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Protein

tRNA (cytidine(32)-2'-O)-methyltransferase non-catalytic subunit TRM732

Gene

TRM732

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required together with TRM7 for the methylation of the 2'-O-ribose of cytidine at position 32 of the tRNA anticodon loop of tRNA(Phe) and tRNA(Leu(UAA)).1 Publication

Miscellaneous

Present with 7110 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • tRNA methylation Source: SGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processtRNA processing

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-32934-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
tRNA (cytidine(32)-2'-O)-methyltransferase non-catalytic subunit TRM732
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRM732
Ordered Locus Names:YMR259C
ORF Names:YM8156.01C, YM9920.13C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XIII

Organism-specific databases

Saccharomyces Genome Database

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SGDi
S000004872 TRM732

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002033431 – 1420tRNA (cytidine(32)-2'-O)-methyltransferase non-catalytic subunit TRM732Add BLAST1420

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
Q03496

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q03496

PRoteomics IDEntifications database

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PRIDEi
Q03496

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q03496

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TRM7; for 2'-O-methylation of cytidine 32 in substrate tRNAs.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
35437, 30 interactors

Molecular INTeraction database

More...
MINTi
Q03496

STRING: functional protein association networks

More...
STRINGi
4932.YMR259C

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q03496

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015500

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000142020

Identification of Orthologs from Complete Genome Data

More...
OMAi
IRHSGAF

Database of Orthologous Groups

More...
OrthoDBi
EOG092C0PDA

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR019442 DUF2428_death-receptor-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10350 DUF2428, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q03496-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTDVQFSSQ EIELFRVKEF LIANNPAKIN NENKDAVLTQ IEHDFRYLIQ
60 70 80 90 100
YIKDGLPNLN ESTRLIFPDT FSICLLRSHQ IIASKKIDSQ EFLSAVKEQL
110 120 130 140 150
LTEANANIIF EYVLDFWADG GAPLMNALRD LFSKLLNLLK ITYPMSTLKD
160 170 180 190 200
VLFNWMNEIL EVPSTLRVQY YLIDALSSDF DLYYIIEKKP HFIDNSFSLM
210 220 230 240 250
NSDLLANSVG KCIVSLLLNI YEKHFKKNES FVQEWIQLWK SCALKYIHDK
260 270 280 290 300
QYTKSINLYI MIPLFKNMPN SAFTLFLECM SNKDPSLLLS LLKIGQELGI
310 320 330 340 350
EEEPFCDNKY TTVDSVNKLI EQDEYKLQVF EILTFSTKKS KPIRPFVFKT
360 370 380 390 400
IKQYLYVFFV DTELERRNYF CSSMKHFIFR TRDCAYSLAR DARKLKKAEK
410 420 430 440 450
FPDEQREKLA QVEEARAFLV WLCNFIKYNL APGTLYQANV TSLKLMHILI
460 470 480 490 500
KSGVDKSTPQ KFLDNQNKRE YPFSIPILQD VTFLRLLIDL LVSNYADVRE
510 520 530 540 550
LSKEMLFIMI SADESRGLFL DTLDANALKW TATSLLSDYE KGDAGATVYE
560 570 580 590 600
FIFTVMGSQR SFIDQTIDIL AQMVQNLQND SIGCAENSIG PHFAALSLIL
610 620 630 640 650
NKFNSEENHQ DTSKIISKLI NLVLKSWEAT RNVVCHDSAH GILPEKYANC
660 670 680 690 700
GVPDQVIISH AFRAIKEASY LLETILKKYP LTRDQLDSIG DLFIVQLSTI
710 720 730 740 750
RHSGAFQAVL PGLKAFCIRC QLEFPAILEE LLSKSVKSLK SKTQHITRRS
760 770 780 790 800
GGLPFLVTTV LSAEVTKGRP LLQKTFENLL LVARLPIPPH QDEFDLPQVN
810 820 830 840 850
AINCINAIFV EPKLSVHCTS FVSEALELAL LNFDCDIWAL RNCSIMLFTS
860 870 880 890 900
LQNRIFGKVG RSVSAKLFFT KYSGLRQLLL NILNSSIAQY SGSERKSYQI
910 920 930 940 950
ESIFLVLNVL LRLRPTAGYT GLKEFNVSVY ECLSNENWKI RDMASRVLHM
960 970 980 990 1000
LSENFEEEIR KLLDLASIAK QNQLHGHLLA LQQLVPQYLS GTRDMELIQR
1010 1020 1030 1040 1050
ILEKKRMLLL ENKCFITKKA YLKLTCCILE TCDIPDSILK DYISTLRNTF
1060 1070 1080 1090 1100
IAENNEYVVD GSKQLYLAQI LDMLLKYEDS IYLDDICLLG LYSPFYEAQL
1110 1120 1130 1140 1150
STLQYMNTNF HWETTRNSEF LEQLQLLLRV PDLLPMAKAL VVKILSRKKN
1160 1170 1180 1190 1200
TLSLTTCTDL LKTNNSEDTK LAAVSSLSAK LSSQTFHQVW NLLQGFFADS
1210 1220 1230 1240 1250
CSKDFRLASL ECLTAYPESC KNSRILLQLY NFLWDDDSEI REKASFYLNK
1260 1270 1280 1290 1300
NFIQTADWEY NRNTSVTALI FTKKFVDVFT SSEVVEELCL QLFQYLNEYD
1310 1320 1330 1340 1350
MFAAEESAKN CLFTIEKDNQ FINELQKAMH ILNMIKLTGR DISKCYKDQI
1360 1370 1380 1390 1400
HHLKSALLEH FNTEDFKDSP LGWCSNAEIF SRITLLKELI QHYSPSDYEN
1410 1420
FINVLTKHSV HPLIISYSQL
Length:1,420
Mass (Da):163,577
Last modified:November 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAFBB0CF83CBB169D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z49260 Genomic DNA Translation: CAA89242.1
Z48639 Genomic DNA Translation: CAA88586.1
BK006946 Genomic DNA Translation: DAA10159.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S54471

NCBI Reference Sequences

More...
RefSeqi
NP_013986.1, NM_001182766.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YMR259C_mRNA; YMR259C_mRNA; YMR259C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
855301

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YMR259C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49260 Genomic DNA Translation: CAA89242.1
Z48639 Genomic DNA Translation: CAA88586.1
BK006946 Genomic DNA Translation: DAA10159.1
PIRiS54471
RefSeqiNP_013986.1, NM_001182766.1

3D structure databases

ProteinModelPortaliQ03496
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35437, 30 interactors
MINTiQ03496
STRINGi4932.YMR259C

PTM databases

iPTMnetiQ03496

Proteomic databases

MaxQBiQ03496
PaxDbiQ03496
PRIDEiQ03496

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR259C_mRNA; YMR259C_mRNA; YMR259C
GeneIDi855301
KEGGisce:YMR259C

Organism-specific databases

SGDiS000004872 TRM732

Phylogenomic databases

GeneTreeiENSGT00390000015500
HOGENOMiHOG000142020
OMAiIRHSGAF
OrthoDBiEOG092C0PDA

Enzyme and pathway databases

BioCyciYEAST:G3O-32934-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q03496

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR019442 DUF2428_death-receptor-like
PfamiView protein in Pfam
PF10350 DUF2428, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTR732_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q03496
Secondary accession number(s): D6W085, Q04862
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: December 5, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names
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