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Protein

Alanine racemase

Gene

alr

Organism
Lactobacillus paracasei (strain ATCC 334 / BCRC 17002 / CIP 107868 / KCTC 3260 / NRRL B-441)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei40Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei140SubstrateUniRule annotation1
Active sitei270Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei317Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alr
Ordered Locus Names:LSEI_2560
OrganismiLactobacillus paracasei (strain ATCC 334 / BCRC 17002 / CIP 107868 / KCTC 3260 / NRRL B-441)
Taxonomic identifieri321967 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000001651 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000659971 – 378Alanine racemaseAdd BLAST378

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei40N6-(pyridoxal phosphate)lysineUniRule annotation1

Structurei

3D structure databases

ProteinModelPortaliQ034T9
SMRiQ034T9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031444
KOiK01775
OMAiWEILCGF

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q034T9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIGNFRPAT VLIDETAILH NIQHEVARLK KQTQLFAVVK ADAYGHGMLR
60 70 80 90 100
VARVAKAAGA TGFCVAILDE ALGLRKADYS EPVLVLGIVP SQYAAIAAAQ
110 120 130 140 150
TISLPVSSTE WLEQALPVLE AQPELPPLRI HLALDTGMGR IGFTEDQALK
160 170 180 190 200
TAVAFVEAHP KQFVIEGVFT HFATADAPDD TYFKQQVDKF NHLVNLLPSR
210 220 230 240 250
PRYVHVSNSA TSLWHAACNG NMIRYGVAIY GLNPSGDAIP TTPFPLEPAL
260 270 280 290 300
SLKSELTYCK QVHAGDGISY GVTYRAKGDE FIGTVPIGYA DGWLRRLQGF
310 320 330 340 350
HVLVDGQYCE IVGRICMDQF MIRLPKAYPA GTKVVLVGQS GDQEITLLDV
360 370
AKYSKTIHYE IACNLTPRLK RQSVNPVD
Length:378
Mass (Da):41,299
Last modified:November 14, 2006 - v1
Checksum:iC2E578C32939F7CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000423 Genomic DNA Translation: ABJ71283.1
RefSeqiWP_003596242.1, NC_008526.1
YP_807725.1, NC_008526.1

Genome annotation databases

EnsemblBacteriaiABJ71283; ABJ71283; LSEI_2560
GeneIDi4418820
KEGGilca:LSEI_2560
PATRICifig|321967.11.peg.2501

Similar proteinsi

Entry informationi

Entry nameiALR_LACP3
AccessioniPrimary (citable) accession number: Q034T9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 14, 2006
Last modified: February 28, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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