQEME RLAKVSKRIP VGSLKNEDTP NRQYLDEDML LKVLEYLNQE
610
QAEQGREHLA KRAMENM
Length:617
Mass (Da):70,644
Last modified:October 1, 1993 - v1
Checksum:i42D0D5D5546F4BDD
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q4W8U9Q4W8U9_MOUSE
Scg2 protein
Scg2
577Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti238T → A in BAB22476 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68837 Genomic DNA Translation: CAA48727.1
AK002953 mRNA Translation: BAB22476.2
CCDSiCCDS15089.1
PIRiS27389
RefSeqiNP_033155.1, NM_009129.2
UniGeneiMm.5038

Genome annotation databases

EnsembliENSMUST00000049972; ENSMUSP00000062556; ENSMUSG00000050711
GeneIDi20254
KEGGimmu:20254
UCSCiuc007bqr.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68837 Genomic DNA Translation: CAA48727.1
AK002953 mRNA Translation: BAB22476.2
CCDSiCCDS15089.1
PIRiS27389
RefSeqiNP_033155.1, NM_009129.2
UniGeneiMm.5038

3D structure databases

ProteinModelPortaliQ03517
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203090, 1 interactor
IntActiQ03517, 1 interactor
MINTiQ03517
STRINGi10090.ENSMUSP00000062556

PTM databases

iPTMnetiQ03517
PhosphoSitePlusiQ03517

Proteomic databases

MaxQBiQ03517
PaxDbiQ03517
PeptideAtlasiQ03517
PRIDEiQ03517

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049972; ENSMUSP00000062556; ENSMUSG00000050711
GeneIDi20254
KEGGimmu:20254
UCSCiuc007bqr.1 mouse

Organism-specific databases

CTDi7857
MGIiMGI:103033 Scg2

Phylogenomic databases

eggNOGiENOG410IFXN Eukaryota
ENOG4111F4G LUCA
GeneTreeiENSGT00390000010895
HOGENOMiHOG000059543
HOVERGENiHBG054148
InParanoidiQ03517
OrthoDBiEOG091G03GC
PhylomeDBiQ03517
TreeFamiTF334018

Enzyme and pathway databases

ReactomeiR-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Miscellaneous databases

ChiTaRSiScg2 mouse
PROiPR:Q03517
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050711 Expressed in 177 organ(s), highest expression level in islet of Langerhans
CleanExiMM_SCG2
ExpressionAtlasiQ03517 baseline and differential
GenevisibleiQ03517 MM

Family and domain databases

InterProiView protein in InterPro
IPR001990 Granin
IPR038858 ScgII
PANTHERiPTHR15119 PTHR15119, 1 hit
PfamiView protein in Pfam
PF01271 Granin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSCG2_MOUSE
AccessioniPrimary (citable) accession number: Q03517
Secondary accession number(s): Q80Y79, Q9CW80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 7, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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